A major gene influences variation in large HDL particles and their response to diet in baboons.


:Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets differing in levels of fat and cholesterol. The HDL(1) trait was highly heritable on each diet (0.390< or =h(2)< or =0.528). Segregation analyses yielded significant evidence that a single major gene plus polygenes affected HDL(1) on a high-fat low-cholesterol diet. The major gene explained approximately 56% of total trait variance and 90% of the additive genetic variance in HDL(1) levels in these baboons. Bivariate one-locus segregation analyses indicated that this major gene exerts significant pleiotropic effects on a number of traditional HDL traits on all three diets, including HDL size distributions, and concentrations of HDL-C, apoAI, and apoE. Linkage analyses showed that this major gene was not located in chromosomal regions that contain six candidate genes whose protein products are important to HDL metabolism (LCAT, CETP, APOA1, APOE, ABCA1, LIPC). Our results suggest this major gene in baboons plays a pivotal role in HDL metabolism, but is unlikely to code for any of the proteins previously implicated in studies of human HDL(1).






Rainwater DL,Kammerer CM,Cox LA,Rogers J,Carey KD,Dyke B,Mahaney MC,McGill HC Jr,VandeBerg JL





Has Abstract


2002-08-01 00:00:00














  • Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation.

    abstract::Leukotriene B(4) (LTB(4)) is a pro-inflammatory lipid mediator generated by the enzymes 5-lipoxygenase (5-LO) and LTA(4)-hydrolase. LTB(4) signals primarily through its G protein-coupled receptor BLT1, which is highly expressed on specific leukocyte subsets. Recent genetic studies in humans as well as knockout studies...


    pub_type: 杂志文章


    authors: Kristo F,Hardy GJ,Anderson TJ,Sinha S,Ahluwalia N,Lin AY,Passeri J,Scherrer-Crosbie M,Gerszten RE

    更新日期:2010-05-01 00:00:00

  • Species variation in ABCG1 isoform expression: implications for the use of animal models in elucidating ABCG1 function.

    abstract::The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane do...


    pub_type: 杂志文章


    authors: Burns V,Sharpe LJ,Gelissen IC,Brown AJ

    更新日期:2013-02-01 00:00:00

  • Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells.

    abstract:OBJECTIVE:Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis. Its expression is increased during inflammation and by inflammatory cytokines. Sulforaphane (SFN) is a natura...


    pub_type: 杂志文章


    authors: Kivelä AM,Mäkinen PI,Jyrkkänen HK,Mella-Aho E,Xia Y,Kansanen E,Leinonen H,Verma IM,Ylä-Herttuala S,Levonen AL

    更新日期:2010-11-01 00:00:00

  • Lipid metabolism after an oral fat test meal is affected by age-associated features of metabolic syndrome, but not by age.

    abstract:OBJECTIVE:Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. METHODS:To investigate if age is ...


    pub_type: 杂志文章


    authors: Perez-Caballero AI,Alcala-Diaz JF,Perez-Martinez P,Garcia-Rios A,Delgado-Casado N,Marin C,Yubero-Serrano E,Camargo A,Caballero J,Malagon MM,Tinahones FJ,Perez-Jimenez F,Lopez-Miranda J,Delgado-Lista J

    更新日期:2013-01-01 00:00:00

  • The effect of chlorthalidone on serum lipids and lipoproteins.

    abstract::The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...


    pub_type: 杂志文章


    authors: Rosenthal T,Holtzman E,Segal P

    更新日期:1980-05-01 00:00:00

  • Does the presence of the 3500 mutant apolipoprotein B-100 in low density lipoprotein particles affect their atherogenicity?

    abstract::Apolipoprotein B-100 (apo B-100) is the protein component of low density lipoprotein (LDL) responsible for its binding and clearance by LDL receptors (LDL-R). In familial defective apo B-100 (FDB), a mutation in apo B-100 at residue 3500 markedly reduces its affinity for LDL-R, often causing accumulation of defective ...


    pub_type: 杂志文章


    authors: Maher VM,Gallagher JJ,Thompson GR,Myant NB

    更新日期:1995-11-01 00:00:00

  • Acid cholesteryl ester hydrolase activity of mononuclear leukocytes in patients with non-insulin-dependent diabetes mellitus: studies before and after treatment of diabetes.

    abstract::The change of acid cholesteryl ester hydrolase activity in mononuclear leukocyte following treatment of diabetes mellitus was studied in 21 patients with non-insulin-dependent diabetes mellitus (NIDDM). Enzyme activity before treatment in the patients was significantly lower than that in 14 age-matched healthy subject...


    pub_type: 杂志文章


    authors: Onuma T,Tsutsui M,Boku A,Yanada A,Ochiai S,Takebe K

    更新日期:1992-02-01 00:00:00

  • Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches.

    abstract::The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...


    pub_type: 杂志文章


    authors: Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

    更新日期:2004-01-01 00:00:00

  • Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits.

    abstract::Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...


    pub_type: 杂志文章


    authors: Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

    更新日期:1995-06-01 00:00:00

  • Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis.

    abstract::The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified lo...


    pub_type: 杂志文章


    authors: George J,Afek A,Gilburd B,Levkovitz H,Shaish A,Goldberg I,Kopolovic Y,Wick G,Shoenfeld Y,Harats D

    更新日期:1998-05-01 00:00:00

  • A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity.

    abstract:OBJECTIVE:Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent in subjects presenting premature atherosclerosis. It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL part...


    pub_type: 杂志文章


    authors: Kontush A,de Faria EC,Chantepie S,Chapman MJ

    更新日期:2005-10-01 00:00:00

  • Adipose tissue diacylglycerol acyltransferase activity and blood lipoprotein triglyceride enrichment in women with abdominal obesity.

    abstract:UNLABELLED:Previous studies have suggested altered triglyceride (TG) storage in patients with abdominal obesity and blood lipid disorders. OBJECTIVE:We hypothesized that women with abdominal obesity and a dysmetabolic profile have low DGAT activity in their abdominal fat compartments. METHODS:Paired omental (OM) and ...


    pub_type: 杂志文章


    authors: Côté JA,Nadeau M,Leboeuf M,Blackburn L,Tchernof A

    更新日期:2014-03-01 00:00:00

  • Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: The KORA F4 study.

    abstract:BACKGROUND AND AIMS:The exact mechanism of premature atherosclerosis in diabetes is still unclear. Inappropriate activation of the renin-aldosterone-angiotensin system may be an important risk factor for cardiovascular disease. We investigated whether renin and aldosterone are associated with vasoactive peptides midreg...


    pub_type: 杂志文章


    authors: Then C,Rottenkolber M,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Rathmann W,Bidlingmaier M,Reincke M,Seissler J

    更新日期:2016-09-01 00:00:00

  • Vascular risk factors, vascular disease, lipids and lipid targets in patients with familial dysbetalipoproteinemia: a European cross-sectional study.

    abstract:BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...


    pub_type: 杂志文章,多中心研究


    authors: Koopal C,Retterstøl K,Sjouke B,Hovingh GK,Ros E,de Graaf J,Dullaart RP,Bertolini S,Visseren FL

    更新日期:2015-05-01 00:00:00

  • Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes.

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    pub_type: 信件


    authors: Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

    更新日期:2009-03-01 00:00:00

  • Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively.

    abstract::Colesevelam hydrochloride is a novel, potent, non-absorbed lipid-lowering agent previously shown to reduce low density lipoprotein (LDL) cholesterol. To examine the efficacy and safety of coadministration of colesevelam and atorvastatin, administration of these agents alone or in combination was examined in a double-b...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hunninghake D,Insull W Jr,Toth P,Davidson D,Donovan JM,Burke SK

    更新日期:2001-10-01 00:00:00

  • Influence of sialic acid content of low-density lipoprotein particles on endothelium-dependent vasorelaxation in rabbit aorta.

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    pub_type: 杂志文章


    authors: Stratton PD,Lumb PJ,Paganga G,Crook MA,Ferro A

    更新日期:2001-02-01 00:00:00

  • Moderate to high intensity statin in dialysis patients after acute myocardial infarction: A national cohort study in Asia.

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    pub_type: 杂志文章


    authors: Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

    更新日期:2017-12-01 00:00:00

  • Circulating cadmium concentration and risk of aortic aneurysms: A nested case-control study within the Malmö Diet and Cancer cohort.

    abstract:BACKGROUND AND AIMS:Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether bloo...


    pub_type: 杂志文章


    authors: Fagerberg B,Borné Y,Sallsten G,Smith JG,Acosta S,Persson M,Melander O,Forsgard N,Gottsäter A,Hedblad B,Barregard L,Engström G

    更新日期:2017-06-01 00:00:00

  • EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques.

    abstract::The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has ye...


    pub_type: 杂志文章


    authors: Lamb DJ,Modjtahedi H,Plant NJ,Ferns GA

    更新日期:2004-09-01 00:00:00

  • Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice.

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    pub_type: 杂志文章


    authors: Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

    更新日期:2012-10-01 00:00:00

  • Protein content and composition of human high density lipoprotein subfractions.

    abstract::High density lipoprotein (HDL) was fractionated by ion exchange column chromatography using a continuous NaCl gradient of 0.06--0.13 M. It was found that, on the basic C apoprotein content, HDL is comprised of 3 subfractions. All 3 subfractions contain apo A-I and apo A-II but the apo A-I/apo A-II ratio is different i...


    pub_type: 杂志文章


    authors: Rubenstein B

    更新日期:1979-08-01 00:00:00

  • Plasma lipoprotein changes in humans induced by beta-interferon.

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    pub_type: 临床试验,杂志文章


    authors: Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

    更新日期:1987-10-01 00:00:00

  • SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion.

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    pub_type: 杂志文章


    authors: Hofnagel O,Engel T,Severs NJ,Robenek H,Buers I

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  • Interrelationships between plasma levels of plasminogen activator inhibitor, tissue plasminogen activator, lipoprotein (a), and established cardiovascular risk factors in a north Swedish population.

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    pub_type: 杂志文章


    authors: Sundell IB,Nilsson TK,Hallmans G,Hellsten G,Dahlén GH

    更新日期:1989-11-01 00:00:00

  • Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping.

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    pub_type: 杂志文章


    authors: Segev H,Honigman A,Rosen H,Leitersdorf E

    更新日期:2001-06-01 00:00:00

  • The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies.

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    pub_type: 杂志文章


    authors: Di Minno MND,Scalera A,Tufano A,Ambrosino P,Bettiol A,Silvestri E,Emmi G,Prisco D

    更新日期:2018-11-01 00:00:00

  • Postmenopausal estrogen and heart disease.

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    pub_type: 杂志文章,评审


    authors: Barrett-Connor E

    更新日期:1995-12-01 00:00:00

  • Arteriosclerosis in the African elephant: Part 2. Medial sclerosis.

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    pub_type: 杂志文章


    authors: McCullagh KG

    更新日期:1975-01-01 00:00:00

  • Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: the Nagasaki Islands Study.

    abstract:OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...


    pub_type: 杂志文章


    authors: Shimizu Y,Nakazato M,Sekita T,Kadota K,Yamasaki H,Takamura N,Aoyagi K,Maeda T

    更新日期:2013-06-01 00:00:00