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Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: the GOCADAN study.

Abstract：

BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent a physical exam, personal interview, collection of biological specimens, and diagnostic tests. SETTING:This study was conducted in the Norton Sound region of Alaska. PARTICIPANTS:One thousand one hundred fifty-eight Inupiat Eskimo adults (women=653, men=505). MAIN OUTCOME MEASURES:Lipoprotein particle profile was evaluated by nuclear magnetic resonance (NMR) and related to presence of MS and level of IR. RESULTS:Participants with MS had (a) significantly higher concentrations of all VLDLs and a larger VLDL size (women, p=0.007; men, p=0.0001); (b) higher concentrations of small LDL (women, p<0.0001; men, p=0.09) and lower concentrations of large LDL (women, p<0.0001), leading to a smaller overall LDL size (women, p<0.0001; men, p<0.05); (c) significantly lower concentrations of large HDL (both genders, p<0.0001) and an increase in intermediate (women, p<0.05) and small HDL (women, p<0.0001; men, p<0.004). Lipoprotein profile with increasing HOMA-IR resembled that of individuals with MS. CONCLUSIONS:In this population MS is characterized by lipoprotein distribution and size abnormalities independent of obesity, age, and other cardiovascular risk factors, including lipid concentration. IR seems the major determinant.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

doi

10.1016/j.atherosclerosis.2007.12.041

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

350-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(07)00809-X

journal_volume

200

pub_type

杂志文章

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