当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Propranolol in hypoglycaemia unawareness.

Propranolol in hypoglycaemia unawareness.

Abstract：

:The effect of propranolol on the occurrence of hypoglycaemic symptoms was assessed in insulin-dependent diabetic patients with hypoglycaemia unawareness. A double-blind, randomised parallel group study (2:1 fashion) was conducted over 4-week period. The propranolol group (n = 9) received 20 mg (week 1 and 2) and 30 mg (week 3 and 4) twice daily, and the other group (n = 5) a matched placebo for 4 weeks. Patients included had experienced at least two severe hypoglycaemic episodes (coma or seizures) during the previous year, which were characterised by a lack of adrenergic symptoms and required the assistance of another person. The mean number of hypoglycaemias during the study period was similar in both groups (placebo: 13 +/- 2 propranolol: 11 +/- 1), whereas the number of totally asymptomatic hypoglycaemias (< 0.6 g/l) was lower on propranolol than on placebo (3 +/- 1 vs 8 +/- 3, NS) and the number of symptomatic hypoglycaemias was higher (7.2 +/- 2 vs 4.6 +/- 1, NS). Subjective evaluation of treatment by the investigators showed 0/5 successes in the placebo group and 5/9 in the propranolol group (chi2 = 4.32, p = 0.038). The main advantage of propranolol over placebo was an increased incidence of sweating. The ratio [number of hypoglycaemias with sweating/total number of hypoglycaemias] being higher with propranolol (0.28 +/- 0.08 vs 0.06 +/- 0.02, p = 0.06). This pilot study suggests that beta-blockers may be useful in restoring adrenergic symptoms during hypoglycaemia in insulin-dependent diabetic patients without warning symptoms of hypoglycaemia. This beneficial effect seems to be predominantly related to an increase in hypoglycaemia-induced sweating. A larger study is needed to confirm or invalidate these preliminary results.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Chalon S,Berlin I,Sachon C,Bosquet F,Grimaldi A

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

23-6

issue

1

eissn

1262-3636

issn

1878-1780

pii

MDOI-DM-05-1999-25-1-1262-3636-101019-ART56

journal_volume

25

pub_type

临床试验,杂志文章,随机对照试验

相关文献

DIABETES & METABOLISM文献大全
  • Improved metabolic control in diabetic adolescents using the continuous glucose monitoring system (CGMS).

    abstract：OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70076-9

    authors： Schaepelynck-Bélicar P,Vague P,Simonin G,Lassmann-Vague V

    更新日期：2003-12-01 00:00:00

  • The metabolic syndrome: prevalence, main characteristics and association with socio-economic status in adults living in Great Tunis.

    abstract：AIMS:This study aimed to determine the prevalence of the metabolic syndrome (MetS) and its association with socio-economic status in the population of Great Tunis. METHODS:The study included 2712 subjects (1228 men and 1484 women), aged 35-70 years and living in the Great Tunis region, all of whom were recruited betwe...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.11.009

    authors： Allal-Elasmi M,Haj Taieb S,Hsairi M,Zayani Y,Omar S,Sanhaji H,Jemaa R,Feki M,Elati J,Mebazaa A,Kaabachi N

    更新日期：2010-06-01 00:00:00

  • Type 1 diabetes control and pregnancy outcomes in women treated with continuous subcutaneous insulin infusion (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI).

    abstract：AIM:The best way to treat pregnant patients who have type 1 diabetes is still unclear. For this reason, the present study compared metabolic control and maternal-fetal outcomes in patients treated with continuous subcutaneous infusions of rapid-acting insulin analogues (CSII) or with insulin glargine and multiple daily...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2011.02.002

    authors： Bruttomesso D,Bonomo M,Costa S,Dal Pos M,Di Cianni G,Pellicano F,Vitacolonna E,Dodesini AR,Tonutti L,Lapolla A,Di Benedetto A,Torlone E,Italian Group for Continuous Subcutaneous Insulin Infusion in Pregnancy.

    更新日期：2011-11-01 00:00:00

  • Consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndrome.

    abstract：:The Diabetes and Cardiovascular Disease study group of the Société francophone du diabète (SFD, French Society of Diabetes) in collaboration with the Société française de cardiologie (SFC, French Society of Cardiology) have devised a consensus statement on the care of the hyperglycaemic/diabetic patient during and in ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,实务指引

    doi：10.1016/j.diabet.2011.11.003

    authors： Vergès B,Avignon A,Bonnet F,Catargi B,Cattan S,Cosson E,Ducrocq G,Elbaz M,Fredenrich A,Gourdy P,Henry P,Lairez O,Leguerrier AM,Monpère C,Moulin P,Vergès-Patois B,Roussel R,Steg G,Valensi P,Diabetes and Cardiovascula

    更新日期：2012-04-01 00:00:00

  • Adiponectin is expressed in the pancreas of high-fat-diet-fed mice and protects pancreatic endothelial function during the development of type 2 diabetes.

    abstract：AIM:Adiponectin levels in skeletal muscle and adipose tissue have been reported to be involved in insulin resistance in rats fed with a high-fat diet (HFD). Our objective was to explore whether adiponectin is also expressed in the pancreas and what its potential role is during the development of type 2 diabetes (T2D) i...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.05.004

    authors： Liu XX,Liu KY,Li P,Han S,Peng XD,Shen L

    更新日期：2014-11-01 00:00:00

  • Accuracy assessment of online glucose monitoring by a subcutaneous enzymatic glucose sensor during exercise in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion.

    abstract：AIM:Online continuous glucose monitoring (CGM) during physical exercise would be highly useful in patients with insulin-treated diabetes. For this reason, this study assessed whether such a goal could be reached with a subcutaneous 'needle-type' enzymatic sensor. METHODS:Ten patients (five women/five men), aged 51 ± 1...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.12.004

    authors： Radermecker RP,Fayolle C,Brun JF,Bringer J,Renard E

    更新日期：2013-05-01 00:00:00

  • Relationship between achieved personalized glycaemic targets and monitoring of clinical events in elderly diabetic patients.

    abstract：AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2016.05.008

    authors： Bucher S,Panjo H,Al-Salameh A,Bauduceau B,Benattar-Zibi L,Bertin P,Berrut G,Corruble E,Danchin N,Derumeaux G,Doucet J,Falissard B,Forette F,Hanon O,Ourabah R,Pasquier F,Piedvache C,Pinget M,Becquemont L,Ringa V,re

    更新日期：2017-02-01 00:00:00

  • Added benfluorex in obese insulin-requiring type 2 diabetes.

    abstract：:To determine the effect of benfluorex on glycaemic control in obese insulin-requiring Type 2 diabetes, 76 patients (aged 53.8 +/- 12.8 years) receiving insulin (> or = 0.5 IU/kg) and an appropriate low-calorie diet were evaluated after a 1-month run-in followed by a 3-month double-blind treatment period (3 tablets dai...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Leutenegger M,Bauduceau B,Brun JM,Guillon-Metz F,Martin C,Nicolino-Peltier C,Richard JL,Vannereau D

    更新日期：1998-02-01 00:00:00

  • When should ultrasonography be used to detect asymptomatic carotid atheroma in diabetic patients?

    abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/S1262-3636(07)70321-X

    authors： Duval M,Altman JJ

    更新日期：2006-12-01 00:00:00

  • Short-term intensive insulin therapy in insulin-requiring diabetes: effectiveness and factors predicting success.

    abstract：:Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Meyer L,Grulet H,Guerci B,Gross A,Durlach V,Leutenegger M

    更新日期：1997-02-01 00:00:00

  • Serum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: An observational cross-sectional study.

    abstract：AIM:While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. METHODS:In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2019.07.003

    authors： Poupon P,Foussard N,Helmer C,Cougnard-Gregoire A,Rajaobelina K,Delcourt C,Lamireau T,Haissaguerre M,Blanco L,Alexandre L,Mohammedi K,Rigalleau V

    更新日期：2020-06-01 00:00:00

  • Correspondence between first-trimester fasting glycaemia, and oral glucose tolerance test in gestational diabetes diagnosis.

    abstract：AIM:To evaluate the correspondence between first-trimester fasting glycaemia and the results of the OGTT in diagnosing gestational diabetes (GDM). METHODS:The medical records of all consecutive women who had undergone a diagnostic OGTT, performed according to the IADPSG, during the past year were retrospectively revie...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.03.006

    authors： Corrado F,D'Anna R,Cannata ML,Interdonato ML,Pintaudi B,Di Benedetto A

    更新日期：2012-11-01 00:00:00

  • Optimal nephroprotection: use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trials.

    abstract：:Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (es...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2009.05.003

    authors： Halimi JM,Asmar R,Ribstein J

    更新日期：2009-12-01 00:00:00

  • Blood glucose changes and adjustments of diet and insulin doses in type 1 diabetic patients during scuba diving (for a change in French regulations).

    abstract：OBJECTIVE:In France, diabetic subjects were not allowed to dive. The principal risk is hypoglycemia during immersion. However scuba diving is allowed in many countries. To follow blood glucose changes, food intake and insulin adjustments in type 1 diabetic patients when diving, and to propose specific guidelines for su...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70180-5

    authors： Lormeau B,Sola A,Tabah A,Chiheb S,Dufaitre L,Thurninger O,Bresson R,Lormeau C,Attali JR,Valensi P

    更新日期：2005-04-01 00:00:00

  • Review and case report of idiopathic lower extremity compartment syndrome and its treatment in diabetic patients.

    abstract：:Diabetic muscle infarction is a rare complication of diabetes mellitus. However, idiopathic compartment syndrome in the diabetic patient is even a rarer disease, which has been reported only in three cases up to date. The disease seems to occur in patients affected by type 1 diabetes mellitus with a history of poorly ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Pamoukian VN,Rubino F,Iraci JC

    更新日期：2000-12-01 00:00:00

  • [Role of bariatric surgery in the obese diabetic].

    abstract：:Bariatric surgery can be proposed to address severe obesity associated with comorbid conditions, when medical treatment has failed. Three surgical techniques are currently available, including 2 using coelioscopy. Short term results are encouraging regarding weight loss, which is linked with a reduction in comorbid co...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Simon C

    更新日期：2000-06-01 00:00:00

  • Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients.

    abstract：AIM:To investigate the balance between parameters of oxidative stress and antioxidant defences in the mitochondria of peripheral blood mononuclear cells (PBMCs) of type 2 diabetic patients with late complications. METHODS:Ten type 2 diabetic patients with late diabetic complications and 10 age-matched healthy voluntee...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.10.011

    authors： García-Ramírez M,Francisco G,García-Arumí E,Hernández C,Martínez R,Andreu AL,Simó R

    更新日期：2008-04-01 00:00:00

  • Seasonality and temperature effects on fasting plasma glucose: A population-based longitudinal study in China.

    abstract：AIMS:To examine the seasonality and effects of temperature on levels of fasting plasma glucose (FPG). METHODS:We collected health data from the Kailuan cohort study. FPG, blood pressure and individual information including age, gender, body mass index, smoking status, drinking habit, physical activities, income, work ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2016.01.002

    authors： Li S,Zhou Y,Williams G,Jaakkola JJ,Ou C,Chen S,Yao T,Qin T,Wu S,Guo Y

    更新日期：2016-09-01 00:00:00

  • Hypothermia with acute renal failure in a patient suffering from diabetic nephropathy and malnutrition.

    abstract：:We report a rare case of hypothermia with acute renal failure in a patient suffering from diabetic nephropathy. A 71-year-old male who had been receiving insulin therapy for the treatment of diabetes mellitus complicated with advanced diabetic nephropathy since 1998 was malnourished with an extremely decreased muscle ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Yokoyama M,Noto Y,Kida H

    更新日期：2000-04-01 00:00:00

  • High prevalence of undiagnosed diabetes and high risk for diabetes using HbA1c criteria in middle-aged patients undergoing cataract surgery.

    abstract：AIM:This study assessed the prevalence of undiagnosed diabetes and a high risk for diabetes using glycated haemoglobin (HbA(1c)) values in middle-aged patients undergoing cataract surgery. METHODS:The study comprised 137 consecutive patients, aged 40 to 65 years, with no known diabetes undergoing cataract surgery at a...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.10.009

    authors： Feldman-Billard S,Sedira N,Boelle PY,Poisson F,Héron E

    更新日期：2013-05-01 00:00:00

  • [The insulin sensitivity concept].

    abstract：:Insulin resistance was already suspected in the thirties from clinical observations in diabetic patients, then better appreciated in the early sixties with the development of insulin radioimmunoassay, and finally confirmed in the last 20 years by using various sophisticated methods able to quantify insulin action. Fir...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Scheen AJ

    更新日期：2001-04-01 00:00:00

  • Anthropometric markers for detection of the metabolic syndrome in adolescents.

    abstract：OBJECTIVES:This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.07.001

    authors： Benmohammed K,Valensi P,Benlatreche M,Nguyen MT,Benmohammed F,Pariès J,Khensal S,Benlatreche C,Lezzar A

    更新日期：2015-04-01 00:00:00

  • Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure.

    abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels b...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(17)30071-X

    authors： Joubert M,Reznik Y

    更新日期：2017-04-01 00:00:00

  • Incretin-based therapy in combination with basal insulin: a promising tactic for the treatment of type 2 diabetes.

    abstract：:Incretin therapies such as dipeptidyl peptidase-4 inhibitors (DPP-4Is) and GLP-1 receptor agonists (GLP-1RAs) have become well-established treatments for type 2 diabetes. Both drug classes reduce blood glucose through physiological pathways mediated by the GLP-1 receptor, resulting in glucose-dependent enhancement of ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2012.08.002

    authors： Vora J,Bain SC,Damci T,Dzida G,Hollander P,Meneghini LF,Ross SA

    更新日期：2013-02-01 00:00:00

  • Metabolic syndrome and Framingham risk score for prediction of cardiovascular events in Caribbean Indian patients with blood glucose abnormalities.

    abstract：OBJECTIVE:To evaluate the metabolic syndrome (MS) and Framingham risk score (FRS) as predictors of cardiovascular (CV) events in Caribbean Indian patients who have type 2 diabetes (T2D) or impaired glucose tolerance (IGT). METHOD:A longitudinal and retrospective study was conducted involving patients classified as T2D...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.10.005

    authors： Jaquet A,Deloumeaux J,Dumoulin M,Bangou J,Donnet JP,Foucan L

    更新日期：2008-04-01 00:00:00

  • Evaluation of the locus of control in patients with type 2 diabetes after long-term management by group care.

    abstract：AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70250-1

    authors： Trento M,Passera P,Miselli V,Bajardi M,Borgo E,Tomelini M,Tomalino M,Cavallo F,Porta M

    更新日期：2006-02-01 00:00:00

  • Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

    abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)73399-8

    authors： Penfornis A,Borot S,Raccah D

    更新日期：2008-02-01 00:00:00

  • Factors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.

    abstract：AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insuli...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2016.10.005

    authors： Scheen AJ,Schmitt H,Jiang HH,Ivanyi T

    更新日期：2017-02-01 00:00:00

  • Long-term outcome in children of mothers with gestational diabetes.

    abstract：OBJECTIVES:To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. METHOD:A literature search on Medline was performed for the period from 01 January 1990...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2010.11.018

    authors： Burguet A

    更新日期：2010-12-01 00:00:00

  • The association of type 2 diabetes and insulin resistance/secretion with persistent organic pollutants in two First Nations communities in northern Ontario.

    abstract：AIMS:Recent evidence suggests an association between persistent organic pollutants (POPs) and type 2 diabetes. In two First Nations communities where wild food is consumed by a large portion of the population, we compared pollutants in plasma between diabetic and non-diabetic individuals, and investigated the strength ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.01.006

    authors： Pal S,Blais JM,Robidoux MA,Haman F,Krümmel E,Seabert TA,Imbeault P

    更新日期：2013-12-01 00:00:00