当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > IL-33 receptor ST2 deficiency attenuates renal ischaemia-reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice.

IL-33 receptor ST2 deficiency attenuates renal ischaemia-reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice.

Abstract：

AIM:Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS:Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice. Unilateral renal IRI was achieved 3months after STZ treatment by left kidney nephrectomy (non-ischaemic control kidney) and clamping of the right renal artery for 32min in STZ- and vehicle-treated animals. At 24h after reperfusion, renal function and injury were determined by levels of plasma creatinine, blood urea nitrogen (BUN) and histological tubule scores. Also, in a complementary pilot clinical study, soluble ST2 concentrations were compared in diabetics and non-diabetics. RESULTS:Urinary albumin was significantly increased in STZ-induced hyperglycaemic mice, regardless of genotypic background. At 24h post-ischaemia, plasma creatinine, BUN and tubular injury were significantly reduced in ST2-/- mice compared with vehicle-treated WT mice, but this protective effect was lost in the STZ-induced hyperglycaemic ST2-/- animals. Plasma concentrations of soluble ST2 were significantly greater in type 2 diabetes patients vs non-diabetics. CONCLUSION:Our data suggest that the IL-33/ST2 pathway exerts differential effects depending on the glucose environment, opening-up new avenues for future research on alarmins and diabetes in ischaemia-related diseases.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Sehnine M,Ferhat M,Sena S,Gombert JM,Goujon JM,Thierry A,Touchard G,Hauet T,Herbelin A,Hadjadj S

doi

10.1016/j.diabet.2017.06.008

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

55-60

issue

1

eissn

1262-3636

issn

1878-1780

pii

S1262-3636(17)30475-5

journal_volume

44

pub_type

杂志文章

相关文献

DIABETES & METABOLISM文献大全
  • Pancreas transplantation: results and indications.

    abstract：:Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Dubernard JM,Tajra LC,Lefrançois N,Dawahra M,Martin C,Thivolet C,Martin X

    更新日期：1998-06-01 00:00:00

  • Hyperosmolar nonketotic syndrome with hypernatremia: how can we monitor treatment?

    abstract：:We report the case of a 62 year-old symptomatic patient with severe hyperglycemic hyperosmolality associated with hypernatremia. During treatment, the progressive decrease in serum tonicity, which resulted in the amelioration of the neurological symptoms, followed the decrease in serum glucose and mainly the corrected...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Liamis G,Gianoutsos C,Elisaf MS

    更新日期：2000-11-01 00:00:00

  • Acute consequences of hypoglycaemia in diabetic patients.

    abstract：:Strict glycaemic control is a major concern in many people with diabetes, hypoglycaemia being the most limiting factor in the daily management of patients with diabetes. Acute consequences of hypoglycaemic attacks are not precisely evaluated. Acute cardiovascular (CV) complications as myocardial ischaemia or stroke se...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(10)70471-7

    authors： Halimi S

    更新日期：2010-10-01 00:00:00

  • Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method?

    abstract：AIM:The objective of the study was to examine the correlation between three methods of measuring insulin sensitivity (IS) - namely, the frequently sampled intravenous glucose tolerance test (FSIVGTT), indices derived from the oral glucose tolerance test (OGTT) and fasting indices (HOMA-IR, QUICKI, fasting insulin [INS(...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.diabet.2010.06.008

    authors： Henderson M,Rabasa-Lhoret R,Bastard JP,Chiasson JL,Baillargeon JP,Hanley JA,Lambert M

    更新日期：2011-02-01 00:00:00

  • Screening of cardiovascular autonomic neuropathy in patients with diabetes using non-invasive quick and simple assessment of sudomotor function.

    abstract：AIM:Cardiovascular autonomic neuropathy (CAN) is a common but often overlooked complication of diabetes. Sympathetic C-fibers innervating sweat glands can be impaired early on in patients with diabetes. In this study, SUDOSCAN, a new non-invasive device that assesses sudomotor function was compared to methods generally...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.09.004

    authors： Yajnik CS,Kantikar V,Pande A,Deslypere JP,Dupin J,Calvet JH,Bauduceau B

    更新日期：2013-04-01 00:00:00

  • Glycaemic control and hypoglycaemia with insulin glargine 300U/mL versus insulin glargine 100U/mL in insulin-naïve people with type 2 diabetes: 12-month results from the EDITION 3 trial.

    abstract：AIM:To explore if efficacy and safety findings for insulin glargine 300U/mL (Gla-300) versus insulin glargine 100U/mL (Gla-100), observed over 6 months in insulin-naïve people with type 2 diabetes, are maintained after 12 months. METHODS:EDITION 3 was a phase 3a, randomized, multicentre, open-label, parallel-group, tr...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabet.2017.04.007

    authors： Bolli GB,Riddle MC,Bergenstal RM,Wardecki M,Goyeau H,Home PD,EDITION 3 study investigators.

    更新日期：2017-09-01 00:00:00

  • NOD1 activation induces innate immune responses and insulin resistance in human adipocytes.

    abstract：AIMS:The innate immune-receptor nucleotide oligomerization domain (NOD) protein recognizes intracellular bacterial peptidoglycan. Activation of the innate immune system contributes to the development and progression of insulin resistance. The present study aimed to determine the presence of NOD1 and NOD2 in human adipo...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.08.001

    authors： Zhou YJ,Zhou H,Li Y,Song YL

    更新日期：2012-12-01 00:00:00

  • Vitamin D deficiency, vitamin D receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes.

    abstract：AIM:The prevalence of diabetes in the French West Indies is three times higher than in mainland France. We aimed to assess the associations between vitamin D deficiency, vitamin D receptor (VDR) gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes (T2D). METHODS:In this cross-s...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2011.05.005

    authors： Vélayoudom-Céphise FL,Larifla L,Donnet JP,Maimaitiming S,Deloumeaux J,Blanchet A,Massart C,Munoz-Bellili N,Merle S,Chout R,Bonnet F,Foucan L

    更新日期：2011-12-01 00:00:00

  • Insulin therapy for type 2 diabetes: premixed or basal-prandial?

    abstract：:It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.01.005

    authors： Halbron M,Jacqueminet S,Sachon C,Bosquet F,Hartemann-Heurtier A,Grimaldi A

    更新日期：2007-09-01 00:00:00

  • Higher liver stiffness scores are associated with early kidney dysfunction in patients with histologically proven non-cirrhotic NAFLD.

    abstract：AIM:The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2019.11.003

    authors： Sun DQ,Ye FZ,Kani HT,Yang JR,Zheng KI,Zhang HY,Targher G,Byrne CD,Chen YP,Yuan WJ,Yilmaz Y,Zheng MH

    更新日期：2020-09-01 00:00:00

  • Hypoglycaemic episodes in patients with type 2 diabetes--risk factors and associations with patient-reported outcomes: The PANORAMA Study.

    abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2015.08.007

    authors： Simon D,de Pablos-Velasco P,Parhofer KG,Gönder-Frederick L,Duprat Lomon I,Vandenberghe H,Eschwège E,Bradley C

    更新日期：2015-12-01 00:00:00

  • Continuous subcutaneous insulin infusion (CSII) using an external insulin pump for the treatment of type 2 diabetes.

    abstract：:Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compare...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2010.08.002

    authors： Reznik Y

    更新日期：2010-12-01 00:00:00

  • Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes.

    abstract：:The stimulation of muscle and adipose tissue glucose metabolism, which is ultimately responsible for bringing about post-absorptive blood glucose clearance, is the primary clinically relevant action of insulin. Insulin acts on many steps of glucose metabolism, but one of the most important effects is its ability to in...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Ducluzeau PH,Fletcher LM,Vidal H,Laville M,Tavaré JM

    更新日期：2002-04-01 00:00:00

  • Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ.

    abstract：:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.02.012

    authors： Castell AL,Hiéronimus S,Lascols O,Fournier T,Fénichel P

    更新日期：2012-10-01 00:00:00

  • Relation of C-reactive protein to features of the metabolic syndrome in normal glucose tolerant, impaired glucose tolerant, and newly diagnosed type 2 diabetic subjects.

    abstract：OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70009-5

    authors： Guerrero-Romero F,Rodríguez-Morán M

    更新日期：2003-02-01 00:00:00

  • Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.

    abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70104-0

    authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

    更新日期：2004-04-01 00:00:00

  • Multicenter randomized evaluation of a nutritional education software in obese patients.

    abstract：OBJECTIVE:To study the efficacy of the nutritional education software, Nutri-Expert, in the management of obese adult patients. MATERIAL AND METHODS:Two groups of obese patients were followed up over one year in a randomized study: the first group received close traditional management (seven nutritional visits over th...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Turnin MC,Bourgeois O,Cathelineau G,Leguerrier AM,Halimi S,Sandre-Banon D,Coliche V,Breux M,Verlet E,Labrousse F,Bensoussan D,Grenier JL,Poncet MF,Tordjmann F,Brun JM,Blickle JF,Mattei C,Bolzonella C,Buisson JC,Fabr

    更新日期：2001-04-01 00:00:00

  • Imaging and endovascular treatment of renal artery stenosis in the diabetic patient.

    abstract：:Although diabetes is a classical risk factor for macroangiopathy, the prevalence of renal artery stenosis (RAS) in this type of pathology has not been clearly determined. More than 50% of RAS occur in diabetic patients (almost exclusively Type 2), whereas autopsy findings and the few clinical surveys reported indicate...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Otal P,Janne D'othee B,Chabbert V,Meites G,Rousseau H,Joffre F

    更新日期：2000-07-01 00:00:00

  • Looking for an insulin pill? Use the BRET methodology!

    abstract：:Insulin exerts its biological effects through a plasma membrane receptor that possesses a tyrosine-kinase activity. This tyrosine-kinase activity depends on the autophosphorylation of the receptor on tyrosine residues and on its dephosphorylation by protein tyrosine-phosphatases. The discovery of pharmacological agent...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/s1262-3636(07)70016-2

    authors： Issad T,Boute N,Boubekeur S,Lacasa D,Pernet K

    更新日期：2003-04-01 00:00:00

  • Trends from 1995 to 2006 in the prevalence of self-reported cardiovascular risk factors among elderly Spanish diabetics.

    abstract：AIM:In this study, we examined the trends from 1995 to 2006 in cardiovascular risk factors (CVRF) in Spaniards aged 65 years or older with diabetes. METHODS:We looked at the individual data from adults aged > or =65 years from the Spanish National Health Surveys of 1995 (n=1117), 1997 (n=1111), 2001 (n=4328), 2003 (n=...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.06.007

    authors： Jiménez Trujillo I,Jiménez García R,Vazquez-Fernandez del Pozo S,Hernández Barrera V,Carrasco Garrido P,Suarez P,Gil de Miguel A

    更新日期：2010-02-01 00:00:00

  • Incidence of insulin-dependent diabetes mellitus in Benghazi, Libya (1991-1995).

    abstract：:This report concerns the incidence rate of insulin-dependent diabetes mellitus (IDDM) in the 0-14 year age group in Benghazi, Libya. Incidence data are based on prospective registration of patients as part of the WHO Diamond Project from 1991 to 1995. A total of 126 IDDM incident cases (73 girls, 53 boys) were identif...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Kadiki OA,Roaeid RB,Bhairi AM,Elamari IM

    更新日期：1998-11-01 00:00:00

  • Association between metabolically unhealthy overweight/obesity and chronic kidney disease: the role of inflammation.

    abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.08.005

    authors： Chen S,Zhou S,Wu B,Zhao Y,Liu X,Liang Y,Shao X,Holthöfer H,Zou H

    更新日期：2014-12-01 00:00:00

  • Accuracy assessment of online glucose monitoring by a subcutaneous enzymatic glucose sensor during exercise in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion.

    abstract：AIM:Online continuous glucose monitoring (CGM) during physical exercise would be highly useful in patients with insulin-treated diabetes. For this reason, this study assessed whether such a goal could be reached with a subcutaneous 'needle-type' enzymatic sensor. METHODS:Ten patients (five women/five men), aged 51 ± 1...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.12.004

    authors： Radermecker RP,Fayolle C,Brun JF,Bringer J,Renard E

    更新日期：2013-05-01 00:00:00

  • Metabolic syndrome and Framingham risk score for prediction of cardiovascular events in Caribbean Indian patients with blood glucose abnormalities.

    abstract：OBJECTIVE:To evaluate the metabolic syndrome (MS) and Framingham risk score (FRS) as predictors of cardiovascular (CV) events in Caribbean Indian patients who have type 2 diabetes (T2D) or impaired glucose tolerance (IGT). METHOD:A longitudinal and retrospective study was conducted involving patients classified as T2D...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.10.005

    authors： Jaquet A,Deloumeaux J,Dumoulin M,Bangou J,Donnet JP,Foucan L

    更新日期：2008-04-01 00:00:00

  • [Gestational diabetes: long-term maternal consequences].

    abstract：:Gestational diabetes, a glucose tolerance disorder of variable severity which occurs or is diagnosed for the first time during pregnancy, constitutes a public health problem because of its frequency (1 to 6% of all pregnancies) and its short- or long-term consequences for the fetus and/or the mother. The classical mat...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Vambergue A,Fontaine P

    更新日期：1997-11-01 00:00:00

  • Propranolol in hypoglycaemia unawareness.

    abstract：:The effect of propranolol on the occurrence of hypoglycaemic symptoms was assessed in insulin-dependent diabetic patients with hypoglycaemia unawareness. A double-blind, randomised parallel group study (2:1 fashion) was conducted over 4-week period. The propranolol group (n = 9) received 20 mg (week 1 and 2) and 30 mg...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Chalon S,Berlin I,Sachon C,Bosquet F,Grimaldi A

    更新日期：1999-03-01 00:00:00

  • Glycaemic control and hypoglycaemia with insulin glargine 300 U/mL compared with glargine 100 U/mL in Japanese adults with type 2 diabetes using basal insulin plus oral anti-hyperglycaemic drugs (EDITION JP 2 randomised 12-month trial including 6-month ex

    abstract：AIMS:To compare insulin glargine 300 U/mL (Gla-300) with glargine 100 U/mL (Gla-100) in Japanese adults with uncontrolled type 2 diabetes on basal insulin and oral anti-hyperglycaemic drugs over 12 months. METHODS:EDITION JP 2 was a randomised, open-label, phase 3 study. Following a 6-month treatment period, participa...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabet.2017.03.001

    authors： Terauchi Y,Koyama M,Cheng X,Sumi M,Riddle MC,Bolli GB,Hirose T,EDITION JP 2 study group.

    更新日期：2017-10-01 00:00:00

  • Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients.

    abstract：AIM:To investigate the balance between parameters of oxidative stress and antioxidant defences in the mitochondria of peripheral blood mononuclear cells (PBMCs) of type 2 diabetic patients with late complications. METHODS:Ten type 2 diabetic patients with late diabetic complications and 10 age-matched healthy voluntee...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.10.011

    authors： García-Ramírez M,Francisco G,García-Arumí E,Hernández C,Martínez R,Andreu AL,Simó R

    更新日期：2008-04-01 00:00:00

  • Metabolic effects of SGLT-2 inhibitors beyond increased glucosuria: A review of the clinical evidence.

    abstract：:Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin, empagliflozin) are new glucose-lowering agents that exert their therapeutic activity independently of insulin by facilitating glucose excretion through the kidneys. However, this simple renal mechanism that results in sustained gluc...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(14)72689-8

    authors： Scheen AJ,Paquot N

    更新日期：2014-12-01 00:00:00

  • Individualizing treatment of type 2 diabetes by targeting postprandial or fasting hyperglycaemia: Response to a basal vs a premixed insulin regimen by HbA1c quartiles and ethnicity.

    abstract：AIM:This study evaluated the proportions of prandial (PHG) vs fasting hyperglycaemia (FHG) over 24h in a group of patients with type 2 diabetes (overall and for Caucasian vs Asian patients), and tested the hypothesis that an insulin regimen with a prandial component allows a greater response than basal insulin at low g...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2015.03.002

    authors： Scheen AJ,Schmitt H,Jiang HH,Ivanyi T

    更新日期：2015-06-01 00:00:00