Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.

abstract：OBJECTIVE:Atherosclerosis is a multi-step process, where lipids, inflammatory and hemostatic mediators orchestrate plaque formation and progression, which subsequently may lead to myocardial infarction and ischemic stroke. Familial hypercholesterolemia (FH) is associated with increased risk of premature atherosclerosis...

journal_title：Atherosclerosis

authors： Narverud I,Retterstøl K,Iversen PO,Halvorsen B,Ueland T,Ulven SM,Ose L,Aukrust P,Veierød MB,Holven KB

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has esta...

journal_title：Atherosclerosis

authors： Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J

更新日期：2018-10-01 00:00:00

abstract：:The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...

journal_title：Atherosclerosis

authors： Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, r...

journal_title：Atherosclerosis

authors： Chen S,Wang X,Wang J,Zhao Y,Wang D,Tan C,Fa J,Zhang R,Wang F,Xu C,Huang Y,Li S,Yin D,Xiong X,Li X,Chen Q,Tu X,Yang Y,Xia Y,Xu C,Wang QK

更新日期：2016-03-01 00:00:00

abstract：:Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...

journal_title：Atherosclerosis

authors： Jay RH,Rampling MW,Betteridge DJ

更新日期：1990-12-01 00:00:00

abstract：:Apolipoprotein E (apo E) is a component of all the classes of lipoproteins and can be distributed among apo B- (LpB) and non apo B-containing lipoproteins (Lp-non-B). Using a new electroimmunoassay kit, plasma apo E, apo E in Lp-non-B (apo E-Lp-non-B) and apo E in LpB (apo E-LpB) levels were measured in healthy contro...

journal_title：Atherosclerosis

authors： Luc G,Ducimetiere P,Bard JM,Arveiler D,Evans A,Cambien F,Fruchart JC,Fievet C

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

journal_title：Atherosclerosis

authors： Inaba Y,Chen JA,Bergmann SR

更新日期：2012-01-01 00:00:00

abstract：:Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...

journal_title：Atherosclerosis

authors： Mount PF,Lane N,Venkatesan S,Steinberg GR,Fraser SA,Kemp BE,Power DA

更新日期：2008-09-01 00:00:00

abstract：:Investigations to date have demonstrated that the underlying etiology, causes and burden of stroke may be different for women and men. However, data regarding sex differences among young cerebral ischemic stroke patients remains scarce. We conducted this study in 669 young Chinese adults with acute ischemic stroke as ...

journal_title：Atherosclerosis

authors： Zhang B,Pu S,Zhang W,Yang N,Shen G,Yin J,Yi Y,Gao Q,Gao C

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic. METHODS:We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Datab...

journal_title：Atherosclerosis

authors： Huang C,Huang J,Tian Y,Yang X,Gu D

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset an...

journal_title：Atherosclerosis

authors： Nagarajan UM,Sikes JD,Burris RL,Jha R,Popovic B,Fraungruber P,Hennings L,Haggerty CL,Nagarajan S

更新日期：2019-11-01 00:00:00

abstract：:High-density lipoproteins (HDL) have several antiatherogenic actions, including the ability to sequester cellular cholesterol, to protect low-density lipoproteins from oxidation and to inhibit platelet aggregation. An early event in atherogenesis is the adhesion and recruitment of blood monocytes, a process mediated b...

journal_title：Atherosclerosis

authors： Stannard AK,Khan S,Graham A,Owen JS,Allen SP

更新日期：2001-01-01 00:00:00

abstract：:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances....

journal_title：Atherosclerosis

authors： Schmidt V,Willnow TE

更新日期：2016-02-01 00:00:00

abstract：:Chylomicron retention disease (CRD) is a rare autosomal recessive disorder characterized by the absence of post-prandial chylomicrons and apolipoprotein (apo) B-48 in sera from affected individuals. Apo B-100 is synthesized, and apo B-100-containing lipoproteins are present in sera. A crucial difference between the sy...

journal_title：Atherosclerosis

authors： Patel S,Pessah M,Beucler I,Navarro J,Infante R

更新日期：1994-08-01 00:00:00

abstract：:To examine a long-term effect of community-based education program for hypercholesterolemia and an effect modification by apolipoprotein E polymorphism, we conducted a 1-year randomized clinical trial with 8 year-follow-up. One hundred four persons aged 40-64 years who had serum total cholesterol levels between 6.21 a...

journal_title：Atherosclerosis

authors： Iso H,Imano H,Nakagawa Y,Kiyama M,Kitamura A,Sato S,Naito Y,Shimamoto T,Iida M

更新日期：2002-09-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified several risk loci for coronary artery calcification. Four single-nucleotide polymorphisms (SNPs, rs1537370, rs1333049, rs2026458 and rs9349379) were associated with coronary artery calcification with P values less than 5 × 10(-8) in GWASs. It is unclear if these ...

journal_title：Atherosclerosis

authors： Zhang Y,Wang L,Zhang Z,Zhang Z,Zhou S,Cao L,Cai B,Liu K,Bai W,Xie X,Fan W,Liu X,Lu G,Xu G

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:The principal aim of this study was to determine whether the amount of visceral adipose tissue (VAT) is more related than subcutaneous adipose tissue (SAT) to atherosclerosis assessed by whole-body MRA (WBMRA). A further objective was to investigate whether traditional risk factors, inflammation, or adipokine...

journal_title：Atherosclerosis

authors： Hansen T,Ahlström H,Söderberg S,Hulthe J,Wikström J,Lind L,Johansson L

更新日期：2009-07-01 00:00:00

abstract：:Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of the underlying mutations. Patients presenting in infancy have the most rapidly pr...

journal_title：Atherosclerosis

authors： Reiner Ž,Guardamagna O,Nair D,Soran H,Hovingh K,Bertolini S,Jones S,Ćorić M,Calandra S,Hamilton J,Eagleton T,Ros E

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The association of egg consumption with subclinical coronary atherosclerosis remains unknown. Our aim was to examine the association between egg consumption and prevalence of coronary artery calcium (CAC). METHODS:Cross-sectional study of 23,417 asymptomatic adult men and women without a history of cardiovas...

journal_title：Atherosclerosis

authors： Choi Y,Chang Y,Lee JE,Chun S,Cho J,Sung E,Suh BS,Rampal S,Zhao D,Zhang Y,Pastor-Barriuso R,Lima JA,Shin H,Ryu S,Guallar E

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs apoptosis and associated mechanisms are still elusive. METHODS:The human EPCs we...

journal_title：Atherosclerosis

authors： Jiang H,Liang C,Liu X,Jiang Q,He Z,Wu J,Pan X,Ren Y,Fan M,Li M,Wu Z

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Increasing age and cholesterol levels, male gender, and family history of early coronary heart disease (CHD) are associated with early onset of CHD in familial hypercholesterolemia (FH). OBJECTIVE:Assess subclinical atherosclerosis by computed tomography coronary angiography (CTCA) and its association with ...

journal_title：Atherosclerosis

authors： Miname MH,Ribeiro MS 2nd,Parga Filho J,Avila LF,Bortolotto LA,Martinez LR,Rochitte CE,Santos RD

更新日期：2010-12-01 00:00:00

abstract：:Several studies indicate that the inter-individual variation in plasma concentrations of lipoprotein(a) (Lp(a)) is mainly under genetic control. To define the effect of three DNA polymorphisms on apolipoprotein(a) (apo(a)) expression, we have determined plasma Lp(a) concentrations, apo(a) isoform size, KpnI allele siz...

journal_title：Atherosclerosis

authors： Valenti K,Aveynier E,Leauté S,Laporte F,Hadjian AJ

更新日期：1999-11-01 00:00:00

abstract：:The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...

journal_title：Atherosclerosis

authors： Silkworth JB,McLean B,Stehbens WE

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endo...

journal_title：Atherosclerosis

authors： Tuttolomondo A,Casuccio A,Della Corte V,Maida C,Pecoraro R,Di Raimondo D,Vassallo V,Simonetta I,Arnao V,Pinto A

更新日期：2017-01-01 00:00:00

abstract：:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined...

journal_title：Atherosclerosis

authors： Boquist S,Karpe F,Danell-Toverud K,Hamsten A

更新日期：2002-05-01 00:00:00

abstract：:The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...

journal_title：Atherosclerosis

authors： Glick JM,Adelman SJ,Rothblat GH

更新日期：1987-04-01 00:00:00

abstract：:Fifty-seven sections of human vessels, collected in the Pathobiological Determinants of Atherosclerosis in Youth study from individuals aged 25-34, were stained with two monoclonal antibodies to oxidatively-modified lysine. Intensity and extent of immunoreactivity were graded by three pathologists. Aorta from a Watana...

journal_title：Atherosclerosis

authors： Sloop GD,Fallon KB,Lipscomb G,Takei H,Zieske A

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the pot...

journal_title：Atherosclerosis

authors： Maingrette F,Dussault S,Dhahri W,Desjarlais M,Mathieu R,Turgeon J,Haddad P,Groleau J,Perez G,Rivard A

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

journal_title：Atherosclerosis

authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

更新日期：2003-03-01 00:00:00

abstract：:Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...

journal_title：Atherosclerosis

authors： Scholz KE,Beynen AC,West CE

更新日期：1982-07-01 00:00:00