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Cell cycle-dependent inhibition of DNA synthesis by prostaglandin I2 in cultured rabbit aortic smooth muscle cells.

Abstract：

:The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA (DNA synthesis). Cyclooxygenase inhibitors such as indomethacin and aspirin enhanced DNA synthesis, suggesting that endogenously synthesized prostaglandins inhibit DNA synthesis. Added PGE1 or PGE2 had little effect on DNA synthesis. PGI2 inhibited DNA synthesis only when added from 10 to 16 h after stimulation of SMC in the G0 state with serum. Addition of CS-570, a stable PGI2 analogue, inhibited DNA synthesis at any time after serum stimulation. The endogenous syntheses of PGI2 and DNA were negatively correlated. These results suggest that PGI2 inhibits DNA synthesis by acting on the progression stage of the G1 state.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

doi

10.1016/0021-9150(88)90140-2

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

165-71

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(88)90140-2

journal_volume

71

pub_type

杂志文章

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