IL-33 receptor ST2 deficiency attenuates renal ischaemia-reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice.


AIM:Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS:Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice. Unilateral renal IRI was achieved 3months after STZ treatment by left kidney nephrectomy (non-ischaemic control kidney) and clamping of the right renal artery for 32min in STZ- and vehicle-treated animals. At 24h after reperfusion, renal function and injury were determined by levels of plasma creatinine, blood urea nitrogen (BUN) and histological tubule scores. Also, in a complementary pilot clinical study, soluble ST2 concentrations were compared in diabetics and non-diabetics. RESULTS:Urinary albumin was significantly increased in STZ-induced hyperglycaemic mice, regardless of genotypic background. At 24h post-ischaemia, plasma creatinine, BUN and tubular injury were significantly reduced in ST2-/- mice compared with vehicle-treated WT mice, but this protective effect was lost in the STZ-induced hyperglycaemic ST2-/- animals. Plasma concentrations of soluble ST2 were significantly greater in type 2 diabetes patients vs non-diabetics. CONCLUSION:Our data suggest that the IL-33/ST2 pathway exerts differential effects depending on the glucose environment, opening-up new avenues for future research on alarmins and diabetes in ischaemia-related diseases.


Diabetes Metab


Diabetes & metabolism


Sehnine M,Ferhat M,Sena S,Gombert JM,Goujon JM,Thierry A,Touchard G,Hauet T,Herbelin A,Hadjadj S




Has Abstract


2018-02-01 00:00:00














  • Diabetes and cognitive impairment: how to evaluate the cognitive status?

    abstract:AIM:Patients with diabetes have shown lower performance in tests of cognitive function especially those testing memory, executive functions, and psychomotor efficiency. They also have an elevated risk of both vascular dementia and Alzheimer's disease. Cognitive impairment may have consequence on treatment compliance. ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Pasquier F

    更新日期:2010-10-01 00:00:00

  • Trajectories of fasting plasma glucose variability and mortality in type 2 diabetes.

    abstract:AIM:To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D). METHODS:From 2009 to 2012, outpatients with T2D, aged>18 years, were enrolled from a medical centre. FPG was measured ev...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Lee CL,Sheu WH,Lee IT,Lin SY,Liang WM,Wang JS,Li YF

    更新日期:2018-03-01 00:00:00

  • Insulin therapy for type 2 diabetes: premixed or basal-prandial?

    abstract::It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Halbron M,Jacqueminet S,Sachon C,Bosquet F,Hartemann-Heurtier A,Grimaldi A

    更新日期:2007-09-01 00:00:00

  • Osteoprotegerin levels are associated with liver fat and liver markers in dysmetabolic adults.

    abstract:AIM:This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS:Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. The...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Monseu M,Dubois S,Boursier J,Aubé C,Gagnadoux F,Lefthériotis G,Ducluzeau PH

    更新日期:2016-11-01 00:00:00

  • Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study.

    abstract:AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Hanssen NMJ,Scheijen JLJM,Houben AJHM,van de Waarenburg M,Berendschot TTJM,Webers CAB,Reesink KD,van Greevenbroek MMJ,van der Kallen C,Schaper NC,Schram MT,Henry RMA,Stehouwer CDA,Schalkwijk CG

    更新日期:2020-02-10 00:00:00

  • Effectiveness of patient education on glycemic control in insulin treated patients in general practice.

    abstract:OBJECTIVE:To assess the effectiveness of a patient education program on diabetes control. METHODS:A pre-test post-test pre experimental study was performed with 87 insulin treated diabetic patients followed in the chronic disease unit of Kelibia district (Nabeul, Tunisia). Subjects received education in 6 monthly sess...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Jenhani M,Gaha K,Nabouli R,Ghedira A,Ben Abdelaziz A

    更新日期:2005-09-01 00:00:00

  • Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients.

    abstract:AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Harada M,Fujihara K,Osawa T,Yamamoto M,Kaneko M,Ishizawa M,Matsubayashi Y,Yamada T,Yamanaka N,Seida H,Kodama S,Ogawa W,Sone H

    更新日期:2020-09-01 00:00:00

  • Treating diabetes with islet transplantation: lessons from the past decade in Lille.

    abstract::Type 1 diabetes (T1D) is due to the loss of both beta-cell insulin secretion and glucose sensing, leading to glucose variability and a lack of predictability, a daily issue for patients. Guidelines for the treatment of T1D have become stricter as results from the Diabetes Control and Complications Trial (DCCT) demonst...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Vantyghem MC,Defrance F,Quintin D,Leroy C,Raverdi V,Prévost G,Caiazzo R,Kerr-Conte J,Glowacki F,Hazzan M,Noel C,Pattou F,Diamenord AS,Bresson R,Bourdelle-Hego MF,Cazaubiel M,Cordonnier M,Delefosse D,Dorey F,Fayard A

    更新日期:2014-04-01 00:00:00

  • Serum levels of osteopontin predict diabetes remission after bariatric surgery.

    abstract:AIM:Bariatric surgery has been shown to effectively improve glycaemic control in morbidly obese subjects. However, the molecular bases of this association are still elusive and may act independently of weight loss. Here, our retrospective study has investigated the inflammatory molecule osteopontin (OPN) as a potential...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Carbone F,Adami G,Liberale L,Bonaventura A,Bertolotto M,Andraghetti G,Scopinaro N,Camerini GB,Papadia FS,Cordera R,Dallegri F,Montecucco F

    更新日期:2019-09-01 00:00:00

  • Relationship between the hyperinsulinemic-euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women.

    abstract:OBJECTIVE:The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT). SUBJECTS AND METHODS:Cross-sectional study with 107 sedentary non-diabetic overweight and obese postmenopausal (B...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Bastard JP,Vandernotte JM,Faraj M,Karelis AD,Messier L,Malita FM,Garrel D,Prud'homme D,Rabasa-Lhoret R

    更新日期:2007-09-01 00:00:00

  • Correspondence between first-trimester fasting glycaemia, and oral glucose tolerance test in gestational diabetes diagnosis.

    abstract:AIM:To evaluate the correspondence between first-trimester fasting glycaemia and the results of the OGTT in diagnosing gestational diabetes (GDM). METHODS:The medical records of all consecutive women who had undergone a diagnostic OGTT, performed according to the IADPSG, during the past year were retrospectively revie...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Corrado F,D'Anna R,Cannata ML,Interdonato ML,Pintaudi B,Di Benedetto A

    更新日期:2012-11-01 00:00:00

  • Obesity or diabetes: what is worse for the mother and for the baby?

    abstract:OBJECTIVES:The aim of the present study is to evaluate pregnancy outcomes in a cohort of Caucasian pregnant women in relation to their body mass index and glucose tolerance status; the role of central fat distribution, as indicated by waist-to-hip circumference ratio, was also considered. METHODS:Seven hundred women w...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Bo S,Menato G,Signorile A,Bardelli C,Lezo A,Gallo ML,Gambino R,Cassader M,Massobrio M,Pagano G

    更新日期:2003-04-01 00:00:00

  • Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.

    abstract:OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

    更新日期:2004-04-01 00:00:00

  • Insulinemia and leptinemia in geriatric patients: markers of the metabolic syndrome or of undernutrition?

    abstract::The metabolic syndrome (MS) describes a cluster of metabolic disturbances including type 2 diabetes and/or insulin resistance, hypertension, dyslipidemia and obesity, which predict a high risk of cardiovascular disorders. The associated hyperinsulinemia and hyperleptinemia may contribute to the cardiovascular risk. Ho...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Bonin-Guillaume S,Herrmann FR,Boillat D,Szanto I,Michel JP,Rohner-Jeanrenaud F,Vischer UM

    更新日期:2006-06-01 00:00:00

  • The metabolic syndrome in smokers. The D.E.S.I.R. study.

    abstract:OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,多中心研究


    authors: Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

    更新日期:2003-06-01 00:00:00

  • WISE recommendations to ensure the safety of injections in diabetes.

    abstract:AIM:Injections and fingersticks administered to patients with diabetes in health care settings present a risk of blood exposure to the injector as well as other workers in potential contact with sharps. Such exposures could lead to transmission of bloodborne pathogens such as hepatitis and HIV. A recent EU Directive re...

    journal_title:Diabetes & metabolism

    pub_type: 共识发展会议,杂志文章,实务指引,评审


    authors: Strauss K,WISE Consensus Group.

    更新日期:2012-01-01 00:00:00

  • Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis.

    abstract::Prevalence of non-alcoholic steatohepatitis (NASH) rises steadily in Western countries with the obesity epidemic. NASH is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. The cannabinoid system is increasingly emerging as a crucial mediator of acute and chro...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Mallat A,Lotersztajn S

    更新日期:2008-12-01 00:00:00

  • Pancreas transplantation: results and indications.

    abstract::Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Dubernard JM,Tajra LC,Lefrançois N,Dawahra M,Martin C,Thivolet C,Martin X

    更新日期:1998-06-01 00:00:00

  • Relationship between achieved personalized glycaemic targets and monitoring of clinical events in elderly diabetic patients.

    abstract:AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,多中心研究


    authors: Bucher S,Panjo H,Al-Salameh A,Bauduceau B,Benattar-Zibi L,Bertin P,Berrut G,Corruble E,Danchin N,Derumeaux G,Doucet J,Falissard B,Forette F,Hanon O,Ourabah R,Pasquier F,Piedvache C,Pinget M,Becquemont L,Ringa V,re

    更新日期:2017-02-01 00:00:00

  • Bone density and markers of bone remodeling in type 1 male diabetic patients.

    abstract:AIMS:To assess the prevalence and severity of bone disease in type 1 diabetic patients and to determine serum markers of bone remodeling as well as their relationship with bone mineral density (BMD). METHODS:BMD [by dual energy x-ray absorptiometry (DXA)] and serum markers of bone remodeling [osteocalcin, c-terminal t...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Alexopoulou O,Jamart J,Devogelaer JP,Brichard S,de Nayer P,Buysschaert M

    更新日期:2006-11-01 00:00:00

  • Determination of HbA1c concentrations in patients with acute myocardial infarction: comparison of the DCA 2000 device with the HPLC method.

    abstract:BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Hadjadj S,Duengler F,Barriere M,Mauco G,Coisne D,Warnier F,Sosner P,Torremocha F,Herpin D,Marechaud R

    更新日期:2005-06-01 00:00:00

  • Incretins: what is known, new and controversial in 2013?

    abstract::Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Burcelin R,Thorens B,European Club for the study of GLP-1 (EuCSGLP-1).

    更新日期:2013-04-01 00:00:00

  • Continuous subcutaneous insulin infusion (CSII) using an external insulin pump for the treatment of type 2 diabetes.

    abstract::Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compare...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Reznik Y

    更新日期:2010-12-01 00:00:00

  • [Role of bariatric surgery in the obese diabetic].

    abstract::Bariatric surgery can be proposed to address severe obesity associated with comorbid conditions, when medical treatment has failed. Three surgical techniques are currently available, including 2 using coelioscopy. Short term results are encouraging regarding weight loss, which is linked with a reduction in comorbid co...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Simon C

    更新日期:2000-06-01 00:00:00

  • Fetal macrosomia and maternal weight gain during pregnancy.

    abstract:BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Lepercq J,Hauguel-De Mouzon S,Timsit J,Catalano PM

    更新日期:2002-09-01 00:00:00

  • Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

    abstract:BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Benalia M,Zeller M,Mouhat B,Guenancia C,Yameogo V,Greco C,Yao H,Maza M,Vergès B,Cottin Y

    更新日期:2019-10-01 00:00:00

  • The metabolic syndrome and cancer: Is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components?

    abstract:AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Harding J,Sooriyakumaran M,Anstey KJ,Adams R,Balkau B,Briffa T,Davis TM,Davis WA,Dobson A,Giles GG,Grant J,Knuiman M,Luszcz M,Mitchell P,Pasco JA,Reid C,Simmons D,Simons L,Tonkin A,Woodward M,Shaw JE,Magliano DJ

    更新日期:2015-12-01 00:00:00

  • Hypoglycaemia unawareness.

    abstract::Hypoglycaemia unawareness, a frequent syndrome in insulin-dependent diabetes mellitus (IDDM), involves a decrease or absence of perception of specific symptoms which normally inform the subject that plasma glucose is decreasing to dangerous levels leading to neuroglycopenia. Without warning symptoms, IDDM patients are...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Bolli GB

    更新日期:1997-09-01 00:00:00

  • Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD.

    abstract:AIM:The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章


    authors: Sun DQ,Ye FZ,Kani HT,Yang JR,Zheng KI,Zhang HY,Targher G,Byrne CD,Chen YP,Yuan WJ,Yilmaz Y,Zheng MH

    更新日期:2020-09-01 00:00:00

  • Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease.

    abstract::Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i...

    journal_title:Diabetes & metabolism

    pub_type: 杂志文章,评审


    authors: Vigouroux C,Gharakhanian S,Salhi Y,Nguyên TH,Adda N,Rozenbaum W,Capeau J

    更新日期:1999-11-01 00:00:00