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Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults.

Abstract：

AIMS:The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking. METHODS AND RESULTS:Our study is based on a subset of participants in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examination during visit 4 (1996-1998). The outcome was mean carotid IMT>/=1mm assessed by B-mode ultrasound. The exposures were serum IgG antibody levels against 17 periodontal organisms using a whole bacterial checkerboard immunoblotting technique. Evaluation of all 17 antibodies indicated that antibody to Campylobacter rectus resulted in the best-fitting model (OR=2.3, 95% CI=1.83-2.84) and individuals with both high C. rectus and Peptostreptococcus micros titers had almost twice the prevalence of IMT>/=1mm than those with only a high C. rectus antibody (8.3% versus 16.3%). Stratification by smoking indicated that all microbial models significant for smokers were also significant for never smokers except for Porphyromonas gingivalis (p=0.08). CONCLUSIONS:This is the first study to report a relationship between IgG antibody reactive to oral organisms and subclinical atherosclerosis with significant relationships evident in both ever and never smokers.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Beck JD,Eke P,Lin D,Madianos P,Couper D,Moss K,Elter J,Heiss G,Offenbacher S

doi

10.1016/j.atherosclerosis.2005.03.017

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

342-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00226-1

journal_volume

183

pub_type

杂志文章

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