Abstract:
:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual pen and insulin cartridge. Cytopathological examination was performed on the material obtained from the needles and found in cartridges after centrifugation. Non-inert material was found in 28% of needles and 58% of cartridges, including squama (18 and 50% respectively) and epithelial cells (20 and 42% respectively). These data, which suggest a non-passive capture of biological material into the delivery system after injection, emphasise the rule of strictly individual use of insulin delivery systems, including cartridges. The precise impact of self-injection of this non-inert material on individuals during repeated pen injections remains uncertain.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Le Floch JP,Herbreteau C,Lange F,Perlemuter Lsubject
Has Abstractpub_date
1997-06-01 00:00:00pages
228-9issue
3eissn
1262-3636issn
1878-1780pii
MDOI-DM-06-1997-23-3-1262-3636-101019-ART88journal_volume
23pub_type
临床试验,杂志文章abstract::We scrutinized the relation between body height and renal involvement in a large population-based sample of newly diagnosed diabetic patients aged 40 years or over. The urinary albumin concentration (UAC) was measured in freshly voided morning urine in 1,284 newly diagnosed diabetic patients. The course of insulin tre...
journal_title:Diabetes & metabolism
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2001-02-01 00:00:00
abstract:AIM:Oxytocin administration to diet-induced obese (DIO) rodents, monkeys and humans decreases body weight and fat mass with concomitant improvements in glucose metabolism. Moreover, several studies show an immunomodulatory role of oxytocin in a number of settings (such as atherosclerosis, injury, sepsis). This study ai...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2017.10.004
更新日期:2018-06-01 00:00:00
abstract::ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/S1262-3636(07)70311-7
更新日期:2006-12-01 00:00:00
abstract:AIM:To evaluate the correspondence between first-trimester fasting glycaemia and the results of the OGTT in diagnosing gestational diabetes (GDM). METHODS:The medical records of all consecutive women who had undergone a diagnostic OGTT, performed according to the IADPSG, during the past year were retrospectively revie...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2012.03.006
更新日期:2012-11-01 00:00:00
abstract::Insulin resistance was already suspected in the thirties from clinical observations in diabetic patients, then better appreciated in the early sixties with the development of insulin radioimmunoassay, and finally confirmed in the last 20 years by using various sophisticated methods able to quantify insulin action. Fir...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2001-04-01 00:00:00
abstract::The main purpose of intensive insulin therapy in insulin-dependent diabetes mellitus is to prevent complications by maintaining short- and long-term euglycaemia. This therapeutic approach implies a high frequency of hypoglycaemic events which can be disturbing when hypoglycaemia unawareness is involved. Although this ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract:AIM:Experimental evidence suggests that osteocalcin is a key messenger that affects both adipocytes and insulin-producing β cells. Epidemiological cross-sectional studies have shown a negative association between plasma levels of osteocalcin and glucose. For this reason, the hypothesis that lower baseline osteocalcin p...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2014.01.001
更新日期:2014-06-01 00:00:00
abstract::The prevalence of diabetes in African communities is increasing with ageing of the population and lifestyle changes associated with rapid urbanisation and westernisation. Traditional rural communities still have very low prevalence, at most 1-2%, except in some specific high-risk groups, whereas 1-13% or more adults i...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2001-12-01 00:00:00
abstract:AIM:This study assessed whether or not elevated serum uric acid can predict impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) in Japanese people undergoing health checkups. METHODS:Altogether, 7114 male and 5529 female participants in both 2000 and 2005 were targeted for the study. After excluding tho...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2010.10.009
更新日期:2011-06-01 00:00:00
abstract::The CGMS (Continuous Glucose Monitoring System) is a portable device allowing continuous measuring of glucose. It provides recordings of at least 72 h, during which 288 measures/day are performed. Results are visualised in the form of a set of curves, illustrating the variations in blood glucose levels over time. The ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/s1262-3636(07)70258-6
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Low magnesium (Mg) status has been implied as a factor in the development of type 2 diabetes mellitus (DM) and its complications. We therefore studied Mg-status in identical twins, discordant for type 2 DM and in matched controls. Through correlation analysis, possible associations between Mg-status and gluc...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...
journal_title:Diabetes & metabolism
pub_type: 评论,杂志文章,评审
doi:
更新日期:2002-12-01 00:00:00
abstract:AIM:This study assessed the prevalence of undiagnosed diabetes and a high risk for diabetes using glycated haemoglobin (HbA(1c)) values in middle-aged patients undergoing cataract surgery. METHODS:The study comprised 137 consecutive patients, aged 40 to 65 years, with no known diabetes undergoing cataract surgery at a...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2012.10.009
更新日期:2013-05-01 00:00:00
abstract:AIMS:To assess the prevalence and severity of bone disease in type 1 diabetic patients and to determine serum markers of bone remodeling as well as their relationship with bone mineral density (BMD). METHODS:BMD [by dual energy x-ray absorptiometry (DXA)] and serum markers of bone remodeling [osteocalcin, c-terminal t...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70303-8
更新日期:2006-11-01 00:00:00
abstract::Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/s1262-3636(05)73656-9
更新日期:2005-12-01 00:00:00
abstract::Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (es...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2009.05.003
更新日期:2009-12-01 00:00:00
abstract:AIMS:Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS:Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fa...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2017.10.010
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70009-5
更新日期:2003-02-01 00:00:00
abstract::Renal remodelling in hyperinsulinic/insulinopenic states is mediated by glucotoxicity, endothelial dysfunction and vascular and nephron collagen turnover. Hypertensive and renal links are renewed by renoprotective interventions of renin-angiotensin. Vasoactive peptide processing and vascular collagen deposition are un...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Insulin aspart (IAsp) is one of the three rapid-acting insulin analogues (RAAs) registered for the treatment of diabetes. However, there is an ongoing debate concerning the efficacy and safety of RAAs. For this reason, a systematic review-based study was performed to compare clinical outcomes of treatment wi...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.diabet.2010.12.003
更新日期:2011-06-01 00:00:00
abstract::Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...
journal_title:Diabetes & metabolism
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::We report a rare case of hypothermia with acute renal failure in a patient suffering from diabetic nephropathy. A 71-year-old male who had been receiving insulin therapy for the treatment of diabetes mellitus complicated with advanced diabetic nephropathy since 1998 was malnourished with an extremely decreased muscle ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract:AIMS:There is a need for evaluation of screening and grading services for diabetic retinopathy (DR) in compliance with quality-assurance (QA) standards. We describe the screening/grading QA programme set up for OPHDIAT over the 2005-2006 period. METHODS:Screening and grading objectives, evaluation criteria and minimum...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,多中心研究
doi:10.1016/j.diabet.2008.01.004
更新日期:2008-06-01 00:00:00
abstract::Gestational diabetes, a glucose tolerance disorder of variable severity which occurs or is diagnosed for the first time during pregnancy, constitutes a public health problem because of its frequency (1 to 6% of all pregnancies) and its short- or long-term consequences for the fetus and/or the mother. The classical mat...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2012.02.012
更新日期:2012-10-01 00:00:00
abstract::The association of diabetes with HLA class I alleles in the early 1970s and with HLA class II alleles in the late 1970s provided a crucial, though indirect, indication of the role of immune phenomena in the development of insulin-dependent diabetes mellitus (IDDM). Genotyping of HLA alleles in the mid-1980s opened up ...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract:AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2018.08.009
更新日期:2020-09-01 00:00:00
abstract:AIM:Online continuous glucose monitoring (CGM) during physical exercise would be highly useful in patients with insulin-treated diabetes. For this reason, this study assessed whether such a goal could be reached with a subcutaneous 'needle-type' enzymatic sensor. METHODS:Ten patients (five women/five men), aged 51 ± 1...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2012.12.004
更新日期:2013-05-01 00:00:00
abstract::With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality. New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation, and is a strong predictor of graft failure and c...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2010.09.003
更新日期:2011-02-01 00:00:00