Abstract:
AIM:To evaluate the correspondence between first-trimester fasting glycaemia and the results of the OGTT in diagnosing gestational diabetes (GDM). METHODS:The medical records of all consecutive women who had undergone a diagnostic OGTT, performed according to the IADPSG, during the past year were retrospectively reviewed. All first-trimester fasting glucose values greater or equal to 5.1 mmol/L (92 mg/dL), recommended as a diagnostic value, were also verified for each patient in this cohort. Moreover, a ROC curve and a multiple logistic-regression model were constructed to calculate the predictive capability of this cut-off value in diagnosing GDM. RESULTS:In our population of 738 eligible pregnant women, an 11.9% prevalence of GDM was revealed by OGTT. However, when the first-trimester fasting glucose value for each patient was retrospectively considered, there were a further 29 patients who should have been diagnosed as GDM cases (glycaemia ≥ 5.1 mmol/L), although their OGTT was normal. Yet, when the value of fasting glucose was considered not diagnostic, but only predictive, an AUC of 0.614 (95% CI: 0.544-0.684) and an aOR of 7.1 (95% CI: 3.8-13.1) was obtained in these patients compared with the reference group (fasting glucose < 5.1 mmol/L). CONCLUSION:There was no complete correspondence in diagnosing GDM between the first-trimester fasting glucose value and the results of a 2-h 75-g OGTT performed early in the third trimester. However, albeit not diagnostic, a fasting glucose value greater or equal to 5.1 mmol/L may be considered a highly predictive risk factor for GDM.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Corrado F,D'Anna R,Cannata ML,Interdonato ML,Pintaudi B,Di Benedetto Adoi
10.1016/j.diabet.2012.03.006subject
Has Abstractpub_date
2012-11-01 00:00:00pages
458-61issue
5eissn
1262-3636issn
1878-1780pii
S1262-3636(12)00071-7journal_volume
38pub_type
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2007.08.002
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pub_type: 杂志文章,多中心研究
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更新日期:2001-06-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 评论,杂志文章,评审
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更新日期:2002-12-01 00:00:00
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更新日期:2014-06-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2010.08.002
更新日期:2010-12-01 00:00:00
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更新日期:2002-06-01 00:00:00