Abstract：
AIM:To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D). METHODS:From 2009 to 2012, outpatients with T2D, aged>18 years, were enrolled from a medical centre. FPG was measured every 3 months for 2 years in 3569 people. For each of the eight 3-month intervals, FPG variability and means were calculated, with variability defined as the coefficient of variation of FPG. Also, trajectories of FPG variability and means were determined separately, using group-based trajectory analysis with latent class growth models. These models were fitted using the SAS Proc Traj procedure. The primary outcome was all-cause mortality, which was followed-up to the end of 2014. RESULTS:Five distinct trajectories of FPG variability (low, increasing, fluctuating, decreasing and high) and means (well controlled, stable control, worsening control, improving control and poor control) were established. The five trajectories of mean FPG were all associated with the same mortality risk. In contrast, in comparison to the low FPG variability trajectory, the fluctuating, decreasing and high variability trajectories all had significantly higher risks of mortality, with respective hazards ratios of 2.63 (95% CI: 1.40-4.93; P=0.003), 2.78 (95% CI: 1.33-5.80; P=0.007) and 4.44 (95% CI: 1.78-11.06; P=0.001) after multivariable adjustment. CONCLUSION:Changes in FPG variability were independently associated with increased mortality risk in patients with T2D.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Lee CL,Sheu WH,Lee IT,Lin SY,Liang WM,Wang JS,Li YFdoi
10.1016/j.diabet.2017.09.001subject
Has Abstractpub_date
2018-03-01 00:00:00pages
121-128issue
2eissn
1262-3636issn
1878-1780pii
S1262-3636(17)30512-8journal_volume
44pub_type
杂志文章abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.02.005
更新日期：2013-04-01 00:00:00
abstract：:The effect of propranolol on the occurrence of hypoglycaemic symptoms was assessed in insulin-dependent diabetic patients with hypoglycaemia unawareness. A double-blind, randomised parallel group study (2:1 fashion) was conducted over 4-week period. The propranolol group (n = 9) received 20 mg (week 1 and 2) and 30 mg...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-03-01 00:00:00
abstract：:Although diabetes is a classical risk factor for macroangiopathy, the prevalence of renal artery stenosis (RAS) in this type of pathology has not been clearly determined. More than 50% of RAS occur in diabetic patients (almost exclusively Type 2), whereas autopsy findings and the few clinical surveys reported indicate...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2021.101233
更新日期：2021-01-23 00:00:00
abstract：AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2018.08.009
更新日期：2020-09-01 00:00:00
abstract：:The timely series of state-of-the-art reviews contained within this supplement provide a valuable overview of the current state of diabetes care, and the pharmacological interventions we have available. Our experts agree that one of the most important lessons to emerge recently concerns the magnitude of the malign inf...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(03)72797-9
更新日期：2003-09-01 00:00:00
abstract：AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70250-1
更新日期：2006-02-01 00:00:00
abstract：AIM:To investigate the association between mean fasting glucose (FG) and variability in visit-to-visit FG and risk of mortality in people with type 2 diabetes (T2D). METHODS:This retrospective cohort study included 48,077 Chinese men and women with T2D. The yearly mean and coefficient of variation for fasting glucose ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.05.003
更新日期：2020-05-26 00:00:00
abstract：AIM:In this study, we examined the trends from 1995 to 2006 in cardiovascular risk factors (CVRF) in Spaniards aged 65 years or older with diabetes. METHODS:We looked at the individual data from adults aged > or =65 years from the Spanish National Health Surveys of 1995 (n=1117), 1997 (n=1111), 2001 (n=4328), 2003 (n=...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2009.06.007
更新日期：2010-02-01 00:00:00
abstract：AIM:The present study investigated the cyclooxygenase (COX) pathway to elucidate any changes that may be involved in the mechanism(s) underlying diabetic fetopathy. METHODS:Diabetes was induced in female rats (n=12) by two successive daily injections of 55 mg/kg streptozotocin, while control animals (n=10) were inject...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2009.06.009
更新日期：2010-02-01 00:00:00
abstract：AIM:Oxytocin administration to diet-induced obese (DIO) rodents, monkeys and humans decreases body weight and fat mass with concomitant improvements in glucose metabolism. Moreover, several studies show an immunomodulatory role of oxytocin in a number of settings (such as atherosclerosis, injury, sepsis). This study ai...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.10.004
更新日期：2018-06-01 00:00:00
abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(08)73399-8
更新日期：2008-02-01 00:00:00
abstract：:The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesit...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2007.08.002
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Although the management of diabetes mellitus varies according to non medical factors, the influence of socioprofessional category has been not fully studied. This study compared the management of type 2 diabetes mellitus in craftsmen or tradesmen with professionals categories. METHODS:All claims to the Fren...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/s1262-3636(07)70148-9
更新日期：2004-12-01 00:00:00
abstract：AIMS:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS:Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2)...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.12.002
更新日期：2017-06-01 00:00:00
abstract：:The association of diabetes with HLA class I alleles in the early 1970s and with HLA class II alleles in the late 1970s provided a crucial, though indirect, indication of the role of immune phenomena in the development of insulin-dependent diabetes mellitus (IDDM). Genotyping of HLA alleles in the mid-1980s opened up ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVES:To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. METHOD:A literature search on Medline was performed for the period from 01 January 1990...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2010.11.018
更新日期：2010-12-01 00:00:00
abstract：AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabet.2016.05.008
更新日期：2017-02-01 00:00:00
abstract：AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.01.006
更新日期：2017-10-01 00:00:00
abstract：AIMS:To evaluate whether perception of insulin therapy differs between patients with type 2 diabetes treated with insulin and those treated with oral hypoglycaemic agents (OHAs), and to examine whether gender, education level, injection duration and mode of injection were associated with the patients' perception of ins...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2010.12.008
更新日期：2011-11-01 00:00:00
abstract：:Prevalence of non-alcoholic steatohepatitis (NASH) rises steadily in Western countries with the obesity epidemic. NASH is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. The cannabinoid system is increasingly emerging as a crucial mediator of acute and chro...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/S1262-3636(08)74604-4
更新日期：2008-12-01 00:00:00
abstract：:This report concerns the incidence rate of insulin-dependent diabetes mellitus (IDDM) in the 0-14 year age group in Benghazi, Libya. Incidence data are based on prospective registration of patients as part of the WHO Diamond Project from 1991 to 1995. A total of 126 IDDM incident cases (73 girls, 53 boys) were identif...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：AIM:The aim of this study was to examine the racial and ethnic differences in the relationship between body fat distribution variables and serum lipid profiles. METHODS:Secondary data analyses were conducted on 708 healthy women (204 blacks, 247 whites and 257 Hispanics), aged 16-33 years, seen in an outpatients clini...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2010.01.010
更新日期：2010-09-01 00:00:00
abstract：:Diabetic muscle infarction is a rare complication of diabetes mellitus. However, idiopathic compartment syndrome in the diabetic patient is even a rarer disease, which has been reported only in three cases up to date. The disease seems to occur in patients affected by type 1 diabetes mellitus with a history of poorly ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could chal...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,实务指引
doi：10.1016/j.diabet.2009.09.002
更新日期：2010-02-01 00:00:00
abstract：:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2012.02.012
更新日期：2012-10-01 00:00:00
abstract：AIMS:To describe insulin therapy in patients with diabetes, to determine treatment costs and to compare costs among treatment regimens. METHODS:This observational study was performed by 734 French pharmacists. Adult patients filling an insulin prescription were invited to participate. Participants provided information...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2011.10.003
更新日期：2012-04-01 00:00:00
abstract：AIM:This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS:Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. The...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.02.004
更新日期：2016-11-01 00:00:00
abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.08.007
更新日期：2015-12-01 00:00:00
