Abstract：
:Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A moderately differentiated adenocarcinoma of the cardia with metastatic extension to the stomach and the liver was demonstrated. Octreotide failed to control the hypoglycaemia, therefore prednisolone (2 mg/kg per day) and enteral feeding prevented new episodes of severe hypoglycaemia.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Morbois-Trabut L,Maillot F,De Widerspach-Thor A,Lamisse F,Couet Cdoi
10.1016/s1262-3636(07)70119-2subject
Has Abstractpub_date
2004-06-01 00:00:00pages
276-9issue
3eissn
1262-3636issn
1878-1780pii
s1262-3636(07)70119-2journal_volume
30pub_type
杂志文章abstract：AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2018.08.009
更新日期：2020-09-01 00:00:00
abstract：AIMS:Recent evidence suggests an association between persistent organic pollutants (POPs) and type 2 diabetes. In two First Nations communities where wild food is consumed by a large portion of the population, we compared pollutants in plasma between diabetic and non-diabetic individuals, and investigated the strength ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.01.006
更新日期：2013-12-01 00:00:00
abstract：:In Type 1 diabetes, high circulating growth hormone (GH) in conjunction with low plasma insulin-like growth factor-I (IGF-I) is indicative of a hepatic GH-resistance profile since the liver is the main source of circulating IGF-I. The reduction in specific growth hormone binding protein (GHBP), corresponding to the ex...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：AIM:Previous studies have reported inconsistent results regarding the association between metformin use and clinical outcomes in diabetes mellitus (DM) patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the association between metformin use and clinical outcomes in DM patients with COVID-19...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2020.10.006
更新日期：2020-11-04 00:00:00
abstract：OBJECTIVES:We hypothesized that molecules active in vascular remodeling (i.e. MMPs and their TIMPs) could be modified in diabetic patients, as indirect markers of the diabetes related generalized abnormality of vascular activity. To test this hypothesis, we measured the plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabet.2006.11.008
更新日期：2007-04-01 00:00:00
abstract：AIM:Patients with diabetes have higher rates of depression than does the general population, but diabetes management mainly aims to maintain glucose stability. For this reason, our study assessed the relationship between 1-year variations in fasting plasma glucose (FPG) and risk of depression in Chinese patients with t...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2019.08.003
更新日期：2020-06-01 00:00:00
abstract：:TNF-alpha is considered as one of the potential determinants of insulin resistance. However several data suggest that TNF-alpha expression itself, could be modulated by the degree of adiposity and/or plasma insulin levels. To clarify the determinants of plasma TNF-alpha levels in type 2 diabetes mellitus, we studied t...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：AIMS:The objective of the present investigation was to study the production of IL-1, IL-6, IL-10, IFNgamma and TNFalpha in cultures of peripheral blood mononuclear cells (PBMC) taken from type 1 diabetic patients with inadequate metabolic control. METHODS:Seventeen type 1 diabetic patients and a gender- and age-matche...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.10.001
更新日期：2007-12-01 00:00:00
abstract：:Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canaglifl...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2015.10.003
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of a patient education program on diabetes control. METHODS:A pre-test post-test pre experimental study was performed with 87 insulin treated diabetic patients followed in the chronic disease unit of Kelibia district (Nabeul, Tunisia). Subjects received education in 6 monthly sess...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70207-0
更新日期：2005-09-01 00:00:00
abstract：:Insulin secretion from the beta-cells in the islets of Langerhans is mainly regulated by glucose entry via its transporter. The intracellular glucose metabolism induces a rise in ATP/ADP ratio which increases the degree of closure of ATP-sensitive potassium channels (K(ATP) channels), inducing a higher intracellular K...
journal_title：Diabetes & metabolism
pub_type： 评论,杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT). SUBJECTS AND METHODS:Cross-sectional study with 107 sedentary non-diabetic overweight and obese postmenopausal (B...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.02.004
更新日期：2007-09-01 00:00:00
abstract：AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.04.006
更新日期：2015-12-01 00:00:00
abstract：:Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin, empagliflozin) are new glucose-lowering agents that exert their therapeutic activity independently of insulin by facilitating glucose excretion through the kidneys. However, this simple renal mechanism that results in sustained gluc...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(14)72689-8
更新日期：2014-12-01 00:00:00
abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(08)73399-8
更新日期：2008-02-01 00:00:00
abstract：:Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(08)70096-X
更新日期：2008-02-01 00:00:00
abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.08.005
更新日期：2014-12-01 00:00:00
abstract：:There are few studies on the effects of postprandial hyperglycaemia, and usually it is assumed that its effects are the same as those of post-glucose-load hyperglycaemia, following a standard 75 g oral glucose tolerance test. There is some evidence from a study with blood drawn following ingestion of a standardised "d...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(06)70478-5
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the metabolic syndrome (MS) and Framingham risk score (FRS) as predictors of cardiovascular (CV) events in Caribbean Indian patients who have type 2 diabetes (T2D) or impaired glucose tolerance (IGT). METHOD:A longitudinal and retrospective study was conducted involving patients classified as T2D...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.10.005
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To study the efficacy of the nutritional education software, Nutri-Expert, in the management of obese adult patients. MATERIAL AND METHODS:Two groups of obese patients were followed up over one year in a randomized study: the first group received close traditional management (seven nutritional visits over th...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-04-01 00:00:00
abstract：:A major aim of glucose-lowering therapy in people with diabetes is to delay or prevent the late-developing complications of diabetes that threaten the quality and duration of life. While intensive interventions to control hyperglycaemia may impair well-being to some extent, the balance of quality of life is usually hi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/s1262-3636(07)70148-9
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVES:This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.07.001
更新日期：2015-04-01 00:00:00
abstract：AIM:There is growing evidence that periodontal disease may favour the incidence or aggravation of diabetes and its complications. To investigate the issue, we conducted a meta-analysis of the effect of periodontal therapy on glycaemic control in diabetic patients. METHODS:A literature search was carried out using seve...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabet.2008.03.006
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Granulocytes from healthy subjects and from patients suffering from diabetes mellitus present differences in reactivity to stimulation with cyclic nucleotide-elevating agents. The production of reactive oxygen species (ROS) is inhibited in cells from non-diabetic subjects following such stimulation, but acti...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70287-2
更新日期：2006-09-01 00:00:00
abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insuli...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2016.10.005
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Accumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites. We sought to examine the association of PTH with the incidence of diabetes. ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.12.004
更新日期：2016-06-01 00:00:00
abstract：:Prevalence of diabetes is increasing worldwide in epidemic proportions. Its appropriate clinical management requires a careful etiological diagnosis. Laminopathies recently emerged as clinically heterogeneous genetic disorders due to mutations in lamins or lamin-associated proteins, which are components of the nuclear...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/s1262-3636(07)70227-6
更新日期：2005-12-01 00:00:00
