Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis.

abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

journal_title：Atherosclerosis

authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

更新日期：2009-02-01 00:00:00

abstract：:The Framingham risk score (FRS), developed in a white cohort aged 30-74 years, is increasingly used in the early risk identification for coronary artery disease (CAD). This study examines the relationship between FRS and carotid artery intima-media thickness (IMT), a surrogate marker of coronary atherosclerosis, in bl...

journal_title：Atherosclerosis

authors： Kieltyka L,Urbina EM,Tang R,Bond MG,Srinivasan SR,Berenson GS

更新日期：2003-09-01 00:00:00

abstract：:The relative importance of reduced plasma high density lipoprotein-cholesterol (HDL-C) levels and elevated plasma triglyceride (TG) concentrations as risk factors for ischemic heart disease (IHD) was examined in a sample of 2177 men from the Québec City suburbs. The sample included 202 men with known IHD. The relation...

journal_title：Atherosclerosis

authors： Lamarche B,Després JP,Moorjani S,Cantin B,Dagenais GR,Lupien PJ

更新日期：1996-01-26 00:00:00

abstract：:Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...

journal_title：Atherosclerosis

authors： Chen H,Zhuang H,Han Q

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid whe...

journal_title：Atherosclerosis

authors： Ballantyne CM,Banach M,Mancini GBJ,Lepor NE,Hanselman JC,Zhao X,Leiter LA

更新日期：2018-10-01 00:00:00

abstract：:The effect of the apolipoprotein C-II/C-III1 ratio on the capacity of purified bovine milk lipoprotein lipase to hydrolyse triglycerides was measured in a controlled model of pyrene-labeled nonanoyltriglycerides (1-2 ditetradecyl 3-pyrene nonanoyl glyceride) monolayer vesicles. Monolayer was composed of triglycerides,...

journal_title：Atherosclerosis

authors： Lambert DA,Catapano AL,Smith LC,Sparrow JT,Gotto AM Jr

更新日期：1996-12-20 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...

journal_title：Atherosclerosis

authors： Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

更新日期：2008-10-01 00:00:00

abstract：:An inverse relationship between moderate alcohol consumption and coronary artery disease (CAD) has been observed in several epidemiologic studies. Whether improvement of endothelial function is involved in this beneficial effect is unknown. We investigated endothelial function of the brachial artery in 108 men with CA...

journal_title：Atherosclerosis

authors： Teragawa H,Fukuda Y,Matsuda K,Higashi Y,Yamagata T,Matsuura H,Chayama K

更新日期：2002-11-01 00:00:00

abstract：:Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As ...

journal_title：Atherosclerosis

authors： Iritani N,Fukuda E,Nara Y,Yamori Y

更新日期：1977-11-01 00:00:00

abstract：:Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...

journal_title：Atherosclerosis

authors： Liu SX,Chen Y,Zhou M,Wan J

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

journal_title：Atherosclerosis

authors： Khang YH,Cho SI,Kim HR

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has esta...

journal_title：Atherosclerosis

authors： Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of estrogen on growth and smooth muscle cell (SMC)-differentiation of vascular wall-resident CD34(+) stem/progenitor cells (VRS/Pcs). METHODS AND RESULTS:The existence of CD34(+) VRS/Pcs was confirmed by immunohistochemistry in the adventitia of arteries of young (2-month-old) and...

journal_title：Atherosclerosis

authors： Wu Y,Shen Y,Kang K,Zhang Y,Ao F,Wan Y,Song J

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...

journal_title：Atherosclerosis

authors： Dale MA,Suh MK,Zhao S,Meisinger T,Gu L,Swier VJ,Agrawal DK,Greiner TC,Carson JS,Baxter BT,Xiong W

更新日期：2015-12-01 00:00:00

abstract：:Recent studies on mice demonstrated that lipoprotein lipase (LPL) located in the arterial wall might play a pro-atherogenic role. There are major differences between humans and mice in lipoprotein metabolism and in susceptibility to atherosclerosis. We have therefore used rabbits fed normal chow diet as a model to ass...

journal_title：Atherosclerosis

authors： Wu X,Wang J,Fan J,Chen M,Chen L,Huang W,Liu G

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including PDGF receptors, Abl, and c-kit. The objective of ...

journal_title：Atherosclerosis

authors： Vorkapic E,Dugic E,Vikingsson S,Roy J,Mäyränpää MI,Eriksson P,Wågsäter D

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Trials of antibiotic treatment of vascular diseases, in attempts to eradicate possible microbial initiators, have had mixed results. We sought to evaluate the efficacy of antibiotics in treating patients with atherosclerotic vascular diseases, using a meta-analysis. METHODS:We searched MEDLINE, EMBASE, and ...

journal_title：Atherosclerosis

authors： Illoh KO,Illoh OC,Feseha HB,Hallenbeck JM

更新日期：2005-04-01 00:00:00

abstract：AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...

journal_title：Atherosclerosis

authors： Raitoharju E,Seppälä I,Lyytikäinen LP,Levula M,Oksala N,Klopp N,Illig T,Laaksonen R,Kähönen M,Lehtimäki T

更新日期：2013-01-01 00:00:00

abstract：:Previous studies have shown that the A to G transition occurring at position -75 bp upstream of the transcriptional start site in the human apolipoprotein A-I gene may affect plasma high density lipoprotein cholesterol (HDL-C) levels and low density lipoprotein cholesterol (LDL-C) response to changes in amount of diet...

journal_title：Atherosclerosis

authors： Mata P,Lopez-Miranda J,Pocovi M,Alonso R,Lahoz C,Marin C,Garces C,Cenarro A,Perez-Jimenez F,de Oya M,Ordovas JM

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking. METHODS:The subjects were 4492 male employees aged 40-59 years who worked fo...

journal_title：Atherosclerosis

authors： Imano H,Sato S,Kitamura A,Kiyama M,Ohira T,Shimamoto T,Iso H

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endo...

journal_title：Atherosclerosis

authors： Tuttolomondo A,Casuccio A,Della Corte V,Maida C,Pecoraro R,Di Raimondo D,Vassallo V,Simonetta I,Arnao V,Pinto A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to ...

journal_title：Atherosclerosis

authors： Parra S,Vives G,Ferré R,González M,Guardiola M,Ribalta J,Castro A

更新日期：2012-11-01 00:00:00

abstract：:Fifty-seven sections of human vessels, collected in the Pathobiological Determinants of Atherosclerosis in Youth study from individuals aged 25-34, were stained with two monoclonal antibodies to oxidatively-modified lysine. Intensity and extent of immunoreactivity were graded by three pathologists. Aorta from a Watana...

journal_title：Atherosclerosis

authors： Sloop GD,Fallon KB,Lipscomb G,Takei H,Zieske A

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS:We included 6617 participants from...

journal_title：Atherosclerosis

authors： Cainzos-Achirica M,Enjuanes C,Greenland P,McEvoy JW,Cushman M,Dardari Z,Nasir K,Budoff MJ,Al-Mallah MH,Yeboah J,Miedema MD,Blumenthal RS,Comin-Colet J,Blaha MJ

更新日期：2018-11-01 00:00:00

abstract：:We have recently established that low density lipoprotein (LDL) of most patients with coronary atherosclerosis differs from the LDL of most healthy subjects by its ability to cause primary atherosclerotic changes, i.e. the accumulation of intracellular cholesterol in the cells of smooth muscle origin cultured from una...

journal_title：Atherosclerosis

authors： Orekhov AN,Tertov VV,Mukhin DN

更新日期：1991-02-01 00:00:00

abstract：:When rabbits are fed a cholesterol-rich diet they accumulate beta-migrating very low density lipoprotein (beta-VLDL) in their plasma. beta-VLDL are cholesteryl ester-rich lipoproteins which contain apolipoproteins B and E. There are 2 forms of apolipoprotein B in beta-VLDL. About 90% of apolipoprotein B is present as ...

journal_title：Atherosclerosis

authors： Kroon PA,Thompson GM,Chao YS

更新日期：1985-09-01 00:00:00

abstract：:Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed...

journal_title：Atherosclerosis

authors： Seet RC,Kasiman K,Gruber J,Tang SY,Wong MC,Chang HM,Chan YH,Halliwell B,Chen CP

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS:In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation. RESULTS:...

journal_title：Atherosclerosis

authors： Sniderman AD,Tremblay AJ,De Graaf J,Couture P

更新日期：2014-06-01 00:00:00

abstract：:When smoke from single cigarettes containing [4-14C]cholesterol or beta-[4-14C]sitosterol was delivered to the lungs of Rhesus macaques, plasma contained radiolabeled sterols up to 50 days later. Since cholesterol, as well as plant sterols (campesterol, stigmasterol and beta-sitosterol), are normally present in cigare...

journal_title：Atherosclerosis

authors： Malinow MR,McLaughlin P,Aigner-Held R,Upson B,Isabelle LM,Connor WE,Lin D

更新日期：1986-04-01 00:00:00

abstract：:We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....

journal_title：Atherosclerosis

authors： Ueda Y,Arai H,Kawashima A,Nagano Y,Cho M,Tanaka M,Kita T

更新日期：1993-06-01 00:00:00