当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.

IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.

Abstract：

:Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. IFN-gamma decreased ABCA1 expression at both transcriptional and translational levels in a dose-dependent manner. Cellular cholesterol content was increased while cholesterol efflux was decreased by IFN-gamma treatment. Liver X receptor alpha (LXRalpha), which can regulate the expression of ABCA1, was also down-regulated by IFN-gamma treatment. LXRalpha-specific activation by LXRalpha agonist almost compensated the down-regulation of ABCA1 expression by IFN-gamma, while siRNA of LXRalpha led to down-regulation of ABCA1 expression more significantly than IFN-gamma. IFN-gamma induced phosphorylation of STAT1 and expression of STAT1alpha in the nucleus, which was inhibited by a JAK inhibitor AG-490. Treatment with STAT1 siRNA further enhanced down-regulation of LXRalpha mRNA by IFN-gamma. Furthermore, AG-490 and STAT1 siRNA almost compensated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux. In conclusion, IFN-gamma may first down-regulate expression of LXRalpha through the JAK/STAT1 signaling pathway and then decrease expression of ABCA1 and cholesterol efflux in THP-1 macrophage-derived foam cells. Therefore, our study may be useful in understanding the critical effect of IFN-gamma in pathogenesis of atherosclerosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Hao XR,Cao DL,Hu YW,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

doi

10.1016/j.atherosclerosis.2008.07.029

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

417-28

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00532-7

journal_volume

203

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Further studies on serum lipoproteins in connective tissue diseases.

    abstract：:Men with ankylosing spondylitis (AS) and females with systemic lupus erythematosus (SLE) were found to have low total serum lipid concentrations similar to results previously obtained in patients with rheumatoid arthritis (RA). In AS men total serum TG was about 50% of control values and in AS men and SLE women total ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90041-2

    authors： Rössner S

    更新日期：1978-09-01 00:00:00

  • Fasting plasma glucose and subsequent cardiovascular disease among young adults: Analysis of a nationwide epidemiological database.

    abstract：BACKGROUND AND AIMS:Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. METHODS AND RESULTS:Medical records of 1,180,062 young adults (20-49 years old) without a prior history of CVD and w...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.12.024

    authors： Kaneko H,Itoh H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

    更新日期：2021-01-16 00:00:00

  • Effects of atorvastatin on postprandial plasma lipoproteins in postinfarction patients with combined hyperlipidaemia.

    abstract：:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(01)00689-x

    authors： Boquist S,Karpe F,Danell-Toverud K,Hamsten A

    更新日期：2002-05-01 00:00:00

  • Possible relationship of cholesterol accumulation and collagen synthesis in rabbit aortic tissues.

    abstract：:Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the num...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90006-4

    authors： Modrak JB,Langner RO

    更新日期：1980-10-01 00:00:00

  • Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability.

    abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2020.05.017

    authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

    更新日期：2020-08-01 00:00:00

  • Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions.

    abstract：:Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic lesions with those of purified types I and III collagen fibers. Cell-free homogenates from the human plaques effectiv...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.12.037

    authors： Cosemans JM,Kuijpers MJ,Lecut C,Loubele ST,Heeneman S,Jandrot-Perrus M,Heemskerk JW

    更新日期：2005-07-01 00:00:00

  • Serum high density lipoprotein cholesterol levels in Chinese healthy subjects and patients with certain diseases.

    abstract：:Serum high density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG) were determined, and values of low density lipoprotein cholesterol (LDL-C), HDL-C/TC (%), and the LDL-C/HDL-C (ratio) were calculated in 1101 healthy Chinese men and women, 77 patients with coronary heart disease (CHD), 7...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90022-3

    authors： Cai HJ,Li ZX,Yang SM

    更新日期：1982-06-01 00:00:00

  • Changes of HDL subfraction concentration and particle size by intralipid in vivo.

    abstract：:The effects of the artificial triglyceride-phospholipid emulsion (10% intralipid) on HDL subfraction were studied in vivo. After a 14-h fast, subjects received intralipid via a 4-h infusion. Serum lipoproteins were analyzed before and at 4 and 6 h after the start of the infusion. At 4-h the following acute changes by ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90195-5

    authors： Sakuma N,Lin C,Matsumoto Y,Ikeuchi R,Ichikawa T,Hirata H,Noguchi Y,Fujinami T

    更新日期：1988-11-01 00:00:00

  • Kinetics of triglyceride rich lipoproteins: chylomicrons and very low density lipoproteins.

    abstract：:Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/s0021-9150(98)00215-9

    authors： Hugh P,Barrett R

    更新日期：1998-12-01 00:00:00

  • Management of non-high-density lipoprotein abnormalities.

    abstract：:Epidemiological evidence supports the use of non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B-100 (apoB), and low-density lipoprotein particles as markers of atherogenic risk. Treatment guidelines also identify these as additional targets of lipid-modifying intervention in patients with elevated ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2009.05.020

    authors： Rosenson RS

    更新日期：2009-12-01 00:00:00

  • Depression symptoms and the progression of carotid intima-media thickness: a 5-year follow-up study.

    abstract：OBJECTIVE:Only a few studies have investigated the changes in carotid intima-media thickness (IMT) over time, and uncertainties remain on the underlying mechanisms linking depression and subclinical atherosclerosis. We carried out a prospective cohort study to evaluate whether depression is associated with changes in c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.01.012

    authors： Pizzi C,Costa GM,Santarella L,Flacco ME,Capasso L,Bert F,Manzoli L

    更新日期：2014-04-01 00:00:00

  • Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein.

    abstract：:Consumption of oily fish and fish oils is associated with protection against cardiovascular disease. Paradoxically, long-chain polyunsaturated fatty acids present in low-density lipoprotein (LDL) are suggested to be susceptible to oxidation. It is not clear whether eicosapentaenoic acid (EPA) and docosahexaenoic acid ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2004.04.004

    authors： Mesa MD,Buckley R,Minihane AM,Yaqoob P

    更新日期：2004-08-01 00:00:00

  • Risk factors and haemodynamic variables in patients with low toe-brachial index but normal ankle-brachial index.

    abstract：BACKGROUND AND AIMS:Classically, peripheral arterial disease (PAD) is diagnosed by a low ankle-brachial index (ABI), but the diagnosis can also be made based on toe-brachial index (TBI) measurements. The objective of this study was to characterize patients with low TBI but normal ABI, and chart potential underestimatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.08.005

    authors： Høyer C,Høgh AL,Sandermann J,Zacho HD,Petersen LJ

    更新日期：2019-10-01 00:00:00

  • Human cardiac microvascular and macrovascular endothelial cells respond differently to oxidatively modified LDL.

    abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00258-x

    authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

    更新日期：1998-03-01 00:00:00

  • The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis.

    abstract：AIMS:The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.02.016

    authors： Qin Z,Cui B,Jin J,Song M,Zhou B,Guo H,Qian D,He Y,Huang L

    更新日期：2016-04-01 00:00:00

  • Atherosclerotic lesions in coronary arteries of hyperlipidemic swine. Part 2. Endothelial cell kinetics and leukocyte adherence associated with early lesions.

    abstract：:The role of endothelial cells (EC) in the development and progression of early swine intimal cell mass (ICM)-derived coronary artery lesions in 55 swine fed either a mash or hyperlipidemic diet for 14, 49 or 90 days was investigated. Characteristics studied were endothelial cell turnover (using tritiated thymidine aut...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90013-4

    authors： Scott RF,Kim DN,Schmee J,Thomas WA

    更新日期：1986-10-01 00:00:00

  • Carotid artery and left ventricular structural relationship in asymptomatic men at risk for cardiovascular disease.

    abstract：:To determine whether a relationship between echographically assessed carotid artery and left ventricular (LV) structures existed in asymptomatic men at risk for cardiovascular disease, we evaluated carotid and LV parameters in 69 subjects (23-62 years) without LV hypertrophy. The right common carotid far wall intima-m...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)05940-0

    authors： Linhart A,Gariepy J,Giral P,Levenson J,Simon A

    更新日期：1996-11-15 00:00:00

  • Comparison of coronary and aortic atherosclerosis in youth from Japan and the USA.

    abstract：:This paper reports the results of the largest autopsy-based comparative study of atherosclerotic lesions between young Japanese and Americans, aged 15-34 years and autopsied between 1987 and 1995, by analyzing the data from the Japanese second nation-wide study of atherosclerosis and Pathobiological Determinants of At...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.11.014

    authors： Takei H,Strong JP,Yutani C,Malcom GT

    更新日期：2005-05-01 00:00:00

  • pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.

    abstract：BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00018-7

    authors： Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

    更新日期：2002-09-01 00:00:00

  • Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages.

    abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.09.046

    authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

    更新日期：2011-12-01 00:00:00

  • PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH.

    abstract：BACKGROUND:Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are complex pathologies characterized by lipid accumulation, chronic inflammation and extensive tissue remodelling. Microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, might not only be biomarkers, but also fun...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.03.009

    authors： Baron M,Leroyer AS,Majd Z,Lalloyer F,Vallez E,Bantubungi K,Chinetti-Gbaguidi G,Delerive P,Boulanger CM,Staels B,Tailleux A

    更新日期：2011-09-01 00:00:00

  • Diabetes mellitus in a new kindred with familial hypobetalipoproteinemia and an apolipoprotein B truncation (apoB-55).

    abstract：:Familial hypobetalipoproteinemia is an autosomal co-dominant disorder, which in a minority of cases is due to a truncation producing mutation in the apoB gene. We have identified an apoB mutation in a 40-year old hypobetalipoproteinemic man with Type II diabetes mellitus. Immunoblotting of plasma revealed a major band...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00222-0

    authors： Pulai JI,Latour MA,Kwok PY,Schonfeld G

    更新日期：1998-02-01 00:00:00

  • A monoclonal antibody that recognizes hyaluronic acid binding region of aorta proteoglycans.

    abstract：:A chondroitin sulfate-dermatan sulfate proteoglycan was isolated from bovine aorta intima by extraction of the tissue with 4 M guanidine hydrochloride. The proteoglycan was purified by CsCl isopycnic centrifugation followed by gel filtration and ion exchange chromatography. A monoclonal antibody C8F4 was developed to ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90127-g

    authors： Radhakrishnamurthy B,Jeansonne N,Tracy RE,Berenson GS

    更新日期：1993-01-25 00:00:00

  • In vivo stable-isotope kinetic study suggests intracellular assembly of lipoprotein(a).

    abstract：OBJECTIVE:Lipoprotein(a) [Lp(a)] consists of apolipoprotein B-100 (apoB-100) as part of an LDL-like particle and the covalently linked glycoprotein apolipoprotein(a) [apo(a)]. Detailed mechanisms of its biosynthesis, assembly, secretion and catabolism are still poorly understood. To address the Lp(a) assembly mechanism...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.09.031

    authors： Frischmann ME,Ikewaki K,Trenkwalder E,Lamina C,Dieplinger B,Soufi M,Schweer H,Schaefer JR,König P,Kronenberg F,Dieplinger H

    更新日期：2012-12-01 00:00:00

  • Removal of fatty acid labelled cholesterol ester, phospholipid and triglyceride from atherosclerotic rabbit aorta in vitro.

    abstract：:An organ culture technique was used to investigate the removal of fatty acids incorporated into various lipid fractions in intimal segments of atherosclerotic rabbit aorta. Segments of aorta were pulse-labelled in vitro with [9,10-3H]oleic acid and [1-14C]linoleic acid for 24 h. The incubation medium was replaced with...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(77)90069-7

    authors： Hudson K,Day AJ,Horsch AK

    更新日期：1977-12-01 00:00:00

  • Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation.

    abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.07.034

    authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

    更新日期：2014-10-01 00:00:00

  • Effects of low-dose pravastatin sodium on plasma cholesterol levels and aortic atherosclerosis of heterozygous WHHL rabbits fed a low cholesterol (0.03%) enriched diet for one year.

    abstract：:The aim of this study was to evaluate the cholesterol-lowering and antiatherosclerotic effect of the HMG-CoA reductase inhibitor pravastatin sodium at a dosage comparable to human therapy. Twelve heterozygous WHHL rabbits (13 months old) were fed 100 g per day of a low cholesterol (0.03%) enriched diet for 12 months. ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)05986-2

    authors： Harsch M,Braesen JH,Niendorf A

    更新日期：1997-02-10 00:00:00

  • Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

    abstract：:We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation and the cyclic 3',5'-guanosine monophosphate (cGMP) production elicited by acetylcholine (ACh) were much weaker in OLETF rats than in age-matc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.06.005

    authors： Matsumoto T,Kobayashi T,Wachi H,Seyama Y,Kamata K

    更新日期：2007-05-01 00:00:00

  • Differential distribution of vasa vasorum in different vascular beds in humans.

    abstract：OBJECTIVE:Vasa vasorum (VV) have been implicated to play a role in the pathogenesis of atherosclerosis. This study was designed to describe the distribution of VV density in different vascular beds in humans and to investigate the association between VV density and the known distribution of atherosclerosis in human art...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.015

    authors： Hildebrandt HA,Gossl M,Mannheim D,Versari D,Herrmann J,Spendlove D,Bajanowski T,Malyar NM,Erbel R,Lerman LO,Lerman A

    更新日期：2008-07-01 00:00:00

  • Profound resolution of early atherosclerosis with conjugated linoleic acid.

    abstract：:Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.08.024

    authors： Toomey S,Harhen B,Roche HM,Fitzgerald D,Belton O

    更新日期：2006-07-01 00:00:00