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Modified plasma-derived lipoproteins in human atherosclerotic plaques.

Abstract：

:Low density lipoproteins extracted from surgical specimens of human atherosclerotic plaques (A-LDL) showed altered electrophoretic mobility indicating a greater negative charge than that of plasma LDL (P-LDL). A-LDL but not P-LDL showed high affinity binding/degradation by human monocyte-derived macrophages; this was inhibited by acetylated LDL but not by native P-LDL. Following injection of 125I-labelled autologous P-LDL prior to reconstructive arterial surgery, polyacrylamide and agarose gel electrophoresis of A-LDL extracted from arterial intima showed that the A-LDL and its apolipoprotein B moiety were derived from P-LDL; the electrophoretic mobility of the product A-LDL was greater than that of native P-LDL. The compositions of arterial intermediate density lipoprotein (A-IDL) and A-LDL differed from those obtained from human plasma intermediate density lipoprotein (P-IDL) and P-LDL. A-IDL showed a reduced triglyceride content and increased esterified and unesterified cholesterol. Although the total cholesterol content of A-LDL was similar to that of P-LDL, there was an increase in unesterified cholesterol and a decrease of cholesteryl ester. These studies indicate that LDL extracted from human atherosclerotic plaque is derived from and modified from P-LDL in vivo. Compared with native P-LDL, A-LDL showed differences in charge and composition, associated with its high affinity binding by the acetyl LDL receptor of human macrophages.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Shaikh M,Martini S,Quiney JR,Baskerville P,La Ville AE,Browse NL,Duffield R,Turner PR,Lewis B

doi

10.1016/0021-9150(88)90011-1

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

165-72

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(88)90011-1

journal_volume

69

pub_type

杂志文章

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