当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease.

Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease.

Abstract：

OBJECTIVES:Compare carotid plaque morphology of acute symptomatic, recently symptomatic and asymptomatic patients (groups 1, 2 and 3 respectively) with carotid artery disease using high resolution magnetic resonance imaging (MRI), to identify high-risk plaque characteristics best associated with risk of recurrent thrombo-embolic events. METHODS:60 patients underwent multi-contrast imaging of their internal carotid arteries. Different plaque components were manually delineated on acquired axial images to assess the difference in prevalence of plaque hemorrhage, fibrous cap (FC) rupture and FC thickness among the three groups. RESULTS:55% acute symptomatic patients had plaque hemorrhage vs. 35% for recently symptomatic group and 5% for asymptomatic group (p-value: group 1 vs. 3: 0.001, group 2 vs. 3: 0.04). Type 1 hemorrhage was more common in acute symptomatic patients than recently symptomatic patients (40% vs. 5%, p=0.01). Type 2 hemorrhage was more common in recently symptomatic vs. acute symptomatic patients (15% vs. 30%). FC rupture was observed in 50% of patients in group 1 vs. 35% of group 2 patients (p=0.02) but none in group 3. The mean minimum FC thickness was same in acute and recently symptomatic groups (600+/-200microm), compared to 800+/-200microm for asymptomatic patients (p-value: 0.03 and 0.007 respectively). Good correlation was present among the three MR readers (intra-class correlation coefficient=0.71). CONCLUSION:High resolution MRI can differentiate plaque components associated with increased risk of thrombo-embolic events.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Sadat U,Weerakkody RA,Bowden DJ,Young VE,Graves MJ,Li ZY,Tang TY,Gaunt ME,Hayes PD,Gillard JH

doi

10.1016/j.atherosclerosis.2009.05.002

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

434-9

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(09)00343-8

journal_volume

207

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL.

    abstract：OBJECTIVE:Given the role of estrogen in the regulation of lipid metabolism, we screened for functional polymorphisms in the estrogen receptor alpha (ER*), and examined for their influence on serum cholesterol. METHODS AND RESULTS:We identified a novel C>T polymorphism (ERNE-145), with a minor allele frequency of 41%. ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.02.012

    authors： Figtree GA,Grieve SM,Speller B,Geiger MJ,Robinson BG,Channon KM,Ragoussis J,Collins P,Watkins H

    更新日期：2008-08-01 00:00:00

  • LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease.

    abstract：:In animal model studies, the uptake of chylomicron remnants after entering in the space of Disse occurs mainly by low-density lipoprotein (LDL) receptor and LDL receptor-related protein (LRP). In subjects, the relative importance of each one of these receptors for the clearance of chylomicron remnants is not fully und...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00661-x

    authors： Sposito AC,Santos RD,Hueb W,Ventura LI,Vinagre CC,Ramires JA,Maranhão RC

    更新日期：2002-04-01 00:00:00

  • Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men.

    abstract：BACKGROUND AND AIMS:Depressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse. METHODS:The study included 3428 men aged 45-74 years who participated in one of three population-based MONICA/KORA Augsbu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.12.003

    authors： Ladwig KH,Baumert J,Marten-Mittag B,Lukaschek K,Johar H,Fang X,Ronel J,Meisinger C,Peters A,KORA Investigators.

    更新日期：2017-02-01 00:00:00

  • Ghrelin inhibits angiotensin II-induced migration of human aortic endothelial cells.

    abstract：:Ghrelin, the endogenous ligand for the GH secretagogue receptor, is produced by the oxyntic cells of the stomach and is involved in the regulation of energy balance. However, an increasing number of direct ghrelin cardiovascular effects, and, among them, high ghrelin binding in atherosclerotic coronary arteries, are b...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.07.021

    authors： Rossi F,Bertone C,Petricca S,Santiemma V

    更新日期：2007-06-01 00:00:00

  • 18Fluoride-based molecular imaging of coronary atherosclerosis in HIV infected patients.

    abstract：BACKGROUND AND AIMS:Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques. METHODS:We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living wi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.02.014

    authors： Guaraldi G,Milic J,Prandini N,Ligabue G,Esposito F,Ciusa G,Malagoli A,Scaglioni R,Besutti G,Beghetto B,Nardini G,Roncaglia E,Mussini C,Raggi P

    更新日期：2020-03-01 00:00:00

  • Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study).

    abstract：BACKGROUND:Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. METHODS AND RESULTS:Hemoglobin and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.07.002

    authors： Grammer TB,Kleber ME,Silbernagel G,Pilz S,Scharnagl H,Tomaschitz A,König W,März W

    更新日期：2014-10-01 00:00:00

  • Accumulation of cholesteryl esters in macrophages incubated with human lipoprotein-antibody autoimmune complex.

    abstract：:The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90189-x

    authors： Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

    更新日期：1988-11-01 00:00:00

  • The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes.

    abstract：BACKGROUND:Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight. METHODS:Serum and lipoprotein squalene and non-cholesterol sterols were quantitated with gas-liquid chromatography in 33 d...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.07.030

    authors： Simonen PP,Gylling H,Miettinen TA

    更新日期：2007-09-01 00:00:00

  • Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease.

    abstract：:Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00387-1

    authors： Schwertner HA,Fischer JR Jr

    更新日期：2000-06-01 00:00:00

  • Baseline and on-statin treatment lipoprotein(a) levels for predicting cardiovascular events in patients with familial hypercholesterolemia.

    abstract：BACKGROUND AND AIMS:Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.10.010

    authors： Cao YX,Jin JL,Guo YL,Sun D,Liu HH,Wu NQ,Xu RX,Zhu CG,Liu G,Dong Q,Sun J,Li JJ

    更新日期：2019-12-01 00:00:00

  • Influence of cholesterol feeding on the production of eicosanoids, tissue plasminogen activator and superoxide anion (O2-) by rabbit blood monocytes.

    abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90074-2

    authors： Saito H,Salmon JA,Moncada S

    更新日期：1986-08-01 00:00:00

  • Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.

    abstract：BACKGROUND AND AIMS:Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs. We aimed at investigati...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.06.916

    authors： Berbée JFP,Mol IM,Milne GL,Pollock E,Hoeke G,Lütjohann D,Monaco C,Rensen PCN,van der Ploeg LHT,Shchepinov MS

    更新日期：2017-09-01 00:00:00

  • A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure.

    abstract：:Angiotensin II plays an important role in diastolic heart failure (DHF). However, genetic studies of DHF are scarce in the literature. We hypothesized that RAS genes might be the susceptible genes for DHF and conducted a propensity score-based case-control study to prove this hypothesis. A total of 666 subjects (285 d...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.12.033

    authors： Wu CK,Luo JL,Wu XM,Tsai CT,Lin JW,Hwang JJ,Lin JL,Tseng CD,Chiang FT

    更新日期：2009-08-01 00:00:00

  • A sensitive RNase protection assay for the quantitation of the mRNAs for the LDL receptor and HMG-CoA reductase in human total RNA. Effects of treatments on cells in culture designed to up- and down-regulate expression of the LDL receptor.

    abstract：:Regulation of expression of the genes for the low density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is of central importance in the control of cholesterol metabolism and thus in influencing the concentration of low density lipoprotein in the plasma. This can be studied by i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90246-y

    authors： Le Cras TD,Gherardi E,Bowyer DE

    更新日期：1991-09-01 00:00:00

  • Genetic and environmental covariance of serum cholesterol and blood pressure in female twins.

    abstract：:Blood pressure elevation is frequently associated with elevated cholesterol, triglyceride or low density lipoprotein (LDL-C) or low high density lipoprotein (HDL-C). The relative importance of genetic and environmental factors in these associations is unclear. We examined the relative contribution of genetic and envir...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90064-2

    authors： Williams PD,Puddey IB,Martin NG,Beilin LJ

    更新日期：1993-04-01 00:00:00

  • Time sequence of the inhibition of endothelial adhesion molecule expression by reconstituted high density lipoproteins.

    abstract：:We have used discoidal reconstituted high density lipoproteins (rHDL) containing apolipoprotein (apo) A-I and dimyristoyl phosphatidylcholine (DMPC) as a tool to investigate the time sequence of the HDL-mediated inhibition of vascular cell adhesion molecule (VCAM)-1 and E-selectin expression in cytokine-activated huma...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00659-6

    authors： Clay MA,Pyle DH,Rye KA,Vadas MA,Gamble JR,Barter PJ

    更新日期：2001-07-01 00:00:00

  • Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.

    abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.05.040

    authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

    更新日期：2010-10-01 00:00:00

  • Lipids, lipoproteins, women and cardiovascular disease.

    abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/0021-9150(94)90154-6

    authors： Miller VT

    更新日期：1994-08-01 00:00:00

  • Sialic acid-containing components of lipoproteins influence lipoprotein-proteoglycan interactions.

    abstract：:Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. Sialic acid has been hypothesised to play an anti-atherogenic role in lipoprotein metabolism through the electrostatic inhibition of lipoprotein interactions with chondroitin-6-sulphate-rich arterial proteoglycans...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00071-4

    authors： Millar JS,Anber V,Shepherd J,Packard CJ

    更新日期：1999-08-01 00:00:00

  • Detection of the terminal complement complex in patient plasma following acute myocardial infarction.

    abstract：:The mechanisms of inflammation responsible for the myocardial tissue damage seen after an acute myocardial infarction (AMI) have not been clearly identified. Recent lines of evidence, demonstrating depressed sera levels of individual complement components in patients after myocardial infarction, have suggested involve...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90103-7

    authors： Langlois PF,Gawryl MS

    更新日期：1988-03-01 00:00:00

  • Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men.

    abstract：:The insulin response to a standard oral glucose tolerance test (OGTT) and other anthropometric and biochemical risk factors for coronary heart disease (CHD) were measured in a random sample of 107 Edinburgh men, who were initially studied in 1976 when they were 40 and who were reexamined in 1988-89. Fasting glucose an...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90188-m

    authors： Hargreaves AD,Logan RL,Elton RA,Buchanan KD,Oliver MF,Riemersma RA

    更新日期：1992-05-01 00:00:00

  • Apolipoprotein C-III, a strong discriminant of coronary risk in men and a determinant of the metabolic syndrome in both genders.

    abstract：AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(03)00025-x

    authors： Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

    更新日期：2003-05-01 00:00:00

  • Platelet "-omics" in health and cardiovascular disease.

    abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2020.05.022

    authors： Gutmann C,Joshi A,Mayr M

    更新日期：2020-08-01 00:00:00

  • Effect of carbon monoxide exposure on aortic and coronary intimal morphology in the rabbit. A revaluation.

    abstract：:Non-cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 parts per million (=0.02, 0.2 or 0.4%, vol/vol). Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90126-0

    authors： Hugod C,Hawkins LH,Kjeldsen K,Thomsen HK,Astrup P

    更新日期：1978-08-01 00:00:00

  • Histamine as an activator of cell growth and extracellular matrix reconstruction for human vascular smooth muscle cells.

    abstract：:Atherosclerosis is characterised by unusual growth of vascular smooth muscle cells (VSMCs) in the intima. We examined the effects of histamine on human VSMCs and the VSMC-derived cell line, ISS10. Histamine enhanced phosphoinositide hydrolysis, increased cytoplasmic Ca2+ level and stimulated the transcription of c-fos...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90067-1

    authors： Satoh T,Sugama K,Matsuo A,Kato S,Ito S,Hatanaka M,Sasaguri Y

    更新日期：1994-09-30 00:00:00

  • Oxidized-LDL induce apoptosis in HUVEC but not in the endothelial cell line EA.hy 926.

    abstract：:We studied the cytotoxic effect of copper-oxidized LDL in human primary human umbilical vein endothelial cells (HUVEC) and the immortalized EA.hy 926 cell line. Copper oxidized LDL (50-200 microg apoB/ml) induced concentration-dependent apoptotic cell death in HUVEC but did not induce apoptosis in EA.hy 926 cells. Onl...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00170-7

    authors： Claise C,Edeas M,Chaouchi N,Chalas J,Capel L,Kalimouttou S,Vazquez A,Lindenbaum A

    更新日期：1999-11-01 00:00:00

  • Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysm.

    abstract：BACKGROUND:The relative expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), key regulators in remodeling of extracellular matrix, are considered to play a pivotal role in the development of abdominal aortic aneurysm (AAA). However, few data exist regarding quantita...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.07.013

    authors： Higashikata T,Yamagishi M,Sasaki H,Minatoya K,Ogino H,Ishibashi-Ueda H,Hao H,Nagaya N,Tomoike H,Sakamoto A

    更新日期：2004-12-01 00:00:00

  • AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease.

    abstract：:Activation of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of endothelial dysfunction and atherosclerosis. Studies evaluating the effect of AT1-receptor blockers on endothelial dysfunction in patients with coronary artery disease (CAD) revealed mixed results. Studies addressing ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2006.08.034

    authors： Warnholtz A,Ostad MA,Heitzer T,Thuneke F,Fröhlich M,Tschentscher P,Schwedhelm E,Böger R,Meinertz T,Munzel T

    更新日期：2007-10-01 00:00:00

  • Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia.

    abstract：:The St. Thomas mixed hyperlipidaemic (SMHL) rabbit exhibits an inherited hyperlipidaemia similar to that seen in familial combined hyperlipidaemia (FCHL). In this study, we investigated whether the SMHL rabbit is insulin resistant, a condition often associated with FCHL. Six young and six mature combined hyperlipidaem...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00614-6

    authors： de Roos B,Caslake MJ,Ardern HA,Martin Benson G,Suckling KE,Packard CJ

    更新日期：2001-06-01 00:00:00

  • C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract：BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.038

    authors： Lind L,Siegbahn A,Hulthe J,Elmgren A

    更新日期：2008-07-01 00:00:00