Endothelial progenitor cells as therapeutic agents in the microcirculation: an update.


:This review evaluates novel beneficial effects of circulating endothelial progenitor cells (EPCs) as shown by several preclinical studies and clinical trials carried out to test the safety and feasibility of using EPCs. There are 31 registered clinical trials (and many others still ongoing) and 19 published studies. EPCs originate in the bone marrow and migrate into the bloodstream where they undergo a differentiation program leading to major changes in their antigenic characteristics. EPCs lose typical progenitor markers and acquire endothelial markers, and two important receptors, (VEGFR and CXCR-4), which recruit circulating EPCs to damaged or ischemic microcirculatory (homing to damaged tissues) beds. Overall, therapeutic angiogenesis will likely change the face of regenerative medicine in the next decade with many patients worldwide predicted to benefit from these treatments.






Napoli C,Hayashi T,Cacciatore F,Casamassimi A,Casini C,Al-Omran M,Ignarro LJ




Has Abstract


2011-03-01 00:00:00














  • Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.

    abstract:OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...


    pub_type: 杂志文章


    authors: Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ

    更新日期:2014-07-01 00:00:00

  • Solid phase radioimmunoassay of apolipoprotein B (apo B) in normal human plasma.

    abstract::A solid phase radioimmunoassay (RIA) has been developed for apolipoprotein B (apoB), a major constituent of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in man. Antisera were prepared against apoB in goats and rabbits, coupled to bromoacetyle cellulose, and the complex was incubated with [125I...


    pub_type: 杂志文章


    authors: Thompson GR,Birnbaumer ME,Levy RI,Gotto AM Jr

    更新日期:1976-07-01 00:00:00

  • The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters.

    abstract::This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...


    pub_type: 杂志文章


    authors: Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

    更新日期:1998-05-01 00:00:00

  • Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.

    abstract:OBJECTIVE:To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function. METHODS AND RESULTS:In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoro...


    pub_type: 杂志文章


    authors: Maas R,Quitzau K,Schwedhelm E,Spieker L,Rafflenbeul W,Steenpass A,Lüscher TF,Böger RH

    更新日期:2007-03-01 00:00:00

  • Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.

    abstract:BACKGROUND AND AIMS:Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. ...


    pub_type: 杂志文章


    authors: do Vale GT,Simplicio JA,Gonzaga NA,Yokota R,Ribeiro AA,Casarini DE,de Martinis BS,Tirapelli CR

    更新日期:2018-07-01 00:00:00

  • Quantitative and qualitative pleiotropic differences between Simvastatin single and Vytorin combination therapy in hypercholesterolemic subjects.

    abstract:AIMS:This cross-sectional study tested the hypothesis that treatment with the combination of Ezetimibe/Simvastatin (Vytorin) leads to broader changes in the expression levels of immunomodulatory genes as compared to Simvastatin monotherapy. METHODS:Illumina's GenomeStudio gene expression module was used to compare gen...


    pub_type: 杂志文章,随机对照试验


    authors: Sternberg Z,Chichelli T,Sternberg D,Hojnacki D,Drake A,Liu S,Hu Q,Munschauer F

    更新日期:2013-12-01 00:00:00

  • Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...


    pub_type: 杂志文章,meta分析,评审


    authors: Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

    更新日期:2012-06-01 00:00:00

  • Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI).

    abstract:UNLABELLED:Recent studies have shown, that chronic flavonoids treatment improves vascular function and cardiovascular remodeling by decreasing superoxide anion production as well as by increasing NO realize from endothelial cells. A progressive decrease in systolic blood pressure and reduction of low-density lipoprotei...


    pub_type: 杂志文章,随机对照试验


    authors: Naruszewicz M,Laniewska I,Millo B,Dłuzniewski M

    更新日期:2007-10-01 00:00:00

  • Age-associated ultrastructural changes in the aortic intima of rats with diet-induced hypercholesterolemia.

    abstract::The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...


    pub_type: 杂志文章


    authors: Nakamura H,Izumiyama N,Nakamura K,Ohtsubo K

    更新日期:1989-10-01 00:00:00

  • Effects of thrice weekly nocturnal hemodialysis on arterial stiffness.

    abstract:OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...


    pub_type: 杂志文章,多中心研究


    authors: Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

    更新日期:2012-02-01 00:00:00

  • Effects of exercise training and detraining on atheromatous matrix metalloproteinase activity in mice.

    abstract:BACKGROUND AND AIMS:Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexist...


    pub_type: 杂志文章


    authors: Kim J,Jang HJ,Schellingerhout D,Kang JW,Choi S,Oh H,Kim EJ,Lee SK,Lee JS,Kwon IC,Kim K,Koh YJ,Ryu WS,Kim DE

    更新日期:2020-04-01 00:00:00

  • Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.

    abstract:BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...


    pub_type: 杂志文章


    authors: Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

    更新日期:2002-02-01 00:00:00

  • Effects of high-cholesterol diet on the interendothelial clefts and the associated junctional complexes in rat aorta.

    abstract::The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...


    pub_type: 杂志文章


    authors: Lee WC,Chao WT,Yang VC

    更新日期:2001-04-01 00:00:00

  • Effect of gemfibrozil on the concentration and composition of serum lipoproteins. A controlled study with special reference to initial triglyceride levels.

    abstract::We investigated the modulating effect of serum total triglycerides on the lipid composition of various lipoproteins, and on the response to gemfibrozil treatment. This placebo controlled study was conducted blind in 60 participants of the Helsinki Heart Study. An inverse relationship was observed between cholesterol c...


    pub_type: 临床试验,杂志文章


    authors: Mänttäri M,Koskinen P,Manninen V,Huttunen JK,Frick MH,Nikkilä EA

    更新日期:1990-02-01 00:00:00

  • Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes.

    abstract::Atherosclerosis is a complex disease that gene and environment interaction influences the progression of atherosclerotic lesion development. Our laboratory used mice lacking both the low density lipoprotein (LDL) receptor and Apobec1 genes (LDLR-/-Apobec1-/-, designated LDb) to investigate gene-gene interaction and th...


    pub_type: 杂志文章


    authors: Dutta R,Singh U,Li TB,Fornage M,Teng BB

    更新日期:2003-07-01 00:00:00

  • Carotid atherosclerosis and risk for ischemic stroke in patients with atrial fibrillation on oral anticoagulant treatment.

    abstract:BACKGROUND AND AIMS:Whether carotid atherosclerosis is associated with an increased risk for ischemic stroke in patients with atrial fibrillation (AF) on anticoagulant treatment is undefined. To explore this association, patients with AF on treatment with vitamin K antagonists were included in a multicenter, prospectiv...


    pub_type: 杂志文章,多中心研究


    authors: Becattini C,Dentali F,Camporese G,Sembolini A,Rancan E,Tonello C,Manina G,Padayattil S,Agnelli G

    更新日期:2018-04-01 00:00:00

  • The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.

    abstract:BACKGROUND:Atherosclerosis is characterized by lipid accumulation and chronic inflammation in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high-density lipoprotein (HDL) and apoA-I are pr...


    pub_type: 杂志文章


    authors: Hennuyer N,Duplan I,Paquet C,Vanhoutte J,Woitrain E,Touche V,Colin S,Vallez E,Lestavel S,Lefebvre P,Staels B

    更新日期:2016-06-01 00:00:00

  • Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:OBJECTIVE:We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND:MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary hear...


    pub_type: 杂志文章,多中心研究


    authors: Pandey AK,Blaha MJ,Sharma K,Rivera J,Budoff MJ,Blankstein R,Al-Mallah M,Wong ND,Shaw L,Carr J,O'Leary D,Lima JA,Szklo M,Blumenthal RS,Nasir K

    更新日期:2014-02-01 00:00:00

  • The use of polymorphic DNA and protein markers for the third complement component for determining linkage of familial hypercholesterolaemia.

    abstract::We have used DNA and protein polymorphisms for the third complement component (C3) to assess the potential of DNA markers in the diagnosis and study of familial hypercholesterolaemia (FH), and to confirm the reported linkage between FH and C3. The inheritance of FH and the C3 gene has been studied in 10 families by co...


    pub_type: 杂志文章


    authors: Humphries SE,Donald JA,McFadden JJ,Shull S,Williamson R,Jowett NI,Galton DJ,Julsrud JO,Berg K,Heiberg A

    更新日期:1984-09-01 00:00:00

  • Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice.

    abstract::Previous studies in mouse models showed that 12/15lipoxygenase (12/15LO) gene disruption diminishes atherosclerosis. Pharmacologic suppression of thromboxane (Tx) A(2) biosynthesis or blockade of its receptor also reduces the development of the disease in the same models. We tested the hypothesis that simultaneous gen...


    pub_type: 杂志文章


    authors: Tang L,Ding T,Praticò D

    更新日期:2008-08-01 00:00:00

  • Evidence concerning resistance to atheroma by media-like islands in the intima of coronary arteries.

    abstract::Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censo...


    pub_type: 杂志文章


    authors: Tracy RE

    更新日期:2005-01-01 00:00:00

  • Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits.

    abstract::Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...


    pub_type: 杂志文章


    authors: Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

    更新日期:1995-06-01 00:00:00

  • Q192R polymorphism of the paraoxanase 1 gene and its association with serum lipoprotein variables and carotid artery intima-media thickness in young adults from a biracial community. The Bogalusa Heart Study.

    abstract::Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...


    pub_type: 杂志文章


    authors: Srinivasan SR,Li S,Chen W,Tang R,Bond MG,Boerwinkle E,Berenson GS

    更新日期:2004-11-01 00:00:00

  • Soluble P-selectin predicts lower extremity peripheral artery disease incidence and change in the ankle brachial index: the Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:OBJECTIVE:To determine the association of circulating P-selectin with prevalent and incident peripheral artery disease (PAD), the ankle brachial index (ABI), and change in the ABI. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective population-based cohort study including 6814 European descent, A...


    pub_type: 杂志文章


    authors: Wassel CL,Berardi C,Pankow JS,Larson NB,Decker PA,Hanson NQ,Tsai MY,Criqui MH,Allison MA,Bielinski SJ

    更新日期:2015-04-01 00:00:00

  • High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.

    abstract::We tested whether low high-density lipoprotein cholesterol (HDL-C) and/or high triglycerides are associated to abnormal HDL subclasses distribution and composition, and their relationships with fasting insulin and C-reactive protein (CRP). Four groups of adolescents were studied: group 1 (HDL-C< or =35 mg/dl+TG> or =1...


    pub_type: 杂志文章


    authors: Medina-Urrutia A,Juarez-Rojas JG,Martínez-Alvarado R,Jorge-Galarza E,Posadas-Sánchez R,Cardoso-Saldaña G,Caracas-Portilla N,Mendoza-Perez E,Posadas-Romero C

    更新日期:2008-12-01 00:00:00

  • Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia.

    abstract::Mild hyperhomocysteinemia is considered an important risk factor for vascular disease. A common polymorphism (677C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased enzyme activity and consequent higher circulating levels of homocysteine. We hypothesized that the serum levels ...


    pub_type: 杂志文章


    authors: Pisciotta L,Cortese C,Gnasso A,Liberatoscioli L,Pastore A,Mannucci L,Irace C,Federici G,Bertolini S

    更新日期:2005-04-01 00:00:00

  • Decreased concentration of high density lipoprotein cholesterol in schizophrenic patients treated with phenothiazines.

    abstract::In chronic schizophrenic patients treated with phenothiazines (Chlorpromazine, Levomepromazine, Perphenazine) for long periods (average = 8 years), high density lipoprotein cholesterol (HDL-C) levels were significantly lower (P less than 0.001) compared with normal controls. The HDL subfractions showed that HDL3-C was...


    pub_type: 杂志文章


    authors: Sasaki J,Kumagae G,Sata T,Kuramitsu M,Arakawa K

    更新日期:1984-05-01 00:00:00

  • Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100.

    abstract::The primary objective of this study was to determine the variability in cholesterol carrying capacity of low density lipoproteins (LDLs) and other apolipoprotein B (apo B)-containing lipoproteins in normolipidemic men. One hundred and fifty-nine normolipidemic men, ages 21 to 73 years, were enrolled. In addition to de...


    pub_type: 杂志文章


    authors: Abate N,Vega GL,Grundy SM

    更新日期:1993-12-01 00:00:00

  • Incretin drugs as modulators of atherosclerosis.

    abstract::Atherosclerosis is a major underlying cause of ischemic heart diseases, ischemic stroke, and peripheral artery disease. Atherosclerotic plaque progression is characterized by chronic progressive inflammation of the arterial wall, endothelial cell dysfunction, and subendothelial lipoprotein retention. Incretin drugs, g...


    pub_type: 杂志文章,评审


    authors: Gallego-Colon E,Wojakowski W,Francuz T

    更新日期:2018-11-01 00:00:00

  • Large brachial and common carotid artery diameter in postmenopausal women with carotid atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:It is recognized that arteries can enlarge to compensate atherosclerosis. The role of diameter enlargement of unaffected arteries is not well known. We hypothesized that brachial and common carotid arteries diameters were larger in subjects with carotid atherosclerosis compared to subjects withou...


    pub_type: 杂志文章


    authors: Montalcini T,Gorgone G,Gazzaruso C,Sesti G,Perticone F,Pujia A

    更新日期:2008-01-01 00:00:00