Abstract:
AIM:To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS:Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 men and 288 women had type 2 diabetes and were treated by glucose-lowering drugs. RESULTS:Overall, 31% were treated only with insulin, 28% with combinations of insulin and another drug, 42% with non-insulin glucose-lowering drugs. In CKD stage 3, 40% of patients used metformin, 12% at stages 4&5, similar for men and women; in CKD stage 3, 53% used insulin, similar for men and women, but at stages 4&5, 59% of men and 77% of women used insulin. Patients were reasonably well controlled, with a median HbA1c of 7.1% (54mmol/mol) in men, 7.4% (57mmol/mol) in women (P=0.0003). Hypoglycaemic symptoms were reported by 40% of men and 59% of women; they were not associated with the estimated glomerular filtration rate, nor with albuminuria or with HbA1c in multivariable analyses, but they were more frequent in people treated with insulin, particularly with fast-acting and pre-mixed insulins. CONCLUSION:Glucose-lowering treatment, HbA1c and hypoglycaemic symptoms were sex dependent. Metformin use was similar in men and women, but unexpectedly low in CKD stage 3; its use could be encouraged rather than resorting to insulin. Hypoglycaemic symptoms were frequent and need to be more closely monitored, with appropriate patient-education, especially in women.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Balkau B,Metzger M,Andreelli F,Frimat L,Speyer E,Combe C,Laville M,Jacquelinet C,Briançon S,Ayav C,Massy Z,Pisoni RL,Stengel B,Fouque Ddoi
10.1016/j.diabet.2018.03.007subject
Has Abstractpub_date
2019-04-01 00:00:00pages
175-183issue
2eissn
1262-3636issn
1878-1780pii
S1262-3636(18)30076-4journal_volume
45pub_type
杂志文章abstract:OBJECTIVES:The aim of the present study was to investigate insulin secretion, insulin-receptor binding and peripheral insulin sensitivity in subjects with different degrees of obesity. METHODS:36 obese subjects with normal glucose tolerance and different degrees of obesity and 40 healthy normal-weight subjects partici...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
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abstract:OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...
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journal_title:Diabetes & metabolism
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abstract:AIM:This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS:Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. The...
journal_title:Diabetes & metabolism
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abstract::Diabetes Mellitus frankly increases the prevalence of sexual problems in men, mainly in the form of erectile dysfunctions. Its effects on sexual function of the diabetic women have been less objectively studied, due to cultural reasons and methodological difficulties. The different phases of the sexual cycle, as well ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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journal_title:Diabetes & metabolism
pub_type: 历史文章,杂志文章,评审
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更新日期:2003-04-01 00:00:00
abstract::Remittent isolated palsy of peripheral or of upper cranial nerves in diabetic patients is well documented, but paralysis of a lower cranial nerve or an isolated branch of any cranial nerve has rarely been reported. In the case described, besides temporary hypoglossal and facial nerve palsies previously, unilateral tem...
journal_title:Diabetes & metabolism
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更新日期:2002-11-01 00:00:00
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
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更新日期:1998-04-01 00:00:00
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
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更新日期:2007-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-04-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Diabetes & metabolism
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更新日期:2012-11-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2017.09.001
更新日期:2018-03-01 00:00:00
abstract::A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
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更新日期:2021-01-23 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2010.12.008
更新日期:2011-11-01 00:00:00