Endothelial progenitor cells as therapeutic agents in the microcirculation: an update.

abstract：:Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...

journal_title：Atherosclerosis

authors： Hoang A,Tefft C,Duffy SJ,Formosa M,Henstridge DC,Kingwell BA,Sviridov D

更新日期：2008-03-01 00:00:00

abstract：:Mast cells (MCs) contribute to atherogenesis by releasing pro-inflammatory mediators to activate vascular cells and other inflammatory cells. This study examined whether MC activation or stabilization affects diet-induced atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. When Ldlr(-/-) mi...

journal_title：Atherosclerosis

authors： Wang J,Sjöberg S,Tia V,Secco B,Chen H,Yang M,Sukhova GK,Shi GP

更新日期：2013-08-01 00:00:00

abstract：:Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal mo...

journal_title：Atherosclerosis

authors： Herrera VL,Tsikoudakis A,Didishvili T,Ponce LR,Bagamasbad P,Gantz D,Herscovitz H,Van Tol A,Ruiz-Opazo N

更新日期：2004-11-01 00:00:00

abstract：:Laying and genetically defective non-laying hens were evaluated for plasma lipid and plasma peroxidation levels. The non-layers developed extreme hyperlipidemia as well as greatly increased levels of lipid peroxidation. It was concluded that the concurrent presence of lipid peroxidation products must be considered whe...

journal_title：Atherosclerosis

authors： Smith T,Toda T,Kummerow FA

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:To explore the cardiovascular disease (CVD) risk in prehypertensive subjects and evaluate whether high blood pressure (BP) is associated with insulin resistance (IR) and β-cell dysfunction. METHODS:A total of 2949 people aged 20-94 years old were selected in Fujian province of China. We assessed CVD risk usi...

journal_title：Atherosclerosis

authors： Chen G,Lai X,Jiang Q,Chen F,Chen N,Huang H,Liang J,Li L,Wen J,Lin L,Yao J

更新日期：2011-07-01 00:00:00

abstract：:Fatty acids have been implicated in having both anti- or pro-inflammatory actions, which may contribute to the progression and severity of atherosclerosis. Linoleic acid has been shown by others to decrease CD18 expression and leukocyte adhesion under static conditions. We investigated the effect of steric acid (18:0)...

journal_title：Atherosclerosis

authors： Rinker KD,Kirkpatrick AP,Ting-Beall HP,Shepherd RD,Levin JD,Irick J,Thomas JL,Truskey GA

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

journal_title：Atherosclerosis

authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

更新日期：2010-10-01 00:00:00

abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...

journal_title：Atherosclerosis

authors： Calabresi L,Simonelli S,Gomaraschi M,Franceschini G

更新日期：2012-06-01 00:00:00

abstract：:Ultrasound measurements are both surrogate markers and risk factors for atherosclerosis end points. Carotid intima-media thickness (IMT) is most commonly used, but ultrasound can also define structures in higher spatial dimensions, such as total plaque area (TPA) and total plaque volume (TPV). Because there are minima...

journal_title：Atherosclerosis

authors： Al-Shali K,House AA,Hanley AJ,Khan HM,Harris SB,Mamakeesick M,Zinman B,Fenster A,Spence JD,Hegele RA

更新日期：2005-02-01 00:00:00

abstract：:Long-term dietary omega-3 fatty acids improve coronary endothelial function in CAD patients, heart transplant recipients and diabetics. This study assessed whether short term omega-3 fatty acids affect radial artery function in CAD patients. A high resolution A-mode echotracking device (NIUS 02) was used to measure co...

journal_title：Atherosclerosis

authors： Kothny W,Angerer P,Störk S,von Schacky C

更新日期：1998-09-01 00:00:00

abstract：:We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...

journal_title：Atherosclerosis

authors： Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

更新日期：1995-04-24 00:00:00

abstract：BACKGROUND AND AIMS:Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have recently been associated with processes in CHD development, and may therefore represent new potential risk markers. ...

journal_title：Atherosclerosis

authors： Velle-Forbord T,Eidlaug M,Debik J,Sæther JC,Follestad T,Nauman J,Gigante B,Røsjø H,Omland T,Langaas M,Bye A

更新日期：2019-10-01 00:00:00

abstract：:We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

journal_title：Atherosclerosis

authors： Park HS,Cho SI,Song YM,Sung J

更新日期：2006-07-01 00:00:00

abstract：:Rabbit apolipoprotein A-I (apo A-I) of molecular weight 27,612 contained 241 amino acids. In contrast to its human counterpart which has 3 methionine residues, the rabbit protein possesses only one and therefore produces 2 fragments after CNBr cleavage (CNBr I and II, NH2- and COOH-terminal, respectively). From a seri...

journal_title：Atherosclerosis

authors： Leroy A,Vu-Dac N,Theret N,Pio F,Fruchart JC

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Epicardial adipose tissue (EAT) mass correlates with metabolic syndrome and coronary artery disease (CAD). However, little is known about the expression of genes involved in triglyceride (TG) storage and mobilization in EAT. We therefore analyzed the expression of genes involved in fat mobilization in EAT in...

journal_title：Atherosclerosis

authors： Jaffer I,Riederer M,Shah P,Peters P,Quehenberger F,Wood A,Scharnagl H,März W,Kostner KM,Kostner GM

更新日期：2012-01-01 00:00:00

abstract：:The heavy and light subfractions of low density lipoprotein (LDL) were bound to the same extent and with the same affinity by the LDL receptors of cultured human fibroblasts, both when assayed at 4 degrees C and when assayed at 37 degrees C. They were also degraded similarly by the low affinity, LDL-receptor-mediated ...

journal_title：Atherosclerosis

authors： Knight BL,Thompson GR,Soutar AK

更新日期：1986-03-01 00:00:00

abstract：:MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

journal_title：Atherosclerosis

authors： Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

更新日期：2013-10-01 00:00:00

abstract：:Activation of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of endothelial dysfunction and atherosclerosis. Studies evaluating the effect of AT1-receptor blockers on endothelial dysfunction in patients with coronary artery disease (CAD) revealed mixed results. Studies addressing ...

journal_title：Atherosclerosis

authors： Warnholtz A,Ostad MA,Heitzer T,Thuneke F,Fröhlich M,Tschentscher P,Schwedhelm E,Böger R,Meinertz T,Munzel T

更新日期：2007-10-01 00:00:00

abstract：:Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)-associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway. An apoD protein polymorphism has been previously reported by us. The cathodically shifted pattern seen on isoelectric focusing gels, control...

journal_title：Atherosclerosis

authors： Desai PP,Bunker CH,Ukoli FA,Kamboh MI

更新日期：2002-08-01 00:00:00

abstract：:Changes in the concentration and composition of serum very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were studied in rabbits transferred from chow diet to cholesterol-free, semipurified diets containing casein or isolated soy protein. The fat and fibre content of ...

journal_title：Atherosclerosis

authors： Kurowska EM,Hrabek-Smith JM,Carroll KK

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Transient receptor potential vanilloid type 1 channel (TRPV1) is found to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase (eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However, the mechanisms underlying the beneficial effects rem...

journal_title：Atherosclerosis

authors： Wang Y,Cui L,Xu H,Liu S,Zhu F,Yan F,Shen S,Zhu M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Observations in the past have hypothesized an association between body iron status and coronary heart disease (CHD). Epidemiological studies to date have however been inconclusive without the existence of strongly positive or strongly negative associations between iron status and coronary heart disease. OBJ...

journal_title：Atherosclerosis

authors： Das De S,Krishna S,Jethwa A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Micro-particles (MP) are secreted by various cells. Their biological roles in health and in disease remain unknown. Here we describe formation of MP in the process of ABCA1-dependent cholesterol efflux in different cell types. METHODS:The ATP-binding cassette transporter, subfamily A, member 1 (ABC...

journal_title：Atherosclerosis

authors： Hafiane A,Genest J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined wh...

journal_title：Atherosclerosis

authors： Qian S,Regan JN,Shelton MT,Hoggatt A,Mohammad KS,Herring PB,Seye CI

更新日期：2017-02-01 00:00:00

abstract：:Serum total and HDL cholesterol concentrations were measured in schoolboy populations from 16 countries. Total and HDL cholesterol concentrations were determined in one laboratory to reduce methodological variability as much as possible. A standardized protocol was used for the drawing of blood, preparation, storage a...

journal_title：Atherosclerosis

authors： Knuiman JT,Hermus RJ,Hautvast JG

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated the changes in carotid intima-media thickness (IMT) over time, and uncertainties remain on the underlying mechanisms linking depression and subclinical atherosclerosis. We carried out a prospective cohort study to evaluate whether depression is associated with changes in c...

journal_title：Atherosclerosis

authors： Pizzi C,Costa GM,Santarella L,Flacco ME,Capasso L,Bert F,Manzoli L

更新日期：2014-04-01 00:00:00

abstract：:Hypertriglyceridemia affects approximately 33% of the US population. Elevated triglyceride levels are independently associated with cardiovascular disease (CVD) risk, and severe hypertriglyceridemia is a risk factor for acute pancreatitis. Guidelines for the management of severe hypertriglyceridemia (≥5.6 mmol/L [≥500...

journal_title：Atherosclerosis

authors： Ito MK

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (DM2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. Impaired endothelial synthesis of nitric oxide (NO) is an important feature of atherothrombosis and can be estimated from endothelium-dependent flow-mediated dilation (FMD). It is controv...

journal_title：Atherosclerosis

authors： Henry RM,Ferreira I,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...

journal_title：Atherosclerosis

authors： Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

更新日期：2012-02-01 00:00:00

abstract：:The well established 'systemic' risk factors for atherosclerosis can explain only half of the variability in its occurrence. To account for some of the remaining variability, it was suggested that certain geometric features of atherosclerosis-prone segments ('geometric risk factors') can increase the likelihood of dis...

journal_title：Atherosclerosis

authors： Friedman MH,Baker PB,Ding Z,Kuban BD

更新日期：1996-09-06 00:00:00