Hepatocyte-like cells derived from induced pluripotent stem cells: A versatile tool to understand lipid disorders.

abstract：:High-density lipoproteins (HDL) have several antiatherogenic actions, including the ability to sequester cellular cholesterol, to protect low-density lipoproteins from oxidation and to inhibit platelet aggregation. An early event in atherogenesis is the adhesion and recruitment of blood monocytes, a process mediated b...

journal_title：Atherosclerosis

authors： Stannard AK,Khan S,Graham A,Owen JS,Allen SP

更新日期：2001-01-01 00:00:00

abstract：:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 4...

journal_title：Atherosclerosis

authors： Inoue T,Hayashi M,Takayanagi K,Morooka S

更新日期：2002-02-01 00:00:00

abstract：:The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505), could reduce atherosclerotic lesions beyond and independent of the reduction achieved by cholesterol lowering alone from two different types of lesions. (1) Early lesio...

journal_title：Atherosclerosis

authors： Terasaka N,Miyazaki A,Kasanuki N,Ito K,Ubukata N,Koieyama T,Kitayama K,Tanimoto T,Maeda N,Inaba T

更新日期：2007-02-01 00:00:00

abstract：:The lifetime cardiovascular risk of a diabetic patient is approximately 4-5 times higher than that of an age and sex matched individual without diabetes mellitus. Despite the well-publicized cardiovascular risk equivalence of diabetes mellitus, it has become apparent that not all diabetic patients are equally at high-...

journal_title：Atherosclerosis

authors： Raggi P

更新日期：2018-04-01 00:00:00

abstract：:The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The inflammatory arterial diseases abdominal aortic aneurysm (AAA) and atherosclerosis involve extensive v...

journal_title：Atherosclerosis

authors： Liu J,Sukhova GK,Yang JT,Sun J,Ma L,Ren A,Xu WH,Fu H,Dolganov GM,Hu C,Libby P,Shi GP

更新日期：2006-02-01 00:00:00

abstract：:This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...

journal_title：Atherosclerosis

authors： Schwertner HA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:PPARgamma (PPARg) is a nuclear transcription factor involved in the control of lipid and glucose homeostasis. Two PPARg common polymorphisms, Pro12Ala and 161C>T, have been found to be associated with cardiovascular disease. In this study, in addition to PPARg coding region, we looked for genetic variations ...

journal_title：Atherosclerosis

authors： Evangelisti L,Attanasio M,Lucarini L,Sofi F,Marcucci R,Giglioli C,Valente S,Gensini G,Abbate R,Pepe G

更新日期：2009-07-01 00:00:00

abstract：:The relations between triglyceride-rich lipoproteins, alimentary lipaemia and coronary heart disease (CHD) have remained obscure and much debated. We studied the basal and postprandial plasma levels of chylomicron remnants and very low density lipoproteins (VLDL) of varying particle size in 32 male postinfarction pati...

journal_title：Atherosclerosis

authors： Karpe F,Steiner G,Uffelman K,Olivecrona T,Hamsten A

更新日期：1994-03-01 00:00:00

abstract：:Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can be used to guide ...

journal_title：Atherosclerosis

authors： Hoenig MR,Rolfe BE,Campbell JH

更新日期：2006-02-01 00:00:00

abstract：:The St. Thomas mixed hyperlipidaemic (SMHL) rabbit exhibits an inherited hyperlipidaemia similar to that seen in familial combined hyperlipidaemia (FCHL). In this study, we investigated whether the SMHL rabbit is insulin resistant, a condition often associated with FCHL. Six young and six mature combined hyperlipidaem...

journal_title：Atherosclerosis

authors： de Roos B,Caslake MJ,Ardern HA,Martin Benson G,Suckling KE,Packard CJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression. METHODS AND RESULTS:We performed studies in peritoneal macrophages (MPM) from C57BL/6 control mice, or fr...

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Aviram M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

journal_title：Atherosclerosis

authors： Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

更新日期：2018-08-01 00:00:00

abstract：:A total of ten healthy elderly subjects ingested one capsule of 600 mg (corresponding to 150 mg docosahexaenoic acid and 30 mg eicosapentaenoic acid) RO-PUFA triglycerides per day and ten others ingested one capsule of 600 mg sunflower oil as a placebo for 42 days. In the n-3 polyunsaturated fatty acids (PUFA) group, ...

journal_title：Atherosclerosis

authors： Véricel E,Calzada C,Chapuy P,Lagarde M

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...

journal_title：Atherosclerosis

authors： Koopal C,Retterstøl K,Sjouke B,Hovingh GK,Ros E,de Graaf J,Dullaart RP,Bertolini S,Visseren FL

更新日期：2015-05-01 00:00:00

abstract：:Incorporation of 125I-labeled cholesterol ester rich lipoproteins from cholesterol fed rabbits into normal rabbit aorta in vitro was inhibited by heparin, lecithin, and collagenase and by succinylation of the lipoprotein. Aortic uptake of lipoprotein was increased by neuraminidase, proteases, lipase, and beta-glucuron...

journal_title：Atherosclerosis

authors： Day CE

更新日期：1976-11-01 00:00:00

abstract：:Endothelium-derived relaxing and contracting factors play an important role in atherosclerosis, re-stenosis and graft survival. Internal thoracic artery (ITA) and saphenous vein (SV) are used as conduit vessels in coronary artery bypass graft surgery (CABG). The long-term graft patency rate is higher with ITA than SV....

journal_title：Atherosclerosis

authors： Hamilton CA,Berg G,Mcintyre M,Mcphaden AR,Reid JL,Dominiczak AF

更新日期：1997-08-01 00:00:00

abstract：:Dietary plant proteins may lower plasma cholesterol and LDL concentrations in hypercholesterolemic patients when substituted for animal proteins, particularly in diets with low cholesterol and saturated fat content. Plant protein diets appear, however, to be without effect on plasma lipoprotein levels in normal subjec...

journal_title：Atherosclerosis

authors： Meinertz H,Faergeman O,Nilausen K,Chapman MJ,Goldstein S,Laplaud PM

更新日期：1988-07-01 00:00:00

abstract：:The hypolipidaemic effect of guar gum (30 g/day) was examined in a double blind placebo-controlled crossover study in 9 patients with primary hyperlipidaemia. The treatment periods were of six weeks duration. Cholesterol levels in low density lipoprotein (LDL) were decreased by 11.5% and in intermediate density lipopr...

journal_title：Atherosclerosis

authors： Turner PR,Tuomilehto J,Happonen P,La Ville AE,Shaikh M,Lewis B

更新日期：1990-03-01 00:00:00

abstract：:Whether cardiorespiratory fitness relates to early subclinical atherosclerotic vascular disease remains unknown. We investigated the relation of cardiorespiratory fitness to coronary artery calcification (CAC) in 2373 African-American and White young adults from the Coronary Artery Risk Development in Young Adults (CA...

journal_title：Atherosclerosis

authors： Lee CD,Jacobs DR Jr,Hankinson A,Iribarren C,Sidney S

更新日期：2009-03-01 00:00:00

abstract：:We looked for antibodies against endothelial cells, monocytes, fibroblasts, lymphocytes and Epstein-Barr virus transformed lymphocytes in the sera of 28 elderly and 18 middle-aged patients with atherosclerotic peripheral arterial disease and 13 controls. Inclusion criteria were symptomatic peripheral arterial disease ...

journal_title：Atherosclerosis

authors： D'Anastasio C,Impallomeni M,McPherson GA,Clements WG,Howells GL,Brooks PA,Batchelor JR

更新日期：1988-11-01 00:00:00

abstract：:DNA probes for all eight of the major apolipoprotein genes are now available. The chromosomal location, the basic structure and in many cases the nucleotide sequences of the normal genes are known. Common DNA polymorphisms of all of the genes have been detected. These have been been used in a number of ways to investi...

journal_title：Atherosclerosis

authors： Humphries SE

更新日期：1988-08-01 00:00:00

abstract：:An inverse relationship between moderate alcohol consumption and coronary artery disease (CAD) has been observed in several epidemiologic studies. Whether improvement of endothelial function is involved in this beneficial effect is unknown. We investigated endothelial function of the brachial artery in 108 men with CA...

journal_title：Atherosclerosis

authors： Teragawa H,Fukuda Y,Matsuda K,Higashi Y,Yamagata T,Matsuura H,Chayama K

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and incident peripheral arterial disease (PAD) have been mixed. We investigated whether higher Lp-PLA2 levels are associated with increased risk of incident PAD an...

journal_title：Atherosclerosis

authors： Garg PK,Norby FL,Polfus LM,Boerwinkle E,Gibbs RA,Grove ML,Folsom AR,Garimella PS,Matsushita K,Hoogeveen RC,Ballantyne CM

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke; however it is rather neglected. Vessel wall visualization by high resolution magnetic resonance imaging (HRMRI) might provide more accurate information. METHODS:A total of 219 consecutive patients with acute ischemic stroke underwent MR...

journal_title：Atherosclerosis

authors： Kim YS,Lim SH,Oh KW,Kim JY,Koh SH,Kim J,Heo SH,Chang DI,Lee YJ,Kim HY

更新日期：2012-10-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：:Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...

journal_title：Atherosclerosis

authors： Chen H,Zhuang H,Han Q

更新日期：1983-07-01 00:00:00

abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...

journal_title：Atherosclerosis

authors： Puranik R,Bao S,Nobecourt E,Nicholls SJ,Dusting GJ,Barter PJ,Celermajer DS,Rye KA

更新日期：2008-01-01 00:00:00

abstract：:The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofib...

journal_title：Atherosclerosis

authors： Cellai AP,Lami D,Fedi S,Marcucci R,Mannini L,Cenci C,Rogolino A,Sodi A,Menchini U,Abbate R,Prisco D

更新日期：2012-09-01 00:00:00

abstract：:Local accumulation of cells (hypercellularity) in the intima of the arterial wall as a result of cell proliferation is recognized as one of the major manifestations of human atherosclerosis. In the present study we have used a monoclonal antibody against PCNA to identify the proliferative activity, in uninvolved intim...

journal_title：Atherosclerosis

authors： Orekhov AN,Andreeva ER,Mikhailova IA,Gordon D

更新日期：1998-07-01 00:00:00

abstract：:It has been shown that triglyceride levels are one of the determinants of factor VII levels. In this study we have simultaneously evaluated, in a group of 102 healthy individuals, the different forms of factor VII, namely factor VII mass, factor VII coagulant activity, activated factor VII double-chain form and factor...

journal_title：Atherosclerosis

authors： Negri M,Arigliano PL,Talamini G,Carlini S,Manzato F,Bonadonna G

更新日期：1993-02-01 00:00:00