当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages.

Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages.

Abstract：

:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial, demonstrated that highly purified eicosapentaenoic acid (EPA) prevented the onset of cardiovascular events in LDL-cholesterol independent fashion. In this study, we investigated the impact of EPA on pro-inflammatory properties of VLDL. Effects of VLDL prepared from mice fed 5% EPA diet for 1 week (EPA-VLDL) or mice fed normal diet (Ctrl-VLDL) on the mRNA expression of pro-inflammatory factors were examined in human THP-1 macrophages. Ctrl-VLDL increased mRNA expression of pro-inflammatory factors such as interleukin-1β and tumor necrosis factor-α in macrophages. In contrast, the increases in pro-inflammatory factors by EPA-VLDL were lower than those by Ctrl-VLDL. Moreover, EPA-VLDL-treated macrophages had less triglyceride accumulation than Ctrl-VLDL-treated macrophages. Inhibition of lipoprotein lipase (LPL) appeared to suppress inflammation and triglyceride accumulation by Ctrl-VLDL suggesting that hydrolysis of VLDL is required for the pro-inflammatory properties of VLDL. Free fatty acid release from EPA-VLDL by macrophages and purified LPL was less than that from Ctrl-VLDL. Extracellular LPL mass was decreased by EPA-VLDL. Taken together, these findings indicate that the pro-inflammatory properties of VLDL were attenuated by EPA administration via decrease in susceptibility of VLDL to LPL. It appears possible that anti-inflammatory effects of EPA on VLDL contribute to the suppression of cardiovascular risk by EPA.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

doi

10.1016/j.atherosclerosis.2011.09.046

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

566-72

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(11)00952-X

journal_volume

219

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Dose-response effect of single and combined clofibrate (Atromidin) and niceritrol (Perycit) treatment on serum lipids and lipoproteins in type II hyperlipoproteinaemia.

    abstract：:The dose-response effects of clofibrate and niceritrol on serum cholesterol and triglycerides (TG) were studied in 29 patients with Type IIa and IIb hyperlipoproteinaemia. In 17 patients, clofibrate and niceritrol were then given as combined treatment, and the effects of this combination on serum lipoproteins were stu...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/0021-9150(75)90070-2

    authors： Olsson AG,Orö L,Rössner S

    更新日期：1975-07-01 00:00:00

  • A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice.

    abstract：:Chronic renal failure markedly accelerates atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. To study the putative role of receptor for advanced glycation end products (RAGE) in development of uremic atherosclerosis, apoE(-/-) mice received intraperitoneal injections thrice weekly of a neutralizing murine ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.01.015

    authors： Bro S,Flyvbjerg A,Binder CJ,Bang CA,Denner L,Olgaard K,Nielsen LB

    更新日期：2008-12-01 00:00:00

  • C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract：BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.038

    authors： Lind L,Siegbahn A,Hulthe J,Elmgren A

    更新日期：2008-07-01 00:00:00

  • Triiodothyronine stimulates prostacyclin production by rat aortic smooth muscle cells in culture.

    abstract：:The effect of triiodothyronine (T3) on prostacyclin production in rat aortic smooth muscle cells was investigated by using an intact cell assay system. T3 at its physiological concentrations has no significant effect on smooth muscle cell proliferation, but it does significantly stimulate prostacyclin production by th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90001-0

    authors： Nakao J,Chang WC,Murota S,Orimo H

    更新日期：1981-07-01 00:00:00

  • Control of the interaction of cholesterol ester-rich lipoproteins with arterial receptors.

    abstract：:Incorporation of 125I-labeled cholesterol ester rich lipoproteins from cholesterol fed rabbits into normal rabbit aorta in vitro was inhibited by heparin, lecithin, and collagenase and by succinylation of the lipoprotein. Aortic uptake of lipoprotein was increased by neuraminidase, proteases, lipase, and beta-glucuron...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(76)90026-5

    authors： Day CE

    更新日期：1976-11-01 00:00:00

  • Effects of exercise training and detraining on atheromatous matrix metalloproteinase activity in mice.

    abstract：BACKGROUND AND AIMS:Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexist...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.02.022

    authors： Kim J,Jang HJ,Schellingerhout D,Kang JW,Choi S,Oh H,Kim EJ,Lee SK,Lee JS,Kwon IC,Kim K,Koh YJ,Ryu WS,Kim DE

    更新日期：2020-04-01 00:00:00

  • The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes.

    abstract：BACKGROUND:Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight. METHODS:Serum and lipoprotein squalene and non-cholesterol sterols were quantitated with gas-liquid chromatography in 33 d...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.07.030

    authors： Simonen PP,Gylling H,Miettinen TA

    更新日期：2007-09-01 00:00:00

  • Catheter-based adenovirus-mediated anti-monocyte chemoattractant gene therapy attenuates in-stent neointima formation in cynomolgus monkeys.

    abstract：:We have previously demonstrated great benefit from anti-monocyte chemoattractant protein-1 (MCP-1) gene therapy by "systemic" transfer of an N-terminal deletion mutant of human MCP-1 (called 7ND) gene into skeletal muscle for treatment of restenosis and atherosclerosis. However, recent evidence suggests that "local" g...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.10.029

    authors： Nakano K,Egashira K,Ohtani K,Zhao G,Funakoshi K,Ihara Y,Sunagawa K

    更新日期：2007-10-01 00:00:00

  • Menopausal estrogen therapy counteracts normal aging effects on intima thickness, media thickness and intima/media ratio in carotid and femoral arteries. An investigation using noninvasive high-frequency ultrasound.

    abstract：BACKGROUND:Estrogen therapy that is started at the time of menopause seems to protect against the development of atherosclerosis and cardiovascular diseases, in contrast to the initial increased cardiovascular risk when hormone therapy is initiated in older women. With increased aging and degree of atherosclerosis, the...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.12.023

    authors： Naessen T,Rodriguez-Macias K

    更新日期：2006-12-01 00:00:00

  • Sugar sweetened beverages consumption and risk of coronary heart disease: a meta-analysis of prospective studies.

    abstract：OBJECTIVE:To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic. METHODS:We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Datab...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.atherosclerosis.2014.01.037

    authors： Huang C,Huang J,Tian Y,Yang X,Gu D

    更新日期：2014-05-01 00:00:00

  • Blood pressure disturbances and endothelial dysfunction markers in children and adolescents with type 1 diabetes.

    abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.09.006

    authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

    更新日期：2014-11-01 00:00:00

  • Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol.

    abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05448-r

    authors： Opper C,Clement C,Schwarz H,Krappe J,Steinmetz A,Schneider J,Wesemann W

    更新日期：1995-03-01 00:00:00

  • Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin.

    abstract：:Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(03)00193-x

    authors： Nawawi H,Osman NS,Annuar R,Khalid BA,Yusoff K

    更新日期：2003-08-01 00:00:00

  • Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.

    abstract：BACKGROUND AND AIMS:Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. METHODS:We measur...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.10.010

    authors： Lu TM,Hsu CP,Chang CF,Lin CC,Lee TS,Lin SJ,Chan WL

    更新日期：2016-11-01 00:00:00

  • Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis.

    abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.04.042

    authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

    更新日期：2009-02-01 00:00:00

  • FABP4 predicts atherogenic dyslipidemia development. The PREDIMED study.

    abstract：OBJECTIVE:Atherogenic dyslipidemia (AD), characterized by high plasma triglycerides and low HDL particles, is considered one of the main effectors of vascular damage associated with obesity, metabolic syndrome (MS) and type 2 diabetes. Adipocyte fatty acid-binding protein (FABP4) plasma concentrations have been linked ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2012.02.003

    authors： Cabré A,Babio N,Lázaro I,Bulló M,Garcia-Arellano A,Masana L,Salas-Salvadó J

    更新日期：2012-05-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract：BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.097

    authors： Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期：2014-12-01 00:00:00

  • Galectin-3 binding protein, coronary artery disease and cardiovascular mortality: Insights from the LURIC study.

    abstract：BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role in coronary artery disease (CAD) and cardiovascular outcome remains unclear. METHODS:Gal-3BP plasma levels were measured by ELISA in 2922 individuals from the LURIC study (62.7 ± 10.6 years, 62....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.03.031

    authors： Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Helmes CM,Doesch AO,Kleber ME,Katus HA,Maerz W

    更新日期：2017-05-01 00:00:00

  • Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL.

    abstract：:High density lipoproteins (HDL) induce prostacyclin (PGI(2)) release in vascular smooth muscle cells (VSMC) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyse the mechanisms underlying this effect, and its potential modulation by HMG-CoA reductase inhibition in human VSMC. The contribution of mitoge...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.01.037

    authors： Martínez-González J,Escudero I,Badimon L

    更新日期：2004-06-01 00:00:00

  • Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease.

    abstract：:Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation. Furthermore, reactive oxygen species (ROS) are produced in case of immune activation and inflammation. In a cross-sectional approach, plasma concentrations o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.04.047

    authors： Murr C,Winklhofer-Roob BM,Schroecksnadel K,Maritschnegg M,Mangge H,Böhm BO,Winkelmann BR,März W,Fuchs D

    更新日期：2009-02-01 00:00:00

  • Hyperlipidemia, hyperglycemia and hypertension in repeatedly bred parents of the obese spontaneously hypertensive rat (obese/SHR) unaccompanied by arteriosclerosis.

    abstract：:A sub-strain of male and female spontaneously hypertensive rats (SHR) capable of having massively obese or non-obese offspring were bred repeatedly or were maintained as virgin controls. When the male and female breeders had sired or given birth to 5 litters of young, they were autopsied along with their 10-month-old ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(84)90169-2

    authors： Wexler BC

    更新日期：1984-05-01 00:00:00

  • Scoring of coronary artery calcium scans: history, assumptions, current limitations, and future directions.

    abstract：:Coronary artery calcium (CAC) scanning is a reliable, noninvasive technique for estimating overall coronary plaque burden and for identifying risk for future cardiac events. Arthur Agatston and Warren Janowitz published the first technique for scoring CAC scans in 1990. Given the lack of available data correlating CAC...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2014.12.040

    authors： Alluri K,Joshi PH,Henry TS,Blumenthal RS,Nasir K,Blaha MJ

    更新日期：2015-03-01 00:00:00

  • Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study.

    abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2018.05.001

    authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

    更新日期：2018-07-01 00:00:00

  • Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis.

    abstract：BACKGROUND:To evaluate the impact of familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS:We meta-analyzed 51 studies providing data for 4,057 FH patients and 732 FCH patients with random-effects models, meta-regression analysis and pu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2010.10.008

    authors： Masoura C,Pitsavos C,Aznaouridis K,Skoumas I,Vlachopoulos C,Stefanadis C

    更新日期：2011-01-01 00:00:00

  • Lack of association between plasma homocysteine and angiographic coronary artery disease in the era of fortification of cereal grain flour with folic acid.

    abstract：:Homocysteine is associated with coronary disease (CAD). However, the strength of the association after accounting for traditional and emerging risk factors is unclear, particularly since flour fortification with folate was mandated in the USA. We analyzed the association between traditional and emerging risk factors a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00303-9

    authors： Brilakis ES,McConnell JP,Ballman KV,Klee GG,Berger PB

    更新日期：2002-12-01 00:00:00

  • The effect of chlorthalidone on serum lipids and lipoproteins.

    abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90204-x

    authors： Rosenthal T,Holtzman E,Segal P

    更新日期：1980-05-01 00:00:00

  • Serum high density lipoprotein cholesterol and factors influencing its level in healthy Chinese.

    abstract：:Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(83)90018-7

    authors： Chen H,Zhuang H,Han Q

    更新日期：1983-07-01 00:00:00

  • Relation of N-glycosylation of apolipoprotein B-100 to cellular metabolism of low density lipoprotein.

    abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90040-x

    authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

    更新日期：1994-07-01 00:00:00

  • Atheroprotective mechanisms of HDL.

    abstract：:The aim of this review was to bring together results obtained from studies on different aspects of HDL as related to CHD and atherosclerosis. As atherosclerosis is a multistep process, the various components of HDL can intervene at different stages, such as induction of monocyte adhesion molecules, prevention of LDL m...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/s0021-9150(99)00065-9

    authors： Stein O,Stein Y

    更新日期：1999-06-01 00:00:00

  • Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man.

    abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90178-8

    authors： Nikkilä EA,Taskinen MR,Kekki M

    更新日期：1978-04-01 00:00:00