New-onset diabetes after transplantation: risk factors and clinical impact.

Abstract:

:With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality. New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation, and is a strong predictor of graft failure and cardiovascular mortality in the transplant population. Risk factors for NODAT in transplant recipients are similar to those in non-transplant patients, but transplant-specific risk factors such as hepatitis C (HCV) infection, corticosteroids and calcineurin inhibitors play a dominant role in NODAT pathogenesis. Management of NODAT is similar to type 2 diabetes management in the general population. However, adjusting the immunosuppressant regimen to improve glucose tolerance must be weighed against the risk of allograft rejection. Lifestyle modification is currently the strategy with the least risk and the most benefit.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Räkel A,Karelis AD

doi

10.1016/j.diabet.2010.09.003

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

1-14

issue

1

eissn

1262-3636

issn

1878-1780

pii

S1262-3636(10)00193-X

journal_volume

37

pub_type

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