Serum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: An observational cross-sectional study.


AIM:While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. METHODS:In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels were measured at 25±7 weeks of gestation. Levels in mothers of infants with and without macrosomic newborns (birth weight>4000g and/or large-for-gestational-age birth weight>90th percentile) were compared using logistic regression analysis adjusted for macrosomia risk factors. RESULTS:These 130 pregnant women were 33±5 years old; their BMI before pregnancy was 27.7±6.9kg/m2, and they gained 7.5±5.1kg during the first 6 months of gestation. Glucose control was good according to HbA1c levels (5.3±0.3%; 34±2mmol/mol), yet 17/130 (13%) newborns had macrosomia: 3900±227g vs 3057±512g (P<0.001) in the others. These mothers were older and had higher parity, whereas their BMI scores before pregnancy and gestational weight gains did not differ. Fructosamine levels were also higher at 221±40μmol/L vs 192±22μmol/l (P<0.001), respectively, and remained significant even after adjusting for maternal age, BMI, parity, type of diabetes, antecedents of macrosomia and excessive gestational weight gain. By contrast, HbA1c did not differ between the two groups. In fact, nearly two-thirds (64.7%) of the mothers of macrosomic newborns had fructosamine levels>200μmol/l vs 31.9% of mothers with non-macrosomic newborns (P<0.05). CONCLUSION:High fructosamine levels are associated with macrosomia in the newborns of well-controlled hyperglycaemic pregnant women.


Diabetes Metab


Diabetes & metabolism


Poupon P,Foussard N,Helmer C,Cougnard-Gregoire A,Rajaobelina K,Delcourt C,Lamireau T,Haissaguerre M,Blanco L,Alexandre L,Mohammedi K,Rigalleau V




Has Abstract


2020-06-01 00:00:00














  • Determination of HbA1c concentrations in patients with acute myocardial infarction: comparison of the DCA 2000 device with the HPLC method.

    abstract:BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Hadjadj S,Duengler F,Barriere M,Mauco G,Coisne D,Warnier F,Sosner P,Torremocha F,Herpin D,Marechaud R

    更新日期:2005-06-01 00:00:00

  • Initiating oral glucose-lowering therapy with metformin in type 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications.

    abstract::A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Consoli A,Gomis R,Halimi S,Home PD,Mehnert H,Strojek K,Van Gaal LF

    更新日期:2004-12-01 00:00:00

  • Review of heart failure treatment in type 2 diabetes patients: It's at least as effective as in non-diabetic patients!

    abstract::Our society is currently facing an epidemic of diabetes and heart failure. Historically, certain cardiology treatments, mainly beta-blockers, have been considered 'dangerous' in diabetic patients, but the time has come for personalized medicine to be applied in the field of cardiology, especially in heart failure (HF)...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Girerd N,Zannad F,Rossignol P

    更新日期:2015-12-01 00:00:00

  • "Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma.

    abstract::Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A mod...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Morbois-Trabut L,Maillot F,De Widerspach-Thor A,Lamisse F,Couet C

    更新日期:2004-06-01 00:00:00

  • Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies.

    abstract:AIM:There is growing evidence that periodontal disease may favour the incidence or aggravation of diabetes and its complications. To investigate the issue, we conducted a meta-analysis of the effect of periodontal therapy on glycaemic control in diabetic patients. METHODS:A literature search was carried out using seve...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,meta分析


    authors: Darré L,Vergnes JN,Gourdy P,Sixou M

    更新日期:2008-11-01 00:00:00

  • Bone density and markers of bone remodeling in type 1 male diabetic patients.

    abstract:AIMS:To assess the prevalence and severity of bone disease in type 1 diabetic patients and to determine serum markers of bone remodeling as well as their relationship with bone mineral density (BMD). METHODS:BMD [by dual energy x-ray absorptiometry (DXA)] and serum markers of bone remodeling [osteocalcin, c-terminal t...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Alexopoulou O,Jamart J,Devogelaer JP,Brichard S,de Nayer P,Buysschaert M

    更新日期:2006-11-01 00:00:00

  • Moderate intensity sports and exercise is associated with glycaemic control in women with gestational diabetes.

    abstract:AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Ehrlich SF,Hedderson MM,Brown SD,Sternfeld B,Chasan-Taber L,Feng J,Adams J,Ching J,Crites Y,Quesenberry CP,Ferrara A

    更新日期:2017-10-01 00:00:00

  • Methods for the screening and diagnosis of gestational diabetes mellitus between 24 and 28 weeks of pregnancy.

    abstract::The aim of this review is to provide answers to the question “How does one screen for and diagnose gestational diabetes mellitus (GDM) between 24 and 28 weeks gestation?” Two methods are currently widely used: a one-step approach (the 75g-Oral Glucose Tolerance Test, OGTT) and a two-step approach (the 50g Glucose Chal...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Virally M,Laloi-Michelin M

    更新日期:2010-12-01 00:00:00

  • Adiponectin: an update.

    abstract::The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesit...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Guerre-Millo M

    更新日期:2008-02-01 00:00:00

  • Obesity or diabetes: what is worse for the mother and for the baby?

    abstract:OBJECTIVES:The aim of the present study is to evaluate pregnancy outcomes in a cohort of Caucasian pregnant women in relation to their body mass index and glucose tolerance status; the role of central fat distribution, as indicated by waist-to-hip circumference ratio, was also considered. METHODS:Seven hundred women w...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Bo S,Menato G,Signorile A,Bardelli C,Lezo A,Gallo ML,Gambino R,Cassader M,Massobrio M,Pagano G

    更新日期:2003-04-01 00:00:00

  • Anthropometric markers for detection of the metabolic syndrome in adolescents.

    abstract:OBJECTIVES:This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Benmohammed K,Valensi P,Benlatreche M,Nguyen MT,Benmohammed F,Pariès J,Khensal S,Benlatreche C,Lezzar A

    更新日期:2015-04-01 00:00:00

  • Quarterly individual outpatients lifestyle counseling after initial inpatients education on type 2 diabetes: the REDIA Prev-2 randomized controlled trial in Reunion Island.

    abstract:AIMS:This study aimed to describe the 1-year evolution of type 2 diabetes (T2D) patients who attended inpatients education, and to assess whether quarterly outpatients counseling visits by nurses and dietitians can improve metabolic control and health-related behaviours. METHODS:Following in-hospital educational sessi...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,随机对照试验


    authors: Debussche X,Rollot O,Le Pommelet C,Fianu A,Le Moullec N,Régnier C,Boyer MC,Cogne M,Bakiri F,Schwager JC,Favier F

    更新日期:2012-02-01 00:00:00

  • [Sexuality of the diabetic woman].

    abstract::Diabetes Mellitus frankly increases the prevalence of sexual problems in men, mainly in the form of erectile dysfunctions. Its effects on sexual function of the diabetic women have been less objectively studied, due to cultural reasons and methodological difficulties. The different phases of the sexual cycle, as well ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Buvat J,Lemaire A

    更新日期:2001-09-01 00:00:00

  • [Totally reimbursed care for type 2 diabetes in 1994: characteristics and follow-up].

    abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is an important health issue in France. According to projections from current data, the problem should increase over the upcoming years. The aim of this study was to determine the characteristics of patients with NIDDM who are enrolled on the list of 30 long term disease...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Vauzelle-Kervroëdan F,Cherou-Debregeas S,Forhan A,Fender P,Eschwège E

    更新日期:2000-09-01 00:00:00

  • Balance of substrate oxidation during submaximal exercise in lean and obese people.

    abstract:OBJECTIVES:To compare fat and carbohydrate oxidation at different exercise intensities between overweight and normal-weight subjects, in order to analyze the influence of muscular metabolic abnormalities in obese people on substrate utilization during exercise. MATERIAL AND METHODS:32 healthy sedentary overweight subj...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Pérez-Martin A,Dumortier M,Raynaud E,Brun JF,Fédou C,Bringer J,Mercier J

    更新日期:2001-09-01 00:00:00

  • Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

    abstract::ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Flechtner I,de Lonlay P,Polak M

    更新日期:2006-12-01 00:00:00

  • Chronic diarrhoea and diabetes mellitus: prevalence of small intestinal bacterial overgrowth.

    abstract::The mechanisms of chronic diarrhoea, a frequent symptom in diabetes mellitus, are multifactorial and complex, although small intestinal bacterial overgrowth and autonomic neuropathy seem to play a major role. This study evaluated the prevalence of small intestinal bacterial overgrowth and the effects of antibiotic tre...

    journal_title:Diabetes & metabolism

    pub_type: 临床试验,杂志文章


    authors: Virally-Monod M,Tielmans D,Kevorkian JP,Bouhnik Y,Flourie B,Porokhov B,Ajzenberg C,Warnet A,Guillausseau PJ

    更新日期:1998-12-01 00:00:00

  • Chromium in the prevention and control of diabetes.

    abstract::Chromium is an essential nutrient involved in the metabolism of glucose, insulin and blood lipids. Suboptimal dietary intake of chromium is associated with increased risk factors associated with diabetes and cardiovascular diseases. Within the past five years, chromium has been shown to improve glucose and related var...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Anderson RA

    更新日期:2000-02-01 00:00:00

  • Different TH2-TH1 balance in V beta 8 and V beta 6 subsets of splenocytes in NOD females in the early phase of diabetogenesis.

    abstract::Non-obese diabetic (NOD) mice spontaneously develop T-cell-mediated autoimmune diabetes. Initial work on the diabetogenic T-cell repertoire indicated that autoreactive T lymphocytes were polyclonal but that the presence of specific subsets (V beta 8 or V beta 6) might be required for induction of the disease. Further ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Atlan-Gepner C,Hermitte L,Janand-Delenne B,Naquet P,Vialettes B

    更新日期:1997-11-01 00:00:00

  • Interest of pronostic score for optimal clinical management of obese patients.

    abstract:OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Ybarra J,de Stefano M,Kammer A,de Tonnac N,Lehmann T,Golay A

    更新日期:2003-09-01 00:00:00

  • OPHDIAT: a telemedical network screening system for diabetic retinopathy in the Ile-de-France.

    abstract:OBJECTIVE:International and national guidelines recommend an annual funduscopic examination for all diabetic patients, but such annual fundus examinations are not sufficiently performed in France. Non-mydriatic fundus photography is a valid method of evaluation for diabetic retinopathy (DR) and a viable alternative to ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Massin P,Chabouis A,Erginay A,Viens-Bitker C,Lecleire-Collet A,Meas T,Guillausseau PJ,Choupot G,André B,Denormandie P

    更新日期:2008-06-01 00:00:00

  • Factors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.

    abstract:AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insuli...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,随机对照试验


    authors: Scheen AJ,Schmitt H,Jiang HH,Ivanyi T

    更新日期:2017-02-01 00:00:00

  • Competing risk analysis on visit-to-visit glucose variations and risk of depression: The Taiwan Diabetes Study.

    abstract:AIM:Patients with diabetes have higher rates of depression than does the general population, but diabetes management mainly aims to maintain glucose stability. For this reason, our study assessed the relationship between 1-year variations in fasting plasma glucose (FPG) and risk of depression in Chinese patients with t...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Li CI,Liu CS,Lin CH,Lin WY,Lee YD,Yang SY,Li TC,Lin CC

    更新日期:2020-06-01 00:00:00

  • Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:AIM:Determine whether plasma omega-7 vaccenic acid and palmitoleic acid levels are related to homeostasis model of insulin resistance scores and incident type II diabetes, and whether race/ethnicity modifies these associations. METHODS:Plasma phospholipid fatty acids were measured by gas chromatography with flame-ioni...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Weir NL,Steffen BT,Guan W,Johnson LM,Djousse L,Mukamal KJ,Tsai MY

    更新日期:2020-09-01 00:00:00

  • HBA1c: clinical and biological agreement for standardization of assay methods. Report by the experts of ALFEDIAM (Association de Langue Française pour lEtude du Diabète et des Maladies Métabolique) and SFBC (Société Française de Biologie Clinique).

    abstract::Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...

    journal_title:Diabetes & metabolism

    pub_type: 指南,杂志文章


    authors: Gillery P,Bordas-Fonfrède M,Chapelle JP,Drouin P,Hue G,Lévy-Marchal C,Périer C,Sélam JL,Slama G,Thivolet C,Vialettes B

    更新日期:1999-09-01 00:00:00

  • A systematic review of nudge theories and strategies used to influence adult health behaviour and outcome in diabetes management.

    abstract:BACKGROUND:Diabetes is a chronic disease associated with a variety of complications, and nudging may be a potential solution to improve diabetes control. Since nudging is a new concept, no review of literature on nudging diabetic patients into improving their health behaviour has been done. Therefore, we aim to collate...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Kwan YH,Cheng TY,Yoon S,Ho LYC,Huang CW,Chew EH,Thumboo J,Østbye T,Low LL

    更新日期:2020-11-01 00:00:00

  • Acute consequences of hypoglycaemia in diabetic patients.

    abstract::Strict glycaemic control is a major concern in many people with diabetes, hypoglycaemia being the most limiting factor in the daily management of patients with diabetes. Acute consequences of hypoglycaemic attacks are not precisely evaluated. Acute cardiovascular (CV) complications as myocardial ischaemia or stroke se...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Halimi S

    更新日期:2010-10-01 00:00:00

  • Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats.

    abstract:AIM:Our objective was to verify the energy balance in streptozotocin-induced diabetic rats chronically treated with lipoic acid (LA). METHODS:Diabetes was induced in rats by streptozotocin and the animals divided into four groups, comprising controls and diabetic rats, with each group receiving either daily intraperit...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Luz J,Zemdegs JC,Amaral LS

    更新日期:2009-04-01 00:00:00

  • Insulin action in man.

    abstract::Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues an...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Scheen AJ,Lefèbvre PJ

    更新日期:1996-04-01 00:00:00

  • Imaging and endovascular treatment of renal artery stenosis in the diabetic patient.

    abstract::Although diabetes is a classical risk factor for macroangiopathy, the prevalence of renal artery stenosis (RAS) in this type of pathology has not been clearly determined. More than 50% of RAS occur in diabetic patients (almost exclusively Type 2), whereas autopsy findings and the few clinical surveys reported indicate...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Otal P,Janne D'othee B,Chabbert V,Meites G,Rousseau H,Joffre F

    更新日期:2000-07-01 00:00:00