HBA1c: clinical and biological agreement for standardization of assay methods. Report by the experts of ALFEDIAM (Association de Langue Française pour lEtude du Diabète et des Maladies Métabolique) and SFBC (Société Française de Biologie Clinique).

Abstract:

:Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and all of them are not yet standardized. The consequence is an under-utilization of this test, especially in non-hospital practice. In this context, working groups of Société Française de Biologie Clinique (SFBC), Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques (ALFEDIAM) and Société Française d'Endocrinologie (SFE) have met together, in order to analyze the national status, and to propose practical recommendations for implementing a standardization process on the basis of international experiences. It is recommended to exclusively express results as HbA1c percentage, using methods standardized and certified by comparison to reference methods such as those using Diabetes Control and Complications Trial (DCCT) values. Simultaneously, contacts have been established with manufacturers, and the realisation of periodic quality control surveys was encouraged.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Gillery P,Bordas-Fonfrède M,Chapelle JP,Drouin P,Hue G,Lévy-Marchal C,Périer C,Sélam JL,Slama G,Thivolet C,Vialettes B

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

283-7

issue

3

eissn

1262-3636

issn

1878-1780

pii

MDOI-DM-08-1999-25-3-1262-3636-101019-ART80

journal_volume

25

pub_type

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