当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Modulation of the production of reactive oxygen species (ROS) by cAMP-elevating agents in granulocytes from diabetic patients: an Akt/PKB-dependent phenomenon.

Modulation of the production of reactive oxygen species (ROS) by cAMP-elevating agents in granulocytes from diabetic patients: an Akt/PKB-dependent phenomenon.

Abstract：

BACKGROUND:Granulocytes from healthy subjects and from patients suffering from diabetes mellitus present differences in reactivity to stimulation with cyclic nucleotide-elevating agents. The production of reactive oxygen species (ROS) is inhibited in cells from non-diabetic subjects following such stimulation, but activated through a PKA-independent signaling pathway in granulocytes from type 1 and type 2 diabetic patients. The aim of the present study was to understand better the changes in signaling mechanisms induced by the disease. METHODS:ROS production in granulocytes from healthy subjects and from type 1 and type 2 diabetic patients was measured using a luminol-dependent chemiluminescence assay. Granulocytes were stimulated by the addition of the cAMP-elevating agent dibutyryl cAMP. In some experiments, granulocytes were pre-treated with an inhibitor of PKA or Akt/PKB prior to cAMP stimulation. RESULTS:Intracellular elevation of cAMP induced a PKA-dependent and Akt/PKB-independent inhibition of ROS production in granulocytes from healthy subjects, but a significant activation in cells from both type 1 and type 2 diabetic patients. Most significantly, activation of ROS generation in cells from diabetic patients was shown to be Akt/PKB-dependent and PKA-independent. CONCLUSIONS:These results suggest that chronic hyperglycaemia could induce metabolic adaptation in cAMP-related signaling mechanisms. Epac (exchange protein directly activated by cAMP) is a novel cAMP receptor besides PKA involved in different signaling pathways. The cAMP-stimulated inverse ROS response in granulocytes from type 1 and type 2 diabetic patients may be due to a change in signaling pathways from cAMP/PKA to cAMP/Epac/Akt/PKB. These preliminary results require further studies in order to evaluate their consequences on innate immunity and pathogenesis of diabetes mellitus.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Nogueira-Machado JA,Lima e Silva FC,Cunha EP,Calsolari MR,Costa DC,Perilo CS,Horta BC,Ferreira IC,Chaves MM

doi

10.1016/s1262-3636(07)70287-2

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

331-5

issue

4

eissn

1262-3636

issn

1878-1780

pii

s1262-3636(07)70287-2

journal_volume

32

pub_type

杂志文章

相关文献

DIABETES & METABOLISM文献大全
  • Glycaemic control and hypoglycaemia with insulin glargine 300 U/mL compared with glargine 100 U/mL in Japanese adults with type 2 diabetes using basal insulin plus oral anti-hyperglycaemic drugs (EDITION JP 2 randomised 12-month trial including 6-month ex

    abstract：AIMS:To compare insulin glargine 300 U/mL (Gla-300) with glargine 100 U/mL (Gla-100) in Japanese adults with uncontrolled type 2 diabetes on basal insulin and oral anti-hyperglycaemic drugs over 12 months. METHODS:EDITION JP 2 was a randomised, open-label, phase 3 study. Following a 6-month treatment period, participa...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabet.2017.03.001

    authors： Terauchi Y,Koyama M,Cheng X,Sumi M,Riddle MC,Bolli GB,Hirose T,EDITION JP 2 study group.

    更新日期：2017-10-01 00:00:00

  • The metabolic syndrome in smokers. The D.E.S.I.R. study.

    abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s1262-3636(07)70031-9

    authors： Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

    更新日期：2003-06-01 00:00:00

  • [Diabetic retinopathy in children and adolescents].

    abstract：:Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Ben Mehidi A,Massin P,Guyot-Argenton C,Erginay A,Guillausseau PJ,Gaudric A

    更新日期：2003-06-01 00:00:00

  • Imaging and endovascular treatment of renal artery stenosis in the diabetic patient.

    abstract：:Although diabetes is a classical risk factor for macroangiopathy, the prevalence of renal artery stenosis (RAS) in this type of pathology has not been clearly determined. More than 50% of RAS occur in diabetic patients (almost exclusively Type 2), whereas autopsy findings and the few clinical surveys reported indicate...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Otal P,Janne D'othee B,Chabbert V,Meites G,Rousseau H,Joffre F

    更新日期：2000-07-01 00:00:00

  • Significant Association between Blood Lead (Pb) Level and Haemoglobin A1c in Non-diabetic Population.

    abstract：:Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2021.101233

    authors： Chang CW,Wang CW,Wu DW,Lee WH,Chen YC,Liu YH,Li CH,Tsai CC,Lin WY,Chen SC,Hung CH,Kuo CH,Su HM

    更新日期：2021-01-23 00:00:00

  • Metabolic effects of SGLT-2 inhibitors beyond increased glucosuria: A review of the clinical evidence.

    abstract：:Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin, empagliflozin) are new glucose-lowering agents that exert their therapeutic activity independently of insulin by facilitating glucose excretion through the kidneys. However, this simple renal mechanism that results in sustained gluc...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(14)72689-8

    authors： Scheen AJ,Paquot N

    更新日期：2014-12-01 00:00:00

  • Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.

    abstract：AIMS:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS:Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2)...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2016.12.002

    authors： Thorn CE,Knight B,Pastel E,McCulloch LJ,Patel B,Shore AC,Kos K

    更新日期：2017-06-01 00:00:00

  • The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study.

    abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70067-8

    authors： Balkau B,Vernay M,Mhamdi L,Novak M,Arondel D,Vol S,Tichet J,Eschwège E,D.E.S.I.R. Study Group.

    更新日期：2003-11-01 00:00:00

  • Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure.

    abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels b...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(17)30071-X

    authors： Joubert M,Reznik Y

    更新日期：2017-04-01 00:00:00

  • Managing the manager: gut microbes, stem cells and metabolism.

    abstract：:One major discovery of the last decade in the field of metabolic diseases is that the microorganisms comprising the gut microbiota are now considered a metabolic "organ", modulating multiple functions of the host, such as intestinal immune system maturation, adiposity, cardiac metabolism, liver triglyceride storage, a...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2013.12.004

    authors： Serino M,Blasco-Baque V,Nicolas S,Burcelin R

    更新日期：2014-06-01 00:00:00

  • Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are essentially dependent on visceral fat amount in type 2 diabetic patients.

    abstract：:TNF-alpha is considered as one of the potential determinants of insulin resistance. However several data suggest that TNF-alpha expression itself, could be modulated by the degree of adiposity and/or plasma insulin levels. To clarify the determinants of plasma TNF-alpha levels in type 2 diabetes mellitus, we studied t...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Bertin E,Nguyen P,Guenounou M,Durlach V,Potron G,Leutenegger M

    更新日期：2000-05-01 00:00:00

  • Beneficial effects of metformin on haemostasis and vascular function in man.

    abstract：:Type 2 diabetes is characterised by insulin resistance in association with clustering of atherothrombotic risk factors (dysglycaemia, hyperinsulinaemia, hypertension, raised triglyceride, low HDL cholesterol and increased levels of plasminogen activator inhibitor-1 (PAI-1) and clotting factor VII). There is a 3-5 fold...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/s1262-3636(03)72787-6

    authors： Grant PJ

    更新日期：2003-09-01 00:00:00

  • Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method?

    abstract：AIM:The objective of the study was to examine the correlation between three methods of measuring insulin sensitivity (IS) - namely, the frequently sampled intravenous glucose tolerance test (FSIVGTT), indices derived from the oral glucose tolerance test (OGTT) and fasting indices (HOMA-IR, QUICKI, fasting insulin [INS(...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.diabet.2010.06.008

    authors： Henderson M,Rabasa-Lhoret R,Bastard JP,Chiasson JL,Baillargeon JP,Hanley JA,Lambert M

    更新日期：2011-02-01 00:00:00

  • Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes.

    abstract：:The stimulation of muscle and adipose tissue glucose metabolism, which is ultimately responsible for bringing about post-absorptive blood glucose clearance, is the primary clinically relevant action of insulin. Insulin acts on many steps of glucose metabolism, but one of the most important effects is its ability to in...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Ducluzeau PH,Fletcher LM,Vidal H,Laville M,Tavaré JM

    更新日期：2002-04-01 00:00:00

  • OPHDIAT: quality-assurance programme plan and performance of the network.

    abstract：AIMS:There is a need for evaluation of screening and grading services for diabetic retinopathy (DR) in compliance with quality-assurance (QA) standards. We describe the screening/grading QA programme set up for OPHDIAT over the 2005-2006 period. METHODS:Screening and grading objectives, evaluation criteria and minimum...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2008.01.004

    authors： Erginay A,Chabouis A,Viens-Bitker C,Robert N,Lecleire-Collet A,Massin P

    更新日期：2008-06-01 00:00:00

  • Quarterly individual outpatients lifestyle counseling after initial inpatients education on type 2 diabetes: the REDIA Prev-2 randomized controlled trial in Reunion Island.

    abstract：AIMS:This study aimed to describe the 1-year evolution of type 2 diabetes (T2D) patients who attended inpatients education, and to assess whether quarterly outpatients counseling visits by nurses and dietitians can improve metabolic control and health-related behaviours. METHODS:Following in-hospital educational sessi...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2011.07.002

    authors： Debussche X,Rollot O,Le Pommelet C,Fianu A,Le Moullec N,Régnier C,Boyer MC,Cogne M,Bakiri F,Schwager JC,Favier F

    更新日期：2012-02-01 00:00:00

  • Moderate intensity sports and exercise is associated with glycaemic control in women with gestational diabetes.

    abstract：AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2017.01.006

    authors： Ehrlich SF,Hedderson MM,Brown SD,Sternfeld B,Chasan-Taber L,Feng J,Adams J,Ching J,Crites Y,Quesenberry CP,Ferrara A

    更新日期：2017-10-01 00:00:00

  • The effects of adding group-based lifestyle counselling to individual counselling on changes in plasma glucose levels in a randomized controlled trial: the Inter99 study.

    abstract：AIM:This study aimed to assess whether group-based lifestyle counselling offered to a high-risk population subgroup had any effect beyond individual multifactorial interventions on fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) changes. METHODS:In a population-based study of 6784 participants, 4053 were de...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2011.06.001

    authors： Lau C,Vistisen D,Toft U,Tetens I,Glümer C,Pedersen O,Jørgensen T,Borch-Johnsen K

    更新日期：2011-12-01 00:00:00

  • Incretins: what is known, new and controversial in 2013?

    abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.02.005

    authors： Burcelin R,Thorens B,European Club for the study of GLP-1 (EuCSGLP-1).

    更新日期：2013-04-01 00:00:00

  • The DECODE study. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe.

    abstract：:The current criteria for the diagnosis of diabetes used in France are now based on those published by the American Diabetes Association in 1997: fasting plasma glucose >/= 7.0 mmol/l (126 mg/dl) (previously >/= 7.8 mmol/l (140 mg/dl)), 2-hour glucose >/= 11.1 mmol/l (200 mg/dl) following a 75g oral glucose tolerance t...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Balkau B

    更新日期：2000-09-01 00:00:00

  • Management of hypertension in elderly diabetic patients.

    abstract：:Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/s1262-3636(05)73656-9

    authors： Blicklé JF

    更新日期：2005-12-01 00:00:00

  • Vasopressin and urinary concentrating activity in diabetes mellitus.

    abstract：:In diabetes mellitus (DM), the high urine flow rate suggests that urinary concentrating capacity is impaired. However, several studies have shown that vasopressin is elevated in DM and the consequences of this elevation have not yet been characterized. This study reevaluated renal function and water handling in male W...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Ahloulay M,Schmitt F,Déchaux M,Bankir L

    更新日期：1999-09-01 00:00:00

  • Early-stage atherosclerosis in newly diagnosed, untreated type 2 diabetes mellitus and impaired glucose tolerance.

    abstract：AIM:The aim of this study was to investigate early-stage atherosclerosis in newly diagnosed, untreated type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT). METHODS:The study subjects underwent an oral glucose tolerance test (OGTT) and were then divided into three groups, according to plasma glucose le...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.05.005

    authors： Gong W,Lu B,Yang Z,Ye W,Du Y,Wang M,Li Q,Zhang W,Pan Y,Feng X,Zhou W,Zhang Y,Yang Z,Yang Y,Zhu X,Hu R

    更新日期：2009-12-01 00:00:00

  • Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

    abstract：BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2019.01.012

    authors： Benalia M,Zeller M,Mouhat B,Guenancia C,Yameogo V,Greco C,Yao H,Maza M,Vergès B,Cottin Y

    更新日期：2019-10-01 00:00:00

  • Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.

    abstract：AIMS:Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resista...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2020.07.010

    authors： León-Mimila P,Villamil-Ramírez H,Li XS,Shih DM,Hui ST,Ocampo-Medina E,López-Contreras B,Morán-Ramos S,Olivares-Arevalo M,Grandini-Rosales P,Macías-Kauffer L,González-González I,Hernández-Pando R,Gómez-Pérez F,Campos-Pérez F,

    更新日期：2020-08-10 00:00:00

  • Insulin therapy for diabetes mellitus: treatment regimens and associated costs.

    abstract：AIMS:To describe insulin therapy in patients with diabetes, to determine treatment costs and to compare costs among treatment regimens. METHODS:This observational study was performed by 734 French pharmacists. Adult patients filling an insulin prescription were invited to participate. Participants provided information...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2011.10.003

    authors： Charbonnel B,Penfornis A,Varroud-Vial M,Kusnik-Joinville O,Detournay B

    更新日期：2012-04-01 00:00:00

  • Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

    abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)73399-8

    authors： Penfornis A,Borot S,Raccah D

    更新日期：2008-02-01 00:00:00

  • Temporary multiple cranial nerve palsies in a patient with type 1 diabetes mellitus.

    abstract：:Remittent isolated palsy of peripheral or of upper cranial nerves in diabetic patients is well documented, but paralysis of a lower cranial nerve or an isolated branch of any cranial nerve has rarely been reported. In the case described, besides temporary hypoglossal and facial nerve palsies previously, unilateral tem...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Semiz S,Fişenk F,Akçurin S,Bircan I

    更新日期：2002-11-01 00:00:00

  • Effect of canagliflozin on liver function tests in patients with type 2 diabetes.

    abstract：AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canaglifl...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2015.10.003

    authors： Leiter LA,Forst T,Polidori D,Balis DA,Xie J,Sha S

    更新日期：2016-02-01 00:00:00

  • Bariatric surgery in young massively obese diabetic patients.

    abstract：:Obesity is the most important lifestyle-related risk factor for type 2 diabetes (T2DM). The prevalence of T2DM in adolescents is increasing in parallel with the increasing incidence of major obesity. In adult obese subjects, the greatest degree of T2DM prevention, improvement or recovery has been reported in patients ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(09)73462-7

    authors： Ciangura C,Basdevant A

    更新日期：2009-12-01 00:00:00