Abstract:
OBJECTIVE:To determine the relationship between CRP levels and the components of MS in normal glucose tolerant (NGT), impaired glucose tolerant (IGT), and Type 2 diabetic subjects. MATERIAL AND METHODS:A based cross-sectional population study was performed. Eligible subjects, men and non-pregnant women, 30 to 64 year of age, were randomly recruited. Subjects with acute or chronic diseases were excluded. Only newly diagnosed type 2 diabetic or hypertensive subjects were included. Disorders related to CRP increase, also were exclusion criteria. In accordance to WHO proposal, components of MS were: High Blood Pressure, Dyslipidemia, Obesity, and Microalbuminuria, and MS was defined, for the NGT, if at least two of the criteria were fulfilled and in addition the subject had insulin resistance. The MS in IGT and DM subjects was defined if at least two of the criteria were fulfilled. RESULTS:CRP was significantly associated with MS for the NGT (Odds ratio -OR- 3.8, CI(95%) 1.6-14.8), IGT (OR 4.9, CI(95%) 1.2-15.5), and diabetes (OR 5.6, CI(95%) 1.9-10.2). For NGT, after adjustment for obesity, CRP was not longer associated with MS. After adjust for obesity and fasting glucose (FG), the relationship between CRP and MS for IGT was lost. Finally, after adjustment for obesity, FG, and microalbuminuria, CRP was not longer associated with MS for diabetic subjects. CONCLUSIONS:This study show a significant relationship between CRP and MS which is maintained only by obesity in the NGT, by obesity and FG in the IGT, and by obesity, FG, and microalbuminuria in the newly diagnosed diabetic subjects.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Guerrero-Romero F,Rodríguez-Morán Mdoi
10.1016/s1262-3636(07)70009-5subject
Has Abstractpub_date
2003-02-01 00:00:00pages
65-71issue
1eissn
1262-3636issn
1878-1780pii
MDOI-DM-02-2003-29-1-1262-3636-101019-ART9journal_volume
29pub_type
杂志文章abstract::Plasma glucose, insulin and glucose tolerance were quantified in diabetic Goto-Kakizaki (GK) rats (342+/-45 g, n = 5) and compared with weight-matched non-diabetic Wistars (307+/-30 g, n = 8). Compared to Wistars, GK rats had higher fasting plasma insulin (219+/-50 versus 44+/-14 pmol/l, P<0.002) and glucose (9.2+/-2....
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2007.03.002
更新日期:2007-09-01 00:00:00
abstract:AIM:Oxytocin administration to diet-induced obese (DIO) rodents, monkeys and humans decreases body weight and fat mass with concomitant improvements in glucose metabolism. Moreover, several studies show an immunomodulatory role of oxytocin in a number of settings (such as atherosclerosis, injury, sepsis). This study ai...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
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journal_title:Diabetes & metabolism
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更新日期:2002-09-01 00:00:00
abstract::The metabolic syndrome (MS) describes a cluster of metabolic disturbances including type 2 diabetes and/or insulin resistance, hypertension, dyslipidemia and obesity, which predict a high risk of cardiovascular disorders. The associated hyperinsulinemia and hyperleptinemia may contribute to the cardiovascular risk. Ho...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
abstract::Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabo...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2011.01.002
更新日期:2011-06-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain ho...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2014.03.004
更新日期:2014-06-01 00:00:00
abstract::Gestational diabetes, a glucose tolerance disorder of variable severity which occurs or is diagnosed for the first time during pregnancy, constitutes a public health problem because of its frequency (1 to 6% of all pregnancies) and its short- or long-term consequences for the fetus and/or the mother. The classical mat...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality. New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation, and is a strong predictor of graft failure and c...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2010.09.003
更新日期:2011-02-01 00:00:00
abstract:AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2015.08.007
更新日期:2015-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,多中心研究
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更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70076-9
更新日期:2003-12-01 00:00:00
abstract:AIM:To investigate the level of diabetes knowledge in a population with type 2 diabetes (T2D) and a high prevalence of illiteracy, to identify the main gaps in the knowledge and to study the determinants of the knowledge score. METHODS:This cross-sectional survey involved 24 diabetes clinics and Kuwaiti adults with T2...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2008.09.005
更新日期:2009-04-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,meta分析
doi:10.1016/j.diabet.2008.03.006
更新日期:2008-11-01 00:00:00
abstract:AIM:Different treatment strategies have been used to manage adolescents with poorly controlled type 1 diabetes. We investigated whether a brief elective hospital admission improves haemoglobin A(1c) (HbA(1c)) over 12 months. METHODS:We studied a retrospective cohort of adolescents with poorly controlled type 1 diabete...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2013.04.003
更新日期:2013-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:AIM:Injections and fingersticks administered to patients with diabetes in health care settings present a risk of blood exposure to the injector as well as other workers in potential contact with sharps. Such exposures could lead to transmission of bloodborne pathogens such as hepatitis and HIV. A recent EU Directive re...
journal_title:Diabetes & metabolism
pub_type: 共识发展会议,杂志文章,实务指引,评审
doi:10.1016/S1262-3636(12)70975-8
更新日期:2012-01-01 00:00:00
abstract:AIM:Our objective was to verify the energy balance in streptozotocin-induced diabetic rats chronically treated with lipoic acid (LA). METHODS:Diabetes was induced in rats by streptozotocin and the animals divided into four groups, comprising controls and diabetic rats, with each group receiving either daily intraperit...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2008.08.005
更新日期:2009-04-01 00:00:00
abstract::We present the first case of muscle infarction in a 30-year-old woman who had a 5-year history of type 1 diabetes mellitus that was not complicated by nephropathy, retinopathy or neuropathy. All common causes of muscle infarction were excluded, particularly microangiopathy and a hypercoagulable state. The differential...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2007.06.003
更新日期:2007-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2009.11.009
更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::The "Société Française de Gériatrie et Gérontologie" (SFGG) and "Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques" (ALFEDIAM) have decided to join their efforts in actions to improve the management and treatment of the elderly diabetic patients. New knowledge brought by the fundamen...
journal_title:Diabetes & metabolism
pub_type: 社论
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更新日期:2005-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.diabet.2015.10.003
更新日期:2016-02-01 00:00:00
abstract:AIM:This study compared the clinical and biochemical characteristics and microvascular complications found in three groups of type 2 diabetes (T2D) patients: Africans living in Africa; African immigrants living in France; and Caucasians living in France. METHODS:Diagnosed T2D Africans living in Cameroon (n=100) were c...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2013.07.004
更新日期:2014-02-01 00:00:00
abstract::Our society is currently facing an epidemic of diabetes and heart failure. Historically, certain cardiology treatments, mainly beta-blockers, have been considered 'dangerous' in diabetic patients, but the time has come for personalized medicine to be applied in the field of cardiology, especially in heart failure (HF)...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2015.06.004
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...
journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2019.01.012
更新日期:2019-10-01 00:00:00
abstract:AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patien...
journal_title:Diabetes & metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.diabet.2018.05.010
更新日期:2019-01-01 00:00:00