Abstract：
OBJECTIVES:To compare fat and carbohydrate oxidation at different exercise intensities between overweight and normal-weight subjects, in order to analyze the influence of muscular metabolic abnormalities in obese people on substrate utilization during exercise. MATERIAL AND METHODS:32 healthy sedentary overweight subjects (Body Mass Index (BMI): 30.8 +/- 0.8 kg/m(2); body fat: 37.4 +/- 1.1%; mean +/- SEM) and 26 controls (BMI: 23 +/- 0.4 kg/m(2); body fat: 22.7 +/- 1.1%) matched for age and sex were examined. The test consisted in four six-min. submaximal steady-state workloads with calculation of substrate oxidation rates and derived quantitative parameters, i.e., crossover point (defined as the power at which carbohydrate-derived energy becomes predominant) and maximal fat oxidation rate point. In addition, the accuracy of the test was analyzed and was found to be satisfactory. RESULTS:While exercise intensities were similar in both group, fat oxidation rates were significantly lower in overweight group (p<0.05). The crossover and the maximal fat oxidation rate points were significantly lower in overweight subjects than in controls: 33.3 +/- 2 vs 50.1 +/- 3.4% and 30.5 +/- 2.3 vs 44.6 +/- 3.3% of maximal aerobic power, respectively (p<0.001). CONCLUSION:Sedentary overweight subjects, compared to controls at the same exercise intensities, exhibited an alteration of the balance of substrate oxidation, reflected by lower rates of fat oxidation and a shift of quantitative parameters to lower intensities. The test appeared to be reliable and could be of interest to advise an individualized exercise prescription in obese people.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Pérez-Martin A,Dumortier M,Raynaud E,Brun JF,Fédou C,Bringer J,Mercier Jsubject
Has Abstractpub_date
2001-09-01 00:00:00pages
466-74issue
4 Pt 1eissn
1262-3636issn
1878-1780pii
MDOI-DM-09-2001-27-4-1262-3636-101019-ART6journal_volume
27pub_type
杂志文章abstract：:Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A mod...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70119-2
更新日期：2004-06-01 00:00:00
abstract：AIM:Our study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD). METHODS:In this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.08.005
更新日期：2014-12-01 00:00:00
abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Insulin aspart (IAsp) is one of the three rapid-acting insulin analogues (RAAs) registered for the treatment of diabetes. However, there is an ongoing debate concerning the efficacy and safety of RAAs. For this reason, a systematic review-based study was performed to compare clinical outcomes of treatment wi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.diabet.2010.12.003
更新日期：2011-06-01 00:00:00
abstract：AIM:In this study, we examined the trends from 1995 to 2006 in cardiovascular risk factors (CVRF) in Spaniards aged 65 years or older with diabetes. METHODS:We looked at the individual data from adults aged > or =65 years from the Spanish National Health Surveys of 1995 (n=1117), 1997 (n=1111), 2001 (n=4328), 2003 (n=...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2009.06.007
更新日期：2010-02-01 00:00:00
abstract：:Postprandial hyperglycaemia is a phenomenon often neglected by patients as well as doctors. While patients only voluntarily measure morning and preprandial capillary glycaemia, physicians do not encourage the measurement of anything further. The specific role of postprandial hyperglycaemia in the determination of late...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70268-9
更新日期：2006-04-01 00:00:00
abstract：AIM:The aim of this study was to examine the racial and ethnic differences in the relationship between body fat distribution variables and serum lipid profiles. METHODS:Secondary data analyses were conducted on 708 healthy women (204 blacks, 247 whites and 257 Hispanics), aged 16-33 years, seen in an outpatients clini...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2010.01.010
更新日期：2010-09-01 00:00:00
abstract：:Most primary-care physicians have adopted electronic medical records (EMRs) for the management of patients in ambulatory care. Observational trials suggest that the use of EMRs improves the achievement of the recommended standards of diabetes care and intermediate outcomes. A French group of general practitioners has ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(11)70965-X
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The pre...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2011.02.003
更新日期：2011-11-01 00:00:00
abstract：AIM:Cardiovascular autonomic neuropathy (CAN) is a common but often overlooked complication of diabetes. Sympathetic C-fibers innervating sweat glands can be impaired early on in patients with diabetes. In this study, SUDOSCAN, a new non-invasive device that assesses sudomotor function was compared to methods generally...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2012.09.004
更新日期：2013-04-01 00:00:00
abstract：AIM:This study investigated the relationship between endothelial dysfunction (ED) and arterial stiffness (AS) in adults with type 1 diabetes and no clinical cardiovascular (CV) disease. METHODS:A total of 68 patients with type 1 diabetes and 68 age- and gender-matched healthy (non-diabetic) subjects were evaluated. ED...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.03.006
更新日期：2013-09-01 00:00:00
abstract：AIM:This study aimed to assess whether group-based lifestyle counselling offered to a high-risk population subgroup had any effect beyond individual multifactorial interventions on fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) changes. METHODS:In a population-based study of 6784 participants, 4053 were de...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2011.06.001
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT). SUBJECTS AND METHODS:Cross-sectional study with 107 sedentary non-diabetic overweight and obese postmenopausal (B...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.02.004
更新日期：2007-09-01 00:00:00
abstract：:The prevalence of diabetes in African communities is increasing with ageing of the population and lifestyle changes associated with rapid urbanisation and westernisation. Traditional rural communities still have very low prevalence, at most 1-2%, except in some specific high-risk groups, whereas 1-13% or more adults i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2001-12-01 00:00:00
abstract：:We report the case of a 62 year-old symptomatic patient with severe hyperglycemic hyperosmolality associated with hypernatremia. During treatment, the progressive decrease in serum tonicity, which resulted in the amelioration of the neurological symptoms, followed the decrease in serum glucose and mainly the corrected...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compare...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2010.08.002
更新日期：2010-12-01 00:00:00
abstract：AIM:To investigate the balance between parameters of oxidative stress and antioxidant defences in the mitochondria of peripheral blood mononuclear cells (PBMCs) of type 2 diabetic patients with late complications. METHODS:Ten type 2 diabetic patients with late diabetic complications and 10 age-matched healthy voluntee...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.10.011
更新日期：2008-04-01 00:00:00
abstract：AIMS:To evaluate whether perception of insulin therapy differs between patients with type 2 diabetes treated with insulin and those treated with oral hypoglycaemic agents (OHAs), and to examine whether gender, education level, injection duration and mode of injection were associated with the patients' perception of ins...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2010.12.008
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70053-8
更新日期：2003-09-01 00:00:00
abstract：:For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could chal...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,实务指引
doi：10.1016/j.diabet.2009.09.002
更新日期：2010-02-01 00:00:00
abstract：AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patien...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabet.2018.05.010
更新日期：2019-01-01 00:00:00
abstract：:Preretinal neovascularization and chronic retinal oedema are the two major sight-threatening complications that can occur during diabetic retinopathy. Ocular neovascularization is strongly associated with retinal ischaemia, and growth factors have been implicated in its pathogenesis. The ischaemic retina is assumed to...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70104-0
更新日期：2004-04-01 00:00:00
abstract：:It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2007.01.005
更新日期：2007-09-01 00:00:00
abstract：:Optimal glycaemic control is necessary to prevent diabetes-related complications. An intensive treatment, which could mimic physiological insulin secretion, would be the best one. However subcutaneous insulin treatment is not physiologic and represents a heavy burden for patients with type 1 and type 2 diabetes mellit...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/s1262-3636(06)72804-x
更新日期：2006-12-01 00:00:00
abstract：:Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues an...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：:The "Société Française de Gériatrie et Gérontologie" (SFGG) and "Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques" (ALFEDIAM) have decided to join their efforts in actions to improve the management and treatment of the elderly diabetic patients. New knowledge brought by the fundamen...
journal_title：Diabetes & metabolism
pub_type： 社论
doi：10.1016/s1262-3636(05)73646-6
更新日期：2005-12-01 00:00:00
abstract：:Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin, empagliflozin) are new glucose-lowering agents that exert their therapeutic activity independently of insulin by facilitating glucose excretion through the kidneys. However, this simple renal mechanism that results in sustained gluc...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(14)72689-8
更新日期：2014-12-01 00:00:00
abstract：:The project to finalize a 'closed loop' insulin delivery according to blood glucose level, i.e. an implanted artificial beta cell, is born from the development of the first miniaturized portable insulin pumps during the 1970s. Continuous improvements in micro-electronics, as well as in the development of biomaterials ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. METHOD:A literature search on Medline was performed for the period from 01 January 1990...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2010.11.018
更新日期：2010-12-01 00:00:00
