Abstract:
OBJECTIVES:The aim of the present study was to investigate insulin secretion, insulin-receptor binding and peripheral insulin sensitivity in subjects with different degrees of obesity. METHODS:36 obese subjects with normal glucose tolerance and different degrees of obesity and 40 healthy normal-weight subjects participated in the study. Peripheral insulin sensitivity was measured by using the euglycaemic hyperinsulinaemic clamp technique, and insulin-receptor binding-on circulating mononuclear blood cells. Insulin secretion was studied during intravenous tolbutamide test. RESULTS:The subjects with I degree of obesity demonstrated a significant decrease in the number of total (p<0.0001) and high-affinity (p<0.01) insulin receptors per cell, as well as significantly higher insulin receptor affinity (p<0.01) as compared to the normal-weight subjects. The subjects with II degree of obesity also demonstrated a significant decrease in the number of total (p<0.0001) and high-affinity receptors (p<0.001) per cell as well as an increase (p<0.001) in insulin-receptor affinity as compared to the controls. The significantly decreased receptor number in the subjects with I and II degree of obesity was accompanied by an increase in insulin receptor affinity; thus their insulin-receptor binding being maintained similar to the controls. The subjects with III degree obesity presented a significant decrease (p<0.0001) in the number of both the total and high-affinity insulin receptors as well as a reduction in insulin receptor affinity as compared to the controls. Therefore the percentage of specifically bound insulin was significantly lower (p<0.01) as compared to that of the control group. Insulin resistance in the obese subjects is associated with secondary hyperinsulinaemia, which is present in subjects with I and II degree of obesity; while in severely obese subjects exhaustion of beta-cell secretory capacity is observed. CONCLUSION:We consider that III degree of obesity appears to be a risk factor for type 2 diabetes mellitus as the alterations in insulin sensitivity, insulin-receptor binding and beta-cell secretion are quite similar to the reported in diabetic patients.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Borissova AM,Tankova TI,Koev DJdoi
10.1016/s1262-3636(07)70138-6subject
Has Abstractpub_date
2004-11-01 00:00:00pages
425-31issue
5eissn
1262-3636issn
1878-1780pii
s1262-3636(07)70138-6journal_volume
30pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2000-02-01 00:00:00
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更新日期:2004-04-01 00:00:00
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更新日期:2012-11-01 00:00:00
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更新日期:2014-12-01 00:00:00
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更新日期:2000-06-01 00:00:00
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更新日期:2018-03-01 00:00:00
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.diabet.2015.08.007
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2007-04-01 00:00:00