Abstract：
:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly expressed in the syncytiotrophoblast and extravillous cytotrophoblast cells. It has a key role in trophoblast invasion, as shown by studies in vitro, but its precise role during placentation remains to be elucidated, and fetomaternal outcomes of FPLD3 pregnancies also need to be assessed. This report is of a novel missense heterozygous mutation of PPARγ identified during pregnancy in a young diabetic woman who, at 3weeks of amenorrhoea, prematurely delivered a baby who died 24 h later. Histopathological analysis revealed important vascular placental abnormalities. The presence of the PPARγ mutation in placental tissues in the absence of fetal malformations and maternal hypertension suggests that FPLP3 pregnancies may be at high-risk, especially if the fetus has inherited the mutation. It also supports a physiological role for PPARγ during placentation.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Castell AL,Hiéronimus S,Lascols O,Fournier T,Fénichel Pdoi
10.1016/j.diabet.2012.02.012subject
Has Abstractpub_date
2012-10-01 00:00:00pages
367-9issue
4eissn
1262-3636issn
1878-1780pii
S1262-3636(12)00050-Xjournal_volume
38pub_type
杂志文章abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/S1262-3636(07)70321-X
更新日期：2006-12-01 00:00:00
abstract：:Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compare...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2010.08.002
更新日期：2010-12-01 00:00:00
abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70067-8
更新日期：2003-11-01 00:00:00
abstract：:Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues an...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...
journal_title：Diabetes & metabolism
pub_type： 评论,杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:Optimal glycaemic control is necessary to prevent diabetes-related complications. An intensive treatment, which could mimic physiological insulin secretion, would be the best one. However subcutaneous insulin treatment is not physiologic and represents a heavy burden for patients with type 1 and type 2 diabetes mellit...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/s1262-3636(06)72804-x
更新日期：2006-12-01 00:00:00
abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.08.007
更新日期：2015-12-01 00:00:00
abstract：:Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...
journal_title：Diabetes & metabolism
pub_type： 指南,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：AIMS:Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resista...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.07.010
更新日期：2020-08-10 00:00:00
abstract：:Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(08)70096-X
更新日期：2008-02-01 00:00:00
abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.08.005
更新日期：2014-12-01 00:00:00
abstract：:The metabolic syndrome (MS) describes a cluster of metabolic disturbances including type 2 diabetes and/or insulin resistance, hypertension, dyslipidemia and obesity, which predict a high risk of cardiovascular disorders. The associated hyperinsulinemia and hyperleptinemia may contribute to the cardiovascular risk. Ho...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70274-4
更新日期：2006-06-01 00:00:00
abstract：AIM:Online continuous glucose monitoring (CGM) during physical exercise would be highly useful in patients with insulin-treated diabetes. For this reason, this study assessed whether such a goal could be reached with a subcutaneous 'needle-type' enzymatic sensor. METHODS:Ten patients (five women/five men), aged 51 ± 1...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2012.12.004
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canaglifl...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2015.10.003
更新日期：2016-02-01 00:00:00
abstract：:There are few studies on the effects of postprandial hyperglycaemia, and usually it is assumed that its effects are the same as those of post-glucose-load hyperglycaemia, following a standard 75 g oral glucose tolerance test. There is some evidence from a study with blood drawn following ingestion of a standardised "d...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(06)70478-5
更新日期：2006-09-01 00:00:00
abstract：:This study evaluated the effect of cisapride on glycaemic control, well-being and treatment satisfaction in insulin-dependent diabetes mellitus (IDDM) patients with documented moderate to severe glycaemic instability. Thirty-seven patients with glycaemic instability were included in a randomized, double-blind, placebo...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-09-01 00:00:00
abstract：:In Type 1 diabetes, high circulating growth hormone (GH) in conjunction with low plasma insulin-like growth factor-I (IGF-I) is indicative of a hepatic GH-resistance profile since the liver is the main source of circulating IGF-I. The reduction in specific growth hormone binding protein (GHBP), corresponding to the ex...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.01.006
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:Regular physical activity (PA) in young needs to be promoted to prevent obesity and subsequent diabetes. Influences of parental PA on adolescents' activity level have been studied with discordant results and the effect of socioeconomic status (SES) on these relationships is not clarified. METHODS:Cross-sect...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70129-5
更新日期：2004-09-01 00:00:00
abstract：:The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesit...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2007.08.002
更新日期：2008-02-01 00:00:00
abstract：:TNF-alpha is considered as one of the potential determinants of insulin resistance. However several data suggest that TNF-alpha expression itself, could be modulated by the degree of adiposity and/or plasma insulin levels. To clarify the determinants of plasma TNF-alpha levels in type 2 diabetes mellitus, we studied t...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：AIM:The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2019.11.003
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of a patient education program on diabetes control. METHODS:A pre-test post-test pre experimental study was performed with 87 insulin treated diabetic patients followed in the chronic disease unit of Kelibia district (Nabeul, Tunisia). Subjects received education in 6 monthly sess...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70207-0
更新日期：2005-09-01 00:00:00
abstract：:We report the case of a young insulin-dependent diabetic patient in whom acute renal failure led to detection of ureterohydronephrosis secondary to neurogenic bladder. The persistence of a high daily urine volume revealed diabetes insipidus, suggesting Wolfram syndrome, which was confirmed by the diagnosis of optic at...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70009-5
更新日期：2003-02-01 00:00:00
abstract：:Most primary-care physicians have adopted electronic medical records (EMRs) for the management of patients in ambulatory care. Observational trials suggest that the use of EMRs improves the achievement of the recommended standards of diabetes care and intermediate outcomes. A French group of general practitioners has ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(11)70965-X
更新日期：2011-12-01 00:00:00
abstract：:Type 1 diabetes (T1D) is due to the loss of both beta-cell insulin secretion and glucose sensing, leading to glucose variability and a lack of predictability, a daily issue for patients. Guidelines for the treatment of T1D have become stricter as results from the Diabetes Control and Complications Trial (DCCT) demonst...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2013.10.003
更新日期：2014-04-01 00:00:00
abstract：AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insuli...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2016.10.005
更新日期：2017-02-01 00:00:00
abstract：:Obesity and visceral or upper body fat distribution, have a major impact on insulin sensitivity. There is strong evidence to suggest that free fatty acids (FFA) contribute to the pathogenesis of insulin resistance and the metabolic syndrome. Increased FFA release from adipose tissue or failure of FFA using tissues to ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
