Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice.

abstract：:The effects of chronic renal failure (CRF) and corticosteroid treatment on the aortic uptake of labelled free and esterified cholesterol (FC and EC) were investigated in normocholesterolemic rabbits. Methylprednisolone, 0.4 mg/day, or placebo was administered for 14 weeks to rabbits with normal renal function and with...

journal_title：Atherosclerosis

authors： Tvedegaard E,Szpirt W,Nielsen M

更新日期：1983-05-01 00:00:00

abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

journal_title：Atherosclerosis

authors： Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...

journal_title：Atherosclerosis

authors： Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To investigate the effects of estrogen on growth and smooth muscle cell (SMC)-differentiation of vascular wall-resident CD34(+) stem/progenitor cells (VRS/Pcs). METHODS AND RESULTS:The existence of CD34(+) VRS/Pcs was confirmed by immunohistochemistry in the adventitia of arteries of young (2-month-old) and...

journal_title：Atherosclerosis

authors： Wu Y,Shen Y,Kang K,Zhang Y,Ao F,Wan Y,Song J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...

journal_title：Atherosclerosis

authors： Chen Y,Wen S,Jiang M,Zhu Y,Ding L,Shi H,Dong P,Yang J,Yang Y

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...

journal_title：Atherosclerosis

authors： Lind PM,Lind L

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Toll like receptors (TLR) have been recognized for their role in atherosclerotic lesion development and progression. Endogenous TLR ligands that are also expressed in atherosclerotic tissues have been shown to promote atherosclerosis in mice. Since repetitive stimulation of TLR induces an attenuated inflamma...

journal_title：Atherosclerosis

authors： Schoneveld AH,Hoefer I,Sluijter JP,Laman JD,de Kleijn DP,Pasterkamp G

更新日期：2008-03-01 00:00:00

abstract：AIMS:The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development...

journal_title：Atherosclerosis

authors： Qin Z,Cui B,Jin J,Song M,Zhou B,Guo H,Qian D,He Y,Huang L

更新日期：2016-04-01 00:00:00

abstract：:Young pigs with hypertension of 10 weeks duration, resulting from cellophane perinephritis, were injected with 125I-labelled low-density lipoprotein ([125I]LDL) before being killed 24 h or 48 h later. Intimal thickening and increased acid mucopolysaccharide were demonstrated in the aortas and major arteries of the hyp...

journal_title：Atherosclerosis

authors： Sharpe DN,Scott PJ,Flint MH,Donald J

更新日期：1980-04-01 00:00:00

abstract：INTRODUCTION:Fenofibrate has shown to reduce major cardiovascular events and slow angiographic progression of coronary atherosclerosis. The postulated mechanism of action is via the activation of peroxisomal proliferator-activated receptor-alpha (PPAR-alpha), a nuclear transcription factor that controls a variety of ce...

journal_title：Atherosclerosis

authors： Corti R,Osende J,Hutter R,Viles-Gonzalez JF,Zafar U,Valdivieso C,Mizsei G,Fallon JT,Fuster V,Badimon JJ

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...

journal_title：Atherosclerosis

authors： Shimizu Y,Nakazato M,Sekita T,Kadota K,Yamasaki H,Takamura N,Aoyagi K,Maeda T

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Peritoneal macrophages are used in many studies related to atherosclerosis. In situ, they are non-adherent and upon culturing, they adhere and function as scavengers of modified lipoproteins and dead apoptotic cells. They also produce growth factors, suggesting that they may provide life-supporting function a...

journal_title：Atherosclerosis

authors： Selvarajan K,Moldovan L,Chandrakala AN,Litvinov D,Parthasarathy S

更新日期：2011-12-01 00:00:00

abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

journal_title：Atherosclerosis

authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...

journal_title：Atherosclerosis

authors： Naissides M,Mamo JC,James AP,Pal S

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The relative expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), key regulators in remodeling of extracellular matrix, are considered to play a pivotal role in the development of abdominal aortic aneurysm (AAA). However, few data exist regarding quantita...

journal_title：Atherosclerosis

authors： Higashikata T,Yamagishi M,Sasaki H,Minatoya K,Ogino H,Ishibashi-Ueda H,Hao H,Nagaya N,Tomoike H,Sakamoto A

更新日期：2004-12-01 00:00:00

abstract：:Lifibrol (4-(4'-tert-butylphenyl)-1-(4'carboxyphenoxy)-2-butanol), a new hypocholesterolemic drug, effectively reduces total cholesterol (CH), low density lipoprotein (LDL)-CH, and apolipoprotein (apo) B in experimental animals and in humans. The impact of Lifibrol on the metabolism of apoB-100 containing lipoproteins...

journal_title：Atherosclerosis

authors： Winkler K,Schäfer JR,Klima B,Nuber C,Sattler A,Friedrich I,Köster W,Steinmetz A,Wieland H,März W

更新日期：1999-05-01 00:00:00

abstract：:Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to...

journal_title：Atherosclerosis

authors： Gnasso A,Motti C,Irace C,Di Gennaro I,Pujia A,Leto E,Ciamei M,Crivaro A,Bernardini S,Federici G,Cortese C

更新日期：2002-10-01 00:00:00

abstract：:Glycoprotein VI is a platelet collagen receptor binding to subendothelial collagen after a rupture of an atherosclerotic plaque. The GPVI gene is polymorphic with several SNPs and the T13254C polymorphism predicting amino acid substitution (serine to proline) has been associated with the risk of MI in a preliminary st...

journal_title：Atherosclerosis

authors： Ollikainen E,Mikkelsson J,Perola M,Penttilä A,Karhunen PJ

更新日期：2004-09-01 00:00:00

abstract：:High circulating levels of carotenoids have been thought to exhibit a protective function in the development of atherosclerosis. We investigated whether aortic atherosclerosis was associated with lower levels of the major serum carotenoids in alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene, and zea...

journal_title：Atherosclerosis

authors： Klipstein-Grobusch K,Launer LJ,Geleijnse JM,Boeing H,Hofman A,Witteman JC

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians. RESEARCH DESIGN AND METHODS:The present investigation was conducted to replicate this previous association, and to further examine the potential associatio...

journal_title：Atherosclerosis

authors： Zee RY,Germer S,Thomas A,Raji A,Rhees B,Ridker PM,Lindpaintner K,Williams GH,Nathan DM,Martin M

更新日期：2008-04-01 00:00:00

abstract：AIM:To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. METHODS AND RESULTS:Data were collected from 18 Dutch FCHL probands, 202 living fi...

journal_title：Atherosclerosis

authors： Voors-Pette C,de Bruin TW

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:CVD risk increases in women after menopause. Recent data suggest higher levels of complement protein C3 and cardiovascular fat (CF) in postmenopausal women. Whether complement proteins are associated with early markers of atherosclerosis in healthy midlife women has never been evaluated. Additionally, the po...

journal_title：Atherosclerosis

authors： Nagaraj N,Matthews KA,Shields KJ,Barinas-Mitchell E,Budoff MJ,El Khoudary SR

更新日期：2015-12-01 00:00:00

abstract：:The well established 'systemic' risk factors for atherosclerosis can explain only half of the variability in its occurrence. To account for some of the remaining variability, it was suggested that certain geometric features of atherosclerosis-prone segments ('geometric risk factors') can increase the likelihood of dis...

journal_title：Atherosclerosis

authors： Friedman MH,Baker PB,Ding Z,Kuban BD

更新日期：1996-09-06 00:00:00

abstract：RATIONALE:Lipoprotein lipase (LPL) X447 homozygotes are characterized by enhanced conversion of TRL apoB100. Here, we set out to investigate whether this LPL variant is also associated with enhanced apoB48 clearance. Therefore, we evaluated apoB48 kinetics in X447 homozygotes in the fed state by infusion of isotope L-[...

journal_title：Atherosclerosis

authors： Nierman MC,Rip J,Kuivenhoven JA,Sakai N,Kastelein JJ,de Sain-van der Velden MG,Stroes ES,Prinsen BH

更新日期：2007-10-01 00:00:00

abstract：:The hypolipidemic response of rice bran oil (RBO) was investigated in nonhuman primates fed semi-purified diets containing blends of oils which included RBO at 0-35% Kcals as dietary fat. The studies demonstrated the following: (a) the degree of reduction of serum total cholesterol (TC) and low density lipoprotein cho...

journal_title：Atherosclerosis

authors： Nicolosi RJ,Ausman LM,Hegsted DM

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:As apoE(-/-) and LDL-Receptor(-/-) mice are commonly used in atherosclerosis research; our objective was to point out the differences in HDL metabolism between mice and humans regarding the roles of apoE and LDLR. METHODS:We examined HDL particles obtained from wild type (WT), LDLR(-/-), and apoE(-/-) mice, ...

journal_title：Atherosclerosis

authors： Tani M,Matera R,Horvath KV,Hasan TS,Schaefer EJ,Asztalos BF

更新日期：2014-03-01 00:00:00

abstract：:The dose-response effects of clofibrate and niceritrol on serum cholesterol and triglycerides (TG) were studied in 29 patients with Type IIa and IIb hyperlipoproteinaemia. In 17 patients, clofibrate and niceritrol were then given as combined treatment, and the effects of this combination on serum lipoproteins were stu...

journal_title：Atherosclerosis

authors： Olsson AG,Orö L,Rössner S

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

journal_title：Atherosclerosis

authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

更新日期：2011-12-01 00:00:00

abstract：:Coating a silica surface with the isolated lipoprotein receptor proteoheparan sulfate (HS-PG) from arterial endothelium and vascular matrices and adding both the atherogenic VLDL/IDL/LDL lipid fraction in its native composition and Ca(2+) ions, we could observe in vitro the earliest stages of atherosclerotic plaque de...

journal_title：Atherosclerosis

authors： Rodríguez M,Ringstad L,Schäfer P,Just S,Hofer HW,Malmsten M,Siegel G

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was obs...

journal_title：Atherosclerosis

authors： Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

更新日期：2015-04-01 00:00:00