Formation of atherosclerotic lesions is independent of eosinophils in male mice.

Abstract:

BACKGROUND AND AIMS:Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a potential role of type 2 immunity in atherogenesis. However, the involvement of individual type 2 immune cell subsets involved in this process has been incompletely defined. We therefore sought to determine the role of eosinophils during LDL oxidation and the pathogenesis of this disease. METHODS:Using eosinophil-deficient dblGATA1 mice, we studied the role of eosinophils in two established mouse models of atherosclerosis. RESULTS:These experiments revealed that the presence of eosinophils did neither affect biomarkers of LDL oxidation nor atherosclerotic lesion development. CONCLUSIONS:The obtained results show that LDL oxidation and development of atherosclerosis are largely independent of eosinophils or eosinophil-mediated LDL oxidation.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Hofheinz K,Seibert F,Ackermann JA,Dietel B,Tauchi M,Oszvar-Kozma M,Kühn H,Schett G,Binder CJ,Krönke G

doi

10.1016/j.atherosclerosis.2020.08.030

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

67-72

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(20)30494-9

journal_volume

311

pub_type

杂志文章
  • Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients.

    abstract:OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.10.035

    authors: Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

    更新日期:2011-02-01 00:00:00

  • Adiposity has no direct effect on carotid intima-media thickness in adolescents and young adults: Use of structural equation modeling to elucidate indirect & direct pathways.

    abstract:BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.11.033

    authors: Gao Z,Khoury PR,McCoy CE,Shah AS,Kimball TR,Dolan LM,Urbina EM

    更新日期:2016-03-01 00:00:00

  • Endostatin as a novel prognostic biomarker in acute ischemic stroke.

    abstract:BACKGROUND AND AIMS:Endostatin is implicated in the atherosclerosis process and serves as a promising cardiovascular biomarker, while its clinical significance in ischemic stroke patients remains unclear. We aimed to examine the association between endostatin and mortality and disability after ischemic stroke. METHODS...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.atherosclerosis.2019.11.032

    authors: Zhang C,Qian S,Zhang R,Guo D,Wang A,Peng Y,Peng H,Li Q,Ju Z,Geng D,Chen J,Zhang Y,He J,Zhong C,Xu T

    更新日期:2020-01-01 00:00:00

  • Low cardiorespiratory fitness and coronary artery calcification: Complementary cardiovascular risk predictors in asymptomatic type 2 diabetics.

    abstract:BACKGROUND:Despite its well-established prognostic value, cardiorespiratory fitness (CRF) is not incorporated routinely in risk assessment tools. Whether low CRF provides additional predictive information in asymptomatic type 2 diabetics beyond conventional risk scores and coronary artery calcification (CAC) is unclear...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.06.020

    authors: Zafrir B,Azaiza M,Gaspar T,Dobrecky-Mery I,Azencot M,Lewis BS,Rubinshtein R,Halon DA

    更新日期:2015-08-01 00:00:00

  • Effect of sialic acid removal on human low density lipoprotein catabolism in vivo.

    abstract::This study was undertaken to determine whether sialic acid removal alters the catabolism of low density lipoprotein in humans. Human low density lipoproteins labeled in vitro with 125I were incubated in the presence (termed desialylated) or absence (sialylated) of neuraminidase. The treatment with neuraminidase from C...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(80)90013-1

    authors: Malmendier CL,Delcroix C,Fontaine M

    更新日期:1980-10-01 00:00:00

  • The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters.

    abstract::This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(97)00302-x

    authors: Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

    更新日期:1998-05-01 00:00:00

  • The effects of saturated fat and n-6 polyunsaturated fat on postprandial lipemia and hemostatic activity.

    abstract::The effect of different fat loads on postprandial lipemia and hemostatic activity was examined in 10 middle-aged men using 3 different meals. One meal was rich in saturated fatty acids (cream), the other rich in n-6 polyunsaturated fatty acids (sunflower oil) and the third was fat-free containing only carbohydrates. L...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(93)90034-r

    authors: Salomaa V,Rasi V,Pekkanen J,Jauhiainen M,Vahtera E,Pietinen P,Korhonen H,Kuulasmaa K,Ehnholm C

    更新日期:1993-10-01 00:00:00

  • Atherosclerotic plaque-like lesions in synthetic arteriovenous grafts: implications for atherogenesis.

    abstract::Atherosclerotic plaque-like lesions are prevalent in synthetic arteriovenous shunts created to provide vascular access for hemodialysis. Similarities to atherosclerotic plaques in native arteries include eccentric location, immunoreactivity for smooth muscle actin, dystrophic calcifications, superimposed thrombi, and ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(01)00543-3

    authors: Sloop GD,Fallon KB,Zieske AW

    更新日期:2002-01-01 00:00:00

  • Fatty acid patterns in triglycerides, diglycerides, free fatty acids, cholesteryl esters and phosphatidylcholine in serum from vegetarians and non-vegetarians.

    abstract::The differences in the fatty acid spectra of serum samples obtained from vegetarians (62 females, 40 males) and non-vegetarians (70 females, 38 males) were evaluated in a matched-pair study design. This study population made it possible to examine 48 female and 31 male pairs whose age difference did not exceed 3 years...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(87)90017-7

    authors: Melchert HU,Limsathayourat N,Mihajlović H,Eichberg J,Thefeld W,Rottka H

    更新日期:1987-05-01 00:00:00

  • Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease.

    abstract:BACKGROUND:Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. AIM:We aim at assessing CAD burden by coronary ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2016.01.020

    authors: Niccoli G,Cin D,Scalone G,Panebianco M,Abbolito S,Cosentino N,Jacoangeli F,Refaat H,Gallo G,Salerno G,Volpe M,Crea F,De Biase L

    更新日期:2016-03-01 00:00:00

  • Impact of HIV and highly active antiretroviral therapy on leukocyte adhesion molecules, arterial inflammation, dyslipidemia, and atherosclerosis.

    abstract::Highly active antiretroviral therapy (HAART) has greatly extended the lives of people infected with the human immunodeficiency virus (HIV). This reduced risk of early death from opportunistic infections or other sequelae of HIV infection, however, means that other possible causes of death emerge. Myocardial infarction...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2005.09.025

    authors: Fisher SD,Miller TL,Lipshultz SE

    更新日期:2006-03-01 00:00:00

  • Stress-induced cardiovascular reactivity and atherogenesis in adolescents.

    abstract:OBJECTIVE:To examine the association between cardiovascular reactivity to a set of psychological stressors and carotid artery intima-media thickness, a marker of subclinical cardiovascular disease in healthy adolescents. METHODS:Participants were 25 boys and 23 girls age 14.2 ± 0.9 years who were measured for heart ra...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.12.030

    authors: Roemmich JN,Feda DM,Seelbinder AM,Lambiase MJ,Kala GK,Dorn J

    更新日期:2011-04-01 00:00:00

  • IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.

    abstract::Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expressi...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.07.029

    authors: Hao XR,Cao DL,Hu YW,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

    更新日期:2009-04-01 00:00:00

  • Artificial ultraviolet whole-body radiation does not modify serum lipoprotein, plasma fibrinogen, plasminogen or antithrombin III concentrations in post-myocardial infarction patients.

    abstract::The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章

    doi:10.1016/0021-9150(94)90142-2

    authors: Clark P,Cockburn F,Cowan RA,Czapla K,Dunnigan MG,Farish E,Hughes E

    更新日期:1994-05-01 00:00:00

  • Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: a prospective analysis of the Women's Health Study.

    abstract:BACKGROUND:Soluble intercellular adhesion molecule-1 (sICAM-1) is a transmembrane protein involved in the migration and adhesion of leukocytes to the vascular endothelium. While some studies indicate that elevated baseline sICAM-1 levels predict cardiovascular events, most of these studies were done in men; moreover, u...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.04.051

    authors: Albert MA,Glynn RJ,Buring JE,Ridker PM

    更新日期:2008-03-01 00:00:00

  • Inverse relationship between cardiorespiratory fitness and carotid atherosclerosis.

    abstract::The association between cardiorespiratory fitness (VO2max) and carotid atherosclerosis was analyzed in 163 men, aged 50 to 60 years. VO2max was assessed using breath-by-breath respiratory gas analyses during maximal exercise stress test. Atherosclerosis was evaluated quantitatively as intima-media thickness (IMT) of t...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05416-g

    authors: Rauramaa R,Rankinen T,Tuomainen P,Väisänen S,Mercuri M

    更新日期:1995-01-20 00:00:00

  • Identification of a cytoplasmic linker protein as a potential target for neovascularization.

    abstract:OBJECTIVE:Atherosclerosis and other cardiovascular diseases are serious threats to human health and become the leading cause of death in the world. Emerging evidence reveals that inhibition of plaque neovascularization could be an effective approach for the treatment of atherosclerosis. This study was conducted to iden...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.01.009

    authors: Xie S,Dong B,Sun X,Tala,He X,Zhou J,Liu M,Li D

    更新日期:2014-04-01 00:00:00

  • Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study.

    abstract:BACKGROUND AND AIMS:Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2017.11.022

    authors: Maruhashi T,Soga J,Fujimura N,Idei N,Mikami S,Iwamoto Y,Iwamoto A,Kajikawa M,Matsumoto T,Oda N,Kishimoto S,Matsui S,Hashimoto H,Aibara Y,Yusoff FM,Hidaka T,Kihara Y,Chayama K,Noma K,Nakashima A,Goto C,Tomiyama H

    更新日期:2018-01-01 00:00:00

  • Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits.

    abstract::Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05516-l

    authors: Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

    更新日期:1995-06-01 00:00:00

  • Cell cycle-dependent inhibition of DNA synthesis by prostaglandin I2 in cultured rabbit aortic smooth muscle cells.

    abstract::The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(88)90140-2

    authors: Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

    更新日期:1988-06-01 00:00:00

  • PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.

    abstract:OBJECTIVE:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is highly expressed in the kidney, where its function remains unclear. In vitro data suggested that PCSK9 could impair the trafficking of the epithelial Na channel (ENaC). Here, we aimed at determining the consequences of PCSK9-deficiency on blood pressure...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.01.012

    authors: Berger JM,Vaillant N,Le May C,Calderon C,Brégeon J,Prieur X,Hadchouel J,Loirand G,Cariou B

    更新日期:2015-03-01 00:00:00

  • Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.

    abstract:OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.04.020

    authors: Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ

    更新日期:2014-07-01 00:00:00

  • The effect of chlorthalidone on serum lipids and lipoproteins.

    abstract::The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(80)90204-x

    authors: Rosenthal T,Holtzman E,Segal P

    更新日期:1980-05-01 00:00:00

  • Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities.

    abstract::Thrombomodulin, an endothelial membrane glycoprotein, is an essential part of the protein C anti-coagulant pathway. It may also have a role in the regulation of fibrinolysis. We carried out a cross-sectional study to assess the association of soluble thrombomodulin (sTM) with peripheral artery disease (PAD) in a strat...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00729-2

    authors: Salomaa V,Matei C,Aleksic N,Sansores-Garcia L,Folsom AR,Juneja H,Park E,Wu KK

    更新日期:2001-08-01 00:00:00

  • Homocysteine content of lipoproteins in hypercholesterolemia.

    abstract::In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(91)90257-4

    authors: Olszewski AJ,McCully KS

    更新日期:1991-05-01 00:00:00

  • Angiotensin converting enzyme 2 and atherosclerosis.

    abstract::Angiotensin converting enzyme 2 (ACE2) is a homolog of angiotensin converting enzyme (ACE) which generates angiotensin II from angiotensin I. ACE, its product angiotensin II and the downstream angiotensin type I receptor are important components of the renin-angiotensin system (RAS). Angiotensin II, the most important...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2012.08.018

    authors: Wang Y,Tikellis C,Thomas MC,Golledge J

    更新日期:2013-01-01 00:00:00

  • Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.

    abstract:BACKGROUND AND AIMS:Abdominal aortic aneurysms (AAA) is a chronic inflammatory disease in which signal transducer and activator of transcription 3 (STAT3), and disintegrin and metalloproteinase 17 (ADAM17) play important roles. However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid ca...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.02.022

    authors: Zhai M,Guo J,Ma H,Shi W,Jou D,Yan D,Liu T,Tao J,Duan J,Wang Y,Li S,Lv J,Li C,Lin J,Zhang C,Lin L

    更新日期:2018-04-01 00:00:00

  • Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis.

    abstract:AIMS:Leukocyte telomere length (LTL) is shortened in patients with clinical atherosclerosis (AS). Here we aimed to explore the contribution of elevated homocysteine (Hcy) level to LTL shortening in AS patients and the underlying mechanism. METHODS:Circulating leukocytes were collected from 197 patients with AS and 165...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2013.08.029

    authors: Zhang D,Wen X,Wu W,Xu E,Zhang Y,Cui W

    更新日期:2013-11-01 00:00:00

  • Effect of intessive plasmapheresis on the plasma cholesterol concentration with familial hypercholesterolemia.

    abstract::Plasmapheresis was studied as a means of reducing the serum cholesterol concentration in 3 hypercholesterolemic patients who each underwent courses of intensive plasmapheresis with removal of 250--500 ml of plasma each day for 5--9 days. In one homozygous Type II patient, the serum cholesterol concentration decreased ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(78)90157-0

    authors: Apstein CS,Zilversmit DB,Lees RS,George PK

    更新日期:1978-10-01 00:00:00

  • Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia.

    abstract:BACKGROUND:Increasing age and cholesterol levels, male gender, and family history of early coronary heart disease (CHD) are associated with early onset of CHD in familial hypercholesterolemia (FH). OBJECTIVE:Assess subclinical atherosclerosis by computed tomography coronary angiography (CTCA) and its association with ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.10.001

    authors: Miname MH,Ribeiro MS 2nd,Parga Filho J,Avila LF,Bortolotto LA,Martinez LR,Rochitte CE,Santos RD

    更新日期:2010-12-01 00:00:00