Metformin: drug of choice for the prevention of type 2 diabetes and cardiovascular complications in high-risk subjects.

abstract：:Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...

journal_title：Diabetes & metabolism

authors： Ben Mehidi A,Massin P,Guyot-Argenton C,Erginay A,Guillausseau PJ,Gaudric A

更新日期：2003-06-01 00:00:00

abstract：:Postprandial hyperglycaemia is a phenomenon often neglected by patients as well as doctors. While patients only voluntarily measure morning and preprandial capillary glycaemia, physicians do not encourage the measurement of anything further. The specific role of postprandial hyperglycaemia in the determination of late...

journal_title：Diabetes & metabolism

authors： Slama G,Elgrably F,Sola A,Mbemba J,Larger E

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Granulocytes from healthy subjects and from patients suffering from diabetes mellitus present differences in reactivity to stimulation with cyclic nucleotide-elevating agents. The production of reactive oxygen species (ROS) is inhibited in cells from non-diabetic subjects following such stimulation, but acti...

journal_title：Diabetes & metabolism

authors： Nogueira-Machado JA,Lima e Silva FC,Cunha EP,Calsolari MR,Costa DC,Perilo CS,Horta BC,Ferreira IC,Chaves MM

更新日期：2006-09-01 00:00:00

abstract：AIM:There is growing evidence that periodontal disease may favour the incidence or aggravation of diabetes and its complications. To investigate the issue, we conducted a meta-analysis of the effect of periodontal therapy on glycaemic control in diabetic patients. METHODS:A literature search was carried out using seve...

journal_title：Diabetes & metabolism

authors： Darré L,Vergnes JN,Gourdy P,Sixou M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...

journal_title：Diabetes & metabolism

authors： Hadjadj S,Duengler F,Barriere M,Mauco G,Coisne D,Warnier F,Sosner P,Torremocha F,Herpin D,Marechaud R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To determine if fructosamine can be used as a surrogate for HbA(1c) to monitor whether therapeutic goals in diabetes mellitus are achieved when HbA(1c) cannot be used for this purpose (hemoglobinopathies, anemia...). MATERIAL AND METHODS:Blood samples of 76 diabetic patients and 30 healthy subjects character...

journal_title：Diabetes & metabolism

authors： Narbonne H,Renacco E,Pradel V,Portugal H,Vialettes B

更新日期：2001-11-01 00:00:00

abstract：:Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and...

journal_title：Diabetes & metabolism

authors： Gillery P,Bordas-Fonfrède M,Chapelle JP,Drouin P,Hue G,Lévy-Marchal C,Périer C,Sélam JL,Slama G,Thivolet C,Vialettes B

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

journal_title：Diabetes & metabolism

authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Low magnesium (Mg) status has been implied as a factor in the development of type 2 diabetes mellitus (DM) and its complications. We therefore studied Mg-status in identical twins, discordant for type 2 DM and in matched controls. Through correlation analysis, possible associations between Mg-status and gluc...

journal_title：Diabetes & metabolism

authors： Djurhuus MS,Vaag A,Altura BM,Altura BT,Klitgaard NA

更新日期：2002-06-01 00:00:00

abstract：:The association of diabetes with HLA class I alleles in the early 1970s and with HLA class II alleles in the late 1970s provided a crucial, though indirect, indication of the role of immune phenomena in the development of insulin-dependent diabetes mellitus (IDDM). Genotyping of HLA alleles in the mid-1980s opened up ...

journal_title：Diabetes & metabolism

authors： Boitard C,Caillat-Zucman S,Timsit J

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:There is little information about the impact of hyperglycaemia in twin pregnancies. The objective of our study was to evaluate the maternal, foetal and neonatal complications in patients with twin pregnancy and glucose intolerance defined by gestational diabetes mellitus and gestational mild hyperglycaemia. ...

journal_title：Diabetes & metabolism

authors： Poulain C,Duhamel A,Garabedian C,Cazaubiel M,Rejou MC,Vambergue A,Deruelle P

更新日期：2015-11-01 00:00:00

abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...

journal_title：Diabetes & metabolism

authors： Le Floch JP,Herbreteau C,Lange F,Perlemuter L

更新日期：1997-06-01 00:00:00

abstract：AIMS:This study aimed to determine the prevalence of the metabolic syndrome (MetS) and its association with socio-economic status in the population of Great Tunis. METHODS:The study included 2712 subjects (1228 men and 1484 women), aged 35-70 years and living in the Great Tunis region, all of whom were recruited betwe...

journal_title：Diabetes & metabolism

authors： Allal-Elasmi M,Haj Taieb S,Hsairi M,Zayani Y,Omar S,Sanhaji H,Jemaa R,Feki M,Elati J,Mebazaa A,Kaabachi N

更新日期：2010-06-01 00:00:00

abstract：AIM:To investigate the association between mean fasting glucose (FG) and variability in visit-to-visit FG and risk of mortality in people with type 2 diabetes (T2D). METHODS:This retrospective cohort study included 48,077 Chinese men and women with T2D. The yearly mean and coefficient of variation for fasting glucose ...

journal_title：Diabetes & metabolism

authors： Xu H,Zhang Y,Xu W,Chen L,Zhang M,Su H,Cheng Y,Zhao N,Xu D,Qin G

更新日期：2020-05-26 00:00:00

abstract：AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...

journal_title：Diabetes & metabolism

authors： Hanssen NMJ,Scheijen JLJM,Houben AJHM,van de Waarenburg M,Berendschot TTJM,Webers CAB,Reesink KD,van Greevenbroek MMJ,van der Kallen C,Schaper NC,Schram MT,Henry RMA,Stehouwer CDA,Schalkwijk CG

更新日期：2020-02-10 00:00:00

abstract：OBJECTIVE:To study the efficacy of the nutritional education software, Nutri-Expert, in the management of obese adult patients. MATERIAL AND METHODS:Two groups of obese patients were followed up over one year in a randomized study: the first group received close traditional management (seven nutritional visits over th...

journal_title：Diabetes & metabolism

authors： Turnin MC,Bourgeois O,Cathelineau G,Leguerrier AM,Halimi S,Sandre-Banon D,Coliche V,Breux M,Verlet E,Labrousse F,Bensoussan D,Grenier JL,Poncet MF,Tordjmann F,Brun JM,Blickle JF,Mattei C,Bolzonella C,Buisson JC,Fabr

更新日期：2001-04-01 00:00:00

abstract：:Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues an...

journal_title：Diabetes & metabolism

authors： Scheen AJ,Lefèbvre PJ

更新日期：1996-04-01 00:00:00

abstract：:Prevalence of non-alcoholic steatohepatitis (NASH) rises steadily in Western countries with the obesity epidemic. NASH is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. The cannabinoid system is increasingly emerging as a crucial mediator of acute and chro...

journal_title：Diabetes & metabolism

authors： Mallat A,Lotersztajn S

更新日期：2008-12-01 00:00:00

abstract：AIM:To study the foveal avascular zone (FAZ) of the central retina in diabetic patients with retinopathy having undergone metabolic evaluation. METHODS:One hundred and ten digital fluorescein angiograms were chosen from our digital image bank after cross matching diabetic patient lists of the ophthalmology and endocri...

journal_title：Diabetes & metabolism

authors： Conrath J,Giorgi R,Ridings B,Raccah D

更新日期：2005-11-01 00:00:00

abstract：:Renal remodelling in hyperinsulinic/insulinopenic states is mediated by glucotoxicity, endothelial dysfunction and vascular and nephron collagen turnover. Hypertensive and renal links are renewed by renoprotective interventions of renin-angiotensin. Vasoactive peptide processing and vascular collagen deposition are un...

journal_title：Diabetes & metabolism

authors： Zaoui P,Cantin JF,Alimardani-Bessette M,Monier F,Halimi S,Morel F,Cordonnier D

更新日期：2000-07-01 00:00:00

abstract：AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...

journal_title：Diabetes & metabolism

authors： Harding J,Sooriyakumaran M,Anstey KJ,Adams R,Balkau B,Briffa T,Davis TM,Davis WA,Dobson A,Giles GG,Grant J,Knuiman M,Luszcz M,Mitchell P,Pasco JA,Reid C,Simmons D,Simons L,Tonkin A,Woodward M,Shaw JE,Magliano DJ

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

journal_title：Diabetes & metabolism

authors： Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

更新日期：2003-06-01 00:00:00

abstract：:The management of type 2 diabetes continues to evolve as new data emerge. Although glycaemic control is still important, other risk factors--such as hypertension, dyslipidaemia and obesity--must also be addressed in order to reduce the long-term risks of cardiovascular complications and mortality. In this context, tar...

journal_title：Diabetes & metabolism

authors： Cariou B

更新日期：2012-10-01 00:00:00

abstract：:Our society is currently facing an epidemic of diabetes and heart failure. Historically, certain cardiology treatments, mainly beta-blockers, have been considered 'dangerous' in diabetic patients, but the time has come for personalized medicine to be applied in the field of cardiology, especially in heart failure (HF)...

journal_title：Diabetes & metabolism

authors： Girerd N,Zannad F,Rossignol P

更新日期：2015-12-01 00:00:00

abstract：:Optimal glycaemic control is necessary to prevent diabetes-related complications. An intensive treatment, which could mimic physiological insulin secretion, would be the best one. However subcutaneous insulin treatment is not physiologic and represents a heavy burden for patients with type 1 and type 2 diabetes mellit...

journal_title：Diabetes & metabolism

authors： Lassmann-Vague V,Raccah D

更新日期：2006-12-01 00:00:00

abstract：:Serum glycated apolipoprotein B (apo B-G) levels were determined in 31 non-insulin-dependent diabetic patients and 13 control subjects by an enzyme-linked immunosorbent assay. Apo B-G was increased in diabetic patients compared to non-diabetic subjects, whether expressed as a serum concentration (57.7 vs 36.1 mg/l) or...

journal_title：Diabetes & metabolism

authors： Stahl AJ,Rima A,Blickle JF,Brogard JM

更新日期：1998-04-01 00:00:00

abstract：AIM:The best way to treat pregnant patients who have type 1 diabetes is still unclear. For this reason, the present study compared metabolic control and maternal-fetal outcomes in patients treated with continuous subcutaneous infusions of rapid-acting insulin analogues (CSII) or with insulin glargine and multiple daily...

journal_title：Diabetes & metabolism

authors： Bruttomesso D,Bonomo M,Costa S,Dal Pos M,Di Cianni G,Pellicano F,Vitacolonna E,Dodesini AR,Tonutti L,Lapolla A,Di Benedetto A,Torlone E,Italian Group for Continuous Subcutaneous Insulin Infusion in Pregnancy.

更新日期：2011-11-01 00:00:00

abstract：:Chromium is an essential nutrient involved in the metabolism of glucose, insulin and blood lipids. Suboptimal dietary intake of chromium is associated with increased risk factors associated with diabetes and cardiovascular diseases. Within the past five years, chromium has been shown to improve glucose and related var...

journal_title：Diabetes & metabolism

authors： Anderson RA

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:To compare fat and carbohydrate oxidation at different exercise intensities between overweight and normal-weight subjects, in order to analyze the influence of muscular metabolic abnormalities in obese people on substrate utilization during exercise. MATERIAL AND METHODS:32 healthy sedentary overweight subj...

journal_title：Diabetes & metabolism

authors： Pérez-Martin A,Dumortier M,Raynaud E,Brun JF,Fédou C,Bringer J,Mercier J

更新日期：2001-09-01 00:00:00

abstract：:Strict glycaemic control is a major concern in many people with diabetes, hypoglycaemia being the most limiting factor in the daily management of patients with diabetes. Acute consequences of hypoglycaemic attacks are not precisely evaluated. Acute cardiovascular (CV) complications as myocardial ischaemia or stroke se...

journal_title：Diabetes & metabolism

authors： Halimi S

更新日期：2010-10-01 00:00:00