Endothelial progenitor cells as therapeutic agents in the microcirculation: an update.

abstract：OBJECTIVES:To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). METHODS:We compared 28 mg/kg crystalline IR niacin, equimolar doses of crystalline IR ST0702 and control on low densit...

journal_title：Atherosclerosis

authors： Ledwidge MT,Ryan F,Kerins DM,O'Connell D,Cefali G,Harmon S,Jones M,Gilmer JF

更新日期：2012-04-01 00:00:00

abstract：:Intact and ovariectomized, non-arteriosclerotic female rats and arteriosclerotic, breeder female rats were subjected to myocardial infarction by the administration of 2 subcutaneous injections, 24 hr apart, of the beta-adrenergic stimulator, isoproterenol. The animals were sacrificed at regular hourly intervals follow...

journal_title：Atherosclerosis

authors： Lewis BK,Wexler BC

更新日期：1975-05-01 00:00:00

abstract：:An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...

journal_title：Atherosclerosis

authors： Heller RF,Miller NE,Wheeler MJ,Kind PR

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...

journal_title：Atherosclerosis

authors： Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:This study investigated the relation between alcohol consumption and specific vascular events and mortality in a high risk population of patients with clinical manifestations of vascular disease and diabetes. METHODS:Patients with clinically manifest vascular disease or diabetes (n=5447) from the SMART study...

journal_title：Atherosclerosis

authors： Beulens JW,Algra A,Soedamah-Muthu SS,Visseren FL,Grobbee DE,van der Graaf Y,SMART Study Group.

更新日期：2010-09-01 00:00:00

abstract：:The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...

journal_title：Atherosclerosis

authors： Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

更新日期：2007-03-01 00:00:00

abstract：:Measurements of aortic length and circumference in 336 post-mortem specimens confirm earlier, neglected observations on the progressive increase in aortic size which occurs with advancing years. The increase is not related to atherosclerosis , or to hypertension and seems to be part of a true ageing process. The value...

journal_title：Atherosclerosis

authors： Mitchell JR,Adams JH

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...

journal_title：Atherosclerosis

authors： Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

更新日期：2018-10-01 00:00:00

abstract：:Stent implantation causes significant injury to the vascular wall, resulting in inflammatory activation. Although sirolimus-eluting stents (SES) have anti-inflammatory properties, their effect on periprocedural systemic inflammatory response has not been sufficiently investigated. Eighty-one patients with stable coron...

journal_title：Atherosclerosis

authors： Kochiadakis GE,Marketou ME,Arfanakis DA,Sfiridaki K,Skalidis EI,Igoumenidis NE,Hamilos MI,Kolyvaki S,Chlouverakis G,Kantidaki E,Castanas E,Vardas PE

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Compare carotid plaque morphology of acute symptomatic, recently symptomatic and asymptomatic patients (groups 1, 2 and 3 respectively) with carotid artery disease using high resolution magnetic resonance imaging (MRI), to identify high-risk plaque characteristics best associated with risk of recurrent throm...

journal_title：Atherosclerosis

authors： Sadat U,Weerakkody RA,Bowden DJ,Young VE,Graves MJ,Li ZY,Tang TY,Gaunt ME,Hayes PD,Gillard JH

更新日期：2009-12-01 00:00:00

abstract：:The levels, isoforms and distribution of apolipoprotein A-IV (apo A-IV) were investigated in 127 term human umbilical cord sera. In addition, apo A-IV levels and isoforms were determined on the 3rd (n = 82) and 6th (n = 68) day following parturition and compared to apo A-I concentrations. Levels of apo A-IV were low i...

journal_title：Atherosclerosis

authors： Steinmetz A,Czekelius P,Thiemann E,Motzny S,Kaffarnik H

更新日期：1988-01-01 00:00:00

abstract：:Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can be used to guide ...

journal_title：Atherosclerosis

authors： Hoenig MR,Rolfe BE,Campbell JH

更新日期：2006-02-01 00:00:00

abstract：:HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes. Drug-mediated quantitative and qualitative HDL modifications could be involved in these negative results. To evaluate the quantitative and qualitative effects of niacin and fenofibrate ...

journal_title：Atherosclerosis

authors： Masana L,Cabré A,Heras M,Amigó N,Correig X,Martínez-Hervás S,Real JT,Ascaso JF,Quesada H,Julve J,Palomer X,Vázquez-Carrera M,Girona J,Plana N,Blanco-Vaca F

更新日期：2015-02-01 00:00:00

abstract：:The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

journal_title：Atherosclerosis

authors： Terpstra AH

更新日期：1994-04-01 00:00:00

abstract：:Relatively low serum lipid levels are thought to be an important factor contributing to the low incidence of ischemic heart diseases (IHD) in Japanese. It has been proven that obesity or overweight constitutes a basal condition for several risk factors in atherosclerosis. The purpose of this study is to obtain data on...

journal_title：Atherosclerosis

authors： Yamamoto A,Horibe H,Mabuchi H,Kita T,Matsuzawa Y,Saito Y,Nakaya N,Fujioka T,Tenba H,Kawaguchi A,Nakamura H,Goto Y

更新日期：1999-03-01 00:00:00

abstract：:Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...

journal_title：Atherosclerosis

authors： Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

更新日期：1998-06-01 00:00:00

abstract：:In the rabbit, dietary cholesterol downregulates the hepatic LDL receptor and concomitant treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors partly restores its expression. The aim of this study was to determine whether the LDL receptor activity of circulating mononuclear cells would r...

journal_title：Atherosclerosis

authors： Roach PD,Kerry NL,Whiting MJ,Nestel PJ

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To investigate associations between blood low-density lipoprotein cholesterol (LDL-C) levels and the prevalence of acquired color vision impairment (ACVI) in middle-aged Japanese men. METHODS:Participants in this cross-sectional study underwent color vision testing, ophthalmic examination, a standardized int...

journal_title：Atherosclerosis

authors： Shoji T,Sakurai Y,Sato H,Chihara E,Ishida M,Omae K

更新日期：2010-06-01 00:00:00

abstract：:We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...

journal_title：Atherosclerosis

authors： Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

更新日期：1995-04-24 00:00:00

abstract：BACKGROUND AND AIMS:Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2, CHA2DS2-VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding ...

journal_title：Atherosclerosis

authors： Hsieh CY,Lee CH,Wu DP,Sung SF

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Increasing studies have suggested that albuminuria might be an important risk factor for peripheral artery disease (PAD). However, studies focusing on the association between low-grade albuminuria and PAD are limited. It would be of great interest to elucidate the association between low-grade albuminuria an...

journal_title：Atherosclerosis

authors： Xu B,Dai M,Li M,Sun K,Zhang J,Wang T,Sun J,Chen Y,Xu M,Lu J,Bi Y

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

journal_title：Atherosclerosis

authors： Evans D,Aberle J,Beil FU

更新日期：2011-12-01 00:00:00

abstract：:High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by many cells without parallel uptake of HDL apolipoproteins. This selective uptake of HDL CE was investigated in human monocyte-derived macrophages (HMM). HDL3 (d = 1.125-1.21 g/ml) was labeled in its apolipoprotein A-I moiety with 125I and in its CE...

journal_title：Atherosclerosis

authors： Rinninger F,Deichen JT,Jäckle S,Windler E,Greten H

更新日期：1994-02-01 00:00:00

abstract：:The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...

journal_title：Atherosclerosis

authors： Glick JM,Adelman SJ,Rothblat GH

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS:Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was ...

journal_title：Atherosclerosis

authors： Sharma R,Pellerin D,Gaze DC,Mehta RL,Gregson H,Streather CP,Collinson PO,Brecker SJ

更新日期：2007-04-01 00:00:00

abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...

journal_title：Atherosclerosis

authors： Weisweiler P,Drosner M,Janetschek P,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND AND AIMS:A few studies examined association between familial hypercholesterolemia (FH) and atherosclerotic cardiovascular disease (ASCVD) in Asians with low levels of serum cholesterol. The objectives of this study were to estimate the prevalence of familial hypercholesterolemia phenotype (FH-P) and examined...

journal_title：Atherosclerosis

authors： Jung KJ,Koh H,Choi Y,Lee SJ,Ji E,Jee SH

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potentially limited efficacy. Patients with very low levels of HDL-cholester...

journal_title：Atherosclerosis

authors： Zheng KH,Kaiser Y,van Olden CC,Santos RD,Dasseux JL,Genest J,Gaudet D,Westerink J,Keyserling C,Verberne HJ,Leitersdorf E,Hegele RA,Descamps OS,Hopkins P,Nederveen AJ,Stroes ESG

更新日期：2020-10-01 00:00:00

abstract：:Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...

journal_title：Atherosclerosis

authors： Porreca E,Sergi R,Baccante G,Reale M,Orsini L,Febbo CD,Caselli G,Cuccurullo F,Bertini R

更新日期：1999-10-01 00:00:00

abstract：:Changes of serum apolipoprotein levels were studied every hour for 6 h after the administration of 55 g butter to 8 healthy male subjects. The mean serum apo A-IV level was significantly increased at 4 h (P less than 0.05) after fat ingestion compared to the mean initial level, although no significant changes of level...

journal_title：Atherosclerosis

authors： Seishima M,Noma A,Torizawa H,Muto Y

更新日期：1988-09-01 00:00:00