当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial.

Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial.

Abstract：

AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500mg/day) or placebo for 90 days. Losartan (12.5mg/day) was also administered to all participants. Primary outcomes were urinary albumin/creatinine ratio, estimated glomerular filtration rate (eGFR) and serum creatinine levels. Secondary outcomes were oxidative stress markers, and anthropometric and biochemical measures. RESULTS:Mean urine albumin/creatinine ratio was significantly reduced in the resveratrol group vs placebo (-46.4mg/g, 95% CI: -64.5 to -28.3 vs 29.9mg/g, 95% CI: 4.9 to 54.9; P<0.001), whereas eGFR (1.7mL/min/1.73m2, 95% CI: -3.4 to 6.8 vs -4.0, 95% CI: -8.2 to 0.2; P=0.08) and serum creatinine (-0.3mg/dL, 95% CI: -0.1 to 0.1 vs 0.1mg/dL, 95% CI: -0.0 to 0.1; P=0.13) were unchanged. Serum antioxidant enzymes were significantly increased with resveratrol. After adjusting for confounding variables, the effect of resveratrol in reducing urinary albumin excretion was still significant (P<0.001). Regression analysis revealed that every 1-cm decrease in waist circumference and 1-μmol/L increase in nitric oxide (NO) was associated with 9.4mg/g and 4.0mg/g reductions, respectively, of urine albumin/creatinine ratio. CONCLUSION:This clinical trial has shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN (ClinicalTrials.gov: NCT02704494).

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Sattarinezhad A,Roozbeh J,Shirazi Yeganeh B,Omrani GR,Shams M

doi

10.1016/j.diabet.2018.05.010

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

53-59

issue

1

eissn

1262-3636

issn

1878-1780

pii

S1262-3636(18)30114-9

journal_volume

45

pub_type

杂志文章,随机对照试验

相关文献

DIABETES & METABOLISM文献大全
  • Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

    abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)73399-8

    authors： Penfornis A,Borot S,Raccah D

    更新日期：2008-02-01 00:00:00

  • OPHDIAT: a telemedical network screening system for diabetic retinopathy in the Ile-de-France.

    abstract：OBJECTIVE:International and national guidelines recommend an annual funduscopic examination for all diabetic patients, but such annual fundus examinations are not sufficiently performed in France. Non-mydriatic fundus photography is a valid method of evaluation for diabetic retinopathy (DR) and a viable alternative to ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.12.006

    authors： Massin P,Chabouis A,Erginay A,Viens-Bitker C,Lecleire-Collet A,Meas T,Guillausseau PJ,Choupot G,André B,Denormandie P

    更新日期：2008-06-01 00:00:00

  • OPHDIAT: quality-assurance programme plan and performance of the network.

    abstract：AIMS:There is a need for evaluation of screening and grading services for diabetic retinopathy (DR) in compliance with quality-assurance (QA) standards. We describe the screening/grading QA programme set up for OPHDIAT over the 2005-2006 period. METHODS:Screening and grading objectives, evaluation criteria and minimum...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2008.01.004

    authors： Erginay A,Chabouis A,Viens-Bitker C,Robert N,Lecleire-Collet A,Massin P

    更新日期：2008-06-01 00:00:00

  • Parent-child physical activity relationships in 12-year old French students do not depend on family socioeconomic status.

    abstract：OBJECTIVES:Regular physical activity (PA) in young needs to be promoted to prevent obesity and subsequent diabetes. Influences of parental PA on adolescents' activity level have been studied with discordant results and the effect of socioeconomic status (SES) on these relationships is not clarified. METHODS:Cross-sect...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70129-5

    authors： Wagner A,Klein-Platat C,Arveiler D,Haan MC,Schlienger JL,Simon C

    更新日期：2004-09-01 00:00:00

  • Diabetes-related metabolic perturbations in cardiac myocyte.

    abstract：:Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)70096-X

    authors： Feuvray D,Darmellah A

    更新日期：2008-02-01 00:00:00

  • Muscle infarction in a young woman with brittle type 1 diabetes.

    abstract：:We present the first case of muscle infarction in a 30-year-old woman who had a 5-year history of type 1 diabetes mellitus that was not complicated by nephropathy, retinopathy or neuropathy. All common causes of muscle infarction were excluded, particularly microangiopathy and a hypercoagulable state. The differential...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.06.003

    authors： Virally M,Laloi-Michelin M,Médeau V,Meas T,Kévorkian JP,Mouly S,Guillausseau PJ

    更新日期：2007-12-01 00:00:00

  • Pancreas transplantation: results and indications.

    abstract：:Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Dubernard JM,Tajra LC,Lefrançois N,Dawahra M,Martin C,Thivolet C,Martin X

    更新日期：1998-06-01 00:00:00

  • Hypoglycaemic episodes in patients with type 2 diabetes--risk factors and associations with patient-reported outcomes: The PANORAMA Study.

    abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2015.08.007

    authors： Simon D,de Pablos-Velasco P,Parhofer KG,Gönder-Frederick L,Duprat Lomon I,Vandenberghe H,Eschwège E,Bradley C

    更新日期：2015-12-01 00:00:00

  • Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract：AIM:Determine whether plasma omega-7 vaccenic acid and palmitoleic acid levels are related to homeostasis model of insulin resistance scores and incident type II diabetes, and whether race/ethnicity modifies these associations. METHODS:Plasma phospholipid fatty acids were measured by gas chromatography with flame-ioni...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2019.10.005

    authors： Weir NL,Steffen BT,Guan W,Johnson LM,Djousse L,Mukamal KJ,Tsai MY

    更新日期：2020-09-01 00:00:00

  • Interest of pronostic score for optimal clinical management of obese patients.

    abstract：OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70053-8

    authors： Ybarra J,de Stefano M,Kammer A,de Tonnac N,Lehmann T,Golay A

    更新日期：2003-09-01 00:00:00

  • Screening for gestational diabetes in the Lombardy region: A population-based study.

    abstract：AIM:As the treatment of hyperglycaemia during pregnancy with diet or insulin reduces the risk of adverse maternal outcomes and perinatal complications, screening for gestational diabetes mellitus (GDM) is included, albeit to variable extents, in all guidelines of care for pregnant women. The aim of the present investig...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.11.008

    authors： Nicotra F,Molinari C,Dozio N,Castiglioni MT,Ibrahim B,Zambon A,Corrao G,Scavini M

    更新日期：2015-09-01 00:00:00

  • Trends from 1995 to 2006 in the prevalence of self-reported cardiovascular risk factors among elderly Spanish diabetics.

    abstract：AIM:In this study, we examined the trends from 1995 to 2006 in cardiovascular risk factors (CVRF) in Spaniards aged 65 years or older with diabetes. METHODS:We looked at the individual data from adults aged > or =65 years from the Spanish National Health Surveys of 1995 (n=1117), 1997 (n=1111), 2001 (n=4328), 2003 (n=...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.06.007

    authors： Jiménez Trujillo I,Jiménez García R,Vazquez-Fernandez del Pozo S,Hernández Barrera V,Carrasco Garrido P,Suarez P,Gil de Miguel A

    更新日期：2010-02-01 00:00:00

  • Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study.

    abstract：AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2020.02.002

    authors： Hanssen NMJ,Scheijen JLJM,Houben AJHM,van de Waarenburg M,Berendschot TTJM,Webers CAB,Reesink KD,van Greevenbroek MMJ,van der Kallen C,Schaper NC,Schram MT,Henry RMA,Stehouwer CDA,Schalkwijk CG

    更新日期：2020-02-10 00:00:00

  • Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.

    abstract：OBJECTIVE:Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The pre...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2011.02.003

    authors： Horvatovich K,Bokor S,Polgar N,Kisfali P,Hadarits F,Jaromi L,Csongei V,Repasy J,Molnar D,Melegh B

    更新日期：2011-11-01 00:00:00

  • Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method?

    abstract：AIM:The objective of the study was to examine the correlation between three methods of measuring insulin sensitivity (IS) - namely, the frequently sampled intravenous glucose tolerance test (FSIVGTT), indices derived from the oral glucose tolerance test (OGTT) and fasting indices (HOMA-IR, QUICKI, fasting insulin [INS(...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.diabet.2010.06.008

    authors： Henderson M,Rabasa-Lhoret R,Bastard JP,Chiasson JL,Baillargeon JP,Hanley JA,Lambert M

    更新日期：2011-02-01 00:00:00

  • Evidence of non-inert material in needles and cartridges following a single insulin injection with a pen.

    abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Le Floch JP,Herbreteau C,Lange F,Perlemuter L

    更新日期：1997-06-01 00:00:00

  • Insulin-dependent diabetes and human leucocyte antigens.

    abstract：:The association of diabetes with HLA class I alleles in the early 1970s and with HLA class II alleles in the late 1970s provided a crucial, though indirect, indication of the role of immune phenomena in the development of insulin-dependent diabetes mellitus (IDDM). Genotyping of HLA alleles in the mid-1980s opened up ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Boitard C,Caillat-Zucman S,Timsit J

    更新日期：1997-03-01 00:00:00

  • Incretins: what is known, new and controversial in 2013?

    abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.02.005

    authors： Burcelin R,Thorens B,European Club for the study of GLP-1 (EuCSGLP-1).

    更新日期：2013-04-01 00:00:00

  • Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

    abstract：:ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(07)70311-7

    authors： Flechtner I,de Lonlay P,Polak M

    更新日期：2006-12-01 00:00:00

  • The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women.

    abstract：BACKGROUND:NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. In this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects....

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70237-9

    authors： Oliveira CS,Hauache OM,Vieira JG,Maciel RM,Sjöroos M,Canani LH,Velho G,Gross JL,Reis AF

    更新日期：2005-12-01 00:00:00

  • Family history of diabetes is associated with enhanced adipose lipolysis: Evidence for the implication of epigenetic factors.

    abstract：AIMS:Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS:Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fa...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2017.10.010

    authors： Dahlman I,Ryden M,Arner P

    更新日期：2018-03-01 00:00:00

  • Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ.

    abstract：:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.02.012

    authors： Castell AL,Hiéronimus S,Lascols O,Fournier T,Fénichel P

    更新日期：2012-10-01 00:00:00

  • Bariatric surgery in young massively obese diabetic patients.

    abstract：:Obesity is the most important lifestyle-related risk factor for type 2 diabetes (T2DM). The prevalence of T2DM in adolescents is increasing in parallel with the increasing incidence of major obesity. In adult obese subjects, the greatest degree of T2DM prevention, improvement or recovery has been reported in patients ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(09)73462-7

    authors： Ciangura C,Basdevant A

    更新日期：2009-12-01 00:00:00

  • Adiponectin is expressed in the pancreas of high-fat-diet-fed mice and protects pancreatic endothelial function during the development of type 2 diabetes.

    abstract：AIM:Adiponectin levels in skeletal muscle and adipose tissue have been reported to be involved in insulin resistance in rats fed with a high-fat diet (HFD). Our objective was to explore whether adiponectin is also expressed in the pancreas and what its potential role is during the development of type 2 diabetes (T2D) i...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.05.004

    authors： Liu XX,Liu KY,Li P,Han S,Peng XD,Shen L

    更新日期：2014-11-01 00:00:00

  • The metabolic syndrome in smokers. The D.E.S.I.R. study.

    abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s1262-3636(07)70031-9

    authors： Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

    更新日期：2003-06-01 00:00:00

  • The association of type 2 diabetes and insulin resistance/secretion with persistent organic pollutants in two First Nations communities in northern Ontario.

    abstract：AIMS:Recent evidence suggests an association between persistent organic pollutants (POPs) and type 2 diabetes. In two First Nations communities where wild food is consumed by a large portion of the population, we compared pollutants in plasma between diabetic and non-diabetic individuals, and investigated the strength ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.01.006

    authors： Pal S,Blais JM,Robidoux MA,Haman F,Krümmel E,Seabert TA,Imbeault P

    更新日期：2013-12-01 00:00:00

  • Metabolic factors and the foveal avascular zone of the retina in diabetes mellitus.

    abstract：AIM:To study the foveal avascular zone (FAZ) of the central retina in diabetic patients with retinopathy having undergone metabolic evaluation. METHODS:One hundred and ten digital fluorescein angiograms were chosen from our digital image bank after cross matching diabetic patient lists of the ophthalmology and endocri...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70217-3

    authors： Conrath J,Giorgi R,Ridings B,Raccah D

    更新日期：2005-11-01 00:00:00

  • Bone density and markers of bone remodeling in type 1 male diabetic patients.

    abstract：AIMS:To assess the prevalence and severity of bone disease in type 1 diabetic patients and to determine serum markers of bone remodeling as well as their relationship with bone mineral density (BMD). METHODS:BMD [by dual energy x-ray absorptiometry (DXA)] and serum markers of bone remodeling [osteocalcin, c-terminal t...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70303-8

    authors： Alexopoulou O,Jamart J,Devogelaer JP,Brichard S,de Nayer P,Buysschaert M

    更新日期：2006-11-01 00:00:00

  • Relation of C-reactive protein to features of the metabolic syndrome in normal glucose tolerant, impaired glucose tolerant, and newly diagnosed type 2 diabetic subjects.

    abstract：OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70009-5

    authors： Guerrero-Romero F,Rodríguez-Morán M

    更新日期：2003-02-01 00:00:00

  • Short-term intensive insulin therapy in insulin-requiring diabetes: effectiveness and factors predicting success.

    abstract：:Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Meyer L,Grulet H,Guerci B,Gross A,Durlach V,Leutenegger M

    更新日期：1997-02-01 00:00:00