Seropositivity for anti-Borrelia IgG antibody is independently associated with carotid atherosclerosis.

Abstract:

BACKGROUND:Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis. METHODS:The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with endemic Lyme disease. A random sample of 2483 individuals aged 45-79 years was available for the present analysis. Carotid atherosclerosis was sonographically assessed as intima-media thickness of the common carotid artery and as prevalent atherosclerotic plaques in the extracranial carotid arteries. IgG antibodies to Borrelia were determined by ELISA. RESULTS:IgG antibodies to Borrelia were found positive (> 10 IU/mL) in 108 subjects (4.3%). Persons with and without positive anti-Borrelia IgG antibodies differed with respect to carotid intima-media thickness values (0.863 +/- 0.017 mm versus 0.792 +/- 0.004 mm; p < 0.001) and prevalent carotid plaques (odds ratio 2.65, 95% confidence interval 1.53-4.61; p = 0.001), respectively. Seropositivity for anti-Borrelia IgG was also associated with both atherosclerotic endpoints when age, sex and further atherogenic risk factors and confounders were included in multivariable statistical models. CONCLUSIONS:In a region with endemic Lyme disease, seropositivity for anti-Borrelia IgG antibodies is independently associated with atherosclerosis. Our findings add support to the hypothesis that exposure to infectious pathogens increases the atherosclerosis risk.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Völzke H,Wolff B,Lüdemann J,Guertler L,Kramer A,John U,Felix SB

doi

10.1016/j.atherosclerosis.2004.10.048

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

108-12

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00237-6

journal_volume

184

pub_type

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    pub_type: 杂志文章,评审

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