Abstract:
AIM:The objective of the study was to examine the correlation between three methods of measuring insulin sensitivity (IS) - namely, the frequently sampled intravenous glucose tolerance test (FSIVGTT), indices derived from the oral glucose tolerance test (OGTT) and fasting indices (HOMA-IR, QUICKI, fasting insulin [INS(0)]) - and the gold-standard method, the hyperinsulinaemic-euglycaemic clamp (HEC) test, in children. METHODS:A total of 20 children [nine boys and 11 girls; mean (SD) age: 9 (2) years] were studied. Their mean (SD) BMI Z score was 1.5 (0.8). All participants had normal glucose metabolism. Each child underwent a 3-h HEC (40 mU/m(2)/min of insulin), an insulin-modified minimal-model FSIVGTT and a 3-h OGTT. The clamp-derived IS was calculated, using DeFronzo's metabolized glucose index and Bergman's IS index. Correlations were established using Spearman's rank correlations. RESULTS:The two clamp-derived measures were highly correlated (r=0.85), and the IS measured from the FSIVGTT was well correlated with both clamp measures [r=0.69, 0.74]. Of the nine indices derived from the OGTT, the three with the highest correlation with clamp results were the ISI Matsuda [r=0.63, 0.68], SI(is)OGTT [r=0.53, 0.65] and log sum insulin [r=-0.64, -0.75]. Fasting indices of IS had similar correlations to clamp results: HOMA-IR [r=-0.55, -0.56]; QUICKI [r=0.55, 0.57]; and INS(0) [r=-0.59, -0.63]. CONCLUSION:While fasting-based indices of IS are a suitable option for large cohorts, OGTT-derived indices may represent a useful compromise for obtaining both clinical (glucose tolerance) and physiological (insulin sensitivity) information, making them particularly useful for large-scale physiological and epidemiological studies.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Henderson M,Rabasa-Lhoret R,Bastard JP,Chiasson JL,Baillargeon JP,Hanley JA,Lambert Mdoi
10.1016/j.diabet.2010.06.008subject
Has Abstractpub_date
2011-02-01 00:00:00pages
72-8issue
1eissn
1262-3636issn
1878-1780pii
S1262-3636(10)00210-7journal_volume
37pub_type
临床试验,杂志文章abstract:AIMS:This study aimed to determine the prevalence of the metabolic syndrome (MetS) and its association with socio-economic status in the population of Great Tunis. METHODS:The study included 2712 subjects (1228 men and 1484 women), aged 35-70 years and living in the Great Tunis region, all of whom were recruited betwe...
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 临床试验,杂志文章
doi:
更新日期:1997-06-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2001-02-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2020-05-26 00:00:00
abstract:AIM:While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. METHODS:In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels ...
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更新日期:2020-06-01 00:00:00
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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