Ghrelin inhibits angiotensin II-induced migration of human aortic endothelial cells.

abstract：BACKGROUND AND AIMS:Chronic intermittent hypoxia (CIH) exposure causes atherosclerosis, although the underlying mechanisms are poorly understood. This study defines the role of endothelial intrinsic NF-κB signaling in the atherogenic response to CIH. METHODS:We created ApoE-ECI-κBmt mice that are deficient in the apol...

journal_title：Atherosclerosis

authors： Song D,Fang G,Mao SZ,Ye X,Liu G,Miller EJ,Greenberg H,Liu SF

更新日期：2018-03-01 00:00:00

abstract：:To asses the relationship between fibrinogen, factor VII coagulant (VIIc) activity and extent of coronary artery disease, we studied 43 white males shown to have greater than 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and wer...

journal_title：Atherosclerosis

authors： Broadhurst P,Kelleher C,Hughes L,Imeson JD,Raftery EB

更新日期：1990-12-01 00:00:00

abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

journal_title：Atherosclerosis

authors： Saito H,Salmon JA,Moncada S

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:Transplant vasculopathy consists of neointima formation in graft vasculature resulting from vascular smooth muscle cell recruitment and proliferation. Variation in the severity of vasculopathy has been demonstrated. Genetic predisposition is suggested as a putative cause of this variation, although cellular m...

journal_title：Atherosclerosis

authors： Onuta G,van Ark J,Rienstra H,Boer MW,Klatter FA,Bruggeman CA,Zeebregts CJ,Rozing J,Hillebrands JL

更新日期：2010-04-01 00:00:00

abstract：:Non-cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 parts per million (=0.02, 0.2 or 0.4%, vol/vol). Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries o...

journal_title：Atherosclerosis

authors： Hugod C,Hawkins LH,Kjeldsen K,Thomsen HK,Astrup P

更新日期：1978-08-01 00:00:00

abstract：:Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...

journal_title：Atherosclerosis

authors： Seip RL,Otvos J,Bilbie C,Tsongalis GJ,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-09-01 00:00:00

abstract：:HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes. Drug-mediated quantitative and qualitative HDL modifications could be involved in these negative results. To evaluate the quantitative and qualitative effects of niacin and fenofibrate ...

journal_title：Atherosclerosis

authors： Masana L,Cabré A,Heras M,Amigó N,Correig X,Martínez-Hervás S,Real JT,Ascaso JF,Quesada H,Julve J,Palomer X,Vázquez-Carrera M,Girona J,Plana N,Blanco-Vaca F

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score wi...

journal_title：Atherosclerosis

authors： Mazidi M,Katsiki N,Mikhailidis DP,Banach M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

journal_title：Atherosclerosis

authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

更新日期：2012-06-01 00:00:00

abstract：:Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...

journal_title：Atherosclerosis

authors： Srinivasan SR,Li S,Chen W,Tang R,Bond MG,Boerwinkle E,Berenson GS

更新日期：2004-11-01 00:00:00

abstract：:In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI....

journal_title：Atherosclerosis

authors： Pocovi M,Cenarro A,Civeira F,Myers RH,Casao E,Esteban M,Ordovas JM

更新日期：1996-04-26 00:00:00

abstract：:Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of the underlying mutations. Patients presenting in infancy have the most rapidly pr...

journal_title：Atherosclerosis

authors： Reiner Ž,Guardamagna O,Nair D,Soran H,Hovingh K,Bertolini S,Jones S,Ćorić M,Calandra S,Hamilton J,Eagleton T,Ros E

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It has not been fully determined whether non-high-density lipoprotein cholesterol (non-HDLC) levels are involved in vascular events, especially stroke, in general Asian populations. We evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in a pros...

journal_title：Atherosclerosis

authors： Imamura T,Doi Y,Ninomiya T,Hata J,Nagata M,Ikeda F,Mukai N,Hirakawa Y,Yoshida D,Fukuhara M,Kitazono T,Kiyohara Y

更新日期：2014-04-01 00:00:00

abstract：:Oxidized LDL (OxLDL) is a proatherogenic lipoprotein, accumulating in the vascular wall and contributing to the pathogenesis of vascular dysfunction early in the development of atherosclerosis. Enhanced serum levels of OxLDL, as well as antibodies against its epitopes, are predictive for endothelial dysfunction and co...

journal_title：Atherosclerosis

authors： Galle J,Hansen-Hagge T,Wanner C,Seibold S

更新日期：2006-04-01 00:00:00

abstract：:Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...

journal_title：Atherosclerosis

authors： Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

更新日期：1998-08-01 00:00:00

abstract：:Experiments were undertaken on excised rabbit common carotid arteries to assess whether the distribution volume for radioactively labelled albumin is influenced by smooth muscle tone or externally applied stress. In arteries at relaxed length and zero transmural pressure, the distribution volume in the media was reduc...

journal_title：Atherosclerosis

authors： Caro CG,Lever MJ

更新日期：1983-01-01 00:00:00

abstract：:External jugular veins that had been subjected to the hemodynamic stresses produced by experimental arteriovenous anastomosis developed 2% increased total protein contents and 17% increased collagen contents. When the stressed veins were homogenized and extracted with saline solutions, statistically significant increa...

journal_title：Atherosclerosis

authors： Smith RA,Stehbens WE,Weber P

更新日期：1976-05-01 00:00:00

abstract：:Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor...

journal_title：Atherosclerosis

authors： Ronden JE,Groenen-van Dooren MM,Hornstra G,Vermeer C

更新日期：1997-07-11 00:00:00

abstract：OBJECTIVES:Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation cou...

journal_title：Atherosclerosis

authors： Caselli C,De Graaf MA,Lorenzoni V,Rovai D,Marinelli M,Del Ry S,Giannessi D,Bax JJ,Neglia D,Scholte AJ

更新日期：2015-07-01 00:00:00

abstract：:The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...

journal_title：Atherosclerosis

authors： Chajek T,Stein O,Stein Y

更新日期：1977-04-01 00:00:00

abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...

journal_title：Atherosclerosis

authors： Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVE:Blood glucose fluctuations have been found to be relevant to the progression of atherosclerosis in patients with type 2 diabetes and to be more detrimental for the development of atherosclerosis than the sustained hyperglycemia. We aim at evaluating the effect of blunted daily acute glucose fluctuations by DP...

journal_title：Atherosclerosis

authors： Barbieri M,Rizzo MR,Marfella R,Boccardi V,Esposito A,Pansini A,Paolisso G

更新日期：2013-04-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Detection of inflamed atherosclerotic plaques is of crucial importance. The carotid artery cuff-model in ApoE(-/-) mice results in shear-stress induced atherosclerosis with inflamed plaques upstream (US) and 'stable' plaques downstream (DS) of the cuff. We evaluated the potential of F-18-FDG PET/CT to differ...

journal_title：Atherosclerosis

authors： Wenning C,Kloth C,Kuhlmann MT,Jacobs AH,Schober O,Hermann S,Schäfers MA

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of resistance training (RT) on the metabolism of an LDL-like nanoemulsion and on lipid transfer to HDL, an important step of HDL metabolism. METHODS:LDL-like nanoemulsion plasma kinetics was studied in 15 healthy men under regular RT for 1-4 years (age = 25 ± 5 years, VO(2)peak = 50 ±...

journal_title：Atherosclerosis

authors： da Silva JL,Vinagre CG,Morikawa AT,Alves MJ,Mesquita CH,Maranhão RC

更新日期：2011-12-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) exhibits many atherogenic effects, including the promotion of monocyte recruitment to the arterial endothelium and the induction of scavenger receptor expression. However, while atherosclerosis involves chronic inflammation within the arterial intima, it is unclear whether oxLD...

journal_title：Atherosclerosis

authors： Kavanagh IC,Symes CE,Renaudin P,Nova E,Mesa MD,Boukouvalas G,Leake DS,Yaqoob P

更新日期：2003-06-01 00:00:00

abstract：:Statins produce cholesterol-independent, anti-inflammatory effects, which result at least in part from increased endothelial nitric oxide production. These effects may be modulated by polymorphisms in the endothelial nitric oxide synthase (eNOS) gene. Here, we examined whether the T-786C polymorphism of eNOS gene affe...

journal_title：Atherosclerosis

authors： Souza-Costa DC,Sandrim VC,Lopes LF,Gerlach RF,Rego EM,Tanus-Santos JE

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIMS:TRPA1 is a calcium permeable non-selective cation channel, its expression is up-regulated in atherosclerosis plaque, yet its function in macrophages activation is unknown. We sought to establish the role of TRPA1 in inflammatory macrophages activation. METHODS:TRPA1-/-ApoE-/- mice and C57BL/6 J con...

journal_title：Atherosclerosis

authors： Wang Q,Chen K,Zhang F,Peng K,Wang Z,Yang D,Yang Y

更新日期：2020-05-01 00:00:00

abstract：:A single centre randomised placebo-controlled trial was performed to assess the 2-year effects of hormone replacement therapy compared to placebo on mechanical arterial properties in 99 perimenopausal women recruited from the general population. The trial was double-blind with respect to a sequential combined regimen ...

journal_title：Atherosclerosis

authors： Westendorp IC,de Kleijn MJ,Bots ML,Bak AA,Planellas J,Coelingh Bennink HJ,Hofman A,Grobbee DE,Witteman JC

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

journal_title：Atherosclerosis

authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

更新日期：2011-12-01 00:00:00