abstract：BACKGROUND:Primary headaches (migraine, tension headache, cluster headache, and other trigeminal autonomic cephalgias) are common in pregnancy and postpartum. It is unclear how to best and most safely manage them. OBJECTIVE:We conducted a systematic review (SR) of interventions to prevent or treat primary headaches in...

journal_title：Headache

authors： Saldanha IJ,Cao W,Bhuma MR,Konnyu KJ,Adam GP,Mehta S,Zullo AR,Chen KK,Roth JL,Balk EM

更新日期：2021-01-12 00:00:00

abstract：OBJECTIVES:Migraine is a common disabling neurological disorder. Current acute treatments for migraine in adolescents are mostly pharmacological and may have limited effectiveness, can cause side effects, and may lead to medication overuse. There is an unmet need for effective and well-tolerated treatments. Remote elec...

journal_title：Headache

authors： Hershey AD,Lin T,Gruper Y,Harris D,Ironi A,Berk T,Szperka CL,Berenson F

更新日期：2020-12-21 00:00:00

abstract：OBJECTIVE:To determine the pain intensity of cluster headache through a large survey by comparing it to other painful disorders. Furthermore, to investigate the relationship between maximal pain, autonomic, and other clinical symptoms, as well as demographic attributes of cluster headache. BACKGROUND:The pain of clust...

journal_title：Headache

authors： Burish MJ,Pearson SM,Shapiro RE,Zhang W,Schor LI

更新日期：2020-12-18 00:00:00

abstract：OBJECTIVE:This post hoc study investigated the relationship between patient response in terms of migraine headache day reduction and patient-reported outcomes of health-related quality of life (HRQoL) and disability categories. BACKGROUND:Migraine causes considerable disease-related disability and negatively impacts H...

journal_title：Headache

authors： Ford JH,Kurth T,Starling AJ,Ayer DW,Wietecha LA,Port MD,Rettiganti M,Ruff DD

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the safety and efficacy of ketamine-magnesium combination to reduce attacks in a series of patients with refractory chronic cluster headache (rCCH). BACKGROUND:Refractory chronic cluster headache (CCH) is a rare but highly debilitating condition that needs new treatment options. A previous publi...

journal_title：Headache

authors： Moisset X,Giraud P,Meunier E,Condé S,Périé M,Picard P,Pereira B,Ciampi de Andrade D,Clavelou P,Dallel R

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:In this study, we explored the relationship between migraine and sport in a physically active population of students, analyzing the risk of migraine among sporty students. BACKGROUND:The relationship between sport and migraine is controversial; moreover, several studies report on sport as a migraine trigger,...

journal_title：Headache

authors： Pilati L,Battaglia G,Di Stefano V,Di Marco S,Torrente A,Raieli V,Firenze A,Salemi G,Brighina F

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To report the case of a patient enduring migraine attacks preceded by hallucinatory olfactory symptoms, with characteristics which typically define migraine with aura (MWA). BACKGROUND:MWA accounts for about 30-40% of the total cases of migraine and is almost always preceded by visual disorders; and in rare...

journal_title：Headache

authors： Tiriticco M,Vanotti A,Mantica D,Coppola A

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in mi...

journal_title：Headache

authors： Barbanti P,Brighina F,Egeo G,Di Stefano V,Silvestro M,Russo A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:This study sought to compare ambulatory physical activity (PA) between young adults with migraine, tension-type headache (TTH), and non-headache controls and determine if differences in PA were attributable to headache activity or other relevant covariates. BACKGROUND:PA has been implicated in the developmen...

journal_title：Headache

authors： Rogers DG,Bond DS,Bentley JP,Smitherman TA

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Erenumab, a calcitonin gene-related peptide (CGRP) receptor monoclonal antibody, has been well tolerated with good efficacy for the preventive treatment of episodic and chronic migraine in phase 2 and phase 3 clinical trials. Limited post-market observations are available to validate these findings in a real...

journal_title：Headache

authors： Robblee J,Devick KL,Mendez N,Potter J,Slonaker J,Starling AJ

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:A hallmark of migraine is photophobia. In mice, photophobia-like behavior is induced by calcitonin gene-related peptide (CGRP), a neuropeptide known to be a key player in migraine. In this study, we sought to identify sites within the brain from which CGRP could induce photophobia. DESIGN:We focused on the p...

journal_title：Headache

authors： Sowers LP,Wang M,Rea BJ,Taugher RJ,Kuburas A,Kim Y,Wemmie JA,Walker CS,Hay DL,Russo AF

更新日期：2020-10-01 00:00:00

abstract：:Discrimination toward people living with migraine and other headache disorders is widespread and socially accepted. Stigma toward these diseases is both a manifestation of these discriminatory attitudes and a sustainer of them. For those living with migraine and headache disorders, stigma limits the full expression of...

journal_title：Headache

authors： Shapiro RE

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:To describe patterns of perceived stress across stages of the migraine cycle, within and between individuals and migraine episodes as defined for this study. METHODS:Individuals with migraine aged ≥18 years, who were registered to use the digital health platform N1-HeadacheTM , and completed 90 days of dail...

journal_title：Headache

authors： Vives-Mestres M,Casanova A,Buse DC,Donoghue S,Houle TT,Lipton RB,Mian A,Shulman KJ,Orr SL

更新日期：2020-09-12 00:00:00

abstract：OBJECTIVE:To determine whether patients with vestibular migraine are more likely to suffer from an occipital headache than patients with migraine without vestibular symptoms. BACKGROUND:Vestibular migraine is an underdiagnosed disorder in which migraine is associated with vestibular symptoms. Anatomical evidence and s...

journal_title：Headache

authors： Wattiez AS,O'Shea SA,Ten Eyck P,Sowers LP,Recober A,Russo AF,Fattal D

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Previous attempts to develop a pragmatic human model for testing new anti-migraine drugs, have failed. Calcitonin gene-related peptide (CGRP) induces a mild headache in healthy volunteers and migraine-like headache in migraine patients. The induced headache must respond to already established migraine treatme...

journal_title：Headache

authors： Falkenberg K,Rønde Bjerg H,Yamani N,Olesen J

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:The primary objective of the proposed systematic review is to determine if there is an association between internalizing disorders and symptoms (ie, subclinical symptoms) and migraine in children and adolescents. METHODS:We will perform a peer-reviewed Peer Review of Electronic Search Strategies search of M...

journal_title：Headache

authors： Falla K,Ronksley P,Noel M,Orr SL

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura. BACKGROUND:Migraine with aura has been associated with endothelial dysfunction and increased stroke risk. The initiating mechanism of migraine aura symptoms is not known. Experimental pro...

journal_title：Headache

authors： Hougaard A,Younis S,Iljazi A,Sugimoto K,Ayata C,Ashina M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of ubrogepant on patient-reported functional disability, satisfaction with study medication, and global impression of change. BACKGROUND:Ubrogepant is a small-molecule, oral calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine. In 2 phase ...

journal_title：Headache

authors： Dodick DW,Lipton RB,Ailani J,Halker Singh RB,Shewale AR,Zhao S,Trugman JM,Yu SY,Viswanathan HN

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:This cross-sectional study examined the association between adverse childhood experiences (ACEs) and history of frequent headaches (including migraine) among children 3-17 years old using data from the 2016 and 2017 U.S. National Survey of Children's Health (NSCH). BACKGROUND:ACEs include abuse (physical, e...

journal_title：Headache

authors： Mansuri F,Nash MC,Bakour C,Kip K

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:There has been a rise in urgent care centers throughout the country over the past 10 years, leading to an increase in patients accessing medical care in these locations. These centers advertise an alternative to the Emergency Department (ED) for the evaluation and treatment of urgent medical conditions. The g...

journal_title：Headache

authors： Minen MT,Zhou K,Miller L

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Tolosa-Hunt syndrome (THS), a condition characterized by painful ophthalmoplegia and accompanied by cranial nerve palsies, remains as a diagnosis of exclusion. Nevertheless, the 3rd Edition of the International Classification of Headache Disorders (ICHD) has refined its diagnostic criteria to require the d...

journal_title：Headache

authors： Mullen E,Rutland JW,Green MW,Bederson J,Shrivastava R

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To report a case of petrous apicitis that manifested as chronic migraine without aura and to discuss the pathophysiological mechanisms behind this presentation. BACKGROUND:Petrous apicitis is a rare complication of acute otitis media with varied clinical presentations that stem from the close proximity of th...

journal_title：Headache

authors： Mancini AJ,Glassman RD,Chang YM,Burstein R,Ashina S

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:We present a case report of 2 migraine patients engaged in shift work, followed by a narrative review, to assess whether shift work influences headache-related disability and chronification of migraine. BACKGROUND:Numerous modifiable factors can lead to chronification of migraine and to higher headache-relat...

journal_title：Headache

authors： Sandoe CH,Sasikumar S,Lay C,Lawler V

更新日期：2019-10-01 00:00:00

abstract：:Calcitonin-gene-related peptide (CGRP), a neuropeptide broadly distributed in neuronal and non-neuronal regions throughout the body, plays a fundamental role in migraine and cluster headache (CH) pathophysiology. CGRP functional blockade alleviates neurogenic inflammation and reduces pain pathway sensitization. Two ty...

journal_title：Headache

authors： Yuan H,Spare NM,Silberstein SD

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:There is very little literature surrounding the prophylactic use of zonisamide in cluster headaches. The study aims to evaluate the effectiveness of zonisamide for prophylaxis of cluster headache in patients with chronic or episodic cluster headache. BACKGROUND:Both chronic and episodic cluster headaches are...

journal_title：Headache

authors： Limmer AL,Holland LC,Loftus BD

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Presentation of pooled analysis of safety data for fremanezumab in patients with chronic (CM) or episodic migraine (EM) from 4 placebo-controlled phase 2b and phase 3 studies. BACKGROUND:There is a need for an effective, safe, and well-tolerated preventive therapy that specifically targets the pathophysiolog...

journal_title：Headache

authors： Silberstein SD,McAllister P,Ning X,Faulhaber N,Lang N,Yeung P,Schiemann J,Aycardi E,Cohen JM,Janka L,Yang R

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the psychometric properties (component structure, reliability, and construct validity) of the Headache-Specific Locus of Control scale in several clinical migraine populations. BACKGROUND:Headache-specific locus of control beliefs may impact a person's behavioral decisions that...

journal_title：Headache

authors： Grinberg AS,Seng EK

更新日期：2019-05-01 00:00:00

abstract：:Within- and between-study heterogeneity impede identification of valid primary headache biomarkers. Homogenous subgroup identification and investigation of differential biochemical profiles and networks within and across headache categories, based on statistical techniques, might promote biomarker discovery. When stud...

journal_title：Headache

authors： Frederiksen SD

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To understand treatment preferences of people with migraine and the relative importance of improvements in efficacy and avoiding adverse events (AEs), such as cognition problems or weight gain. BACKGROUND:Current preventive migraine medicines are associated with poor adherence and tolerability. There is an u...

journal_title：Headache

authors： Mansfield C,Gebben DJ,Sutphin J,Tepper SJ,Schwedt TJ,Sapra S,Shah N

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To assess the measurement properties of the Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQv2.1) electronic patient-reported outcome (ePRO) Role Function-Restrictive (RFR) domain to evaluate the functional impact of migraine in patients with episodic (EM) or chronic migraine (CM) enrolled in...

journal_title：Headache

authors： Speck RM,Shalhoub H,Wyrwich KW,Yu R,Ayer DW,Ford J,Bush EN,Lipton RB

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To describe a case series of 7 patients presenting cluster headache (CH) criteria and a substance use disorder, reported to a French Addictovigilance center. Then, to assess clinical, pharmacological, and neurobiological linkages between substance use and CH onset. BACKGROUND:CH patients are presenting a hig...

journal_title：Headache

authors： Ponté C,Giron A,Crequy M,Lapeyre-Mestre M,Fabre N,Salles J

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of monthly headache days. Because only a subset of individuals with episodic migraine (EM) progress to chronic migraine (CM) over any given time period, understanding the...

journal_title：Headache

authors： Buse DC,Greisman JD,Baigi K,Lipton RB

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To assess the acute treatment of pregnant women presenting to a hospital with migraine. BACKGROUND:Migraine is a common problem in pregnancy; however, migraine treatment is challenging in pregnant women for fears of medication teratogenicity and lack of data in this population. To date, no study has directly...

journal_title：Headache

authors： Hamilton KT,Robbins MS

更新日期：2019-02-01 00:00:00

abstract：:Genetic mutations of sporadic hemiplegic migraine (SHM) are mostly unknown. SHM pathophysiology relies on cortical spreading depression (CSD), which might be responsible for ischemic brain infarction. Cystic fibrosis (CF) is caused by a monogenic mutation of the chlorine transmembrane conductance regulator (CFTR), pos...

journal_title：Headache

authors： Mancini V,Mastria G,Frantellizzi V,Troiani P,Zampatti S,Carboni S,Giardina E,Campopiano R,Gambardella S,Turchi F,Petolicchio B,Toscano M,Liberatore M,Viganò A,Di Piero V

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To examine the likelihood of response with continued galcanezumab treatment in patients with episodic or chronic migraine without initial clinical improvement. BACKGROUND:A percentage of patients with migraine may require additional time on pharmacotherapy but discontinue treatment prematurely. Additionally,...

journal_title：Headache

authors： Nichols R,Doty E,Sacco S,Ruff D,Pearlman E,Aurora SK

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Migraine headache is the seventh leading cause of disability worldwide causing adverse outcomes in many aspects of an individual's life. Many psychological aspects affect chronic migraine (CM): illness perception, anxiety, depressive symptoms, and job satisfaction. This observational study aim...

journal_title：Headache

authors： Rogante E,Sarubbi S,Lamis DA,Canzonetta V,Sparagna A,De Angelis V,Erbuto D,Martelletti P,Pompili M

更新日期：2019-01-01 00:00:00

abstract：:Objective - To briefly describe the history of and available data on anti-calcitonin gene-related peptide (CGRP) therapies for headache. Background - CGRP was proposed as a target for primary headache therapies. Translational research involved moving from delineating the relationships between CGRP and primary headache...

journal_title：Headache

authors： Tepper SJ

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To examine the disability, health care resource utilization, and direct annual costs among patients with migraine, categorized according to the number of headache days experienced in the past month. BACKGROUND:Migraine exists on a continuum of different attack frequencies and associated levels of disability....

journal_title：Headache

authors： Silberstein SD,Lee L,Gandhi K,Fitzgerald T,Bell J,Cohen JM

更新日期：2018-11-01 00:00:00

abstract：:Headache attributed to temporomandibular disorders (TMDH) is defined as a secondary headache by the International Classification of Headache Disorders 3rd edition (ICHD-3). OBJECTIVE:The objective of this case-control study is to investigate the phenotypic characteristics of chronic TMD with and without TMDH. We hypo...

journal_title：Headache

authors： Vivaldi D,Di Giosia M,Tchivileva IE,Jay GW,Slade GD,Lim PF

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Many children suffering from chronic headache and migraine present with comorbid functional disability, including physical, social, emotional, and academic activities. For children severely impaired by headache, intensive interdisciplinary pain rehabilitation treatment (IIPT) can improve functioning. However...

journal_title：Headache

authors： Benore E,Webster EE,Wang L,Banez G

更新日期：2018-11-01 00:00:00