Abstract:
BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation of the Vasculature in Uppsala Seniors (the PIVUS study), endothelium-dependent vasodilation was evaluated by the invasive forearm technique with acetylcholine given in the brachial artery (EDV), the brachial artery ultrasound technique with measurement of flow-mediated dilatation (FMD) and the pulse wave analysis method with beta-2 receptor agonist (terbutaline) provocation in 1016 subjects aged 70. A panel of 14 inflammatory markers, including cytokines, chemokines, adhesion molecules, CRP, sCD40 ligand and leukocyte count, was measured. RESULTS:After adjustment for gender and coronary risk factors, EDV was independently related to CRP levels and e-selectin in an inverse way (p<0.006 for both). FMD was not significantly related to any marker of inflammation after adjustment. Endothelium-independent vasodilation evaluated by the invasive forearm technique with sodium nitroprusside was also found to be related to both CRP and e-selectin in an inverse way (p=0.005 and p=0.045, respectively). CONCLUSION:Acetylcholine-induced vasodilation in the forearm, but not FMD, was inversely related to CRP and e-selectin levels independently of traditional risk factors in elderly subjects. As also endothelium-independent vasodilation was related to CRP and e-selectin, general vasoreactivity in resistance arteries seems to be effected by low-grade inflammation in elderly subjects.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Lind L,Siegbahn A,Hulthe J,Elmgren Adoi
10.1016/j.atherosclerosis.2007.09.038subject
Has Abstractpub_date
2008-07-01 00:00:00pages
129-37issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(07)00610-7journal_volume
199pub_type
临床试验,杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract:BACKGROUND AND PURPOSE:It has not been fully determined whether non-high-density lipoprotein cholesterol (non-HDLC) levels are involved in vascular events, especially stroke, in general Asian populations. We evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in a pros...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.01.005
更新日期:2014-04-01 00:00:00
abstract::Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00377-9
更新日期:2000-06-01 00:00:00
abstract::The lifetime cardiovascular risk of a diabetic patient is approximately 4-5 times higher than that of an age and sex matched individual without diabetes mellitus. Despite the well-publicized cardiovascular risk equivalence of diabetes mellitus, it has become apparent that not all diabetic patients are equally at high-...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2018.02.021
更新日期:2018-04-01 00:00:00
abstract::Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00654-7
更新日期:2001-06-01 00:00:00
abstract::A potential role for the platelet Fc gammaRIIA immunoreceptor (FcR) in collagen-mediated platelet activation associated with diabetes has recently been described. This study was undertaken to prospectively determine which diabetes patient population (type 1, type 2, or both) was more likely to over express platelet Fc...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.06.002
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes. METHODS:Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery st...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2016.12.011
更新日期:2017-02-01 00:00:00
abstract::Cilostazol is an antiplatelet drug, which has beneficial effects in treatment of intermittent claudication and decreases serum triacyiglycerol level in these patients. In this study, we examined adipogenic potency of cilostazol using 3T3-L1 preadipocyte cell line because cilostazol is one of the tissue specific phosph...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00760-7
更新日期:2001-09-01 00:00:00
abstract:INTRODUCTION:Fenofibrate has shown to reduce major cardiovascular events and slow angiographic progression of coronary atherosclerosis. The postulated mechanism of action is via the activation of peroxisomal proliferator-activated receptor-alpha (PPAR-alpha), a nuclear transcription factor that controls a variety of ce...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.02.036
更新日期:2007-01-01 00:00:00
abstract::Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(95)05553-9
更新日期:1995-08-01 00:00:00
abstract::When smoke from single cigarettes containing [4-14C]cholesterol or beta-[4-14C]sitosterol was delivered to the lungs of Rhesus macaques, plasma contained radiolabeled sterols up to 50 days later. Since cholesterol, as well as plant sterols (campesterol, stigmasterol and beta-sitosterol), are normally present in cigare...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(86)90082-1
更新日期:1986-04-01 00:00:00
abstract::Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(89)90107-x
更新日期:1989-04-01 00:00:00
abstract::The effect of different fat loads on postprandial lipemia and hemostatic activity was examined in 10 middle-aged men using 3 different meals. One meal was rich in saturated fatty acids (cream), the other rich in n-6 polyunsaturated fatty acids (sunflower oil) and the third was fat-free containing only carbohydrates. L...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(93)90034-r
更新日期:1993-10-01 00:00:00
abstract::Earlier we have shown a significant positive association between muscle fiber distribution, i.e. percentage of slow-twitch (ST) fibers in the vastus lateralis muscle, and serum high-density lipoprotein cholesterol (HDL-C) level. This association may be due to the fact that ST fibers have a high capacity for oxidative ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(95)05652-1
更新日期:1996-02-01 00:00:00
abstract::The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(89)90096-8
更新日期:1989-04-01 00:00:00
abstract::The postheparin plasma lipoprotein lipase (LPL) activity and plasma HDL and LDL cholesterol concentrations, decreases significantly during probucol treatment of the rat. The reduction of the LPL activity obviously took place in adipose tissue. The activity of hepatic lipase and the in vitro synthesis of cholesterol in...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90130-1
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:Th1 activation and regulatory T (Treg) cell suppression have been observed in acute coronary syndrome (ACS), including unstable angina (UA) and acute myocardial infarction (AMI). However, the role of Th17 cell or IL-17A remains controversial in ACS patients, and little is known about the role of recently disc...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.03.043
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) parallels the obesity epidemic and associates with components of the metabolic syndrome (MetS). Cholesterol efflux capacity (CEC) represents a key metric of high density lipoprotein (HDL) function which may predict atherosclerotic cardiovascular disease (CVD...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.07.028
更新日期:2018-10-01 00:00:00
abstract::There are no definitive explanations as to why individuals with hypercholesterolemia, a major cardiovascular risk factor, respond differently to dietary change. Fifty five free-living individuals completed a double crossover trial with two dietary regimens, a high saturated fat diet (providing 21% energy from saturate...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0021-9150(99)00490-6
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.06.011
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.05.961
更新日期:2014-08-01 00:00:00
abstract::Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(89)90171-8
更新日期:1989-02-01 00:00:00
abstract::The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(88)90140-2
更新日期:1988-06-01 00:00:00
abstract::HDL has been shown to enhance the removal of cholesterol from cultured fibroblasts, smooth muscle cells and macrophages, but fails to stimulate cholesterol removal from J-774 macrophages. Since J-774 macrophages do not synthesize or secrete apolipoprotein E, the effect of exogenous apolipoprotein E on HDL-mediated cel...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(94)05475-x
更新日期:1995-04-07 00:00:00
abstract:BACKGROUND:Common carotid artery intima-media thickness (CCA-IMT) is an established marker for atherosclerosis. The role of triglycerides in CCA-IMT remains controversial. We sought to determine if elevated fasting and post-challenge triglycerides are associated with CCA-IMT. METHODS:All acute ischemic stroke patients...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.09.003
更新日期:2015-11-01 00:00:00
abstract::External jugular veins that had been subjected to the hemodynamic stresses produced by experimental arteriovenous anastomosis developed 2% increased total protein contents and 17% increased collagen contents. When the stressed veins were homogenized and extracted with saline solutions, statistically significant increa...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(76)90004-6
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVES:Pyrophosphate (PPi) is a potent inhibitor of ectopic mineralization but its role during aortic valve calcification is not known. METHODS:Anti-calcific effect of PPi was investigated by using an in vitro model of serum-driven calcification of collagen sponges and decellularized porcine aortic valve leaflets....
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.10.027
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.05.001
更新日期:2011-09-01 00:00:00
abstract::beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(01)00727-4
更新日期:2002-06-01 00:00:00
abstract::Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00185-8
更新日期:1998-01-01 00:00:00
abstract::Diabetes mellitus is one of the major risk factors for coronary artery disease (CAD). A recent study reported that glimepiride, a new third-generation sulfonylurea, inhibited the formation of atheromatous plaques in high-cholesterol fed rabbits. However, the mechanism by which glimepiride induces atheroprotection rema...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.01.055
更新日期:2005-11-01 00:00:00