Metabolic factors and the foveal avascular zone of the retina in diabetes mellitus.

Abstract:

AIM:To study the foveal avascular zone (FAZ) of the central retina in diabetic patients with retinopathy having undergone metabolic evaluation. METHODS:One hundred and ten digital fluorescein angiograms were chosen from our digital image bank after cross matching diabetic patient lists of the ophthalmology and endocrinology departments of our institution. The patients had undergone day visits with systemic, biological and ophthalmologic evaluation, including digital fluorescein angiography. RESULTS:Sex ratio was M 62/F 48. Average age was 52.4 years (+/- 13.8) with 44 type 1 diabetics and 66 type 2. Retinopathy was present in all patients (54 background (BDR), 30 pre-proliferative (PPDR), 26 proliferative (PDR)). Age was positively correlated with FAZ grade (47.3 years +/- 13.2 for normal FAZ, 53.8 years +/- 13.7 for abnormal FAZ, P=0.03). Lipid profile showed a protective tendency of the Apo A1 fraction of cholesterol on macular vascularization (1.7 gr./l in normal FAZ patients vs 1.43 gr./l in abnormal FAZ patients, P=0.004). Body mass index was negatively correlated with macular ischemia (28.11 if FAZ not severely altered, 25.97 if FAZ severely altered, P=0.03). CONCLUSIONS:We found possible relations between BMI and Apo A 1 cholesterol and macular vascularization which may warrant further investigation.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Conrath J,Giorgi R,Ridings B,Raccah D

doi

10.1016/s1262-3636(07)70217-3

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

465-70

issue

5

eissn

1262-3636

issn

1878-1780

pii

s1262-3636(07)70217-3

journal_volume

31

pub_type

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