当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Effects of short-term modest weight loss on fasting and post-prandial lipoprotein sub-fractions in type 2 diabetes mellitus patients.

Effects of short-term modest weight loss on fasting and post-prandial lipoprotein sub-fractions in type 2 diabetes mellitus patients.

Abstract：

OBJECTIVE:We assessed the efficacy of a modest weight loss (1.5 +/- 0.3 kg) and simultaneous rapid improvement in glycemic control on fasting an post-prandial lipoprotein sub-fractions in nine overweight (BMI=28 +/- 1.7 kg/m(2)) well controlled Type 2 diabetic patients (HbA(1c)=7.3 +/- 0.1%). MATERIAL AND METHODS:They followed a non-drastical hypocaloric balanced diet (1 561 +/- 39 kcal/day) over ten days in hospital. The fat content of the diet was significantly lowered from 96 +/- 12 g/day to 62 +/- 4 g/day (p<0.03). Plasma lipid and lipoprotein levels were measured in fasting and four hours after standard breakfast and four hours after standard lunch twice before and after ten days of hospitalization. The sub-fractions of very low density and low density lipoprotein were obtained by cumulative flotation ultracentrifugation. RESULTS:This weight loss reduced two well known independent cardiovascular risk factors such as the post-prandial glycemic excursions (p<0.05) and the post-prandial lipemia (p<0.05). Multiple linear regression analyses identified weight loss as an independent variable accounting for the ability to predict post-prandial capillary triglyceride clearance (p<0.05). Improvements in post-prandial glycemic excursions which was also entered as a parameter did not appear as a variable being able to predict these changes (p=0.4). In addition to the 23% improvement in post-prandial capillary triglyceride clearance (p<0.02), a decrement in post-prandial VLDL-2 triglyceride enrichment was found (p<0.05). Finally, fasting and post-prandial LDL-3 cholesterol levels were diminished (p<0.05) and the LDL-2/LDL-3 mass ratio post-prandial kinetics were improved (p<0.05). CONCLUSIONS:Even a modest weight loss in overweight, average controlled type 2 diabetic patients can achieve a significant improvement in two cardiovascular risk factors, namely post-prandial triglyceride excursions and the LDL-2/LDL-3 mass ratio kinetics independently from glycemic control improvements.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Ybarra J,James RW,Makoundou V,Bioletto S,Golay A

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

701-8

issue

6

eissn

1262-3636

issn

1878-1780

pii

MDOI-DM-12-2001-27-6-1262-3636-101019-ART11

journal_volume

27

pub_type

杂志文章

相关文献

DIABETES & METABOLISM文献大全
  • Management of hypertension in elderly diabetic patients.

    abstract：:Hypertension is a major vascular risk factor in the elderly diabetic. The benefit of proper management is well recognized, even if treatment has no influence on overall mortality or might even tend to increase it in very elderly subjects. Globally, the efficacy of the major classes of antihypertensive drugs, diuretics...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/s1262-3636(05)73656-9

    authors： Blicklé JF

    更新日期：2005-12-01 00:00:00

  • Continuous subcutaneous insulin infusion (CSII) using an external insulin pump for the treatment of type 2 diabetes.

    abstract：:Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compare...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2010.08.002

    authors： Reznik Y

    更新日期：2010-12-01 00:00:00

  • Insulin therapy for diabetes mellitus: treatment regimens and associated costs.

    abstract：AIMS:To describe insulin therapy in patients with diabetes, to determine treatment costs and to compare costs among treatment regimens. METHODS:This observational study was performed by 734 French pharmacists. Adult patients filling an insulin prescription were invited to participate. Participants provided information...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2011.10.003

    authors： Charbonnel B,Penfornis A,Varroud-Vial M,Kusnik-Joinville O,Detournay B

    更新日期：2012-04-01 00:00:00

  • Serum levels of osteopontin predict diabetes remission after bariatric surgery.

    abstract：AIM:Bariatric surgery has been shown to effectively improve glycaemic control in morbidly obese subjects. However, the molecular bases of this association are still elusive and may act independently of weight loss. Here, our retrospective study has investigated the inflammatory molecule osteopontin (OPN) as a potential...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2018.09.007

    authors： Carbone F,Adami G,Liberale L,Bonaventura A,Bertolotto M,Andraghetti G,Scopinaro N,Camerini GB,Papadia FS,Cordera R,Dallegri F,Montecucco F

    更新日期：2019-09-01 00:00:00

  • Increased cholesterol intake in women with gestational diabetes mellitus.

    abstract：AIM:Cholesterol intake is associated with the risk for type 2 diabetes mellitus, but no previous studies have evaluated its role regarding the risk of gestational diabetes mellitus (GDM). We investigate the relation between cholesterol intake and GDM. METHODS:At screening for GDM, 335 pregnant women were evaluated for...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2006.07.002

    authors： González-Clemente JM,Carro O,Gallach I,Vioque J,Humanes A,Sauret C,Abella M,Giménez-Pérez G,Mauricio D

    更新日期：2007-02-01 00:00:00

  • Baseline osteocalcin levels and incident diabetes in a 3-year prospective study of high-risk individuals.

    abstract：AIM:Experimental evidence suggests that osteocalcin is a key messenger that affects both adipocytes and insulin-producing β cells. Epidemiological cross-sectional studies have shown a negative association between plasma levels of osteocalcin and glucose. For this reason, the hypothesis that lower baseline osteocalcin p...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.01.001

    authors： Liatis S,Sfikakis PP,Tsiakou A,Stathi C,Terpos E,Katsilambros N,Makrilakis K

    更新日期：2014-06-01 00:00:00

  • Quarterly individual outpatients lifestyle counseling after initial inpatients education on type 2 diabetes: the REDIA Prev-2 randomized controlled trial in Reunion Island.

    abstract：AIMS:This study aimed to describe the 1-year evolution of type 2 diabetes (T2D) patients who attended inpatients education, and to assess whether quarterly outpatients counseling visits by nurses and dietitians can improve metabolic control and health-related behaviours. METHODS:Following in-hospital educational sessi...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabet.2011.07.002

    authors： Debussche X,Rollot O,Le Pommelet C,Fianu A,Le Moullec N,Régnier C,Boyer MC,Cogne M,Bakiri F,Schwager JC,Favier F

    更新日期：2012-02-01 00:00:00

  • Interest of pronostic score for optimal clinical management of obese patients.

    abstract：OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70053-8

    authors： Ybarra J,de Stefano M,Kammer A,de Tonnac N,Lehmann T,Golay A

    更新日期：2003-09-01 00:00:00

  • Pulse pressure strongly predicts cardiovascular disease risk in patients with type 2 diabetes from the Swedish National Diabetes Register (NDR).

    abstract：OBJECTIVES:To analyze pulse pressure (PP) as a risk predictor for coronary heart disease (CHD), stroke and cardiovascular disease (CVD; CHD and/or stroke) in type 2 diabetic patients. METHODS:A total of 11,128 female and male type 2 diabetic patients with known baseline PP values and no CVD, aged 50-74 years, were fol...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.04.010

    authors： Nilsson PM,Cederholm J,Eeg-Olofsson K,Eliasson B,Zethelius B,Gudbjörnsdóttir S,Swedish National Diabetes Register (NDR).

    更新日期：2009-12-01 00:00:00

  • Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?

    abstract：AIM:Previous studies have reported inconsistent results regarding the association between metformin use and clinical outcomes in diabetes mellitus (DM) patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the association between metformin use and clinical outcomes in DM patients with COVID-19...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2020.10.006

    authors： Do JY,Kim SW,Park JW,Cho KH,Kang SH

    更新日期：2020-11-04 00:00:00

  • Long-term outcome in children of mothers with gestational diabetes.

    abstract：OBJECTIVES:To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. METHOD:A literature search on Medline was performed for the period from 01 January 1990...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2010.11.018

    authors： Burguet A

    更新日期：2010-12-01 00:00:00

  • Regulation of in vivo ketogenesis: role of free fatty acids and control by epinephrine, thyroid hormones, insulin and glucagon.

    abstract：:The production of ketone bodies (KB) is dependent on the amount of free fatty acids (FFA) supplied to the liver and on the hepatic metabolic fate of fatty acids and their orientation towards oxidation and ketogenesis or reesterification. In vivo ketogenesis can thus be regulated at the pre-hepatic (lipolysis) or hepat...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Beylot M

    更新日期：1996-10-01 00:00:00

  • Optimal nephroprotection: use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trials.

    abstract：:Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (es...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2009.05.003

    authors： Halimi JM,Asmar R,Ribstein J

    更新日期：2009-12-01 00:00:00

  • Growth factors and diabetic retinopathy.

    abstract：:Preretinal neovascularization and chronic retinal oedema are the two major sight-threatening complications that can occur during diabetic retinopathy. Ocular neovascularization is strongly associated with retinal ischaemia, and growth factors have been implicated in its pathogenesis. The ischaemic retina is assumed to...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Paques M,Massin P,Gaudric A

    更新日期：1997-04-01 00:00:00

  • Type 2 diabetes mellitus among beneficiaries of the french national health insurance for self-employed workers (AMPI): comparison of the management of craftsmen or tradesmen with professionals patients.

    abstract：BACKGROUND:Although the management of diabetes mellitus varies according to non medical factors, the influence of socioprofessional category has been not fully studied. This study compared the management of type 2 diabetes mellitus in craftsmen or tradesmen with professionals categories. METHODS:All claims to the Fren...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Auleley GR,Dematons MN,Berchery P,Raynal-Minville F,Suarez F,Heuls-Bernin B,Blum-Boisgard C

    更新日期：2002-12-01 00:00:00

  • Short-term intensive insulin therapy in insulin-requiring diabetes: effectiveness and factors predicting success.

    abstract：:Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Meyer L,Grulet H,Guerci B,Gross A,Durlach V,Leutenegger M

    更新日期：1997-02-01 00:00:00

  • Improved metabolic control in diabetic adolescents using the continuous glucose monitoring system (CGMS).

    abstract：OBJECTIVE:To determine the utility of the continuous glucose monitoring system (CGMS) as an outpatient procedure to improve management of diabetes in adolescents. RESEARCH DESIGN AND METHODS:Twelve adolescents (mean age: 16.2 +/- 3 years) with poorly controlled type 1 diabetes (HbA(1c) > 8%) were included in this tria...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70076-9

    authors： Schaepelynck-Bélicar P,Vague P,Simonin G,Lassmann-Vague V

    更新日期：2003-12-01 00:00:00

  • Anthropometric markers for detection of the metabolic syndrome in adolescents.

    abstract：OBJECTIVES:This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.07.001

    authors： Benmohammed K,Valensi P,Benlatreche M,Nguyen MT,Benmohammed F,Pariès J,Khensal S,Benlatreche C,Lezzar A

    更新日期：2015-04-01 00:00:00

  • Skeletal muscle magnesium content in identical twins, discordant for type 2 diabetes.

    abstract：BACKGROUND:Low magnesium (Mg) status has been implied as a factor in the development of type 2 diabetes mellitus (DM) and its complications. We therefore studied Mg-status in identical twins, discordant for type 2 DM and in matched controls. Through correlation analysis, possible associations between Mg-status and gluc...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Djurhuus MS,Vaag A,Altura BM,Altura BT,Klitgaard NA

    更新日期：2002-06-01 00:00:00

  • When should ultrasonography be used to detect asymptomatic carotid atheroma in diabetic patients?

    abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/S1262-3636(07)70321-X

    authors： Duval M,Altman JJ

    更新日期：2006-12-01 00:00:00

  • [Gestational diabetes: long-term maternal consequences].

    abstract：:Gestational diabetes, a glucose tolerance disorder of variable severity which occurs or is diagnosed for the first time during pregnancy, constitutes a public health problem because of its frequency (1 to 6% of all pregnancies) and its short- or long-term consequences for the fetus and/or the mother. The classical mat...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Vambergue A,Fontaine P

    更新日期：1997-11-01 00:00:00

  • Obesity or diabetes: what is worse for the mother and for the baby?

    abstract：OBJECTIVES:The aim of the present study is to evaluate pregnancy outcomes in a cohort of Caucasian pregnant women in relation to their body mass index and glucose tolerance status; the role of central fat distribution, as indicated by waist-to-hip circumference ratio, was also considered. METHODS:Seven hundred women w...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70026-5

    authors： Bo S,Menato G,Signorile A,Bardelli C,Lezo A,Gallo ML,Gambino R,Cassader M,Massobrio M,Pagano G

    更新日期：2003-04-01 00:00:00

  • Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity.

    abstract：AIMS:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS:Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2)...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2016.12.002

    authors： Thorn CE,Knight B,Pastel E,McCulloch LJ,Patel B,Shore AC,Kos K

    更新日期：2017-06-01 00:00:00

  • Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.

    abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70104-0

    authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

    更新日期：2004-04-01 00:00:00

  • Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes.

    abstract：:The stimulation of muscle and adipose tissue glucose metabolism, which is ultimately responsible for bringing about post-absorptive blood glucose clearance, is the primary clinically relevant action of insulin. Insulin acts on many steps of glucose metabolism, but one of the most important effects is its ability to in...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Ducluzeau PH,Fletcher LM,Vidal H,Laville M,Tavaré JM

    更新日期：2002-04-01 00:00:00

  • Type 1 diabetes control and pregnancy outcomes in women treated with continuous subcutaneous insulin infusion (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI).

    abstract：AIM:The best way to treat pregnant patients who have type 1 diabetes is still unclear. For this reason, the present study compared metabolic control and maternal-fetal outcomes in patients treated with continuous subcutaneous infusions of rapid-acting insulin analogues (CSII) or with insulin glargine and multiple daily...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2011.02.002

    authors： Bruttomesso D,Bonomo M,Costa S,Dal Pos M,Di Cianni G,Pellicano F,Vitacolonna E,Dodesini AR,Tonutti L,Lapolla A,Di Benedetto A,Torlone E,Italian Group for Continuous Subcutaneous Insulin Infusion in Pregnancy.

    更新日期：2011-11-01 00:00:00

  • Screening for gestational diabetes in the Lombardy region: A population-based study.

    abstract：AIM:As the treatment of hyperglycaemia during pregnancy with diet or insulin reduces the risk of adverse maternal outcomes and perinatal complications, screening for gestational diabetes mellitus (GDM) is included, albeit to variable extents, in all guidelines of care for pregnant women. The aim of the present investig...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2014.11.008

    authors： Nicotra F,Molinari C,Dozio N,Castiglioni MT,Ibrahim B,Zambon A,Corrao G,Scavini M

    更新日期：2015-09-01 00:00:00

  • A systematic review of nudge theories and strategies used to influence adult health behaviour and outcome in diabetes management.

    abstract：BACKGROUND:Diabetes is a chronic disease associated with a variety of complications, and nudging may be a potential solution to improve diabetes control. Since nudging is a new concept, no review of literature on nudging diabetic patients into improving their health behaviour has been done. Therefore, we aim to collate...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2020.04.002

    authors： Kwan YH,Cheng TY,Yoon S,Ho LYC,Huang CW,Chew EH,Thumboo J,Østbye T,Low LL

    更新日期：2020-11-01 00:00:00

  • [From external to implantable insulin pump, can we close the loop?].

    abstract：:The project to finalize a 'closed loop' insulin delivery according to blood glucose level, i.e. an implanted artificial beta cell, is born from the development of the first miniaturized portable insulin pumps during the 1970s. Continuous improvements in micro-electronics, as well as in the development of biomaterials ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Renard E,Costalat G,Bringer J

    更新日期：2002-09-01 00:00:00

  • Evaluation of perception of insulin therapy among Chinese patients with type 2 diabetes mellitus.

    abstract：AIMS:To evaluate whether perception of insulin therapy differs between patients with type 2 diabetes treated with insulin and those treated with oral hypoglycaemic agents (OHAs), and to examine whether gender, education level, injection duration and mode of injection were associated with the patients' perception of ins...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2010.12.008

    authors： Chen CC,Chang MP,Hsieh MH,Huang CY,Liao LN,Li TC

    更新日期：2011-11-01 00:00:00