Effect of gemfibrozil on the concentration and composition of serum lipoproteins. A controlled study with special reference to initial triglyceride levels.

abstract：BACKGROUND:Cathepsin L (CatL), cathepsin K (CatK), and cathepsin V (CatV) are potent elastases implicated in human arterial wall remodeling. Whether plasma levels of these cathepsins are altered in patients with abdominal aortic aneurysms (AAAs) remains unknown. METHODS AND RESULTS:Plasma samples were collected from 4...

journal_title：Atherosclerosis

authors： Lv BJ,Lindholt JS,Wang J,Cheng X,Shi GP

更新日期：2013-09-01 00:00:00

abstract：:Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...

journal_title：Atherosclerosis

authors： Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

更新日期：1989-02-01 00:00:00

abstract：:This study was undertaken to determine whether sialic acid removal alters the catabolism of low density lipoprotein in humans. Human low density lipoproteins labeled in vitro with 125I were incubated in the presence (termed desialylated) or absence (sialylated) of neuraminidase. The treatment with neuraminidase from C...

journal_title：Atherosclerosis

authors： Malmendier CL,Delcroix C,Fontaine M

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

journal_title：Atherosclerosis

authors： Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation cou...

journal_title：Atherosclerosis

authors： Caselli C,De Graaf MA,Lorenzoni V,Rovai D,Marinelli M,Del Ry S,Giannessi D,Bax JJ,Neglia D,Scholte AJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

journal_title：Atherosclerosis

authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an impo...

journal_title：Atherosclerosis

authors： Pu X,Chan K,Yang W,Xiao Q,Zhang L,Moore AD,Liu C,Webb TR,Caulfield MJ,Samani NJ,Zhu J,Ye S

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...

journal_title：Atherosclerosis

authors： Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

更新日期：2012-05-01 00:00:00

abstract：:Obesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fa...

journal_title：Atherosclerosis

authors： Heilbronn LK,Noakes M,Morris AM,Kind KL,Clifton PM

更新日期：2000-05-01 00:00:00

abstract：:The St. Thomas mixed hyperlipidaemic (SMHL) rabbit exhibits an inherited hyperlipidaemia similar to that seen in familial combined hyperlipidaemia (FCHL). In this study, we investigated whether the SMHL rabbit is insulin resistant, a condition often associated with FCHL. Six young and six mature combined hyperlipidaem...

journal_title：Atherosclerosis

authors： de Roos B,Caslake MJ,Ardern HA,Martin Benson G,Suckling KE,Packard CJ

更新日期：2001-06-01 00:00:00

abstract：:Serum lipids, lipoprotein (a), plasminogen activator inhibitor and tissue plasminogen activator levels were measured in 260 subjects, constituting a cross-section sample of 30-60-year-old men and women. For Lp(a), there were positive correlations with age and cholesterol, but not with any of other measured parameters....

journal_title：Atherosclerosis

authors： Sundell IB,Nilsson TK,Hallmans G,Hellsten G,Dahlén GH

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that computed tomography coronary angiography (CTA) in patients with suspected coronary artery disease (CAD) predicts short term adverse events. However, there is no current data on whether identifying atherosclerosis on CTA impacts outcomes. We performed a case-control study to a...

journal_title：Atherosclerosis

authors： Budoff MJ,Liu S,Chow D,Flores F,Hsieh B,Gebow D,DeFrance T,Ahmadi N

更新日期：2014-12-01 00:00:00

abstract：:The purpose of this study was to determine whether an angiotensin converting enzyme (ACE) inhibitor, benazepril, and an angiotensin receptor antagonist, valsartan, would decrease atherosclerotic severity in cholesterol-fed rabbits. Male rabbits were fed either: (a) normal rabbit chow; (b) 2% cholesterol diet; (c) 2% c...

journal_title：Atherosclerosis

authors： Li J,Hirose N,Kawamura M,Arai Y

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients aft...

journal_title：Atherosclerosis

authors： Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Vascular calcification is a common finding in abdominal aortic aneurysms (AAA) however whether it predicts aneurysm expansion is controversial. OBJECTIVES:1) To establish a reproducible method of assessing AAA calcification using computed tomography (CT); 2) To investigate the association between AAA calcif...

journal_title：Atherosclerosis

authors： Hendy K,Gunnarsson R,Cronin O,Golledge J

更新日期：2015-11-01 00:00:00

abstract：:We studied the aortic histology of 28 Macaca nigra males and females, from 6 to more than 20 years old, normal and manifesting various degrees of spontaneous diabetes. Correlations of several metabolic and hormonal indicators of diabetes severity with gross and microscopic findings in the aortas demonstrated direct as...

journal_title：Atherosclerosis

authors： Howard CF Jr,Vesselinovitch D,Wissler RW

更新日期：1984-07-01 00:00:00

abstract：:We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation and the cyclic 3',5'-guanosine monophosphate (cGMP) production elicited by acetylcholine (ACh) were much weaker in OLETF rats than in age-matc...

journal_title：Atherosclerosis

authors： Matsumoto T,Kobayashi T,Wachi H,Seyama Y,Kamata K

更新日期：2007-05-01 00:00:00

abstract：:Evidence for chemical and biological heterogeneity of human plasma lipoprotein density classes has been steadily accumulating over the last 15 years. Furthermore, several recent reports have indicated potential clinical significance of certain lipoprotein subspecies as either atherogenic or antiatherogenic. It is gene...

journal_title：Atherosclerosis

authors： Koren E,Armstrong VW,Mueller G,Wilson PR,Schuff-Werner P,Thiery J,Eisenhauer T,Alaupovic P,Seidel D

更新日期：1992-08-01 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：:The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...

journal_title：Atherosclerosis

authors： Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

更新日期：2004-01-01 00:00:00

abstract：:The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel el...

journal_title：Atherosclerosis

authors： Zhao SP,Verhoeven MH,Vink J,Hollaar L,van der Laarse A,de Knijff P,van 't Hooft FM

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Only a few previous studies have investigated endothelium-dependent vasodilation in the metabolic syndrome (MetS). In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, different techniques to assess vasodilation in conduit and resistance arteries were evaluated in relation to the Met...

journal_title：Atherosclerosis

authors： Lind L

更新日期：2008-02-01 00:00:00

abstract：:Accelerated coronary atherosclerosis is a major risk limiting long-term survival after heart transplantation and is commonly associated with dyslipoproteinemia even in subjects who were not dyslipoproteinemic before intervention. The purpose of this study was to analyse the abnormalities in the lipid profiles of 2 dif...

journal_title：Atherosclerosis

authors： Atger V,Cambillau M,Guillemain R,Farge D,Dreyfus G,Hamon S,Girard A,Carpentier A,Moatti N

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS:In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation. RESULTS:...

journal_title：Atherosclerosis

authors： Sniderman AD,Tremblay AJ,De Graaf J,Couture P

更新日期：2014-06-01 00:00:00

abstract：:The current epidemic of obesity with the associated increasing incidence of insulin resistance, diabetes mellitus and atherosclerosis affecting a large proportion of the North American and Western populations, has generated a strong interest in the potential role of visceral adipose tissue in the development of athero...

journal_title：Atherosclerosis

authors： Alexopoulos N,Katritsis D,Raggi P

更新日期：2014-03-01 00:00:00

abstract：:The possibility that Fas/APO 1 is involved in the apoptosis of advanced human coronary atherosclerosis was examined in the present study. Coronary arteries with atherosclerosis were obtained from human hearts with chronic ischemic heart disease at cardiac transplantation. Normal vessels were used as controls. Fas/APO ...

journal_title：Atherosclerosis

authors： Cai W,Devaux B,Schaper W,Schaper J

更新日期：1997-06-01 00:00:00

abstract：:Advanced glycation end-products (AGEs), a group of carbohydrate-derived compounds formed by non-enzymatic glycation and oxidation, are markedly elevated in end-stage renal disease (ESRD) and may be related to both inflammation and oxidative stress. The cellular effects of AGE are largely mediated by their interaction ...

journal_title：Atherosclerosis

authors： Rodríguez-Ayala E,Anderstam B,Suliman ME,Seeberger A,Heimbürger O,Lindholm B,Stenvinkel P

更新日期：2005-06-01 00:00:00

abstract：:Serum and aortic tissue cholesterol levels in parallel with aortic relaxation to endothelium-dependent and independent drugs were determined in Watanabe heritable hyperlipidemic (WHHL) rabbits in comparison with New Zealand (N.Z.) normocholesterolemic rabbits, aged 4-14 months. Serum cholesterol was elevated (626 +/- ...

journal_title：Atherosclerosis

authors： Chinellato A,Banchieri N,Pandolfo L,Ragazzi E,Froldi G,Norido F,Caparrotta L,Fassina G

更新日期：1991-08-01 00:00:00

abstract：:Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expressi...

journal_title：Atherosclerosis

authors： Hao XR,Cao DL,Hu YW,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2009-04-01 00:00:00

abstract：:Monocytes and macrophages synthesize tissue factor (TF) which plays a role in thrombogenicity in coronary artery disease. This study was conducted to investigate the effect of Rho/Rho-kinase inhibition on the synthesis of TF in cultured human monocytes. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

journal_title：Atherosclerosis

authors： Nagata K,Ishibashi T,Sakamoto T,Ohkawara H,Shindo J,Yokoyama K,Sugimoto K,Sakurada S,Takuwa Y,Nakamura S,Teramoto T,Maruyama Y

更新日期：2002-07-01 00:00:00