abstract：BACKGROUND AND AIMS:Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. METHODS AND RESULTS:Medical records of 1,180,062 young adults (20-49 years old) without a prior history of CVD and w...

journal_title：Atherosclerosis

authors： Kaneko H,Itoh H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

更新日期：2021-01-16 00:00:00

abstract：BACKGROUND AND AIMS:The TNF-superfamily member sTWEAK and its scavenger receptor sCD163 are potentially involved in pathophysiological processes of atherosclerosis. In patients with peripheral arterial disease, previous research has shown that sTWEAK and the sCD163/sTWEAK ratio were independently associated with long t...

journal_title：Atherosclerosis

authors： Mrak D,Zierfuss B,Höbaus C,Herz CT,Pesau G,Schernthaner GH

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIMS:There is some evidence of a cross-sectional, and possibly causal, relationship of lipid levels with leukocyte counts in mice and humans. This study investigates the cross-sectional and longitudinal relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort. ME...

journal_title：Atherosclerosis

authors： Tucker B,Sawant S,McDonald H,Rye KA,Patel S,Ong KL,Cochran BJ

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND AND AIMS:Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular pathophysiology but its involvement in atherosclerosis development and its...

journal_title：Atherosclerosis

authors： Rakipovski G,Rolin B,Barascuk N,Lund HE,Bjørn Bonde MF,Djordjevic D,Wulff-Larsen PG,Petersen M,Kirk RK,Hultman K,Manfe V,Blume N,Zahn S,Lengquist M,Maegdefessel L,Hovingh GK,Conde-Knape K,Hedin U,Matic L,Nyberg M

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies suggest that long-term endurance training may be damaging to the heart, thus increasing cardiovascular disease (CVD) risk. However, studies utilizing cardiac imaging are conflicting and lack measures of central and peripheral vascular structure and function, which are also independent...

journal_title：Atherosclerosis

authors： Bachman NP,Terwoord JD,Richards JC,Braun B,Green CP,Luckasen GJ,Dinenno FA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to study subclinical non-invasive vascular markers as predictors of incident long-term cognitive impairment in a longitudinal population-based study. METHODS:The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) study is a population-based study that included a random sample of 93...

journal_title：Atherosclerosis

authors： Crespo-Cuevas AM,Canento T,Hernández-Perez M,Cáceres C,González A,Ispierto L,Mataró M,Vilas D,Planas-Ballvé A,Martin L,Muñoz-Ortiz L,Arenillas JF,Via M,Castañón M,Millan M,Dorado L,López-Cancio E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...

journal_title：Atherosclerosis

authors： Makshood M,Joshi PH,Kanaya AM,Ayers C,Budoff M,Tsai MY,Blaha M,Michos ED,Post WS

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capac...

journal_title：Atherosclerosis

authors： Hirata A,Kakino A,Okamura T,Usami Y,Fujita Y,Kadota A,Fujiyoshi A,Hisamatsu T,Kondo K,Segawa H,Sawamura T,Miura K,Ueshima H,SESSA Research Group.

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The sex- and age-related differences in the composition of iliofemoral atherosclerotic plaques are largely unknown. Therefore, the aim of the current study is to gain insight into plaque composition across strata of age and sex in a large cohort of vascular surgery patients. METHODS:Peripheral athe...

journal_title：Atherosclerosis

authors： de Bakker M,Timmerman N,van Koeverden ID,de Kleijn DPV,de Borst GJ,Pasterkamp G,Boersma E,den Ruijter HM

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potentially limited efficacy. Patients with very low levels of HDL-cholester...

journal_title：Atherosclerosis

authors： Zheng KH,Kaiser Y,van Olden CC,Santos RD,Dasseux JL,Genest J,Gaudet D,Westerink J,Keyserling C,Verberne HJ,Leitersdorf E,Hegele RA,Descamps OS,Hopkins P,Nederveen AJ,Stroes ESG

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a poten...

journal_title：Atherosclerosis

authors： Hofheinz K,Seibert F,Ackermann JA,Dietel B,Tauchi M,Oszvar-Kozma M,Kühn H,Schett G,Binder CJ,Krönke G

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is a powerful risk factor for cardiovascular (CV) events. High levels of low-density lipoprotein cholesterol (LDL-C) since birth are linked to the early onset of atherosclerotic disease. A genetic mutation determining FH is present in about one subject out of 250;...

journal_title：Atherosclerosis

authors： Gulizia MM,Maggioni AP,Abrignani MG,Bilato C,Mangiacapra F,Sanchez FA,Piovaccari G,Montagna L,Marini M,De Biasio M,Averna M,Casula M,Colivicchi F,Fabbri G,Lucci D,Zampoleri V,Catapano AL,POSTER Investigators.

更新日期：2020-09-01 00:00:00

abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

journal_title：Atherosclerosis

authors： Gutmann C,Joshi A,Mayr M

更新日期：2020-08-01 00:00:00

abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

journal_title：Atherosclerosis

authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Low ankle-brachial index (ABI) calculated using systolic blood pressure (SBP) is associated with poor prognosis. However, there is no study assessing ABI calculated using mean artery pressure (MAP) and diastolic blood pressure (DBP) in predicting mortality. METHODS:Two cohort populations were enrol...

journal_title：Atherosclerosis

authors： Hsu PC,Lee WH,Chen YC,Lee MK,Tsai WC,Chu CY,Lee CS,Yen HW,Lin TH,Voon WC,Lai WT,Sheu SH,Su HM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis starts early in life. We aimed to assess the dimension and progression of the intima-media thickness, a surrogate marker for early vascular aging, and its association with a broad palette of cardiovascular risk and lifestyle factors in a large cohort of healthy adolescents. METHODS:...

journal_title：Atherosclerosis

authors： Staudt A,Stock K,Gande N,Bernar B,Hochmayr C,Pechlaner R,Kiechl SJ,Geiger R,Griesmacher A,Anliker M,Kiechl S,Kiechl-Kohlendorfer U,Knoflach M,Early Vascular Ageing (EVA) Study Group.

更新日期：2020-07-01 00:00:00

abstract：:Dyslipidemias are strongly linked to the development of atherosclerotic cardiovascular disease. Most dyslipidemias find their origin in the liver. In recent years, the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells has provided a versatile platform for the functional study of vari...

journal_title：Atherosclerosis

authors： Larsen LE,Smith MA,Abbey D,Korn A,Reeskamp LF,Hand NJ,Holleboom AG

更新日期：2020-06-01 00:00:00

abstract：:The emergence of pathophysiological, epidemiologic, and genetic data strongly supports the causality for lipoprotein(a) [Lp(a)] in cardiovascular disease (CVD) and calcific aortic valve disease (CAVD). In parallel, novel Lp(a) lowering approaches have been developed that have re-invigorated clinical interest in Lp(a)....

journal_title：Atherosclerosis

authors： Tsimikas S,Stroes ESG

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND AIMS:TRPA1 is a calcium permeable non-selective cation channel, its expression is up-regulated in atherosclerosis plaque, yet its function in macrophages activation is unknown. We sought to establish the role of TRPA1 in inflammatory macrophages activation. METHODS:TRPA1-/-ApoE-/- mice and C57BL/6 J con...

journal_title：Atherosclerosis

authors： Wang Q,Chen K,Zhang F,Peng K,Wang Z,Yang D,Yang Y

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Reduced bioavailability of nitric oxide (NO) has been implicated in the pathogenesis of calcific aortic stenosis. Herein, we investigated the effects of l-Arginine, the main precursor of NO, on the osteogenic differentiation of aortic interstitial valve cells (VICs). METHODS:We isolated a clonal po...

journal_title：Atherosclerosis

authors： Rattazzi M,Donato M,Bertacco E,Millioni R,Franchin C,Mortarino C,Faggin E,Nardin C,Scarpa R,Cinetto F,Agostini C,Ferri N,Pauletto P,Arrigoni G

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is characterised by a high, but variable risk of premature coronary artery disease (CAD). Cardiac computed tomography angiography (CCTA) can be employed to assess subclinical coronary atherosclerosis. We investigated the features and distribution of coronary arter...

journal_title：Atherosclerosis

authors： Pang J,Abraham A,Vargas-García C,Bates TR,Chan DC,Hooper AJ,Bell DA,Burnett JR,Schultz CJ,Watts GF

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexist...

journal_title：Atherosclerosis

authors： Kim J,Jang HJ,Schellingerhout D,Kang JW,Choi S,Oh H,Kim EJ,Lee SK,Lee JS,Kwon IC,Kim K,Koh YJ,Ryu WS,Kim DE

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an impo...

journal_title：Atherosclerosis

authors： Pu X,Chan K,Yang W,Xiao Q,Zhang L,Moore AD,Liu C,Webb TR,Caulfield MJ,Samani NJ,Zhu J,Ye S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-invasive surrogates of cardiovascular (CV) disease such as endothelial dysfunction (ED) and peripheral arterial stiffness (AS) have been evaluated in systemic lupus erythematosus (SLE) patients. The aim of this study was to systematically review and meta-analyze reports of cardiovascular disease...

journal_title：Atherosclerosis

authors： Mendoza-Pinto C,Rojas-Villarraga A,Molano-González N,García-Carrasco M,Munguía-Realpozo P,Etchegaray-Morales I,Morales-Sánchez H,Berra-Romani R,Cervera R

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques. METHODS:We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living wi...

journal_title：Atherosclerosis

authors： Guaraldi G,Milic J,Prandini N,Ligabue G,Esposito F,Ciusa G,Malagoli A,Scaglioni R,Besutti G,Beghetto B,Nardini G,Roncaglia E,Mussini C,Raggi P

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Cardiovascular disease (CVD) and cancer are the two leading causes of death in smokers. Lung cancer screening is recommended in a large proportion of smokers. We examined the implication of coronary artery calcium (CAC) score (quantitative and qualitative) for cardiovascular disease (CVD), coronary ...

journal_title：Atherosclerosis

authors： Mirbolouk M,Kianoush S,Dardari Z,Miedema MD,Shaw LJ,Rumberger JA,Berman DS,Budoff MJ,Rozanski A,Al-Mallah MH,McEvoy JW,Nasir K,Blaha MJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Dietary long-chain (≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknow...

journal_title：Atherosclerosis

authors： Wang Z,Sequeira RC,Zabalawi M,Madenspacher J,Boudyguina E,Ou T,Nelson JM,Nie Y,Zhao Q,Fessler MB,Zhu X

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The indications for carotid endarterectomy (CEA) are well established. The aim of the current study was to investigate sex and race-based disparities in the incidence of CEA after adjusting for carotid artery stenosis risk factors. METHODS:We conducted a prospective cohort analysis of 14,492 black ...

journal_title：Atherosclerosis

authors： Hicks CW,Daya NR,Black JH 3rd,Matsushita K,Selvin E

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Osteoporosis and coronary heart disease (CHD) are very common conditions among elderly people, and both represent a public health concern due to their prognostic consequences. Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evi...

journal_title：Atherosclerosis

authors： Campos-Staffico AM,Freitas WM,Carvalho LSF,Coelho-Filho OR,Nadruz W Jr,Oliveira RB,Sposito AC,Brasilia Study on Healthy Aging and Brasilia Heart Study.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Endostatin is implicated in the atherosclerosis process and serves as a promising cardiovascular biomarker, while its clinical significance in ischemic stroke patients remains unclear. We aimed to examine the association between endostatin and mortality and disability after ischemic stroke. METHODS...

journal_title：Atherosclerosis

authors： Zhang C,Qian S,Zhang R,Guo D,Wang A,Peng Y,Peng H,Li Q,Ju Z,Geng D,Chen J,Zhang Y,He J,Zhong C,Xu T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis develops with age and is partially controlled by genetics. Research to date has identified common variants with small effects on atherosclerosis related traits. We aimed to use family-based genome-wide linkage analysis to identify chromosomal regions potentially harboring rare varian...

journal_title：Atherosclerosis

authors： Kuipers AL,Wojczynski MK,Barinas-Mitchell E,Minster RL,Wang L,Feitosa MF,Kulminski A,Thyagarajan B,Lee JH,Province MA,Newman AB,Zmuda JM,Long-Life Family Study.

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) i...

journal_title：Atherosclerosis

authors： Cao YX,Jin JL,Guo YL,Sun D,Liu HH,Wu NQ,Xu RX,Zhu CG,Liu G,Dong Q,Sun J,Li JJ

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. ...

journal_title：Atherosclerosis

authors： Wang XB,Cui NH,Liu X,Ming L

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Both elevated serum uric acid (SUA) and peripheral endothelial dysfunction (PED) are associated independently with cardiovascular disease (CVD). However, the association between SUA and PED is yet to be established. We hypothesized that high normal range of SUA is associated with PED. METHODS:We pe...

journal_title：Atherosclerosis

authors： Taher R,Sara JD,Prasad M,Kolluri N,Toya T,Lerman LO,Lerman A

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset an...

journal_title：Atherosclerosis

authors： Nagarajan UM,Sikes JD,Burris RL,Jha R,Popovic B,Fraungruber P,Hennings L,Haggerty CL,Nagarajan S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have recently been associated with processes in CHD development, and may therefore represent new potential risk markers. ...

journal_title：Atherosclerosis

authors： Velle-Forbord T,Eidlaug M,Debik J,Sæther JC,Follestad T,Nauman J,Gigante B,Røsjø H,Omland T,Langaas M,Bye A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Classically, peripheral arterial disease (PAD) is diagnosed by a low ankle-brachial index (ABI), but the diagnosis can also be made based on toe-brachial index (TBI) measurements. The objective of this study was to characterize patients with low TBI but normal ABI, and chart potential underestimatio...

journal_title：Atherosclerosis

authors： Høyer C,Høgh AL,Sandermann J,Zacho HD,Petersen LJ

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine cross-sectional associations between objectively measured physical activity and sedentary time with ...

journal_title：Atherosclerosis

authors： Jones PR,Rajalahti T,Resaland GK,Aadland E,Steene-Johannessen J,Anderssen SA,Bathen TF,Andreassen T,Kvalheim OM,Ekelund U

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The coronary artery disease-reporting and data system (CAD-RADS) was recently developed to standardize CAD classifications and incorporate clinical management. We aimed to investigate the prognostic value and additional risk stratification benefits of CAD-RADS compared to coronary artery calcium sco...

journal_title：Atherosclerosis

authors： Nam K,Hur J,Han K,Im DJ,Suh YJ,Hong YJ,Lee HJ,Kim YJ,Choi BW

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Cell adhesion molecules (CAMs) are implicated in the initiation and progression of atherosclerosis, but their association with risk of type 2 diabetes remains inconsistent. This meta-analysis aimed to quantify this association with dose-response analysis in the general population without type 2 diab...

journal_title：Atherosclerosis

authors： Qiu S,Cai X,Liu J,Yang B,Zügel M,Steinacker JM,Sun Z,Schumann U

更新日期：2019-08-01 00:00:00