Abstract:
:Non-insulin-dependent diabetes mellitus (NIDDM) is an important health issue in France. According to projections from current data, the problem should increase over the upcoming years. The aim of this study was to determine the characteristics of patients with NIDDM who are enrolled on the list of 30 long term diseases (ALD30) and examine their follow-up and disease-related complications. This study was performed with the data base established by the French National Health Insurance for Salaried Workers (CMANTS) in 1994. Diagnosis and medical information were coded by official physicians, who either examined the patients or consulted their primary care physician (69% of the cases), or relied on available medical records. Eight thousand two hundred forty-seven patients (sex ration=0.95) with NIDDM enrolled on the long term disease list were included. Mean age was 65.1+/- 0.13 years (m+/- SEM). More than one blood glucose level per year was available for 89% of the patients and an HA1c assay in only 34%. In addition, for patient follow-up at least once a year, 80%, 47%, and 42% of the patients had a serum creatinine assay, a funus examination, or an electorcariogram respectively. Irrespective of the criteria retained (fasting glucose=1.26 g/l; fasting glucose=1.40 g/l) there was a high percentage of patients whose level was well above the limit (75% and 63% respectively). For HbA1c, only a quarter of the patients had values lower than the limits defined by the ANAES and AFFSAPS guidelines. The percentage of diabetic patients without complications was 41% (hypertension excluded). The most frequently observed complications isolated peripheral vascular conditions (31%). These results were obtained from a database created in 1994, before guidelines on type 2 diabetes were officially published. They can serve as a reference to follow medical practices.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Vauzelle-Kervroëdan F,Cherou-Debregeas S,Forhan A,Fender P,Eschwège Esubject
Has Abstractpub_date
2000-09-01 00:00:00pages
55-62eissn
1262-3636issn
1878-1780pii
62827journal_volume
26 Suppl 6pub_type
杂志文章abstract::In diabetes mellitus (DM), the high urine flow rate suggests that urinary concentrating capacity is impaired. However, several studies have shown that vasopressin is elevated in DM and the consequences of this elevation have not yet been characterized. This study reevaluated renal function and water handling in male W...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:Although it is important to screen women who have had gestational diabetes mellitus (GDM) for abnormal post-partum glucose levels, such testing is rarely performed. The aim of this study was to use data from the first observational phase of the IMPACT study to determine rates of screening within 6 months o...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,多中心研究
doi:10.1016/j.diabet.2013.12.002
更新日期:2014-04-01 00:00:00
abstract:AIM:Oxytocin administration to diet-induced obese (DIO) rodents, monkeys and humans decreases body weight and fat mass with concomitant improvements in glucose metabolism. Moreover, several studies show an immunomodulatory role of oxytocin in a number of settings (such as atherosclerosis, injury, sepsis). This study ai...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2017.10.004
更新日期:2018-06-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain ho...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2014.03.004
更新日期:2014-06-01 00:00:00
abstract:AIM:To study the foveal avascular zone (FAZ) of the central retina in diabetic patients with retinopathy having undergone metabolic evaluation. METHODS:One hundred and ten digital fluorescein angiograms were chosen from our digital image bank after cross matching diabetic patient lists of the ophthalmology and endocri...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70217-3
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The pre...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2011.02.003
更新日期:2011-11-01 00:00:00
abstract::The main purpose of intensive insulin therapy in insulin-dependent diabetes mellitus is to prevent complications by maintaining short- and long-term euglycaemia. This therapeutic approach implies a high frequency of hypoglycaemic events which can be disturbing when hypoglycaemia unawareness is involved. Although this ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:End-stage renal disease (ESRD) requiring renal replacement therapy (RRT) is a late complication of type 2 diabetes. The correlation between pre-ESRD medical care and outcome has been rarely studied in France. METHODS:Community-based study of case-incIdent ESRD patients. Medical care practices were described ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70091-5
更新日期:2004-02-01 00:00:00
abstract::Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (es...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2009.05.003
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to investigate insulin secretion, insulin-receptor binding and peripheral insulin sensitivity in subjects with different degrees of obesity. METHODS:36 obese subjects with normal glucose tolerance and different degrees of obesity and 40 healthy normal-weight subjects partici...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70138-6
更新日期:2004-11-01 00:00:00
abstract:AIM:This study investigated the relationship between endothelial dysfunction (ED) and arterial stiffness (AS) in adults with type 1 diabetes and no clinical cardiovascular (CV) disease. METHODS:A total of 68 patients with type 1 diabetes and 68 age- and gender-matched healthy (non-diabetic) subjects were evaluated. ED...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2013.03.006
更新日期:2013-09-01 00:00:00
abstract::Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/s1262-3636(05)73656-9
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:Regular physical activity (PA) in young needs to be promoted to prevent obesity and subsequent diabetes. Influences of parental PA on adolescents' activity level have been studied with discordant results and the effect of socioeconomic status (SES) on these relationships is not clarified. METHODS:Cross-sect...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70129-5
更新日期:2004-09-01 00:00:00
abstract::Type 2 diabetes is characterised by insulin resistance in association with clustering of atherothrombotic risk factors (dysglycaemia, hyperinsulinaemia, hypertension, raised triglyceride, low HDL cholesterol and increased levels of plasminogen activator inhibitor-1 (PAI-1) and clotting factor VII). There is a 3-5 fold...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/s1262-3636(03)72787-6
更新日期:2003-09-01 00:00:00
abstract::Hypoglycaemia unawareness, a frequent syndrome in insulin-dependent diabetes mellitus (IDDM), involves a decrease or absence of perception of specific symptoms which normally inform the subject that plasma glucose is decreasing to dangerous levels leading to neuroglycopenia. Without warning symptoms, IDDM patients are...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract::Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2021.101233
更新日期:2021-01-23 00:00:00
abstract::Preretinal neovascularization and chronic retinal oedema are the two major sight-threatening complications that can occur during diabetic retinopathy. Ocular neovascularization is strongly associated with retinal ischaemia, and growth factors have been implicated in its pathogenesis. The ischaemic retina is assumed to...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00
abstract::The "Société Française de Gériatrie et Gérontologie" (SFGG) and "Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques" (ALFEDIAM) have decided to join their efforts in actions to improve the management and treatment of the elderly diabetic patients. New knowledge brought by the fundamen...
journal_title:Diabetes & metabolism
pub_type: 社论
doi:10.1016/s1262-3636(05)73646-6
更新日期:2005-12-01 00:00:00
abstract::A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/s1262-3636(07)70148-9
更新日期:2004-12-01 00:00:00
abstract:AIM:Patients with diabetes have shown lower performance in tests of cognitive function especially those testing memory, executive functions, and psychomotor efficiency. They also have an elevated risk of both vascular dementia and Alzheimer's disease. Cognitive impairment may have consequence on treatment compliance. ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/S1262-3636(10)70475-4
更新日期:2010-10-01 00:00:00
abstract:AIM:To investigate the locus of control in patients with type 2 diabetes followed by systemic group education (Group Care) and traditional one-to-one care. METHODS:In a post-hoc analysis, two questionnaires were administered to 56 patients who had been followed for 5-7 years by Group Care and 51 controls followed by i...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70250-1
更新日期:2006-02-01 00:00:00
abstract:AIM:Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus,...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2017.06.008
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2019.01.012
更新日期:2019-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. Over the last 10years, it has also become increasingly evident that NAFLD is a multisystem disease, affecting many extra-hepatic organ systems and inte...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2016.04.002
更新日期:2016-06-01 00:00:00
abstract::Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...
journal_title:Diabetes & metabolism
pub_type: 指南,杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:AIM:The prevalence of diabetes in the French West Indies is three times higher than in mainland France. We aimed to assess the associations between vitamin D deficiency, vitamin D receptor (VDR) gene polymorphisms and cardiovascular risk factors in Caribbean patients with type 2 diabetes (T2D). METHODS:In this cross-s...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2011.05.005
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70196-9
更新日期:2005-06-01 00:00:00
abstract::Postprandial hyperglycaemia is a phenomenon often neglected by patients as well as doctors. While patients only voluntarily measure morning and preprandial capillary glycaemia, physicians do not encourage the measurement of anything further. The specific role of postprandial hyperglycaemia in the determination of late...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70268-9
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract:AIM:The present study investigated the cyclooxygenase (COX) pathway to elucidate any changes that may be involved in the mechanism(s) underlying diabetic fetopathy. METHODS:Diabetes was induced in female rats (n=12) by two successive daily injections of 55 mg/kg streptozotocin, while control animals (n=10) were inject...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2009.06.009
更新日期:2010-02-01 00:00:00