Influence of cholesterol feeding on the production of eicosanoids, tissue plasminogen activator and superoxide anion (O2-) by rabbit blood monocytes.

abstract：OBJECTIVE:Olive oil protects against cardiovascular disease but the underlying mechanism is still unclear. We speculated that olive oil could inhibit oxidative stress, which is believed to be implicated in the atherosclerotic process. METHODS AND RESULTS:Post-prandial oxidative stress and endothelial dysfunction were ...

journal_title：Atherosclerosis

authors： Carnevale R,Pignatelli P,Nocella C,Loffredo L,Pastori D,Vicario T,Petruccioli A,Bartimoccia S,Violi F

更新日期：2014-08-01 00:00:00

abstract：:The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...

journal_title：Atherosclerosis

authors： Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

更新日期：2002-01-01 00:00:00

abstract：:The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...

journal_title：Atherosclerosis

authors： Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

更新日期：2008-12-01 00:00:00

abstract：:Histologic features of aortic fatty streaks were examined in male subjects aged 10-39 from Guatemala, Jamaica Negro, Durban Bantu, New Orleans Negro, New Orleans white, Lima and Santiago. These groups were selected from the 19 available in the IAP (International Atherosclerosis Project) because they represented the gr...

journal_title：Atherosclerosis

authors： Restrepo C,Tracy RE

更新日期：1975-03-01 00:00:00

abstract：:Consecutive patients (n=964) undergoing coronary angiography were studied and compared with a random population sample regarding serum lipids and lipoproteins with focus on lipoprotein(a) (Lp[a]) levels and apo(a) isoforms. The patients were also followed for 5 years after the angiography, and the prognostic value of ...

journal_title：Atherosclerosis

authors： Lindén T,Taddei-Peters W,Wilhelmsen L,Herlitz J,Karlsson T,Ullström C,Wiklund O

更新日期：1998-03-01 00:00:00

abstract：:High serum concentrations of soluble adhesion molecules are present in diabetics, but whether similar levels are present in patients with impaired glucose tolerance (IGT) is unclear. We measured serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), an...

journal_title：Atherosclerosis

authors： Matsumoto K,Miyake S,Yano M,Ueki Y,Tominaga Y

更新日期：2000-10-01 00:00:00

abstract：:Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...

journal_title：Atherosclerosis

authors： Scholz KE,Beynen AC,West CE

更新日期：1982-07-01 00:00:00

abstract：:The association between cardiorespiratory fitness (VO2max) and carotid atherosclerosis was analyzed in 163 men, aged 50 to 60 years. VO2max was assessed using breath-by-breath respiratory gas analyses during maximal exercise stress test. Atherosclerosis was evaluated quantitatively as intima-media thickness (IMT) of t...

journal_title：Atherosclerosis

authors： Rauramaa R,Rankinen T,Tuomainen P,Väisänen S,Mercuri M

更新日期：1995-01-20 00:00:00

abstract：:Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As ...

journal_title：Atherosclerosis

authors： Iritani N,Fukuda E,Nara Y,Yamori Y

更新日期：1977-11-01 00:00:00

abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...

journal_title：Atherosclerosis

authors： Nabika T,Nasreen S,Kobayashi S,Masuda J

更新日期：2002-12-01 00:00:00

abstract：:Recent studies on mice demonstrated that lipoprotein lipase (LPL) located in the arterial wall might play a pro-atherogenic role. There are major differences between humans and mice in lipoprotein metabolism and in susceptibility to atherosclerosis. We have therefore used rabbits fed normal chow diet as a model to ass...

journal_title：Atherosclerosis

authors： Wu X,Wang J,Fan J,Chen M,Chen L,Huang W,Liu G

更新日期：2006-07-01 00:00:00

abstract：:ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, significantly reduced both serum cholesterol and phospholipid levels in dogs, when used at a dosage higher than 10 mg/kg per day. Triglyceride levels were not consistently changed, but beta- and pre-beta-lipoproteins were preferentially redu...

journal_title：Atherosclerosis

authors： Tsujita Y,Kuroda M,Tanzawa K,Kitano N,Endo A

更新日期：1979-03-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to examine the prevalence and risk factors for cerebral infarction (CI) and carotid artery stenosis (CAS) in patients with peripheral arterial disease (PAD) compared with normal controls. METHOD:A cross-sectional analysis was performed in 857 subjects (PAD: 543, controls: 314). C...

journal_title：Atherosclerosis

authors： Araki Y,Kumakura H,Kanai H,Kasama S,Sumino H,Ichikawa A,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K,Kurabayashi M

更新日期：2012-08-01 00:00:00

abstract：:Recent work identified a high prevalence of modifiable risk factors for cardiovascular disease (CVD) among urban black South Africans. The aim was to track the progression of CVD risk factors in a multi-ethnic sample of South Africans. Participants were 173 black (aged 47.5 ± 7.8 yrs) and 186 white teachers (aged 49.6...

journal_title：Atherosclerosis

authors： Hamer M,von Känel R,Reimann M,Malan NT,Schutte AE,Huisman HW,Malan L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

journal_title：Atherosclerosis

authors： Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

更新日期：2018-08-01 00:00:00

abstract：:Atherosclerosis is a major underlying cause of ischemic heart diseases, ischemic stroke, and peripheral artery disease. Atherosclerotic plaque progression is characterized by chronic progressive inflammation of the arterial wall, endothelial cell dysfunction, and subendothelial lipoprotein retention. Incretin drugs, g...

journal_title：Atherosclerosis

authors： Gallego-Colon E,Wojakowski W,Francuz T

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

journal_title：Atherosclerosis

authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

更新日期：2014-11-01 00:00:00

abstract：:The dose-response effects of clofibrate and niceritrol on serum cholesterol and triglycerides (TG) were studied in 29 patients with Type IIa and IIb hyperlipoproteinaemia. In 17 patients, clofibrate and niceritrol were then given as combined treatment, and the effects of this combination on serum lipoproteins were stu...

journal_title：Atherosclerosis

authors： Olsson AG,Orö L,Rössner S

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes ca...

journal_title：Atherosclerosis

authors： Sharifi M,Higginson E,Bos S,Gallivan A,Harvey D,Li KW,Abeysekera A,Haddon A,Ashby H,Shipman KE,Cooper JA,Futema M,Roeters van Lennep JE,Sijbrands EJG,Labib M,Nair D,Humphries SE

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Dementia is a major public health problem because of its high prevalence in elderly individuals, particularly in the growing category of subjects aged 80 years or more. There is accumulating evidence that cholesterol may be implicated in the pathogenesis of dementia, and this has led us to assess the relatio...

journal_title：Atherosclerosis

authors： Corrao G,Ibrahim B,Nicotra F,Zambon A,Merlino L,Pasini TS,Catapano AL,Mancia G

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Sulforaphane, a naturally occurring organosulfur compound in broccoli, has chemopreventive properties in cancer. However, the effects of sulforaphane in vascular diseases have not been examined. We therefore aimed to investigate the effects of sulforaphane on vascular smooth muscle cell (VSMC) proliferation a...

journal_title：Atherosclerosis

authors： Kwon JS,Joung H,Kim YS,Shim YS,Ahn Y,Jeong MH,Kee HJ

更新日期：2012-11-01 00:00:00

abstract：:Familial hypobetalipoproteinemia is an autosomal co-dominant disorder, which in a minority of cases is due to a truncation producing mutation in the apoB gene. We have identified an apoB mutation in a 40-year old hypobetalipoproteinemic man with Type II diabetes mellitus. Immunoblotting of plasma revealed a major band...

journal_title：Atherosclerosis

authors： Pulai JI,Latour MA,Kwok PY,Schonfeld G

更新日期：1998-02-01 00:00:00

abstract：:The efficacy and safety of bezafibrate were evaluated in 83 patients with type IIa, IIb, or IV hyperlipoproteinemia. Following a 12- to 14-week placebo period on a coronary-prudent diet (Period 1), patients were assigned randomly to receive either bezafibrate 600 mg/day or placebo, plus diet in a double-blind, 12-week...

journal_title：Atherosclerosis

authors： Bradford RH,Goldberg AC,Schonfeld G,Knopp RH

更新日期：1992-01-01 00:00:00

abstract：:The proband is a 50 year-old woman born from a consanguineous marriage. She has been suffering from angina pectoris since the age of 38 and underwent coronary bypass surgery for three-vessel disease at 48. The presence of low plasma levels of total cholesterol and high density lipoprotein (HDL) cholesterol (2.4 and 0....

journal_title：Atherosclerosis

authors： Bertolini S,Pisciotta L,Seri M,Cusano R,Cantafora A,Calabresi L,Franceschini G,Ravazzolo R,Calandra S

更新日期：2001-02-15 00:00:00

abstract：:When smoke from single cigarettes containing [4-14C]cholesterol or beta-[4-14C]sitosterol was delivered to the lungs of Rhesus macaques, plasma contained radiolabeled sterols up to 50 days later. Since cholesterol, as well as plant sterols (campesterol, stigmasterol and beta-sitosterol), are normally present in cigare...

journal_title：Atherosclerosis

authors： Malinow MR,McLaughlin P,Aigner-Held R,Upson B,Isabelle LM,Connor WE,Lin D

更新日期：1986-04-01 00:00:00

abstract：:Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...

journal_title：Atherosclerosis

authors： Waugh DA,Tercyak AM,Small DM

更新日期：1989-04-01 00:00:00

abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...

journal_title：Atherosclerosis

authors： Calabresi L,Simonelli S,Gomaraschi M,Franceschini G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:Dysbiosis of the gut microbiota is associated with increased levels of circulating lipopolysaccharide (LPS) and subsequent activation of systemic inflammation. Diet is an important modulator of the gut microbiome. We aimed to investigate whether circulating markers of gut-related inflammation, LPS bin...

journal_title：Atherosclerosis

authors： Awoyemi A,Trøseid M,Arnesen H,Solheim S,Seljeflot I

更新日期：2019-07-01 00:00:00

abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

journal_title：Atherosclerosis

authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

更新日期：1993-05-01 00:00:00

abstract：:Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and ...

journal_title：Atherosclerosis

authors： Devaraj S,Chien A,Rao B,Chen X,Jialal I

更新日期：2013-05-01 00:00:00