Abstract：
AIM:To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. METHODS AND RESULTS:Data were collected from 18 Dutch FCHL probands, 202 living first and second degree relatives, and 175 spouses. Probands and first degree relatives showed dyslipidemia, increased plasma insulin and glucose concentrations, higher waist--hip ratio (WHR), and blood pressure, than spouses. The frequency of the minor alleles M2 and S2 was increased in probands and first degree relatives. The Odds Ratio for CAD was 5.3 in male FCHL relatives (P=0.005), and 5.1 in all FCHL relatives (P=0.001). First and second degree relatives had a markedly reduced CAD-free life-span (logrank vs. spouses: P<0.001 and P=0.03, respectively). The presence of the S2, but not M2, minor allele, showed a marked reduction in CAD-free life-span (logrank S2 present vs. S2 absent: P=0.035). CONCLUSION:Men with FCHL have a severely increased risk of CAD, that appears to be mediated through genetic relation to the proband as the strongest independent risk factor for CAD, followed by increased WHR.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Voors-Pette C,de Bruin TWdoi
10.1016/s0021-9150(00)00752-8keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
481-9issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(00)00752-8journal_volume
157pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：OBJECTIVE:Hemodynamic forces are potential determinants of aortic atherosclerosis. Aortic regurgitation (AR) alters the flow pattern in the aorta. However, the association between AR and aortic atherosclerosis is not well known. METHODS:We assessed the presence, extent and distribution of atherosclerotic lesions in th...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.05.026
更新日期：2011-09-01 00:00:00
abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00583-4
更新日期：2002-02-01 00:00:00
abstract：:This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms (AAAs), and to examine their role in lymphoid recruitment. AAA T-lymphocytes were CXCR4-positive, CCR7-negative and partially CXCR3 and CCR5-positive. Functionally, AAA T-cell...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.12.043
更新日期：2008-10-01 00:00:00
abstract：:Self-administration of anabolic-androgenic steroids to increase muscular strength and lean body mass has been used widely among athletes. Flow mediated dilatation (FMD) determined by ultrasound of the brachial artery is accepted as both an in vivo index of endothelial function and an indicator for future atheroscleros...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00465-8
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.05.001
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects with the features of the metabolic syndrome. METHODS:In this cross-sectional study, 379 Caucasian men from the general population and coveri...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2014.09.022
更新日期：2014-12-01 00:00:00
abstract：:This study assessed the efficacy of rosuvastatin for reducing plasma low-density lipoprotein (LDL) cholesterol after 18 weeks of open-label, forced titration in patients with homozygous familial hypercholesterolaemia (hoFH) and compared the efficacy of rosuvastatin 80 mg and atorvastatin 80 mg. Forty-four patients age...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.atherosclerosis.2007.06.028
更新日期：2008-03-01 00:00:00
abstract：:This review evaluates novel beneficial effects of circulating endothelial progenitor cells (EPCs) as shown by several preclinical studies and clinical trials carried out to test the safety and feasibility of using EPCs. There are 31 registered clinical trials (and many others still ongoing) and 19 published studies. E...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2010.10.039
更新日期：2011-03-01 00:00:00
abstract：:The new millennium has brought intense focus of interest on the risk of cardiovascular disease in women. The polycystic ovary syndrome (PCOS) is a common endocrine disorder in women characterised by hyperandrogenism and oligomenorrhoea. Most women with PCOS also exhibit features of the metabolic syndrome, including in...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2005.10.007
更新日期：2006-04-01 00:00:00
abstract：:Young pigs with hypertension of 10 weeks duration, resulting from cellophane perinephritis, were injected with 125I-labelled low-density lipoprotein ([125I]LDL) before being killed 24 h or 48 h later. Intimal thickening and increased acid mucopolysaccharide were demonstrated in the aortas and major arteries of the hyp...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(80)90180-x
更新日期：1980-04-01 00:00:00
abstract：:The effect of short-term dietary restriction on plasma cholesterol and cholesterol balance was examined in young While Carneau pigeons. Dietary restriction of 1 month increased plasma cholesterol significantly and subsequently decreased to initial levels at 3 months. The fecal excretion of neutral sterols was signific...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(76)90143-x
更新日期：1976-09-01 00:00:00
abstract：:Interleukin-8 (IL-8) is a potent chemotactic factor that has been implicated in atherogenesis. HMG-CoA reductase inhibitors (statins) may reduce the cardiovascular risk and vulnerability of atherosclerotic plaque through nonlipid mechanisms such as inhibition of cytokine expression. In this study, we investigated the ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(02)00194-6
更新日期：2002-11-01 00:00:00
abstract：:Gross dissection of the coronary arteries of 566 subjects aged 0--45 years from an unselected population sample of Bucharest revealed the presence of a similar anatomical branching pattern in 58% of cases. Starting from this common type of distribution of coronary arteries, some minor deviations were detected coexisti...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(81)90141-6
更新日期：1981-11-01 00:00:00
abstract：OBJECTIVE:To investigate the lipotropic action of betaine on plasma lipoproteins and tissue lipids. METHODS AND RESULTS:Adult mice, wild type (+/+) or heterozygous (+/-) for a disruption of the methylenetetrahydrofolate reductase (Mthfr) gene, were supplemented with betaine for 1 year and compared with mice on control...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.06.030
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND AND AIMS:A small crypt in the Santissima Annunziata Church of Santa Maria della Scala Hospital in Siena (Italy) contained three well-preserved mummies, two of which, dated back to the 15th-16th century, were identified as Salimbene Capacci (1433-1497), Rector of the Hospital, and his wife, Margherita Sozzini...
journal_title：Atherosclerosis
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.atherosclerosis.2018.11.028
更新日期：2019-01-01 00:00:00
abstract：:Inflammation is one of the most important mechanisms that contribute to coronary artery disease (CAD). One of the micro-organisms that is mentioned as a source of the inflammation is Chlamydia pneumoniae. In this study, we investigated the relationship between titres of IgG and IgA antibodies to C. pneumoniae and the ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00436-6
更新日期：2000-12-01 00:00:00
abstract：:Endurance exercise training is known to produce favorable changes in the metabolic profile including reduced plasma triglyceride (TG) and increased high-density lipoprotein (HDL) cholesterol concentrations. These metabolic improvements are likely to contribute to the reduced coronary heart disease (CHD) risk often obs...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00515-9
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin, a receptor that regulates VSMC proliferation and migration. This study determined whether an antibody that had previ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2017.01.030
更新日期：2017-03-01 00:00:00
abstract：:Observational studies suggested that the progression of carotid atherosclerosis and plaques might be an independent risk factor for coronary artery disease (CAD) and stroke, prior researches of different dosage of statins therapy on the progression of carotid atherosclerosis in patients had small sample sizes and diff...
journal_title：Atherosclerosis
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.atherosclerosis.2004.08.005
更新日期：2004-12-01 00:00:00
abstract：AIMS:The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking. METHODS AND RESULTS:Our study is based on a subset of participants in the Atherosclerosis Risk in C...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2005.03.017
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight. METHODS:Serum and lipoprotein squalene and non-cholesterol sterols were quantitated with gas-liquid chromatography in 33 d...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.07.030
更新日期：2007-09-01 00:00:00
abstract：:Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism. We hypothesize that HL expression is regulated as an integral part of intracellular lipid homeostasis. Addition of oleate (1 mM) to HepG2 cells increased HL secretion to 134+/-14% o...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2004.10.027
更新日期：2005-03-01 00:00:00
abstract：:Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokinesis and has been shown in cultures of vascular smooth muscle cells t...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(96)06047-9
更新日期：1997-04-01 00:00:00
abstract：:The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevate...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.03.020
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND AND AIMS:We aimed to study subclinical non-invasive vascular markers as predictors of incident long-term cognitive impairment in a longitudinal population-based study. METHODS:The Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) study is a population-based study that included a random sample of 93...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2020.08.025
更新日期：2020-11-01 00:00:00
abstract：:Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2003.12.003
更新日期：2004-03-01 00:00:00
abstract：:Apolipoprotein E phenotypes and fasting lipid and other biochemical parameters were determined in 51 patients with recently diagnosed coronary heart disease (CHD) and 164 control subjects. The age of the participants was 62.5 +/- 6.6 (S.D.) and 63% were male. Forty-eight CHD cases and 51 control subjects were also stu...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(96)06062-5
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND AND AIMS:Atherosclerosis starts early in life. We aimed to assess the dimension and progression of the intima-media thickness, a surrogate marker for early vascular aging, and its association with a broad palette of cardiovascular risk and lifestyle factors in a large cohort of healthy adolescents. METHODS:...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2020.05.011
更新日期：2020-07-01 00:00:00
abstract：:The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyper-lipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(84)90003-0
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown. METHODS:Data were from 1403 adults (...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2012.03.004
更新日期：2012-06-01 00:00:00
