Endothelial progenitor cells as therapeutic agents in the microcirculation: an update.


:This review evaluates novel beneficial effects of circulating endothelial progenitor cells (EPCs) as shown by several preclinical studies and clinical trials carried out to test the safety and feasibility of using EPCs. There are 31 registered clinical trials (and many others still ongoing) and 19 published studies. EPCs originate in the bone marrow and migrate into the bloodstream where they undergo a differentiation program leading to major changes in their antigenic characteristics. EPCs lose typical progenitor markers and acquire endothelial markers, and two important receptors, (VEGFR and CXCR-4), which recruit circulating EPCs to damaged or ischemic microcirculatory (homing to damaged tissues) beds. Overall, therapeutic angiogenesis will likely change the face of regenerative medicine in the next decade with many patients worldwide predicted to benefit from these treatments.






Napoli C,Hayashi T,Cacciatore F,Casamassimi A,Casini C,Al-Omran M,Ignarro LJ




Has Abstract


2011-03-01 00:00:00














  • In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?

    abstract:OBJECTIVES:To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). METHODS:We compared 28 mg/kg crystalline IR niacin, equimolar doses of crystalline IR ST0702 and control on low densit...


    pub_type: 杂志文章


    authors: Ledwidge MT,Ryan F,Kerins DM,O'Connell D,Cefali G,Harmon S,Jones M,Gilmer JF

    更新日期:2012-04-01 00:00:00

  • Metabolic responses following isoproterenol-induced myocardial infarction in arteriosclerotic breeder vs. non-arteriosclerotic virgin and ovariectomized female rats.

    abstract::Intact and ovariectomized, non-arteriosclerotic female rats and arteriosclerotic, breeder female rats were subjected to myocardial infarction by the administration of 2 subcutaneous injections, 24 hr apart, of the beta-adrenergic stimulator, isoproterenol. The animals were sacrificed at regular hourly intervals follow...


    pub_type: 杂志文章


    authors: Lewis BK,Wexler BC

    更新日期:1975-05-01 00:00:00

  • Coronary heart disease in 'low risk' men.

    abstract::An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...


    pub_type: 杂志文章


    authors: Heller RF,Miller NE,Wheeler MJ,Kind PR

    更新日期:1983-11-01 00:00:00

  • Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice.

    abstract:OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...


    pub_type: 杂志文章


    authors: Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

    更新日期:2012-10-01 00:00:00

  • Alcohol consumption and risk of recurrent cardiovascular events and mortality in patients with clinically manifest vascular disease and diabetes mellitus: the Second Manifestations of ARTerial (SMART) disease study.

    abstract:OBJECTIVE:This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. METHODS:Patients with clinically manifest vascular disease or diabetes (n=5447) from the SMART study...


    pub_type: 杂志文章


    authors: Beulens JW,Algra A,Soedamah-Muthu SS,Visseren FL,Grobbee DE,van der Graaf Y,SMART Study Group.

    更新日期:2010-09-01 00:00:00

  • Topology of protease activities reflects atherothrombotic plaque complexity.

    abstract::The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...


    pub_type: 杂志文章


    authors: Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

    更新日期:2007-03-01 00:00:00

  • Aortic size and aortic calcification. A necropsy Study.

    abstract::Measurements of aortic length and circumference in 336 post-mortem specimens confirm earlier, neglected observations on the progressive increase in aortic size which occurs with advancing years. The increase is not related to atherosclerosis , or to hypertension and seems to be part of a true ageing process. The value...


    pub_type: 杂志文章


    authors: Mitchell JR,Adams JH

    更新日期:1977-08-01 00:00:00

  • Latvian registry of familial hypercholesterolemia: The first report of three-year results.

    abstract:BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...


    pub_type: 杂志文章


    authors: Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

    更新日期:2018-10-01 00:00:00

  • Reduced systemic inflammatory response to implantation of sirolimus-eluting stents in patients with stable coronary artery disease.

    abstract::Stent implantation causes significant injury to the vascular wall, resulting in inflammatory activation. Although sirolimus-eluting stents (SES) have anti-inflammatory properties, their effect on periprocedural systemic inflammatory response has not been sufficiently investigated. Eighty-one patients with stable coron...


    pub_type: 杂志文章,随机对照试验


    authors: Kochiadakis GE,Marketou ME,Arfanakis DA,Sfiridaki K,Skalidis EI,Igoumenidis NE,Hamilos MI,Kolyvaki S,Chlouverakis G,Kantidaki E,Castanas E,Vardas PE

    更新日期:2007-10-01 00:00:00

  • Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease.

    abstract:OBJECTIVES:Compare carotid plaque morphology of acute symptomatic, recently symptomatic and asymptomatic patients (groups 1, 2 and 3 respectively) with carotid artery disease using high resolution magnetic resonance imaging (MRI), to identify high-risk plaque characteristics best associated with risk of recurrent throm...


    pub_type: 杂志文章


    authors: Sadat U,Weerakkody RA,Bowden DJ,Young VE,Graves MJ,Li ZY,Tang TY,Gaunt ME,Hayes PD,Gillard JH

    更新日期:2009-12-01 00:00:00

  • Changes of apolipoprotein A-IV in the human neonate: evidence for different inductions of apolipoproteins A-IV and A-I in the postpartum period.

    abstract::The levels, isoforms and distribution of apolipoprotein A-IV (apo A-IV) were investigated in 127 term human umbilical cord sera. In addition, apo A-IV levels and isoforms were determined on the 3rd (n = 82) and 6th (n = 68) day following parturition and compared to apo A-I concentrations. Levels of apo A-IV were low i...


    pub_type: 杂志文章


    authors: Steinmetz A,Czekelius P,Thiemann E,Motzny S,Kaffarnik H

    更新日期:1988-01-01 00:00:00

  • Cholestanol: a serum marker to guide LDL cholesterol-lowering therapy.

    abstract::Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can be used to guide ...


    pub_type: 杂志文章,评审


    authors: Hoenig MR,Rolfe BE,Campbell JH

    更新日期:2006-02-01 00:00:00

  • Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients.

    abstract::HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes. Drug-mediated quantitative and qualitative HDL modifications could be involved in these negative results. To evaluate the quantitative and qualitative effects of niacin and fenofibrate ...


    pub_type: 杂志文章,随机对照试验


    authors: Masana L,Cabré A,Heras M,Amigó N,Correig X,Martínez-Hervás S,Real JT,Ascaso JF,Quesada H,Julve J,Palomer X,Vázquez-Carrera M,Girona J,Plana N,Blanco-Vaca F

    更新日期:2015-02-01 00:00:00

  • Comparison of the metabolism of [1,2,6,7-3H(N)]cholesteryl oleate, cholesteryl [9,10-3H]oleate, and cholesteryl [1-14C]oleate labeled lipoproteins in the rat.

    abstract::The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...


    pub_type: 杂志文章


    authors: Terpstra AH

    更新日期:1994-04-01 00:00:00

  • Analysis of serum lipid levels in Japanese men and women according to body mass index. Increase in risk of atherosclerosis in postmenopausal women. Research Group on Serum Lipid Survey 1990 in Japan.

    abstract::Relatively low serum lipid levels are thought to be an important factor contributing to the low incidence of ischemic heart diseases (IHD) in Japanese. It has been proven that obesity or overweight constitutes a basal condition for several risk factors in atherosclerosis. The purpose of this study is to obtain data on...


    pub_type: 杂志文章


    authors: Yamamoto A,Horibe H,Mabuchi H,Kita T,Matsuzawa Y,Saito Y,Nakaya N,Fujioka T,Tenba H,Kawaguchi A,Nakamura H,Goto Y

    更新日期:1999-03-01 00:00:00

  • Lack of association between carotid intima-media thickness and paraoxonase gene polymorphism in non-insulin dependent diabetes mellitus.

    abstract::Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...


    pub_type: 杂志文章


    authors: Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

    更新日期:1998-06-01 00:00:00

  • Coordinate changes in the low density lipoprotein receptor activity of liver and mononuclear cells in the rabbit.

    abstract::In the rabbit, dietary cholesterol downregulates the hepatic LDL receptor and concomitant treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors partly restores its expression. The aim of this study was to determine whether the LDL receptor activity of circulating mononuclear cells would r...


    pub_type: 杂志文章


    authors: Roach PD,Kerry NL,Whiting MJ,Nestel PJ

    更新日期:1993-07-01 00:00:00

  • Serum low-density lipoprotein cholesterol level is strong risk factor for acquired color vision impairment in young to middle-aged Japanese men: the Okubo Color Study Report 2.

    abstract:OBJECTIVE:To investigate associations between blood low-density lipoprotein cholesterol (LDL-C) levels and the prevalence of acquired color vision impairment (ACVI) in middle-aged Japanese men. METHODS:Participants in this cross-sectional study underwent color vision testing, ophthalmic examination, a standardized int...


    pub_type: 杂志文章


    authors: Shoji T,Sakurai Y,Sato H,Chihara E,Ishida M,Omae K

    更新日期:2010-06-01 00:00:00

  • Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters.

    abstract::We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...


    pub_type: 杂志文章


    authors: Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

    更新日期:1995-04-24 00:00:00

  • Prediction of new-onset atrial fibrillation after first-ever ischemic stroke: A comparison of CHADS2, CHA2DS2-VASc and HATCH scores and the added value of stroke severity.

    abstract:BACKGROUND AND AIMS:Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2, CHA2DS2-VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding ...


    pub_type: 杂志文章


    authors: Hsieh CY,Lee CH,Wu DP,Sung SF

    更新日期:2018-05-01 00:00:00

  • Low-grade albuminuria is associated with peripheral artery disease in Chinese diabetic patients.

    abstract:BACKGROUND:Increasing studies have suggested that albuminuria might be an important risk factor for peripheral artery disease (PAD). However, studies focusing on the association between low-grade albuminuria and PAD are limited. It would be of great interest to elucidate the association between low-grade albuminuria an...


    pub_type: 杂志文章


    authors: Xu B,Dai M,Li M,Sun K,Zhang J,Wang T,Sun J,Chen Y,Xu M,Lu J,Bi Y

    更新日期:2014-02-01 00:00:00

  • Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia.

    abstract:OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...


    pub_type: 杂志文章


    authors: Evans D,Aberle J,Beil FU

    更新日期:2011-12-01 00:00:00

  • Selective uptake of high-density lipoprotein-associated cholesteryl esters and high-density lipoprotein particle uptake by human monocyte-macrophages.

    abstract::High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by many cells without parallel uptake of HDL apolipoproteins. This selective uptake of HDL CE was investigated in human monocyte-derived macrophages (HMM). HDL3 (d = 1.125-1.21 g/ml) was labeled in its apolipoprotein A-I moiety with 125I and in its CE...


    pub_type: 杂志文章


    authors: Rinninger F,Deichen JT,Jäckle S,Windler E,Greten H

    更新日期:1994-02-01 00:00:00

  • Cholesteryl ester cycle in cultured hepatoma cells.

    abstract::The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...


    pub_type: 杂志文章


    authors: Glick JM,Adelman SJ,Rothblat GH

    更新日期:1987-04-01 00:00:00

  • Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease.

    abstract:BACKGROUND:We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS:Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was ...


    pub_type: 杂志文章


    authors: Sharma R,Pellerin D,Gaze DC,Mehta RL,Gregson H,Streather CP,Collinson PO,Brecker SJ

    更新日期:2007-04-01 00:00:00

  • Changes in very low and low density lipoproteins with dietary fat modification.

    abstract::Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...


    pub_type: 杂志文章


    authors: Weisweiler P,Drosner M,Janetschek P,Schwandt P

    更新日期:1983-12-01 00:00:00

  • Familial hypercholesterolemia and atherosclerotic cardiovascular mortality among Korean adults with low levels of serum cholesterol.

    abstract:BACKGROUND AND AIMS:A few studies examined association between familial hypercholesterolemia (FH) and atherosclerotic cardiovascular disease (ASCVD) in Asians with low levels of serum cholesterol. The objectives of this study were to estimate the prevalence of familial hypercholesterolemia phenotype (FH-P) and examined...


    pub_type: 杂志文章


    authors: Jung KJ,Koh H,Choi Y,Lee SJ,Ji E,Jee SH

    更新日期:2018-11-01 00:00:00

  • No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels.

    abstract:BACKGROUND AND AIMS:Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potentially limited efficacy. Patients with very low levels of HDL-cholester...


    pub_type: 杂志文章


    authors: Zheng KH,Kaiser Y,van Olden CC,Santos RD,Dasseux JL,Genest J,Gaudet D,Westerink J,Keyserling C,Verberne HJ,Leitersdorf E,Hegele RA,Descamps OS,Hopkins P,Nederveen AJ,Stroes ESG

    更新日期:2020-10-01 00:00:00

  • Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients.

    abstract::Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...


    pub_type: 杂志文章


    authors: Porreca E,Sergi R,Baccante G,Reale M,Orsini L,Febbo CD,Caselli G,Cuccurullo F,Bertini R

    更新日期:1999-10-01 00:00:00

  • Changes of serum apolipoprotein levels after oral administration of fat in human subjects.

    abstract::Changes of serum apolipoprotein levels were studied every hour for 6 h after the administration of 55 g butter to 8 healthy male subjects. The mean serum apo A-IV level was significantly increased at 4 h (P less than 0.05) after fat ingestion compared to the mean initial level, although no significant changes of level...


    pub_type: 杂志文章


    authors: Seishima M,Noma A,Torizawa H,Muto Y

    更新日期:1988-09-01 00:00:00