Abstract：
:Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. Over the last 10years, it has also become increasingly evident that NAFLD is a multisystem disease, affecting many extra-hepatic organ systems and interacting with the regulation of multiple metabolic pathways. NAFLD is potentially involved in the aetiology and pathogenesis of type 2 diabetes via its direct contribution to hepatic/peripheral insulin resistance and the systemic release of multiple hepatokines that may adversely affect glucose metabolism and insulin action. In this updated review, we discuss the rapidly expanding body of clinical and epidemiological evidence that supports a strong link between NAFLD and the risk of developing type 2 diabetes. We also briefly examine the conventional and the more innovative pharmacological approaches for the treatment of NAFLD that may influence the risk of developing type 2 diabetes.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Targher G,Marchesini G,Byrne CDdoi
10.1016/j.diabet.2016.04.002subject
Has Abstractpub_date
2016-06-01 00:00:00pages
142-56issue
3eissn
1262-3636issn
1878-1780pii
S1262-3636(16)30394-9journal_volume
42pub_type
杂志文章,评审abstract：AIM:This study evaluated the proportions of prandial (PHG) vs fasting hyperglycaemia (FHG) over 24h in a group of patients with type 2 diabetes (overall and for Caucasian vs Asian patients), and tested the hypothesis that an insulin regimen with a prandial component allows a greater response than basal insulin at low g...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2015.03.002
更新日期：2015-06-01 00:00:00
abstract：AIM:Cardiovascular autonomic neuropathy (CAN) is a common but often overlooked complication of diabetes. Sympathetic C-fibers innervating sweat glands can be impaired early on in patients with diabetes. In this study, SUDOSCAN, a new non-invasive device that assesses sudomotor function was compared to methods generally...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2012.09.004
更新日期：2013-04-01 00:00:00
abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels b...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(17)30071-X
更新日期：2017-04-01 00:00:00
abstract：AIM:Adiponectin is the most abundant adipokine and may play a key role in the interplay between obesity, inflammation, insulin resistance and the metabolic syndrome (MetS). Thus, this large population-based cohort investigated whether adiponectin at baseline and/or a decrease in adiponectin during follow-up is associat...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.07.027
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2019.01.012
更新日期：2019-10-01 00:00:00
abstract：AIM:To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D). METHODS:From 2009 to 2012, outpatients with T2D, aged>18 years, were enrolled from a medical centre. FPG was measured ev...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.09.001
更新日期：2018-03-01 00:00:00
abstract：:One major discovery of the last decade in the field of metabolic diseases is that the microorganisms comprising the gut microbiota are now considered a metabolic "organ", modulating multiple functions of the host, such as intestinal immune system maturation, adiposity, cardiac metabolism, liver triglyceride storage, a...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2013.12.004
更新日期：2014-06-01 00:00:00
abstract：:Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...
journal_title：Diabetes & metabolism
pub_type： 指南,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70250-1
更新日期：2006-02-01 00:00:00
abstract：:Prevalence of non-alcoholic steatohepatitis (NASH) rises steadily in Western countries with the obesity epidemic. NASH is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. The cannabinoid system is increasingly emerging as a crucial mediator of acute and chro...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/S1262-3636(08)74604-4
更新日期：2008-12-01 00:00:00
abstract：AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.02.002
更新日期：2020-02-10 00:00:00
abstract：:Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin, empagliflozin) are new glucose-lowering agents that exert their therapeutic activity independently of insulin by facilitating glucose excretion through the kidneys. However, this simple renal mechanism that results in sustained gluc...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(14)72689-8
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:We hypothesized that molecules active in vascular remodeling (i.e. MMPs and their TIMPs) could be modified in diabetic patients, as indirect markers of the diabetes related generalized abnormality of vascular activity. To test this hypothesis, we measured the plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabet.2006.11.008
更新日期：2007-04-01 00:00:00
abstract：:Bariatric surgery can be proposed to address severe obesity associated with comorbid conditions, when medical treatment has failed. Three surgical techniques are currently available, including 2 using coelioscopy. Short term results are encouraging regarding weight loss, which is linked with a reduction in comorbid co...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：AIMS:Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS:Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fa...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.10.010
更新日期：2018-03-01 00:00:00
abstract：:We report the case of a young insulin-dependent diabetic patient in whom acute renal failure led to detection of ureterohydronephrosis secondary to neurogenic bladder. The persistence of a high daily urine volume revealed diabetes insipidus, suggesting Wolfram syndrome, which was confirmed by the diagnosis of optic at...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Remittent isolated palsy of peripheral or of upper cranial nerves in diabetic patients is well documented, but paralysis of a lower cranial nerve or an isolated branch of any cranial nerve has rarely been reported. In the case described, besides temporary hypoglossal and facial nerve palsies previously, unilateral tem...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：AIM:The clinical guidelines reported by the French-Speaking Diabetes Society (Société francophone du diabète) include updated recommendations for preconceptual planning and care in the management of pregnancy in women with type 1 diabetes mellitus (T1DM). METHODS:The working group included diabetologists, as well as a...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,实务指引
doi：10.1016/j.diabet.2012.02.010
更新日期：2012-06-01 00:00:00
abstract：AIM:To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS:Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 me...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2018.03.007
更新日期：2019-04-01 00:00:00
abstract：:Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabet.2016.05.008
更新日期：2017-02-01 00:00:00
abstract：:Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(08)70096-X
更新日期：2008-02-01 00:00:00
abstract：AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patien...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2018.05.010
更新日期：2019-01-01 00:00:00
abstract：AIM:Previous studies have reported inconsistent results regarding the association between metformin use and clinical outcomes in diabetes mellitus (DM) patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the association between metformin use and clinical outcomes in DM patients with COVID-19...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.10.006
更新日期：2020-11-04 00:00:00
abstract：:With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality. New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation, and is a strong predictor of graft failure and c...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2010.09.003
更新日期：2011-02-01 00:00:00
abstract：:Diabetic muscle infarction is a rare complication of diabetes mellitus. However, idiopathic compartment syndrome in the diabetic patient is even a rarer disease, which has been reported only in three cases up to date. The disease seems to occur in patients affected by type 1 diabetes mellitus with a history of poorly ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:Automated closed-loop (CL) insulin therapy has come of age. This major technological advance is expected to significantly improve the quality of care for adults, adolescents and children with type 1 diabetes. To improve access to this innovation for both patients and healthcare professionals (HCPs), and to promote adh...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.10.004
更新日期：2020-11-02 00:00:00
abstract：:It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.01.005
更新日期：2007-09-01 00:00:00
abstract：AIMS:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS:Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2)...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.12.002
更新日期：2017-06-01 00:00:00
abstract：:This report concerns the incidence rate of insulin-dependent diabetes mellitus (IDDM) in the 0-14 year age group in Benghazi, Libya. Incidence data are based on prospective registration of patients as part of the WHO Diamond Project from 1991 to 1995. A total of 126 IDDM incident cases (73 girls, 53 boys) were identif...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
