Abstract：
:This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms (AAAs), and to examine their role in lymphoid recruitment. AAA T-lymphocytes were CXCR4-positive, CCR7-negative and partially CXCR3 and CCR5-positive. Functionally, AAA T-cells were proinflammatory effector cells, as they produced IFN-gamma and granzyme A. AAA B-lymphocytes were CXCR4-positive and exhibited low CXCR5 expression. A relevant feature of infiltrating T- and B-lymphocytes was the high intensity of CXCR4 expression and the capability to migrate to CXCL12. CXCL12-producing cells were found in the adventitia of AAA. These cells were CD45-negative and partially VCAM-1 and DR-positive. In summary, the present results suggest that CXCR4, expressed on infiltrating lymphocytes, and CXCL12, expressed on stromal cells, is involved in the recruitment of lymphocytes within the arterial wall in AAA.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Ocaña E,Pérez-Requena J,Bohórquez JC,Brieva JA,Rodríguez Cdoi
10.1016/j.atherosclerosis.2007.12.043subject
Has Abstractpub_date
2008-10-01 00:00:00pages
264-70issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(08)00009-9journal_volume
200pub_type
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