Abstract：
:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the contribution of platelets to vascular remodelling and extends beyond cardiovascular disease to haematological disorders and cancer. To address these gaps in our knowledge, a better understanding of the underlying molecular processes is needed. This will be enabled by technologies that capture dysregulated molecular processes and can integrate them into a broader network of biological systems. The advent of -omics technologies, such as mass spectrometry proteomics, metabolomics and lipidomics; highly multiplexed affinity-based proteomics; microarray- or RNA-sequencing-(RNA-seq)-based transcriptomics, and most recently ribosome footprint-based translatomics, has enabled a more holistic understanding of platelet biology. Most of these methods have already been applied to platelets, and this review will summarise this information and discuss future developments in this area of research.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Gutmann C,Joshi A,Mayr Mdoi
10.1016/j.atherosclerosis.2020.05.022subject
Has Abstractpub_date
2020-08-01 00:00:00pages
87-96eissn
0021-9150issn
1879-1484pii
S0021-9150(20)30296-3journal_volume
307pub_type
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