Abstract:
:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances. In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Schmidt V,Willnow TEdoi
10.1016/j.atherosclerosis.2015.11.027subject
Has Abstractpub_date
2016-02-01 00:00:00pages
194-9eissn
0021-9150issn
1879-1484pii
S0021-9150(15)30222-7journal_volume
245pub_type
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