Abstract：
AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insulin regimen in patients with type 2 diabetes. METHODS:This post-hoc analysis of insulin-naïve patients in the DURABLE study randomised to receive either insulin glargine or insulin lispro mix 25 evaluated the percentages of patients achieving a target HbA1c of <7.0% (<53mmol/mol) per baseline HbA1c quartiles, and the effect of each insulin regimen on the relative contributions of PHG and FHG to overall hyperglycaemia. RESULTS:Patients had comparable demographic characteristics and similar HbA1c and FHG values at baseline in each HbA1c quartile regardless of whether they reached the target HbA1c. The higher the HbA1c quartile, the greater was the decrease in HbA1c, but also the smaller the percentage of patients achieving the target HbA1c. HbA1c and FHG decreased more in patients reaching the target, resulting in significantly lower values at endpoint in all baseline HbA1c quartiles with either insulin treatment. Patients not achieving the target HbA1c had slightly higher insulin doses, but lower total hypoglycaemia rates. CONCLUSION:Smaller decreases in FHG were associated with not reaching the target HbA1c, suggesting a need to increase basal or premixed insulin doses to achieve targeted fasting plasma glucose and improve patient response before introducing more intensive prandial insulin regimens.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Scheen AJ,Schmitt H,Jiang HH,Ivanyi Tdoi
10.1016/j.diabet.2016.10.005subject
Has Abstractpub_date
2017-02-01 00:00:00pages
69-78issue
1eissn
1262-3636issn
1878-1780pii
S1262-3636(16)30539-0journal_volume
43pub_type
杂志文章,随机对照试验abstract：OBJECTIVES:There is little information about the impact of hyperglycaemia in twin pregnancies. The objective of our study was to evaluate the maternal, foetal and neonatal complications in patients with twin pregnancy and glucose intolerance defined by gestational diabetes mellitus and gestational mild hyperglycaemia. ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.12.005
更新日期：2015-11-01 00:00:00
abstract：AIM:To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS:Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 me...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2018.03.007
更新日期：2019-04-01 00:00:00
abstract：AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70250-1
更新日期：2006-02-01 00:00:00
abstract：:Preretinal neovascularization and chronic retinal oedema are the two major sight-threatening complications that can occur during diabetic retinopathy. Ocular neovascularization is strongly associated with retinal ischaemia, and growth factors have been implicated in its pathogenesis. The ischaemic retina is assumed to...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:Obesity and visceral or upper body fat distribution, have a major impact on insulin sensitivity. There is strong evidence to suggest that free fatty acids (FFA) contribute to the pathogenesis of insulin resistance and the metabolic syndrome. Increased FFA release from adipose tissue or failure of FFA using tissues to ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...
journal_title：Diabetes & metabolism
pub_type： 评论,杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Accumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites. We sought to examine the association of PTH with the incidence of diabetes. ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.12.004
更新日期：2016-06-01 00:00:00
abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.02.005
更新日期：2013-04-01 00:00:00
abstract：AIM:This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS:Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. The...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.02.004
更新日期：2016-11-01 00:00:00
abstract：AIM:This study investigated the relationship between endothelial dysfunction (ED) and arterial stiffness (AS) in adults with type 1 diabetes and no clinical cardiovascular (CV) disease. METHODS:A total of 68 patients with type 1 diabetes and 68 age- and gender-matched healthy (non-diabetic) subjects were evaluated. ED...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.03.006
更新日期：2013-09-01 00:00:00
abstract：:Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：AIM:Adiponectin is the most abundant adipokine and may play a key role in the interplay between obesity, inflammation, insulin resistance and the metabolic syndrome (MetS). Thus, this large population-based cohort investigated whether adiponectin at baseline and/or a decrease in adiponectin during follow-up is associat...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2016.07.027
更新日期：2017-04-01 00:00:00
abstract：AIM:The clinical guidelines reported by the French-Speaking Diabetes Society (Société francophone du diabète) include updated recommendations for preconceptual planning and care in the management of pregnancy in women with type 1 diabetes mellitus (T1DM). METHODS:The working group included diabetologists, as well as a...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,实务指引
doi：10.1016/j.diabet.2012.02.010
更新日期：2012-06-01 00:00:00
abstract：AIMS:This study aimed to determine the prevalence of the metabolic syndrome (MetS) and its association with socio-economic status in the population of Great Tunis. METHODS:The study included 2712 subjects (1228 men and 1484 women), aged 35-70 years and living in the Great Tunis region, all of whom were recruited betwe...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2009.11.009
更新日期：2010-06-01 00:00:00
abstract：:This report concerns the incidence rate of insulin-dependent diabetes mellitus (IDDM) in the 0-14 year age group in Benghazi, Libya. Incidence data are based on prospective registration of patients as part of the WHO Diamond Project from 1991 to 1995. A total of 126 IDDM incident cases (73 girls, 53 boys) were identif...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：AIM:Experimental evidence suggests that osteocalcin is a key messenger that affects both adipocytes and insulin-producing β cells. Epidemiological cross-sectional studies have shown a negative association between plasma levels of osteocalcin and glucose. For this reason, the hypothesis that lower baseline osteocalcin p...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.01.001
更新日期：2014-06-01 00:00:00
abstract：:Remittent isolated palsy of peripheral or of upper cranial nerves in diabetic patients is well documented, but paralysis of a lower cranial nerve or an isolated branch of any cranial nerve has rarely been reported. In the case described, besides temporary hypoglossal and facial nerve palsies previously, unilateral tem...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.08.005
更新日期：2014-12-01 00:00:00
abstract：AIM:To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D). METHODS:From 2009 to 2012, outpatients with T2D, aged>18 years, were enrolled from a medical centre. FPG was measured ev...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.09.001
更新日期：2018-03-01 00:00:00
abstract：:The production of ketone bodies (KB) is dependent on the amount of free fatty acids (FFA) supplied to the liver and on the hepatic metabolic fate of fatty acids and their orientation towards oxidation and ketogenesis or reesterification. In vivo ketogenesis can thus be regulated at the pre-hepatic (lipolysis) or hepat...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-10-01 00:00:00
abstract：AIM:Hepatic insulin clearance (HIC) is important in regulating plasma insulin levels. Diminished HIC causes inappropriate hyperinsulinaemia, and both obesity and fatty liver (FL), which are known to decrease HIC, can be found either together in the same patient or on their own. The mechanism by which obesity reduces HI...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.12.003
更新日期：2018-03-01 00:00:00
abstract：:Gestational diabetes, a glucose tolerance disorder of variable severity which occurs or is diagnosed for the first time during pregnancy, constitutes a public health problem because of its frequency (1 to 6% of all pregnancies) and its short- or long-term consequences for the fetus and/or the mother. The classical mat...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is an important health issue in France. According to projections from current data, the problem should increase over the upcoming years. The aim of this study was to determine the characteristics of patients with NIDDM who are enrolled on the list of 30 long term disease...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:The mechanisms of chronic diarrhoea, a frequent symptom in diabetes mellitus, are multifactorial and complex, although small intestinal bacterial overgrowth and autonomic neuropathy seem to play a major role. This study evaluated the prevalence of small intestinal bacterial overgrowth and the effects of antibiotic tre...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Renal remodelling in hyperinsulinic/insulinopenic states is mediated by glucotoxicity, endothelial dysfunction and vascular and nephron collagen turnover. Hypertensive and renal links are renewed by renoprotective interventions of renin-angiotensin. Vasoactive peptide processing and vascular collagen deposition are un...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:We assessed the efficacy of a modest weight loss (1.5 +/- 0.3 kg) and simultaneous rapid improvement in glycemic control on fasting an post-prandial lipoprotein sub-fractions in nine overweight (BMI=28 +/- 1.7 kg/m(2)) well controlled Type 2 diabetic patients (HbA(1c)=7.3 +/- 0.1%). MATERIAL AND METHODS:They...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：AIM:To explore if efficacy and safety findings for insulin glargine 300U/mL (Gla-300) versus insulin glargine 100U/mL (Gla-100), observed over 6 months in insulin-naïve people with type 2 diabetes, are maintained after 12 months. METHODS:EDITION 3 was a phase 3a, randomized, multicentre, open-label, parallel-group, tr...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.diabet.2017.04.007
更新日期：2017-09-01 00:00:00
abstract：:Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues an...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：AIMS:The objective of the present investigation was to study the production of IL-1, IL-6, IL-10, IFNgamma and TNFalpha in cultures of peripheral blood mononuclear cells (PBMC) taken from type 1 diabetic patients with inadequate metabolic control. METHODS:Seventeen type 1 diabetic patients and a gender- and age-matche...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.10.001
更新日期：2007-12-01 00:00:00
abstract：AIMS:Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS:Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fa...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.10.010
更新日期：2018-03-01 00:00:00
