Abstract：
AIMS:Recent evidence suggests an association between persistent organic pollutants (POPs) and type 2 diabetes. In two First Nations communities where wild food is consumed by a large portion of the population, we compared pollutants in plasma between diabetic and non-diabetic individuals, and investigated the strength of association between pollutants and insulin resistance/secretion in non-diabetic individuals. METHODS:The study population consisted of 72 participants. Oral Glucose Tolerance Tests were used to assess diabetes status. Plasma was used to determine POP concentrations and mercury concentrations were determined from hair samples. RESULTS:Age-adjusted plasma concentrations of some pollutants were significantly higher in diabetic than in non-diabetic individuals. When taking into account age, adiposity levels, and smoking status, POP levels were not associated with insulin resistance nor with insulin secretion in non-diabetic individuals. CONCLUSIONS:These findings confirm that POP concentrations in plasma may be higher in diabetic than in non-diabetic individuals. No association was however seen between POP concentrations and markers of insulin resistance/secretion in non-diabetic individuals.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Pal S,Blais JM,Robidoux MA,Haman F,Krümmel E,Seabert TA,Imbeault Pdoi
10.1016/j.diabet.2013.01.006subject
Has Abstractpub_date
2013-12-01 00:00:00pages
497-504issue
6eissn
1262-3636issn
1878-1780pii
S1262-3636(13)00033-5journal_volume
39pub_type
杂志文章abstract：:ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(07)70311-7
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.07.001
更新日期：2015-04-01 00:00:00
abstract：:The effect of propranolol on the occurrence of hypoglycaemic symptoms was assessed in insulin-dependent diabetic patients with hypoglycaemia unawareness. A double-blind, randomised parallel group study (2:1 fashion) was conducted over 4-week period. The propranolol group (n = 9) received 20 mg (week 1 and 2) and 30 mg...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-03-01 00:00:00
abstract：AIM:To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS:Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 me...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2018.03.007
更新日期：2019-04-01 00:00:00
abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70067-8
更新日期：2003-11-01 00:00:00
abstract：AIMS:Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resista...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.07.010
更新日期：2020-08-10 00:00:00
abstract：AIMS:To evaluate the current procedures in French general practice of intensifying hypoglycaemic treatment in orally treated type 2 diabetic patients, according to the French recommendations. METHODS:Type 2 diabetic patient characteristics, HbA(1c) values, hypoglycaemic treatment and physician characteristics were col...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/S1262-3636(12)71532-X
更新日期：2012-03-01 00:00:00
abstract：AIM:Experimental evidence suggests that osteocalcin is a key messenger that affects both adipocytes and insulin-producing β cells. Epidemiological cross-sectional studies have shown a negative association between plasma levels of osteocalcin and glucose. For this reason, the hypothesis that lower baseline osteocalcin p...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.01.001
更新日期：2014-06-01 00:00:00
abstract：AIM:The purpose of this prospective study was to investigate the effect of alcohol consumption on the 10-year diabetes incidence. METHODS:In 2001-2002, a random sample of 1514 men (18-89 years old) and 1528 women (18-87 years old) was selected to participate in the ATTICA study (Athens metropolitan area, Greece). Amon...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.06.003
更新日期：2015-04-01 00:00:00
abstract：AIM:Different treatment strategies have been used to manage adolescents with poorly controlled type 1 diabetes. We investigated whether a brief elective hospital admission improves haemoglobin A(1c) (HbA(1c)) over 12 months. METHODS:We studied a retrospective cohort of adolescents with poorly controlled type 1 diabete...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.04.003
更新日期：2013-12-01 00:00:00
abstract：:For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could chal...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,实务指引
doi：10.1016/j.diabet.2009.09.002
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT). SUBJECTS AND METHODS:Cross-sectional study with 107 sedentary non-diabetic overweight and obese postmenopausal (B...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.02.004
更新日期：2007-09-01 00:00:00
abstract：AIMS:The objective of the present investigation was to study the production of IL-1, IL-6, IL-10, IFNgamma and TNFalpha in cultures of peripheral blood mononuclear cells (PBMC) taken from type 1 diabetic patients with inadequate metabolic control. METHODS:Seventeen type 1 diabetic patients and a gender- and age-matche...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.10.001
更新日期：2007-12-01 00:00:00
abstract：:We report the case of a 62 year-old symptomatic patient with severe hyperglycemic hyperosmolality associated with hypernatremia. During treatment, the progressive decrease in serum tonicity, which resulted in the amelioration of the neurological symptoms, followed the decrease in serum glucose and mainly the corrected...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.08.007
更新日期：2015-12-01 00:00:00
abstract：AIMS:To describe insulin therapy in patients with diabetes, to determine treatment costs and to compare costs among treatment regimens. METHODS:This observational study was performed by 734 French pharmacists. Adult patients filling an insulin prescription were invited to participate. Participants provided information...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2011.10.003
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Automated closed-loop (CL) insulin therapy has come of age. This major technological advance is expected to significantly improve the quality of care for adults, adolescents and children with type 1 diabetes. To improve access to this innovation for both patients and healthcare professionals (HCPs), and to promote adh...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.10.004
更新日期：2020-11-02 00:00:00
abstract：BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2019.01.012
更新日期：2019-10-01 00:00:00
abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...
journal_title：Diabetes & metabolism
pub_type： 评论,杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/S1262-3636(07)70321-X
更新日期：2006-12-01 00:00:00
abstract：:Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabo...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2011.01.002
更新日期：2011-06-01 00:00:00
abstract：:One major discovery of the last decade in the field of metabolic diseases is that the microorganisms comprising the gut microbiota are now considered a metabolic "organ", modulating multiple functions of the host, such as intestinal immune system maturation, adiposity, cardiac metabolism, liver triglyceride storage, a...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2013.12.004
更新日期：2014-06-01 00:00:00
abstract：:Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-01 00:00:00
abstract：:Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine the prevalence of type 2 diabetes and impaired fasting glucose (IFG) in a population-based sample of 3 508 subjects, aged 35-64 years, participating in the French MONICA population survey from 1995 to 1997 in three French regions: the Urban Community of Lille, the Bas-R...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：
更新日期：2001-06-01 00:00:00
abstract：:Type 1 diabetes (T1D) is due to the loss of both beta-cell insulin secretion and glucose sensing, leading to glucose variability and a lack of predictability, a daily issue for patients. Guidelines for the treatment of T1D have become stricter as results from the Diabetes Control and Complications Trial (DCCT) demonst...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2013.10.003
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:To analyze pulse pressure (PP) as a risk predictor for coronary heart disease (CHD), stroke and cardiovascular disease (CVD; CHD and/or stroke) in type 2 diabetic patients. METHODS:A total of 11,128 female and male type 2 diabetic patients with known baseline PP values and no CVD, aged 50-74 years, were fol...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2009.04.010
更新日期：2009-12-01 00:00:00
abstract：:The capacity of cardiac myocyte to regulate ATP production to face any change in energy demand is a major determinant of cardiac function. Because FA is the main heart fuel (although the most expensive one in oxygen, and prompt to induce deleterious effects), this process is based on a balanced fatty acid (FA) metabol...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
