Abstract:
:Young pigs with hypertension of 10 weeks duration, resulting from cellophane perinephritis, were injected with 125I-labelled low-density lipoprotein ([125I]LDL) before being killed 24 h or 48 h later. Intimal thickening and increased acid mucopolysaccharide were demonstrated in the aortas and major arteries of the hypertensive animals. Increased accumulation of [125I]LDL was observed in the inner media beneath areas of intimal thickening. It is suggested that the primary effect of hypertension in atherosclerosis is to produce structural changes in arterial connective tissue which allow increased accumulation of LDL by altering the permeability and binding properties of the arterial wall.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Sharpe DN,Scott PJ,Flint MH,Donald Jdoi
10.1016/0021-9150(80)90180-xsubject
Has Abstractpub_date
1980-04-01 00:00:00pages
393-411issue
4eissn
0021-9150issn
1879-1484pii
0021-9150(80)90180-Xjournal_volume
35pub_type
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